http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Yi, Na Young,Park, Shin Ae,Jeong, Man Bok,Kim, Won Tae,Kim, Se Eun,Kim, Ji Youn,Chae, Je Min,Jang, Kyoung Jin,Seong, Je Kyung,Seo, Kang Moon Blackwell Publishing Inc 2009 Veterinary ophthalmology Vol.12 No.3
<P>Abstract</P><P>Objective </P><P>To evaluate motility of silicone orbital implants and corneoscleral prostheses, with and without use of a motility coupling post (MCP) in dogs.</P><P>Animals studied </P><P>Eighteen mixed-breed dogs.</P><P>Procedures </P><P>The motility of an orbital silicone implant and corneoscleral prosthesis after enucleation (<I>n</I> = 6), evisceration (<I>n</I> = 6), or use of a MCP with evisceration (<I>n</I> = 6) in dogs were compared. One eye from each dog had surgery whereas the opposite eye was used as a control. Clinical evaluations were performed three times a week. Histopathology of the orbital tissues was performed 8 and 12 weeks after surgery.</P><P>Results </P><P>Implant motility in dogs with evisceration (vertical movement [VM] 8.04 ± 2.13; horizontal movement [HM] 11 ± 3.05) and evisceration with MCP (VM 9.61 ± 1.59); HM was significantly greater than the enucleation group (VM 0.51 ± 0.5; HM 1.22 ± 0.68) (<I>P <</I> 0.01). Prosthetic motility in dogs with evisceration with MCP was significantly greater than in dogs with evisceration; dogs with evisceration had significantly greater motility than dogs with enucleation (<I>P <</I> 0.01). No postoperative complications were observed in any of the groups. No significant abnormalities were noted on histopathology.</P><P>Conclusions </P><P>MCP placement in silicone orbital implants significantly enhanced the prosthetic motility in dogs. This study supports the use of MCP in silicone orbital implants to enhance corneoscleral prosthesis motility and cosmetics in dogs.</P>
ELSEVIER : Synthesis of novel 5-oxaprotoberberines as bioisosteres of protoberberines
( Yi Feng Jin ),( Daulat Bikram Khadka ),( Su Hui Yang ),( Chao Zhao ),( Won Jea Cho ) 전남대학교 약품개발연구소 2014 약품개발연구지 Vol.23 No.-
5-0xaprotoberberinones and 5-oxaprotoberberinium were synthesized as bioisosteres of protoberberines. 5-0xaprotoberberinones were prepared by linking phenol with the isoquinolone ring of 3-phenoIisoquinoIones by methyleneoxy bridge, while the quaternary 5-oxaprotoberberinium salt was synthesized by reduction and oxidation of the lactam moiety of 5-oxaprotoberberinone. ⓒ 2014 Elsevier Ltd. All rights reserved.
Yi, Hyo-Seung,Park, Won-Hwan,Lim, Sun-Hee,Moon, Jin-Young The Physiological Society of Korean Medicine and T 2008 동의생리병리학회지 Vol.22 No.5
This study was undertaken to elucidate the antioxidant activity of the ethanol (EEPB) and water (WEPB) extracts of Prunus persica branches. The extracts contained a high phenolic content and revealed a potent hydrogen donating activity in DPPH scavenging assay. Compared to $\alpha$-tocopherol, EEPB (p < 0.001) and WEPB (p < 0.05) significantly inhibited $FeCl_2$-ascorbic acid-induced lipid peroxidation, and also exhibited potent antiradical activities against hydroxyl radical, superoxide anion, nitric oxide and peroxynitrite. In copper- and AAPH-mediated human low-density lipoprotein (LDL) oxidation systems, the extracts demonstrated a strong antioxidant function by metal chelating, rather than direct scavenging, action. Furthermore, EEPB at 5 ${\mu}g/mL$ concentration showed 80.77% inhibition of the electrophoretic mobility of LDL, compared to 77.69% for ascorbic acid and 76.92% for BHT. These results suggest that PB branch extracts may protect against oxidative stress-induced diseases.
PTRF/Cavin-1 is Essential for Multidrug Resistance in Cancer Cells
Yi, Jae-Sung,Mun, Dong-Gi,Lee, Hyun,Park, Jun-sub,Lee, Jung-Woo,Lee, Jae-Seon,Kim, Su-Jin,Cho, Bong-Rae,Lee, Sang-Won,Ko, Young-Gyu American Chemical Society 2013 Journal of proteome research Vol.12 No.2
<P>Since detergent-resistant lipid rafts play important roles in multidrug resistance (MDR), their comprehensive proteomics could provide new insights to understand the underlying molecular mechanism of MDR in cancer cells. In the present work, lipid rafts were isolated from MCF-7 and adriamycin-resistant MCF-7/ADR cells and their proteomes were analyzed by label-free quantitative proteomics. Polymerase I and transcript release factor (PTRF)/cavin-1 was measured to be upregulated along with multidrug-resistant P-glycoprotein, caveolin-1, and serum deprivation protein response/cavin-2 in the lipid rafts of MCF-7/ADR cells. PTRF knockdown led to reduction in the amount of lipid rafts on the surface of MCF7/ADR cells as determined by cellular staining with lipid raft-specific dyes such as S-laurdan2 and FITC-conjugated cholera toxin B. PTRF knockdown also reduced MDR in MCF-7/ADR cells. These data indicate that PTRF is necessary for MDR in cancer cells via the fortification of lipid rafts.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2013/jprobs.2013.12.issue-2/pr300651m/production/images/medium/pr-2012-00651m_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr300651m'>ACS Electronic Supporting Info</A></P>
Dual roles of a variable number of tandem repeat polymorphism in the TERT gene in lung cancer
Jin, Guang,Yoo, Seung Soo,Cho, Sukki,Jeon, Hyo-Sung,Lee, Won-Kee,Kang, Hyo-Gyoung,Choi, Yi Young,Choi, Jin Eun,Cha, Sung-Ick,Lee, Eung Bae,Kim, Chang Ho,Jung, Tae Hoon,Kim, Young Tae,Park, Jae Yong Wiley (Blackwell Publishing) 2011 CANCER SCIENCE Vol.102 No.1