http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Yang, Yoosoo,Oh, Jung-Mi,Heo, Paul,Shin, Jae Yoon,Kong, Byoungjae,Shin, Jonghyeok,Lee, Ji-Chun,Oh, Jeong Su,Park, Kye Won,Lee, Choong Hwan,Shin, Yeon-Kyun,Kweon, Dae-Hyuk Biochemical Society 2013 The Biochemical journal Vol.450 No.3
<P>Anti-allergic effects of dietary polyphenols were extensively studied in numerous allergic disease models, but the molecular mechanisms of anti-allergic effects by polyphenols remain poorly understood. In the present study, we show that the release of granular cargo molecules, contained in distinct subsets of granules of mast cells, is specifically mediated by two sets of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins, and that various polyphenols differentially inhibit the formation of those SNARE complexes. Expression analysis of RBL-2H3 cells for 11 SNARE genes and a lipid mixing assay of 24 possible combinations of reconstituted SNAREs indicated that the only two active SNARE complexes involved in mast cell degranulation are Syn (syntaxin) 4/SNAP (23 kDa synaptosome-associated protein)-23/VAMP (vesicle-associated membrane protein) 2 and Syn4/SNAP-23/VAMP8. Various polyphenols selectively or commonly interfered with ternary complex formation of these two SNARE complexes, thereby stopping membrane fusion between granules and plasma membrane. This led to the differential effect of polyphenols on degranulation of three distinct subsets of granules. These results suggest the possibility that formation of a variety of SNARE complexes in numerous cell types is controlled by polyphenols which, in turn, might regulate corresponding membrane trafficking.</P>
Development of a home health care service platform for ostomy patient management
Yang Seongwoo,Park Ji Won,Hur Hyuk,Kim Min Jung,Jeong Seung-Yong,박경훈,김익용 대한대장항문학회 2024 Annals of Coloproctolgy Vol.40 No.1
Purpose: The use of an ostomy for urination and defecation leads to reduced quality of life. Although many ostomy management strategies are needed, such strategies are often implemented by patients. Thus, there is a need for a home health care service platform that can be used in ostomy patient management. Methods: We developed an ostomy patient management platform by identifying the needs of patients and medical staff through the Chronic Care Ostomy Self-Management Training Program in the United States and from studies conducted in Korea. Results: The platform encompassed physical management, psychological management, maintenance of social function, spiritual stability, and home medical care. These components were implemented through monitoring, self-care guidance, and a community platform. For the monitoring function, patients entered their health status in a mobile application (app); the medical staff at the affiliated hospital then monitored the stoma status through a web interface.Conclusion: Our platform allows medical staff to monitor ostomy patients through a web interface and help such patients to fully manage their ostomy at home using an app. We expect that the continued development of patient-oriented functions in our app will allow ostomy patients to experience quality-of-life improvements.
A Continuous SAR-DCC with the Tracking Logic
Yang, Jae-Hyuk,Yoon, Sung-Woo,Kwon, Kee-Won The Institute of Electronics and Information Engin 2018 Journal of semiconductor technology and science Vol.18 No.3
A mixed-mode digital-feedback duty-cycle corrector (DCC) with tracking logic is presented. The proposed DCC is implemented using a 65-nm CMOS process with a 1.2-V supply voltage. It achieves a rapid correction and a wide correction range using the successive approximation register (SAR) method. Furthermore, since the proposed corrector uses the tracking logic, a continuous duty-cycle correction is performed. Further, it accomplishes a duty-correction range of 35-65%, occupies an area of $225{\times}117um^2$, and requires 14 cycles for a correction. The resolutions are within 1 and 2% for the locking and tracking phases, respectively. The maximum operating frequency is 1 GHz, and the measured power consumption at 1 GHz is 3.6 mW.
Safety of modified double-stapling end-to-end gastroduodenostomy in distal subtotal gastrectomy
Yang, Han-Kwang,Lee, Hyuk-Joon,Ahn, Hye-Sung,Yoo, Moon-Won,Lee, In Kyu,Lee, Kuhn Uk Wiley Subscription Services, Inc., A Wiley Company 2007 Journal of surgical oncology Vol.96 No.7
<B>Background and Objectives</B><P>Double-stapling end-to-end gastroduodenostomy (DS-BI) has several potential advantages over other anastomotic techniques in that it is a simple procedure, with no additional gastrotomy on the remnant stomach, and less tension on the anastomosis site. We evaluated the safety of DS-BI by comparing it with the hand-sewn Billroth II gastrojejunostomy (B-II).</P><B>Methods</B><P>Medical records of 933 consecutive patients (DS-BI 428, B-II 505) who underwent distal subtotal gastrectomy were retrospectively reviewed. Several clinicopathological features and treatment results were compared between the two groups.</P><B>Results</B><P>The overall complication rates were 9.3% in the DS-BI group and 15.2% in the B-II group (P = 0.007). Anastomosis-related complications, such as anastomosis-site leakage, stenosis, and intraluminal bleeding, did not differ between the two groups (1.2% in the DS-BI group and 1.8% in the B-II group, P = 0.59). All the anastomosis-related complications were managed conservatively. Postoperative mortality rates were 0% in the DS-BI group and 0.4% (2/505) in the B-II group.</P><B>Conclusions</B><P>Modified DS-BI is a safe procedure, with short-term results similar to those of hand-sewn Billroth II anastomosis. J. Surg. Oncol. 2007;96:624–629. © 2007 Wiley-Liss, Inc.</P>
Yang, Seung Won,Lee, Seung‐,Min,Choi, Eun Young,Lee, Kyung Hye,Kim, Soo Hyuk,Shin, Min‐,Jeong,Han, Ye Sun,Kang, Seok‐,Min,Chung, Ji Hyung Wiley Subscription Services, Inc., A Wiley Company 2011 Journal of cellular biochemistry Vol.112 No.9
<P><B>Abstract</B></P><P>Cell‐penetrating peptides (CPPs), including TAT‐CPP, have been used to deliver exogenous proteins into living cells. Although a number of proteins fused to TAT‐CPP can be delivered into various cells, little is known about the proteolytic cleavage of TAT‐fusion proteins in cells. In this study, we demonstrate that a small heat shock protein (sHSP), alphaB‐crystallin (αB‐crystallin), delivered by TAT‐CPP is susceptible to proteolytic cleavage by matrix metalloproteinase‐1 (MMP‐1) in cardiac myoblast H9c2 cells. Recombinant TAT‐αB‐crystallin was efficiently transduced into H9c2 cells. For a few hours following protein transduction, generation of a 14‐kDa fragment, a cleavage band of TAT‐αB‐crystallin, increased in a time‐dependent manner. This fragment was observed only in detergent‐insoluble fractions. Interestingly, treatment with MMP inhibitors blocked the cleavage of TAT‐αB‐crystallin. In test tubes, recombinant MMP‐1 processed TAT‐αB‐crystallin to generate the major cleavage fragment 14‐kDa, as observed in the cells treated with TAT‐αB‐crystallin. The N‐terminal sequences of the 14‐kDa fragment were identified as Leu‐Arg‐Ala‐Pro‐Ser‐Trp‐Phe, indicating that this fragment is generated by cleavage at Phe54‐Leu55 of αB‐crystallin. The MMP‐1‐selective inhibitor abolished the production of 14‐kDa fragments in cells. In addition, the cleaved fragment of TAT‐αB‐crystallin was significantly reduced in cells transfected with MMP‐1 siRNA. Moreover, the enzymatic activity of MMP‐1 was markedly increased in TAT‐αB‐crystallin‐treated cells. TAT‐αB‐crystallin has a cytoprotective effect on H9c2 cells under hypoxic insult, moreover, MMP‐1‐selective inhibitor treatment led to even increased cell viability. These results suggest that MMP‐1 is responsible for proteolytic cleavage of TAT‐αB‐crystallin during its intracellular transduction in H9c2 cells. J. Cell. Biochem. 112: 2454–2462, 2011. © 2011 Wiley‐Liss, Inc.</P>