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S-665 Non-irritating concentration of skin test with commonly prescribed antibiotics in Kore an
( Ha-kyeong Won ),( Min-suk Yang ),( Woo-jung Song ),( Sea-hoon Kim ),( Heung-woo Park ),( Yoon-seok Chang ),( Kyung-up Min ),( Sang-heon Cho ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Backgrounds: Although the data on validity of skin test with drugs expect for penicillin is still scarce, positive skin reaction at non-irritating concentrations with relevant history is generally accepted for diagnosis of drug allergy. In this study, we investigated the maximal non-irritant drug concentrations for intradermal skin test with commonly prescribed antibiotics in Korean adults. Methods: Sixty one healthy volunteers were recruited. Seventeen parenteral antibiotics including beta-lactams and fluoroquinolones were evaluated. The maximal concentration of antibiotics was investigated by two steps as following; A) Intradermal skin test were repeatedly performed from full strength concentration of each drug and, if the result was positive, then serially diluted concentration till the result was negative in the first volunteer; B) establishing the nonirritating concentration identified in step A in 19 more subjects. All subjects were allowed to participate in multiple testing using different drugs. The established maximal nonirritating concentration for each type of antibiotics from this study were compared with a ‘known nonirritating concentration’ of each drug from the previous studies. Results: The mean age of the subjects is 35.0 and there were more females (77%) than males. The maximal nonirritating concentrations for ampicillin/sulbactam, aztreonam, ciprofloxacin, clindamycin, nafcillin and penicillin G from this study were comparable with the known nonirritating concentration of each agent. The maximal nonirritating concentrations of cephalosporins except for ceftriaxone were different from those from previous studies. In addition, the discrepancy between previous known concentrations and the values from this study was 10-fold and more for azithromycin, levofloxacin, meropenem, piperacillin/tazobactam, SMT/TMP, and vancomycin. The difference in nonirritating concentration among volunteers were greater than 100 fold for cefotetan, azithromycin, and vancomycin. Conclusions: To improve the reliability of skin test, study with the numerous subjects would be necessary to standardize non-irritating drug concentration for skin test.
Ha, Jeong Su,Jin, Dong Eun,Park, Seon Kyeong,Park, Chang Hyeon,Seung, Tae Wan,Bae, Dong-Won,Kim, Dae-Ok,Heo, Ho Jin Hindawi Publishing Corporation 2015 Evidence-based Complementary and Alternative Medic Vol.2015 No.-
<P>The antiamnesic effects of ethyl acetate fraction from <I>Actinidia arguta</I> (EFAA) on trimethyltin- (TMT-) induced memory impairment were investigated to find the possibility of functional food substances. EFAA showed a potent AChE inhibitory effect (IC<SUB>50</SUB> = 53 <I>μ</I>g/mL) and efficient neuroprotection against H<SUB>2</SUB>O<SUB>2</SUB>-induced oxidative stress. The administration of EFAA significantly decreased TMT-induced cognitive deficit in Y-maze, passive avoidance, and Morris water maze (MWM) tests. After the behavioral tests, the antioxidant activities were confirmed using mice brain tissues. EFAA not only showed the inhibition of AChE activity and the decline of malondialdehyde (MDA) level as a sign of lipid peroxidation but also presented the increase of the superoxide dismutase (SOD) level and the decrease of the oxidized glutathione (GSSG)/total glutathione (GSH + GSSG) ratio. Finally, the phenolics in EFAA were identified using liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry, and four main phenolics, such as quinic acid, chlorogenic acid, caffeoyl hexose, and quercetin-3-glucoside, were identified. These results suggest that EFAA containing physiological phenolics might enhance drug-induced amnesia through AChE inhibition and neuroprotection.</P>
Comparing Inhaler Use Technique Based on Inhaler Type in Elderly Patients with Respiratory Disease
( Ha Youn Lee ),( Jin Hwa Song ),( Ha-kyeong Won ),( Yeonkyung Park ),( Keun Bum Chung ),( Hyo-jeong Lim ),( Young Mee Ahn ),( Byoung Jun Lee ) 대한결핵 및 호흡기학회 2021 Tuberculosis and Respiratory Diseases Vol.84 No.1
Background: The aim of this study was to investigate inhaler device handling in elderly patients. Inhaler devices with respect to misuse and error correction were also compared. Methods: Inhaler use technique was assessed using standardized checklists at the first visit and 3-month follow-up visit after retraining. The primary outcome was difference in the acceptable use ratio among inhaler devices. Secondary outcomes included differences in error correction, the most common step of misuse, and factors affecting the accuracy of inhaler use. Results: A total of 251 patients (mean age, 76.4 years) were included. The handling of 320 devices was assessed in the study. All patients had been trained before. However, only 24.7% of them used inhalers correctly. Proportions of acceptable use for Evohaler, Respimat, Turbuhaler, Ellipta, and Breezhaler/Handihaler were 38.7%, 50.0%, 61.4%, 60.8%, and 43.2%, respectively (p=0.026). At the second visit, the acceptable use ratio had increased. There were no significant differences among inhaler types (Evohaler, 63.9%; Respimat, 86.1%; Turbuhaler, 74.3%; Ellipta, 64.6%; and Breezhaler/ Handihaler, 65.3% [p=0.129]). In multivariate analysis, body mass index, Turbuhaler, and Ellipta showed positive correlations with acceptable use of inhalers, whereas Chronic Obstructive Pulmonary Disease Assessment Test score showed a negative correlation. Conclusion: Although new inhalers have been developed, the accuracy of inhaler use remains low. Elderly patients showed more errors when using pressurized metered-dose inhalers than using dry powder inhalers and soft-mist inhalers. However, there were no significant differences in misuse among inhaler devices after individual training. Results of this study suggests that repeat training is more important than inhaler type.
Won Ha-Kyeong,Song Woo-Jung,Moon Sung do,Sohn Kyoung-Hee,Kim Ju-Young,Kim Byung-Keun,Park Heung-Woo,Bachert Claus,Cho Sang Heon 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.2
Purpose: Staphylococcus aureus enterotoxin-specific immunoglobulin E (SE-sIgE) sensitization tends to increase with age and is known to be associated with asthma and severity in older adults. However, the long-term impact of SE-sIgE in the elderly remains unknown. This study aimed to examine the relationships between SE-sIgE and fixed airflow obstruction (FAO) in a cohort of elderly asthmatics. Methods: A total of 223 elderly asthmatics and 89 controls were analyzed. Patients were assessed for demographics, history of chronic rhinosinusitis (CRS), asthma duration, acute exacerbation frequency, and lung function at baseline and then were prospectively followed up for 2 years. Serum total IgE and SE-sIgE levels were measured at baseline. Airflow obstruction was defined as forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio < 0.7 at baseline and FAO was defined as FEV1/FVC ratio < 0.7 over the 2-year follow-up. Results: At baseline, the prevalence of airflow obstruction was 29.1%. Patients with airflow obstruction were significantly more likely to be male, and have a positive smoking history, comorbid CRS, and higher levels of SE-sIgE than those without airflow obstruction. Multivariate logistic regression analysis showed that airflow obstruction was significantly associated with current smoking and SE-sIgE sensitization at baseline. After the 2-year follow-up, baseline SE-sIgE sensitization was consistently related to FAO. Meanwhile, the number of exacerbations per year was significantly correlated with SE-sIgE levels. Conclusions: Baseline SE-sIgE sensitization was significantly associated with the number of asthma exacerbations and FAO after the 2-year follow-up in elderly asthmatics. These findings warrant further investigation of the direct and mediating roles of SE-sIgE sensitization on airway remodeling.
Use of inhaler devices in elderly patients with respiratory disease
( Ha Youn Lee ),( Jin Hwa Song ),( Yeonkyung Park ),( Ha-kyeong Won ),( Keun Bum Chung ),( Young Mee Ahn ),( Byoung Jun Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Introduction: We aimed to investigate inhaler device handling in elderly patients with respiratory disease. Also, we compared the differences between inhaler devices with respect to misuse and error correction. Methods: Participants were eligible if they were aged ≥65 years, using inhaler for at least 3 months, and received inhaler training previously. Patients were assessed for inhaler technique using standardized checklists at first and 90 day follow-up visit after face-to-face retraining. We compared five different types of inhalers. The primary outcome was the differences of adequate use ratio between inhaler devices. Secondary outcomes included comparison of error correction after training, patient satisfaction on each device and most common step of misuse. Results: A total of 256 patients (mean age 76.43±6.13, male 93.4%) were included and the handling of 320 devices (MDI, 75; DPI, 199; Respimat®, 46) was assessed in the study. All have been trained in the past, but only 24.7% of them use it correctly. Appropriate use were respectively 38.7%, 50.0%, 61.4%, 60.8% and 43.2% of inhalation assessment tests with Evohaler® (n=75), Respimat® (n=46), Turbuhaler® (n=44), Ellipta® (n=74), and Breezhaler/Handihaler(n=81) (p=0.026). After retraining, appropriate usage ratio increased and there was no significant difference between inhaler device types (Evohaler® (63.9%), Respimat® (86.1%), Turbuhaler® (74.3%), Ellipta® (64.6%), and Breezhaler/Handihaler (65.3%), respectively; p=0.129). Conclusion: New inhalers were developed, but the accuracy of inhaler use was still low. This study results suggest that repeat training is more important than inhaler type.
Chemical Interface Damping of Silver-coated Gold Nanorods Using Supramolecular Host–Guest Chemistry
Kyeong Rim Ryu,Ji Won Ha 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.8
We present the chemical interface damping (CID) of single Ag-coated Au nanorods (AuNRs@Ag) using cucurbit[7]uril (CB[7])-based host?guest chemistry. The chemisorption of CB[7]-NH2 onto an AuNR@Ag surface resulted in a redshift of its localized surface plasmon resonance (LSPR) scattering peak, with a considerably increased linewidth. This LSPR broadening was ascribed to CID caused by the formation of a strong nitrogen?Ag interaction during the chemisorption of CB[7]-NH2 onto the AuNR@Ag surface. Furthermore, we observed additional broadening of the LSPR linewidth when the guest molecule (oxaliplatin) was encapsulated into CB[7]-NH2 chemisorbed onto the AuNR@Ag surface.