李東垣의 生涯와 醫學思想

崔三燮,洪元植 慶熙大學校韓醫科大學韓醫學硏究所 1981 慶熙韓醫大論文集 Vol.4 No.-

Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

필리핀 여행 후 발생한 쯔쯔가무시병 1예

김계형,김낙현,김문석,김충종,전재현,박완범,장원종,박상원,김익상,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6

Infectious diseases imported from other countries have increased as more and more Koreans are going abroad for various purposes. Tsutsugamushi disease from other endemic area such as Southeast Asia is important, because it can occur in any season and eschar may be absent. We report a case of imported tsutsugamushi disease acquired in the Philippines. A patient presented with fever, headache, and maculopapular skin rash. However, eschar was absent. Polymerase chain reaction (PCR) for 56-kDa gene of Orientia tsutsugamushi using buffy coat was positive. Serum indirect immunofluorescent antibody assay was initially negative but became positive with a titer of 1:320 at follow-up, Sequencing analysis revealed the strain to be 100% identical to the TW73R strain identified in Taiwan. After the patient received doxycycline, body temperature normalized in 12 hours. Tsutsugamushi disease is one of the differential diagnoses that should be included for patients with fever who have recently returned from Southeast Asian countries. PCR for O. tsutsugamushi using patient's buffy coat was useful for early diagnosis.

한말 일제초기 공토 정책과 국유민유 분쟁

최원규 釜山大學校 韓國民族文化硏究所 2012 한국민족문화 Vol.45 No.-

This paper deals with the land policy and land rights in the Late Great Han Empire and Early Japanese Colony. This period under discussion is divided into that of the land reform of the Gabo regime and Kwangmu inspection of the Kwangmu regime and that of the real land inspection of state-owned lands and land survey by Japanese imperialism before and after 1905. Series of these policies was the enterprise of confirming common as state-owned land. At that time disputes over land between the state and national arose mainly in the royal lands, namely second type of lands with ownership. Previously this problem was dealt with in terms of ownership of one owner in one land unit, but this study analyzed it, keeping real rights in mind. In second type of lands with ownership there were rough rice 100 dus type and rough rice 200 dus type. This was a way of atuthorities and reclaimers dividing the land rights. The former was nominal owners with the right of collecting land tax and the latter de facto owners as cultivators. Cultivation rights were considered as customary real rights. Cultivators paid the rent to authorities and paid land taxes to the Ministry of Finance. That is to say, they paid two taxes in one land unit. This was the tenant tax system prescribed by law in 1894 and was carried out until 1908. This measure was started at the same time as the real land inspection of state-owned land acknowledging the exclusive ownership on state-owned lands. In this inspection cultivation right as real right was denied, and disputes over land between the state and national arose. The disputes were terminated, coming to the conclusion that rough rice 100 dus type resulted in state-owned lands, rough rice 200 dus type private lands. 본 논문은 한말 일제초기의 토지정책과 토지권을 다룬 글이다. 다룬 시기는 1905년을 경계로 갑오정권의 甲午陞總과 광무정권의 光武査檢이 시행된 시기와, 국유지실지조사과 토지조사사업이 시행된 시기로 구분된다. 이들 일련의 토지정책은 公土를 국유지로 확정하는 사업이었다. 이때 국유민유분쟁이 격발했는데, 주로 절수사여지=제2종유토에서 발생했다. 종전에는 이 문제를 一地一主의 소유권 차원에서 다루었는데, 본 연구에서는 물권도 시야에 넣고 분석했다. 제2종유토에는 조100두형과 조200두형이 존재했다. 司宮과 개간자가 토지권을 양분한 방식이다. 전자는 수조권자로 명목적 소유자이고, 후자는 경작자로 사실상의 소유자였다. 경작권은 관습 물권으로 인정되었다. 경작자는 사궁에 賭租를, 탁지부에 結稅를 납부하는 ‘一土兩稅’를 부담했다. 1894년 법으로 정한 作人納稅制로, 1908년까지 시행되었다. 이 조치는 국유지를 배타적 소유권으로 정리하는 국유지실지조사와 동시에 시작되었다. 이 조사에서 물권적 경작권(중답주 등)이 부정되고, 국유민유 분쟁이 발생했다. 토지조사사업에서 조100두형은 민유지, 조200두형은 국유지로 결정하면서 분쟁은 종결되었다.

高等學校 生物 實驗實習敎材의 開發硏究 Ⅰ

崔斗文,李元求,文炯泰 공주대학교 사범대학 과학교육연구소 1984 과학교육연구 Vol.16 No.1

Teaching materials available for the effective performance of laboratory experimental work in high school biology were developed, laying emphasis on the following items : environmental pollution and natural conservations, biological concepts that the degree of difficulty is high, applications of teaching materials which are developed in foreign conturies, productions of teaching materials and models. The measuring methods of size of micrography without micrometer or with a hand-made glass micrometer were developed. By observing the morphological characters of liverwort, the methods of telling its sex, distingshing its life cycle into sexual reproduction and asexual reproduction, and comparing its life cycle with those of other plants were presented. By observing the morphological characters of moss, the methods of telling its sex and comparing its life cycle with those of liverwork, ferns and flowering plants were presented. A convenient observing method of cartilaginous and bony tissues in animals was developed using the easily available material in our surrounding The observing method of extension and contraction of chromatophores induced by environmental changes on freshwater fishes was developed. The methods of sorting and identifying the higher plants by observing their leaves and flowers were presented. The improved analytical method of plant community structure was presented by using the artificial plant community within laboratory. The assesing method of harmful effects on plant tissues by sulfur dioxide was improved.

東洋拓殖株式會社의 이민사업과 동척이민 반대운동

최원규 부산대학교 한국민족문화연구소 2000 한국민족문화 Vol.16 No.-

This study deals mainly with the progress of the Oriental Development Company's emigration project and with the Korean resistance against the emigration project. The purpose of the ODC's project was to establish the human resource far permanently dominating Korea, by emigrating Japanese smallholders for an assimilation policy = 'Japanizing Korea'. It was the form creating self-cultivators. However, the ODC changed it's emigration project to landlord style as the tenancy emigrations, group emigrations and self-cultivating emigrations showed the faults. They had the objective of building 'ideal' Japanese towns grouped by birthplace and placed through out the national wide. Generally, more Japanese emigrants ware placed where Japanese landlordism was developed. The emigration project grew less gradually and escape rate grew more. In 1933 there were only 3,895 cases left in Korea. The composition within classes partly had shown the growth but mostly had shown the phenomenon of ruin. Even though the ODC had supported the capital and the technics for the agrarian innovations, the mobilization of labels, the various low-interest loans and welfare facilities, it was difficult to keep propelling the project. And also there were two reasons far this. First reason was the activation of the peasant movement caused by the dispossession of tenure and high rate rant with the emigration. Second reason was that the depression of the economy and decease in profit margin on emigration and the economy situation, which were caused by a fall of a rice price and a rise of a distributed land price. For overcoming this situation, the emigrants developed the petition movement against the ODC and the Japanese government for the better balance. Bongsankun emigration union(봉산군 이민조합) was best known. The emigration project had contributed to 'the assimilation of Japanese-korean' policy by a degree but, on the contrary, brought reverse effects. In essence, it included the national conflicts and the class conflicts. Therefor the more the project was propelled, the more reverse effects got worst. Peasants, who were victims, developed the opposition movement to the emigration and thereby intellectuals rose anti-Japanese emigration campaign. Eventually it was developed to the social movement in which every and each social group as well as Shingan-hoe(新幹會) participated. The mast representative peasant movement was occurred in the ODC' farms on Hanghaedo Jaeryuongkun bukyulmyon namyulri(황해도 재령군 북율면 남율리) and Bongsankun Sainmyon(봉산군 사인면) around the early 1920's. Peasants who experienced the resistance movement to land tax in the past, argued the lower rent rate and the abolition of emigration vigorously, when the Japanese denied the cultivation right and, on the other hand, migrated the Japanese landlords to enforce the landlord system. It produced two significant results. One result is that it prevented Japanese from immigrating to Korea which leaded to stabilize the tenancy for Korean peasants in long term. The other result is the frustration of the assimilation policy.

일제초기 일본인의 사회적 존재형태와 토지소유관계 : 삼랑진 지역 사례

최원규 부산대학교 한국민족문화연구소 2006 한국민족문화 Vol.28 No.-

The purpose of this paper is no analyze the modes of living and the forms of landownership of the Japanese's who resided in Samlangjin, the key point of waterway and railroad traffics by the crossing of the Nakdong River and the Milling River, and the Gayangbu line and the Mason line. The Japanese entered in Samlangjin in earnest with the opening of the Gyeongbu line in 1905. they occupied a lot, built up a town, and run a farm around Samlangjin station(Songjili). On the other hand, most Chosen people lived and worked around Nakdong River station. The former mainly dealt in goods for the Japanese, while the latter did Korean goods and imported cotton goods. Looking an Japanese occupation, 20-30 percent of the Japanese engaged in agriculture and same percent worked as managers and railroad worker. Except for that, they worked in the various fields of commerce, engineering, a service industry, agriculture. Although they were from a master race, There were non a few the lower laborer and a penny and poor farmer. Most cultivated lands were fields. A vegetable, a mulberry tree, and a fruit tree as well as a been and a barley were widely cultivated in these field. Cash crops were mainly cultivated by Japanese independent farmers. Looking an the possessive relations of land, the Japanese owned many lands in Songjili, while The Korean in Samlangli. Sun, most regions around stations was owned by Pajama and Korea Development Company, and others. There were so many absentee landlords in Samlangjin, but there were also many independent farmers and penny farmers as compared with other. Most Korean landowners were local people. There were few large landowners, bun many independent farmers. Sun the majority of Korean people were poor farmers or people who didn't have land. A decrease in population of the Japanese showed that Japanese imperialism abandoned a colonial policy for a permanent settlement of Japanese. The last measure was no make the Korean assimilate no the Japanese.

Rocuronium의 애별투여방법이 모지내전근의 이완에 미치는 영향

최영균,김승수,이원진,조광래,이상은,김영환,임세훈,이정한,이근무,정순호,김영재,신치만 인제대학교 2009 仁濟醫學 Vol.30 No.-

Objective : There are controversies in pnmmg technique of rocuronium whether it can or can't shorten the onset time. We want to compare the effects of two different priming doses and intervals of rocuronium. Materials and Methods : After giving propofol, 50 patients were randomly assigned to 5 groups. Group I received a placebo, followed 3 min later by rocuronium 0.6 mg/kg. Priming doses and intervals of Group II, Ill, N, V were 0.06 rng/kg and 2 min, 0.12 mg/kg and 2 min, 0.06 rug/kg and 3 min, 0.12 mg/kg and 3 min, respectively. Total dose of rocuronium was 0.6mg/kg. Train of four (TOF) count or ratio and 1st twitch height of TOF (T1) were monitored with 15 secondsintervals. TOF ratio of each groups just before bolus injection, duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were compared. Results : Duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were decreased in priming groups compared to Group 1 (P < 0.01) In group V, significant depression of TOF ratio just before bolus injection was seen (P < 0.05). Conclusion : Priming technique with rocuronium is effective method to shorten the onset of neuromuscular block. But priming dose of rocuronium itself could cause hypoxia and aspiration in awake patients and should be used carefully. Priming dose of rocuronium 0.06 mg/kg and 2 minutes interval maybe relatively safe method.

광고디자인이 소비자의 구매 결정에 미치는 영향 연구 : 청소년 의류시장을 중심으로

최원수 대불대학교 1998 論文集 Vol.4 No.1

Today this age that we are living in is the peak of post industrial society of the 20th century in which there are proceeding of information globalization cutting-edge technology. As the level of consumer's income, education progresses Consumers needs become gradually diverse, sensitive and indibidualized, fractionized. In this report I would like to set up a desirable direction with checking up the clothing market for adolescence at the same time analysing the correlation between advertsing design and marketing. This report is illuminating the advertisement in view of mass culture. Mass culture absolutely depends on mass media. Also, advertisement is an important elements of mass media. It is more elastic and active than any other cultural structure and makes the images for itself. The issue theated by this report is an influence of the mass cultural function especially on adolescence and brand decision. In view of the advertising phenomena under the modern capitalism. I would like to point out positive side (supplying information to consumers) and negative side (the possibility of inducing our adolescence culture whice is too lascivious to the wrong directing) Finally, I hope this report could be a part of the desirable direction of advertising creative to suggest the solution for marketing activity of the domestic companies.

대구지역 일부 주민의 음주, 흡연, 운동 및 비만여부에 따른 혈중지질, 혈당 및 간기능에 관한 연구

최원경 ; 강병태 김천대학교 2010 김천대학교 논문집 Vol.31 No.-

The purpose of this study was to identify health practices that would be helpful in order to reduce the prevalence of correctable cardiovascular risk factors. The study involved 114 adults over the 40 year who visited the health examination center from October 2008 to December 2008. We examined their demographic data, past medical history, smoking habits, alcohol intake and exercise through a questionnaire. Serum lipid level, liver function test (LFT), fasting blood sugar were checked after 14 hours of fast-ing. 114 healthy adults (men 46, women 58) were statistically analyzed. The average IDL was higher in women then men. Total cholesterol and TG were more increased in the group of drink. Smokers showed more decrease in HDL than non-smoker. Also, AI showed higher in smoking group than in non-smoking group. HDL level increased more in obesity group than in normal group, and LFT also showed increase in obesity group compared to normal group. In this study, there was no specific difference found in cho-lesterol level by exercise. In correlation between major parameters of male group, there was plus correlation shown in TC, LDL, AI, ALT by the weight and BMI Index, in SBP by WHR, and in TC, AI, AST, ALT by body fat. In correlation between major parameters of female group, there was plus correlation shown in TC , DBP, ALT, ?-GTP by the weight, in SBP, ALT by BMI, in SBP, ?-GTP by WHR Value, and in SBP and ALT, ?-GTP by body fat. Results of this study may not sufficient to apply affecting factors of serum lipid levels and cut off value because this study group was limited and small. But to know the normal value of total cholesterol and triglyceride, several factors were con-sidered, and further study should be performs. Especially, the study result showed that life style of drinking, smoking and obesity affects cholesterol level.