STRINGENT LIMITS ON THE POLARIZED SUBMILLIMETER EMISSION FROM PROTOPLANETARY DISKS

Hughes, A. Meredith,Wilner, David J.,Cho, Jungyeon,Marrone, Daniel P.,Lazarian, Alexandre,Andrews, Sean M.,Rao, Ramprasad IOP Publishing 2009 The Astrophysical journal Vol.704 No.2

<P>We present arcsecond-resolution Submillimeter Array (SMA) polarimetric observations of the 880 mu m continuum emission from the protoplanetary disks around two nearby stars, HD 163296 and TW Hydrae. Although previous observations and theoretical work have suggested that a 2%-3% polarization fraction should be common for the millimeter continuum emission from such disks, we detect no polarized continuum emission above a 3 sigma upper limit of 7 mJy in each arcsecond-scale beam, or <1% in integrated continuum emission. We compare the SMA upper limits with the predictions from the exploratory Cho & Lazarian model of polarized emission from T Tauri disks threaded by toroidal magnetic fields, and rule out their fiducial model at the similar to 10 sigma level. We explore some potential causes for this discrepancy, focusing on model parameters that describe the shape, magnetic field alignment, and size distribution of grains in the disk. We also investigate related effects like the magnetic field strength and geometry, scattering off of large grains, and the efficiency of grain alignment, including recent advances in grain alignment theory, which are not considered in the fiducial model. We discuss the impact each parameter would have on the data and determine that the suppression of polarized emission plausibly arises from rounding of large grains, reduced efficiency of grain alignment with the magnetic field, and/or some degree of magnetic field tangling ( perhaps due to turbulence). A poloidal magnetic field geometry could also reduce the polarization signal, particularly for a face-on viewing geometry like the TW Hya disk. The data provided here offer the most stringent limits to-date on the polarized millimeter-wavelength emission from disks around young stars.</P>

MILLIMETER OBSERVATIONS OF THE TRANSITION DISK AROUND HD 135344B (SAO 206462)

Lyo, A-Ran,Ohashi, Nagayoshi,Qi, Chunhua,Wilner, David J.,Su, Yu-Nung American Institute of Physics 2011 The Astronomical journal Vol.142 No.5

<P>We present ~1'' resolution 1.3 mm dust continuum and spectral line (<SUP>12</SUP>CO and <SUP>13</SUP>CO J = 2-1) observations of the transitional disk system HD 135344B obtained with the Submillimeter Array. The disk shows a Keplerian rotation pattern with an inclination of ~11°, based on the spatially and spectrally resolved <SUP>12</SUP>CO and <SUP>13</SUP>CO emission. The data show clear evidence for both dust and gas surface density reductions in the inner region of the disk (radius <img entity='lsim' SRC='http://ej.iop.org/icons/Entities/lsim.gif' ALT='lsim' ALIGN='BASELINE' /> 50 AU) from the continuum and <SUP>13</SUP>CO J = 2-1 data, respectively. The presence of this inner cavity in both the dust and gas is more consistent with clearing by giant planet formation than by photoevaporation or by grain growth. There is also an indication of global CO gas depletion in the disk, as the mass estimated from <SUP>13</SUP>CO emission (~3.8 × 10<SUP>–4</SUP> M<SUB>☉</SUB>) is about two orders of magnitude lower than that derived from the 1.3 mm continuum (~2.8 × 10<SUP>–2</SUP> M<SUB>☉</SUB>).</P>

Patient-Reported Outcomes and Quality of Life in PROFILE 1007: A Randomized Trial of Crizotinib Compared with Chemotherapy in Previously Treated Patients with ALK-Positive Advanced Non-Small-Cell Lung Cancer

Blackhall, Fiona,Kim, Dong-Wan,Besse, Benjamin,Nokihara, Hiroshi,Han, Ji-Youn,Wilner, Keith D.,Reisman, Arlene,Iyer, Shrividya,Hirsh, Vera,Shaw, Alice T. Elsevier 2014 JOURNAL OF THORACIC ONCOLOGY Vol.9 No.11

<P>Introduction: The main objective of the current post hoc analysis was to compare patient-reported outcomes between crizotinib (N = 172) and chemotherapy subgroups (pemetrexed [N = 99] and docetaxel [N = 72]) in previously treated patients with advanced ALK-positive non-small-cell lung cancer, in PROFILE 1007 study (Pfizer; NCT0093283). Methods: Patient-reported outcomes were assessed at baseline, day 1 of each cycle, and end of treatment. General health status was measured using the EuroQol-5D visual analog scale and health utility index scores were assessed using the EuroQol-5D descriptive system. Functioning, lung cancer symptoms, and global quality of life (QOL) were assessed using European Organisation for Research and Treatment of Cancer QLQ-C30 and the QLQ-LC13 lung cancer module. Repeated measures mixed-effects analyses compared overall scores and change from baseline scores, controlling for baseline scores. Results: The overall mean EQ-5D health utility index scores (95% CI) on treatment were significantly greater (p < 0.05) for crizotinib (0.82 [0.79-0.85]) than for chemotherapy (0.73 [0.70-0.77]; 0.74 [0.70-0.79] for pemetrexed and 0.66 [0.58-0.74] for docetaxel). A significantly greater improvement from baseline was observed with crizotinib versus pemetrexed and versus docetaxel treatment groups for general health status, physical functioning, global QOL, dyspnea, fatigue, and pain. Improvement rates for fatigue, cough, pain, dyspnea, and global QOL were significantly greater on crizotinib compared with pemetrexed and docetaxel, respectively. Worsening rates for diarrhea and constipation were higher with crizotinib. Conclusion: The benefits of crizotinib in improving symptoms and QOL are demonstrated regardless of whether the comparator is pemetrexed or docetaxel.</P>

Phytochemical Profile, and Antiproliferative and Proapoptotic Effects of Pouteria ramiflora (Mart.) Radlk. Leaf Extract, and Its Synergism with Cisplatin in HepG2 Cells

Katiuska Tuttis,Daryne Lu Maldonado Gomes da Costa,Juliana Mara Serpeloni,Lourdes Campaner dos Santos,Eliana Aparecida Varanda,Wagner Vilegas,Wilner Martınez-Lopez,Ilce Mara de Syllos Cólus 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.5

Different species of the genus Pouteria have been used in folk medicine for the treatment of inflammation, fever, ulcers, diabetes, and diarrhea. We analyzed the phytochemical profile of the hydroethanolic extract from Pouteria ramiflora leaves by electrospray ionization ion trap tandem mass spectrometry and high-performance liquid chromatography-diode array detection, and examined whether it alone and in combination with cisplatin interfered with cell proliferation and death processes in HepG2 (human hepatocellular carcinoma) and FGH (human gingival fibroblasts) cells. Five compounds were identified in the extract: gallic acid, myricetin-3-O-α-l-arabinopyranoside, quercetin-3-O-β-d-galactopyranoside, myricetin-3-O-α-l-rhamnopyranoside, and myricetin-3-O-β-d-galactopyranoside. The extract was cytotoxic to both cell lines by inducing apoptotic cell death and acted in synergy with cisplatin; such effect was stronger in HepG2 cells than in FGH cells, demonstrating some selectivity to tumor cells. In HepG2 cells, the extract exerted antiproliferative effect mediated by induction of cell cycle arrest at the S and G2/M phases. Association of the extract with cisplatin enhanced the latter's antiproliferative effect, arrested the cell cycle at the S phase by CDK2 modulation, and reduced the number of anti-cyclin D1-stained HepG2 cells. Simultaneous treatment with the extract and cisplatin increased the latter's cytotoxicity, apoptotic cell death, and BAX expression in HepG2 cells. Altogether, the results reported herein indicate that P. ramiflora extract is a possible adjuvant to cancer therapy, which can circumvent the cisplatin-mediated resistance mechanisms in cancer cells.

Crizotinib versus Chemotherapy in Asian Patients with ALK-Positive Advanced Non-small Cell Lung Cancer

Makoto Nishio,김동완,Yi-Long Wu,Kazuhiko Nakagawa,Benjamin J. Solomon,Alice T. Shaw,Satoshi Hashigaki,Emiko Ohki,Tiziana Usari,Jolanda Paolini,Anna Polli,Keith D. Wilner,Tony Mok 대한암학회 2018 Cancer Research and Treatment Vol.50 No.3

Purpose Crizotinib has demonstrated superior progression-free survival (PFS) and objective response rates (ORRs) versus chemotherapy in previously treated and untreated patients with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC). We report the safety and efficacy of crizotinib in Asian subpopulations of two global phase III trials. Materials and Methods This analysis evaluated previously treated and untreated patients in two randomized, openlabel phase III trials of crizotinib versus chemotherapy in ALK-positive advanced NSCLC in second-line (PROFILE 1007) and first-line settings (PROFILE 1014). Efficacy and safety were analyzed by race in the intention-to-treat and “as-treated” populations for efficacy and safety endpoints, respectively. Results In previously treated (n=157) and untreated (n=157) Asian patients, PFS was statistically significantly longer with crizotinib versus chemotherapy (hazard ratio for PFS, 0.526; 95% confidence interval, 0.363 to 0.762; p < 0.001 and hazard ratio, 0.442; 95% confidence interval, 0.302 to 0.648; p < 0.001, respectively). Similar antitumor activity was seen in the non-Asian and overall populations. ORRs were statistically significantly higher with crizotinib versus chemotherapy in both Asian and non-Asian previously treated and untreated patients (p < 0.05). The most common treatment-emergent adverse events (any grade) with crizotinib were vision disorder, diarrhea, and nausea, which were observed at a comparable incidence across Asian and non-Asian populations, irrespective of previous treatment status. Most adverse events were mild to moderate in severity. Conclusion These data, currently the only analysis showing Asian and non-Asian populations in the same study, support the efficacy and safety of crizotinib in Asian patients with previously treated or untreated ALK-positive advanced NSCLC.

Spiral density waves in a young protoplanetary disk

Pé,rez, Laura M.,Carpenter, John M.,Andrews, Sean M.,Ricci, Luca,Isella, Andrea,Linz, Hendrik,Sargent, Anneila I.,Wilner, David J.,Henning, Thomas,Deller, Adam T.,Chandler, Claire J.,Dullemond, American Association for the Advancement of Scienc 2016 Science Vol.353 No.6307

<P>Gravitational forces are expected to excite spiral density waves in protoplanetary disks, disks of gas and dust orbiting young stars. However, previous observations that showed spiral structure were not able to probe disk midplanes, where most of the mass is concentrated and where planet formation takes place. Using the Atacama Large Millimeter/submillimeter Array, we detected a pair of trailing symmetric spiral arms in the protoplanetary disk surrounding the young star Elias 2-27. The arms extend to the disk outer regions and can be traced down to the midplane. These millimeter-wave observations also reveal an emission gap closer to the star than the spiral arms. We argue that the observed spirals trace shocks of spiral density waves in the midplane of this young disk.</P>

THE AzTEC/SMA INTERFEROMETRIC IMAGING SURVEY OF SUBMILLIMETER-SELECTED HIGH-REDSHIFT GALAXIES

Younger, Joshua D.,Fazio, Giovanni G.,Huang, Jia-Sheng,Yun, Min S.,Wilson, Grant W.,Ashby, Matthew L. N.,Gurwell, Mark A.,Peck, Alison B.,Petitpas, Glen R.,Wilner, David J.,Hughes, David H.,Aretxaga, IOP Publishing 2009 The Astrophysical journal Vol.704 No.1

<P>We present results from a continuing interferometric survey of high-redshift submillimeter galaxies (SMGs) with the Submillimeter Array, including high-resolution (beam size similar to 2 arcsec) imaging of eight additional AzTEC 1.1 mm selected sources in the COSMOS field, for which we obtain six reliable (peak signal-to-noise ratio (S/N) > 5 or peak S/N > 4 with multiwavelength counterparts within the beam) and two moderate significance (peak S/N > 4) detections. When combined with previous detections, this yields an unbiased sample of millimeter-selected SMGs with complete interferometric follow up. With this sample in hand, we (1) empirically confirm the radio-submillimeter association, (2) examine the submillimeter morphology-including the nature of SMGs with multiple radio counterparts and constraints on the physical scale of the far infrared-of the sample, and (3) find additional evidence for a population of extremely luminous, radio-dim SMGs that peaks at higher redshift than previous, radio-selected samples. In particular, the presence of such a population of high-redshift sources has important consequences for models of galaxy formation-which struggle to account for such objects even under liberal assumptions-and dust production models given the limited time since the big bang.</P>

Dust properties across the CO snowline in the HD 163296 disk from ALMA and VLA observations

Guidi, G.,Tazzari, M.,Testi, L.,de Gregorio-Monsalvo, I.,Chandler, C. J.,Pé,rez, L.,Isella, A.,Natta, A.,Ortolani, S.,Henning, Th.,Corder, S.,Linz, H.,Andrews, S.,Wilner, D.,Ricci, L.,Carpenter, Springer-Verlag 2016 Astronomy and astrophysics Vol.588 No.-

The Millimeter Continuum Size-Frequency Relationship in the UZ Tau E Disk

Tripathi, Anjali,Andrews, Sean M.,Birnstiel, Tilman,Chandler, Claire J.,Isella, Andrea,Pé,rez, Laura M.,Harris, R. J.,Ricci, Luca,Wilner, David J.,Carpenter, John M.,Calvet, N.,Corder, S. A.,Del American Astronomical Society 2018 The Astrophysical journal Vol.861 No.1

<P>We present high spatial resolution observations of the continuum emission from the young multiple star system UZ Tau at frequencies from 6 to 340 GHz. To quantify the spatial variation of dust emission in the UZ Tau E circumbinary disk, the observed interferometric visibilities are modeled with a simple parametric prescription for the radial surface brightnesses at each frequency. We find evidence that the spectrum steepens with radius in the disk, manifested as a positive correlation between the observing frequency and the radius that encircles a fixed fraction of the emission (R-eff proportional to nu(0.34 +/- 0.08)). The origins of this size-frequency relation are explored in the context of a theoretical framework for the growth and migration of disk solids. While that framework can reproduce a similar size-frequency relation, it predicts a steeper spectrum than that observed. Moreover, it comes closest to matching the data only on timescales much shorter (<= 1 Myr) than the putative UZ Tau age (similar to 2-3 Myr). These discrepancies are direct consequences of the rapid radial drift rates predicted by models of dust evolution in a smooth gas disk. One way to mitigate that efficiency problem is to invoke small-scale gas pressure modulations that locally concentrate drifting solids. If such particle traps reach high-continuum optical depths at 30-340 GHz with a similar to 30%-60%. filling fraction in the inner disk (r less than or similar to 20 au), they can also explain the observed spatial gradient in the UZ Tau E disk spectrum.</P>