Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

EPRI의 사용후연료 저장방안

Williams, R. F.,Lambert, R. W.,Stahlkopf, K. E. 한국원자력산업회의 1992 원자력산업 Vol.12 No.1

A MICROSTRUCTURAL MODEL OF THE THERMAL CONDUCTIVITY OF DISPERSION TYPE FUELS WITH A FUEL MATRIX INTERACTION LAYER

Williams, A.F.,Leitch, B.W.,Wang, N. Korean Nuclear Society 2013 Nuclear Engineering and Technology Vol.45 No.7

This paper describes a finite element model of the microstructure of dispersion type nuclear fuels, which can be used to determine the effective thermal conductivity of the fuels during irradiation. The model simulates a representative region of the fuel as a prism shaped unit cell made of brick elements. The elements within the unit cell are assigned material properties of either the fuel or the matrix depending on position, in such a way as to represent randomly distributed fuel particles with a size distribution similar to that of the as manufactured fuel. By applying an appropriate heat flux across the unit cell it is possible to determine the effective thermal conductivity of the unit cell as a function of the volume fraction of the fuel particles. The presence of a fuel/matrix interaction layer is simulated by the addition of a third set of material properties that are assigned to the finite elements that surround each fuel particle. In this way the effective thermal conductivity of the material may also be determined as a function of the volume fraction of the interaction layer. Work is on going to add fission gas bubbles in the fuel as a fourth phase to the model.

동아시아 구법승과 상카시야 유적

Williams Joanna G. 미술사와 시각문화학회 2005 미술사와 시각문화 Vol.4 No.-

According to Legge, Faxian wrote: Proceeding 18 yojanas southeast [from Mathurii and 7 yojemas from Kanauj, which he visited next], they found themselves in a kingdom called Sankasya, at the place where the Buddha came down, after ascending to the Trayatrimsa heaven… The bbirsuni Utpalavarna thought in her heart, "Today the kings ... will all be meeting the Buddha. I am but a woman; how shall I succeed in being the first to see him?" Buddha immediately ... changed her into the appearance of a holy cakravartin king, and she was foremost of all in doing reverence to rum. As Buddha descended from his position aloft in the Trayatrimsa heaven, when he was coming down, there were made to appear three flights of precious steps. Buddha was on the middle. composed of the seven precious substances. The king of Brahma-loka also made a flight of silver steps appear on the right side, where he attended with a white chowry in his hand, Sakra, ruler of devas, made steps of purple gold on the left, where he held an umbrella "" When he was come down, the three flights all disappeared in the ground, excepting seven steps ... Afterwards King Asoka, wishing to know where their ends rested, sent men to dig and see, They went down to the yellow springs [the water table] without reaching the bonom of the steps, and from this the king rceived an increase to his reverence"" [Asoka] built a vihara over the steps, with a standing image 16 cubits in height, right over the middle flight. Behind the pillar, he erected a stone pillar, about 50 cubits high, with a lion on the top of it. Let into the pillar, on each of its 4 sides, there is an image of the Buddha, inside and out shining and transparent, and pure as it were of lapis lazuli [which roared in a later monastic debate], Faxian also reported stupas built later where the nun Utpalavarla knelt, where the Buddha cut his hair, where three previous Buddhas sat, as well as offerings made to a white-eared dragon that continued to protect the monastic community, One gets the impression of a crowded, complex site in the early 5th century, with presumably wooden monastic buildings, Over 200 years later, Xuanzang described visiting the site of the descent from Tryatrima named now)iebita (Beal: "written formerly Sengjiashe") and located less than 200 li southeast from Kanauj (in which Beal suggests he is mistaken on the direction), His account reads: Some centuries ago the ladders still existed in their original position, but now they have sunk into the earth and have disappeared. The neighboring princes ... bujlt up of bricks and chased stones, on the ancient foundations 3 ladders resembling the old ones. They are about 70 feet high. Above them they have built a vihara in which is a stone image of Buddha, and on either side of this is a ladder of Brahma and Sma, just as they appeared. On the outside of the vihara, but close by its side, there is a stone column about 70 feet high, which was erected by Asoka-raja, It is of a purple color, and shining as if with moisture. The substance is hard and fmely grained, Above it is a lion sitting on its haunches and facing the ladder. There are carved fig-ures inlaid, of wonderful execution on the four sides of the pillar and around It Xuanzang also records other stupas commemorating Buddhas of the past and the nun Utpalavatma, now eclipsed by Subhoti who had already seen the dharmakaya in the form of the doctrine that all existing things are void of reality, Again, we get a picture of a bustling monastic community in the 7th century. And the resplendent lion pillar with Buddha images stands out in both accounts, On the basis of the name Sankasya, known from the pilgrims and from texts like the Divyavadana, as well as the general location, Cunning-ham identified the modern village Sankfsa in modern Farrukhabad district, up. with the site of the Descent, It lies some 40 km. northeast of Kanauj in the Doab, richly populated with ancient remains, The two Gupta sites Jankhat and Bilsadh took me to this area in 1974, Cunningham included the site in his reports for 1862 and 1876. In the first he recorded the presence of an ASokan capital and worship of a naga named Karewar, which he identified with Faxian's description. In 1876 hecollected objects reproduced on the right. I know these only from this abysmal image and would be delighted to hear that they survive in some museum. Cunningham suggested that #2, a fragment of a tiny soapstone disc, represented the site itself, with a seated Buddha and kneeling Utpalavarna at the top of what survived. The Archaeological Survey of India returned to this site ten years ago and excavated here for at least 2 seasons, as reported in Indian Arcbaeolo-gy, A Review for 1995-96 and 96-97, finding Painted Grey Ware, Northern Black Polished Ware, Sunga, Kushan, and Gupta pottery, pre-Kushan bricks, and terra-conas attributed to the Gupta period, The Aokan capital found here has continued to receive attention. Is this what both Faxian and Xuanzang described as a lion? Cunningham asserted that both were mistaken about the identity of the animal, It might be pointed out that the shorter pillar that stands at the site of the Parinilvana makes some confusion plausible, Xuanzang describes the pillar standing at Sarnath as "bright and shining as a mirror: its surface is glistening and smooth as ice, and on it can be constantly seen the figure of Buddha as a shadow," I. e" he ignored the form of the capital and was mesmerized by the stone's polish, It is also possible that the Buddha figures he mentions here and Sa:nkasya were in fact carved on the pillar like the Gupta pillar at Kahaum, which has four TIrthankaras at the top as well as a single one below. The elephant capital has continued to attract attention for the excep-tional swirls beneath what was long considered a lotiform bottom to the capital, John l1win took these to indicate that the "lotus" in fact originated as a piece of cloth draped over a wood

An experimental and numerical approach in strength prediction of reclaimed rubber concrete

Williams, Kanmalai C.,Partheeban, P. Techno-Press 2018 Advances in concrete construction Vol.6 No.1

Utilization of waste tires may be considered as one of the solution to the problems faced by the local authorities in disposing them. Reclaimed rubber (RR) is being used in concrete for replacing conventional aggregates. This research work is focused on the strength prediction of reclaimed rubber concrete using a Genetic Algorithm (GA) for M40 grade of concrete and comparing it with experimental results. 1000 sets were taken and 100 iterations were run during training of GA models. A base study has been carried out in this research work partially replacing cement with three types of fillers such as Plaster of Paris (POP), Fly Ash (FA) and Silica Fume (SF). A total of 243 cubes were cast and tested for compression using a Universal Testing Machine. It was found that SF produced maximum strength in concrete and was used in the main study with reclaimed rubber. Tests were conducted on 81 cube samples with a combination of optimum SF percent and various proportions of RR replacing coarse aggregates in concrete mix. Compressive strength tests of concrete at 7, 14 and 28 days reveal that the maximum strength is obtained at 12 percent replacement of cement and 9 percent replacement of coarse aggregates respectively. Moreover the GA results were found to be in line with the experimental results obtained.

Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression

Williams, Adam,Lee, Gap Ryol,Spilianakis, Charalampos G.,Hwang, Soo Seok,Eisenbarth, Stephanie C.,Flavell, Richard A. National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.17

<P>The T helper type 2 (Th2) cytokine genes <I>Il4</I>, <I>Il5</I>, and <I>Il13</I> are contained within a 140-kb region of mouse chromosome 11 and their expression is controlled by a locus control region (LCR) embedded within this locus. The LCR is composed of a number of DNase I–hypersensitive sites (HSs), which are believed to encompass the regulatory core of the LCR. To determine the function of these sites, mutant mice were generated in which combinations of these HSs had been deleted from the endogenous LCR, and the effect on Th2 cytokine expression was assessed through the use of in vivo and in vitro models. These experiments revealed that, although all of the hypersensitive sites analyzed are important for appropriate LCR function, some sites are more important than others in regulating cytokine expression. Interestingly, each LCR mutation showed contrasting effects on cytokine expression, in some cases with mutants displaying opposing phenotypes between in vitro cultures and in vivo immunizations. These studies indicated that Rad50 hypersensitive site 6 was the singularly most important HS for Th2 cytokine expression, displaying consistent reductions in cytokine levels in all models tested. Furthermore analysis of chromatin modifications revealed that deletion of Rad50 hypersensitive site 6 impacted epigenetic modifications at the promoters of the <I>Il4</I>, <I>Il5</I>, and <I>Il13</I> genes as well as other regulatory sites within the Th2 locus.</P>

Science , Education , and Modernization

Williams, William Morris 한국화학공학회 1973 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.11 No.4

Synthesis, Photophysical,Electrochemical, Tumor-Imaging,and Phototherapeutic Properties of Purpurinimide-<i>N</i>-substituted Cyanine Dyes Joined with Variable Lengths of Linkers

Williams, MichaelP. A.,Ethirajan, Manivannan,Ohkubo, Kei,Chen, Ping,Pera, Paula,Morgan, Janet,White, William H.,Shibata, Masayuki,Fukuzumi, Shunichi,Kadish, Karl M.,Pandey, Ravindra K. American ChemicalSociety 2011 Bioconjugate chemistry Vol.22 No.11

<P>Purpurinimide methyl esters, bearing variable lengthsof N-substitutions,were conjugated individually to a cyanine dye with a carboxylic acidfunctionality. The results obtained from <I>in vitro</I> and <I>in vivo</I> studies showed a significant impactof the linkers joining the phototherapeutic and fluorescence imagingmoieties. The photosensitizer–fluorophore conjugate with aPEG linker showed the highest uptake in the liver, whereas the conjugatelinked with two carbon units showed excellent tumor-imaging and PDTefficacy at 24 h postinjection. Whole body imaging and biodistributionstudies at variable time points portrayed enhanced fluorescent uptakeof the conjugates in the tumor compared to that in the skin. Interestingly,the conjugate with the shortest linker and the one joining with twocarbon units showed faster clearance from normal organs, e.g., theliver, kidney, spleen, and lung, compared to that in tumors. Bothimaging and PDT efficacy of the conjugates were performed in BALB/cmice bearing Colon26 tumors. Compared to the others, the short linkerconjugate showed poor tumor fluorescent properties and as a corollarydoes not exhibit the dual functionality of the photosensitizer–fluorophoreconjugate. For this reason, it was not evaluated for <I>in vivo</I> PDT efficacy. However, in Colon26 tumor cells (<I>in vitro</I>), the short linker was highly effective. Among the conjugates withvariable linkers, the rate of energy transfer from the purpurinimidemoiety to the cyanine moiety increased with deceasing linker length,as examined by femtosecond laser flash photolysis measurements. Noelectron transfer from the purpurinimide moiety to the singlet excitedstate of the cyanine moiety or from the singlet excited state of thecyanine moiety to the purpurinimide moiety occurred as indicated bya comparison of transient absorption spectra with spectra of the one-electronoxidized and one-electron reduced species of the conjugate obtainedby spectroelectrochemical measurements.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bcches/2011/bcches.2011.22.issue-11/bc200345p/production/images/medium/bc-2011-00345p_0016.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bc200345p'>ACS Electronic Supporting Info</A></P>

Developing ICT Competence in Pre-service Teacher Training : A Singapore case

WILLIAMS, MICHAEL D. 이화여자대학교 국제통상협력연구소 2001 Jounal of APEC Studies Vol.3 No.1

Recent changes to the Singapore education system have moved particularly rapidly in the area of the use of computer technologies in schools, and have produced marked demands on teachers to upgrade their technology skills and practices to meet this new educational environment. This paper describes the process which the Singapore education profession, especially pre-service teacher preparation, has undergone in the past several years in an effort to prepare teachers to integrate information and communications technologies (ICT) into their teaching and learning. A variety of factors producing these changes is presented, followed by an updated set of ICT competencies for teachers, as well as the response by the Singapore National Institute of Education to meet these new professional requirements.

Commitment to Sport and Exercise: Re-examining the Literature for a Practical and Parsimonious Model

Williams, Lavon The Korean Society for Preventive Medicine 2013 Journal of Preventive Medicine and Public Health Vol.46 No.suppl

A commitment to physical activity is necessary for personal health, and is a primary goal of physical activity practitioners. Effective practitioners rely on theory and research as a guide to best practices. Thus, sound theory, which is both practical and parsimonious, is a key to effective practice. The purpose of this paper is to review the literature in search of such a theory - one that applies to and explains commitment to physical activity in the form of sport and exercise for youths and adults. The Sport Commitment Model has been commonly used to study commitment to sport and has more recently been applied to the exercise context. In this paper, research using the Sport Commitment Model is reviewed relative to its utility in both the sport and exercise contexts. Through this process, the relevance of the Investment Model for study of physical activity commitment emerged, and a more parsimonious framework for studying of commitment to physical activity is suggested. Lastly, links between the models of commitment and individuals' participation motives in physical activity are suggested and practical implications forwarded.