A New Approach to Estimate RED Parameters Using Function Regression

Wentao Wang,Hao Wang,Wan Tang,Feng Guo 보안공학연구지원센터 2014 International Journal of Future Generation Communi Vol.7 No.4

Quantitative assessment of compress-type osseointegrated prosthetic implants in human bone using electromechanical impedance spectroscopic methods

Wentao Wang,Jerome P. Lynch 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.1

Osseointegrated (OI) prostheses are a promising alternative to traditional socket prostheses. They can enhance the qualityof life of amputees by avoiding fi t and comfort issues commonly associated with sockets. The main structural element ofthe OI prosthesis is a biocompatible metallic implant that is surgically implanted into the bone of the residual limb. Theimplant is designed to provide a conducive surface for the host bone to osseointegrate with. The osseointegration process ofthe implant is diffi cult to clinically evaluate, leading to conservative postoperative rehabilitation approaches. Elastic stresswaves generated in an OI prosthesis have been previously proposed to interrogate the implant-bone interface for quantitativeassessment of the osseointegration process. This paper provides a detailed overview of the various elastic stress wavemethods previously explored for in situ characterization of OI implants. Specifi cally, the paper explores the use of electromechanicalimpedance spectroscopy (EIS) to assess the OI process in compress-type OI prostheses. The EIS approachmeasures the electrical impedance spectrum of lead zirconate titanate elements bonded to the free end of the implant. Theresearch utilizes both numerical simulation and experimental verifi cation to establish that the electromechanical impedancespectrum is sensitive (between 400 and 460 kHz) to both the degree and location of osseointegration. A baseline-free OIindex is proposed to quantify the degree of osseointegration at the implant-bone interface and to assess the stability of theOI implant for clinical decision making.

Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage

Wang Guangyu,Wang Yongsi,Jiang Shaofeng,Fan Wentao,Mo Chune,Gong Weiwei,Chen Hui,He Dan,Huang Jinqing,Ou Minglin,Hou Xianliang 한국유전학회 2022 Genes & Genomics Vol.44 No.7

Background: The current pandemic of coronavirus disease 2019 (COVID-19), transmitted person-to-person by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2), poses a threat to global public health. Objective: In this study, we performed the comprehensive analysis of the T cell receptor (TCR) repertoire may contribute to a more in-depth understanding of the pathogenesis of COVID-19. Methods: A comprehensive immunological analysis was performed to explore the features of the TCR repertoire and identified TCR sequences correlated with SARS-CoV-2 viral antigens. Results: we analyzed the COVID-19 patients' TCR repertoires in peripheral blood mononuclear cells (PBMC) which obtained before (baseline), during (acute), and after rehabilitation (convalescent) by ImmunoSEQ-technology, and found that repertoire features of TCRβ-chain (TCRβ) complementary-determining region 3 (CDR3) in COVID-19 patients were remarkable difference, including decreased TCR diversity, abnormal CDR3 length, difference of TRBV/J gene usage and higher TCR sequence overlap. Besides, we identified some COVID-19 disease-associated TCRβ clones, and the abundance of them changed with the progression of the disease. Importantly, these disease-associated TCRβ clones could be used to distinguish COVID-19 patients from healthy controls with high accuracy. Conclusions: We provide a clear understanding of the TCR repertoire of COVID-19 patients, which lays the foundation for better diagnosis and treatment of COVID-19 patients.

An Improved Adaptive Scheduling Strategy Utilizing Simulated Annealing Genetic Algorithm for Data Center Networks

( Wentao Wang ),( Lingxia Wang ),( Fang Zhen ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.11

Data center networks provide critical bandwidth for the continuous growth of cloud computing, multimedia storage, data analysis and other businesses. The problem of low link bandwidth utilization in data center network is gradually addressed in more hot fields. However, the current scheduling strategies applied in data center network do not adapt to the real-time dynamic change of the traffic in the network. Thus, they fail to distribute resources due to the lack of intelligent management. In this paper, we present an improved adaptive traffic scheduling strategy utilizing the simulated annealing genetic algorithm (SAGA). Inspired by the idea of software defined network, when a flow arrives, our strategy changes the bandwidth demand dynamically to filter out the flow. Then, SAGA distributes the path for the flow by considering the scheduling of the different pods as well as the same pod. It is implemented through software defined network technology. Simulation results show that the bisection bandwidth of our strategy is higher than state-of-the-art mechanisms.

Research on Routing Protocols and Simulation Analysis for Opportunistic Networks

Wentao Wang,Feng Guo,Fang Zheng,Wan Tang,Jiangqing Wang 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.3

Opportunistic networks are a kind of Ad Hoc networks that make use of meeting opportunities from mobile nodes to realize the network communication which doesn't need a full path between the source nodes and destination nodes. It’s tolerant in latency and network division. It’s a great challenge to design routing protocols in opportunistic networks in that the movements of nodes are uncertain leading to intermittent connection which make it hard to transmit message to its destination. However, the problems have also attracted more and more attention from researchers. Firstly, in this paper, we introduced the basic concept of opportunistic networks. Secondly we classified and interpreted routing protocols according to the infrastructure, scenario, forwarding mechanism etc. Thirdly, we carried out the computer simulation and analysis for opportunistic network routing protocols in aspect of message delivery ratio, network latency, routing overhead and the number of lost packets. Then we summarized the advantages and disadvantages of routing protocol and discussed its applicability. Finally we looked ahead the hotspot of recent routing protocols under opportunistic networks.

중국 금융지주회사의 발전, 문제점 및 감독관리에 관한 연구 - “금융지주회사감독관리시행방법”에 대한 평가를 겸하여-

왕비민 ( Wang Feimin ),최문도 ( Cui Wentao ),왕아령 ( Wang Yaling ),리림령(번역) 한국금융법학회 2021 金融法硏究 Vol.18 No.3

2008년 글로벌 금융위기 직후 중국은 거시적 건전성 감독구조를 부단히 개선하고 있고 금융감독체제 개혁을 안정적으로 추진하고 있는 배경하에서 2020년 9월 11일, “금융지주회사감독관리시행방법”을 정식 공포하였다. 당해 방법의 공포는 필요하고 또한 불가피한 것이었다. “금융지주회사감독관리시행방법”은 거시적 건전성 감독 이념을 반영하였으며 거시적 건전성 감독, 철저한 감독, 조화적 감독 등 3대원칙을 명확히 하여 금융지주회사의 건전한 발전을 보장하는데 도움이 된다. “금융지주회사감독관리시행방법”은 감독 메커니즘, 설립과 진입허가, 금융지주회사 관리와 주식소유구조, 리스크 감독 등 구체적 제도면에서 실질적인 개선을 가져 왔다. 하지만 “금융지주회사감독관리시행방법”은 금융지주회사의 적용범위, 유형별 감독 및 감독의 중점과 기준, 주주가중책임, 시장퇴출시스템, 국제협력 등 면에서 여전히 미흡하다. 금융지주회사에 대한 감독을 개선하기 위해서는 아래와 같은 측면을 고려하여야 한다. 즉 금융지주회사의 정의(定義)를 개선하여 “금융지주회사감독관리시행방법”의 적용주체를 명확히 하고, 금융지주회사의 유형을 구체화하는 동시에 유형별로 차별화 되는 감독을 진행하며, 금융지주회사에 대한 금융지주회사 주주의 가중책임 및 금융지주회사의 피지배금융기관에 대한 가중책임을 강화하고, 금융지주회사의 시장퇴출시스템을 개선하며, 금융지주회사의 감독에 대한 국제협력을 강화해야 한다. Since the outbreak of the global financial crisis in 2008, China has continuously improved the macro-prudential regulatory framework and steadily promoted the reform of the financial regulatory system. On September 11, 2020, the “Trial Measures for the Supervision and Administration of Financial Holding Companies” was officially released. The promulgation of the regulations is necessary and inevitable. The “Trial Measures for the Supervision and Management of Financial Holding Companies” embodies the concept of following macro-prudential management and clarifies the three principles of macro-prudential management, penetrating supervision, and coordinated supervision, which are beneficial to guarantee the healthy development of financial holding companies. The “Trial Measures for the Supervision and Management of Financial Holding Companies” have made substantial breakthroughs in specific systems such as regulatory mechanisms, establishment and access permits, corporate governance and equity institutions, and risk supervision and management. However, the “Trial Measures for the Supervision and Administration of Financial Holding Companies” still have deficiencies in the scope of application of financial holding companies, typed supervision and supervision priorities and standards, increased shareholder responsibilities, market exit mechanisms, and international cooperation. In practice, the supervision of financial holding companies should be continuously promoted by improving the definition of financial holding companies to clarify the applicable subjects of the “Trial Measures for the Supervision and Management of Financial Holding Companies”, refine the types of financial holding companies, implement type-differentiated supervision, and strengthen financial holdings. The company’s shareholders have intensified the financial holding company and the financial holding company’s increased responsibilities to the shareholders of the holding institution, improved the financial holding company’s market exit mechanism, and strengthened international cooperation in the supervision of financial holding companies.

piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination

Zhang Wentao,Zheng Zongtai,Wang Keyi,Mao Weipu,Li Xue,Wang Guangchun,Zhang Yuanyuan,Huang Jianhua,Zhang Ning,Wu Pengfei,Liu Ji,Zhang Haimin,Che Jianping,Peng Bo,Zheng Junhua,Li Wei,Yao Xudong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.

Energy spread minimization in a cascaded laser wakefield accelerator via velocity bunching

Zhang, Zhijun,Li, Wentao,Liu, Jiansheng,Wang, Wentao,Yu, Changhai,Tian, Ye,Nakajima, Kazuhisa,Deng, Aihua,Qi, Rong,Wang, Cheng,Qin, Zhiyong,Fang, Ming,Liu, Jiaqi,Xia, Changquan,Li, Ruxin,Xu, Zhizhan American Institute of Physics 2016 Physics of plasmas Vol.23 No.5

Metformin alleviates chronic obstructive pulmonary disease and cigarette smoke extract-induced glucocorticoid resistance by activating the nuclear factor E2-related factor 2/heme oxygenase-1 signaling pathway

Fulin Tao,Yuanyuan Zhou,Mengwen Wang,Chongyang Wang,Wentao Zhu,Zhili Han,Nianxia Sun,Dianlei Wang 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.2

Chronic obstructive pulmonary disease (COPD) is an important healthcare problem worldwide. Often, glucocorticoid (GC) resistance develops during COPD treatment. As a classic hypoglycemic drug, metformin (MET) can be used as a treatment strategy for COPD due to its anti-inflammatory and antioxidant effects, but its specific mechanism of action is not known. We aimed to clarify the role of MET on COPD and cigarette smoke extract (CSE)-induced GC resistance. Through establishment of a COPD model in rats, we found that MET could improve lung function, reduce pathological injury, as well as reduce the level of inflammation and oxidative stress in COPD, and upregulate expression of nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), multidrug resistance protein 1 (MRP1), and histone deacetylase 2 (HDAC2). By establishing a model of GC resistance in human bronchial epithelial cells stimulated by CSE, we found that MET reduced secretion of interleukin- 8, and could upregulate expression of Nrf2, HO-1, MRP1, and HDAC2. MET could also increase the inhibition of MRP1 efflux by MK571 significantly, and increase expression of HDAC2 mRNA and protein. In conclusion, MET may upregulate MRP1 expression by activating the Nrf2/HO-1 signaling pathway, and then regulate expression of HDAC2 protein to reduce GC resistance

Research on flexural bearing capacity of cold-formed thin-walled steel and reinforced concrete sandwich composite slabs

Wentao Qiao,Zhiyuan Huang,Xiaoshuo Yan,Dong Wang,Lijun Meng 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.45 No.2

The aim of this paper is to study the mechanical behaviors of the cold-formed thin-walled steel and reinforced concrete sandwich composite slab (CTS&RC-SCS) under vertical loads and to develop the calculation methods of its flexural bearing capacity and section stiffness. Two CTS&RC-SCS specimens were designed and manufactured to carry out the static loading test, and meanwhile, the numerical simulation analyses based on finite element method were implemented. The comparison between experimental results and numerical analysis results shows that the CTS&RC-SCS has good flexural capacity and ductility, and the accuracy and rationality of the numerical simulation analysis are verified. Further, the variable parameter analysis results indicate that neither increasing the concrete strength grade nor increasing the thickness of C-sections can significantly improve the flexural capacity of CTS&RC-SCS. With the increase of the ratio of longitudinal bars and the thickness of the composite slab, the flexural capacity of CTS&RC-SCS will be significantly increased. On the basis of experimental research and numerical analysis above, the calculation formula of the flexural capacity of CTS&RC-SCS was deduced according to the plastic section design theory, and section stiffness calculation formula was proposed according to the theory of transformed section. In terms of the ultimate flexural capacity and mid-span deflection, the calculated values based on the formulas and the experimental values are in good agreement.