Endoscopic closure devices: A review of technique and application for hemostasis

Jennifer Wellington,Andrew Canakis,Raymond Kim 소화기인터벤션의학회 2019 International journal of gastrointestinal interven Vol.8 No.3

Acute gastrointestinal bleeding is a common, yet challenging, and potentially problematic medical emergency for clinicians to manage. Given its significantly high health care associated costs and increased morbidity and mortality rate, new endoscopic techniques for managing gastrointestinal bleeding has gained considerable attention. While conventional methods (i.e., injection, cautery, and hemostatic clips) have been widely used, their efficacy and reliability for initial hemostasis has been hindered by high rebleeding and variable success rates. Thus, this review sets out to character-ize recent advancements with the clinical application of endoscopic closure devices as the alternatives in achieving hemostasis. Such devices include hemostatic clips, also known as through-the-scope clips, over-the-scope-clips, endoscopic detachable snare ligation devices, and endoscopic suturing system.

Endoscopic closure devices: A review of technique and application for hemostasis

Jennifer Wellington,Andrew Canakis,Raymond Kim 소화기인터벤션의학회 2019 Gastrointestinal Intervention Vol.8 No.3

Acute gastrointestinal bleeding is a common, yet challenging, and potentially problematic medical emergency for clinicians to manage. Given its significantly high health care associated costs and increased morbidity and mortality rate, new endoscopic techniques for managing gastrointestinal bleeding has gained considerable attention. While conventional methods (i.e., injection, cautery, and hemostatic clips) have been widely used, their efficacy and reliability for initial hemostasis has been hindered by high rebleeding and variable success rates. Thus, this review sets out to character-ize recent advancements with the clinical application of endoscopic closure devices as the alternatives in achieving hemostasis. Such devices include hemostatic clips, also known as through-the-scope clips, over-the-scope-clips, endoscopic detachable snare ligation devices, and endoscopic suturing system.

Prevalence of Malaria in Pregnant Women in Lagos, South-West Nigeria

Chimere O. Agomo,Wellington A. Oyibo,Rose I. Anorlu,Philip U. Agomo 대한기생충학열대의학회 2009 The Korean Journal of Parasitology Vol.47 No.2

Optimal LQI and PID Synthesis for Speed Control of Switched Reluctance Motor Using Metaheuristic Techniques

Darielson A. Souza,Vinícius A. de Mesquita,Laurinda L. N. Reis,Wellington A. Silva,Josias G. Batista 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.1

At present, switched reluctance motors (SRM) become very interesting for many industrial applicationsin variable speed control. For such systems, the linear quadratic regulator with integral action (LQI) method iscommonly used when using plants in state spaces due to its robustness and easy adjustment. All methods from thelinear quadratic regulator (LQR) project provide a weighting of the Q and R matrices, which are manually adjustedto achieve the desired performance. The manual fine tuning of LQI controller parameters is a difficult task thatrequires a high level of domain knowledge. In this work, metaheuristic algorithms are explored to design the LQIcontroller and a comprehensive comparison is made between these algorithms and Proportional-Integral-Derivative(PID) controller as well as to select the best technique for the LQI controller design and adjustment of the Q andR parameters in SR Motor. Simulation and experimental results on a setup prototype are shown to validate theproposed control schemes. This paper has as main contributions the weighting of the parameters of the LQI in anoptimized way and adjustment of the gains of the controller more quickly and the hybrid controller (LQI + GA)becomes more powerful in the sense of a possible extension of the control of a multivariable system.

Comparison of Dental Carcass Maturity in Non-Castrated Male F1 Angus-Nellore Cattle Finished in Feedlot

Bismarck Moreira Santiago,Welder Angelo Baldassini,Laí,s de Aquino Tomaz,Leone Campos Rocha,Wellington Bizarria dos Santos,Rogé,rio Abdallah Curi,Luis Artur Loyola Chardulo,Otá,vio Rodrigu 한국축산식품학회 2021 한국축산식품학회지 Vol.41 No.3

Dental classification of carcasses is used as a parameter of cattle maturity at slaughter, and it can influence carcass and meat quality traits. Brazilian beef-packing companies use the number of permanent incisor (PI) teeth as a parameter for bonus and certification of carcasses with superior quality. However, when non-castrated male such as F1 Angus-Nellore (Bos taurus×Bos indicus) are slaughtered, only animals without PI teeth are subsidized by the breed association. We evaluated these animals finished in feedlot for 180 days with zero versus two PI teeth on the carcass and meat quality traits. At the time of slaughter, 88 carcasses were selected, forming two treatments according to dental carcass maturity (0 versus 2 PI teeth; 44 animals per category). It was demonstrated that the number of PI teeth (0 versus 2 PI) did not influence (p>0.05) carcass (weights, yield, cooling loss, ribeye area and the backfat thickness) and meat quality traits (Longissimus thoracis chemical composition, color, cooking losses, shear force and pH). Thus, dental carcass maturity (zero versus two PI teeth) does not influence non-castrated male F1 Angus-Nellore finished in feedlot for 180 days. This is the first study to demonstrate that carcasses of non-castrated male F1 Angus-Nellore with two PI teeth should be subsidized in a similar way to those with zero PI teeth. Moreover, Brazilian beef-packing companies could produce heavier and leaner carcasses of acceptable quality though the use of crossbred cattle such as non-castrated F1 Angus Nellore.

Second trimester cervical length measurement for prediction spontaneous preterm birth in an unselected risk population

( Alberto Borges Peixoto ),( Taciana Mara Rodrigues Da Cunha Caldas ),( Luisa Almeida Tahan ),( Caetano Galvao Petrini ),( Wellington P Martins ),( Fabricio Da Silva Costa ),( Edward Araujo Junior ) 대한산부인과학회 2017 Obstetrics & Gynecology Science Vol.60 No.4

Objective To assess the predictive capacity of cervical length (CL) measurement underwent during the second trimester ultrasound for prediction preterm birth <32, 34, and 37 weeks of gestation in an unselected risk population. Methods A retrospective cohort study was performed with 751 singleton pregnancies between 20 and 24+6 weeks of gestation. The CL measurement (mm) using the transvaginal route was obtained in a sagittal view and the calipers positioned to measure the linear distance between the triangular area of echodensity at the external os and the internal os. To compare the preterm (<37 weeks) and term births (≥37 weeks), we used unpaired t test. We assessed whether the CL measurement was dependent of gestational age by performing a linear regression and assessing the coefficient of determination (R²). We additionally assessed the accuracy of CL measurement to predict preterm birth by assessing the area under receiver operating characteristics curves with its respective confidence intervals (CIs) 95%. Results Preterm birth <37 weeks was found in 13.6% (102/751) of pregnant women. Short cervix (≤25 mm) was found in 2.7% (20/751) of pregnancies. Only 30% (6/20) of pregnant women with short cervix have used progesterone to prevent preterm birth. There was a weak correlation between CL measurement and gestational age at delivery (R2=0.01, P=0.002). Receiver operating characteristics curve analysis of the ability of CL measurement to predict preterm birth <32, 34, and 37 weeks, showed an area under the curve of 0.693 (95% CI, 0.512 to 0.874), 0.472 (95% CI, 0.353 to 0.591), 0.490 (95% CI, 0.426 to 0.555), respectively. Conclusion There was a weak correlation between CL measurement and gestational age at delivery. In an unselected population, CL measurement screening at 20 to 24+6 weeks of gestation does not seem to be a good predictor of preterm birth.

Prevalence of Benign Diseases Mimicking Lung Cancer: Experience from a University Hospital of Southern Brazil

( Gustavo Kohler Homrich ),( Cristiano Feijo Andrade ),( Roseane Cardoso Marchiori ),( Grazielli Dos Santos Lidtke ),( Fabio Pacheco Martins ),( Jose Wellington Alves Dos Santos ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.2

Background: Lung cancer is the most lethal type of cancer in the world. Several benign lung diseases may mimic lung carcinoma in its clinical and radiological presentation, which makes the differential diagnosis for granulomatous diseases more relevant in endemic regions like Brazil. This study was designed to describe the prevalence and the diagnostic work-up of benign diseases that mimic primary lung cancer in patients hospitalized at a university hospital from south of Brazil. Methods: This was a transversal study, which evaluated the medical records of 1,056 patients hospitalized for lung cancer treatment from September 2003 to September 2013 at University Hospital of Santa Maria. Results: Eight hundred and four patients underwent invasive procedures for suspected primary lung carcinoma. Primary lung cancer was confirmed in 77.4% of the patients. Benign disease was confirmed in 8% of all patients. Tuberculosis (n=14) and paracoccidioidomycosis (n=9) were the most frequent infectious diseases. The diagnosis of benign diseases was obtained by flexible bronchoscopy in 55.6% of the cases and by thoracotomy in 33.4%. Conclusion: Infectious diseases are the most frequent benign diseases mimicking lung cancer at their initial presentation. Many of these cases could be diagnosed by minimally invasive procedures such as flexible bronchoscopy. Benign diseases should be included in the differential diagnosis during the investigation for primary lung cancer in order to avoid higher cost procedures and mortality.

Genome-wide identification and functional prediction of silicon (Si) transporters in poplar (Populus trichocarpa)

Hassan Md Mahmudul,Martin Samir,Feng Kai,Yates Timothy B.,Yuan Guoliang,Martin Madhavi Z.,Martin Stanton,Muchero Wellington,Griffiths Natalie A.,Weston David J.,Yang Xiaohan 한국식물생명공학회 2023 Plant biotechnology reports Vol.17 No.2

Silicon (Si) enhances plant tolerance to various biotic and abiotic stressors such as salinity, drought, and heat. In addition, Si can be biomineralized within plants to form organic carbon-containing phytoliths that can have ecosystem-level consequences by contributing to long-term carbon sequestration. Si is taken up and transported in plants via different transporter proteins such as influx transporters (e.g., Lsi1, Lsi6) and efflux transporters (e.g., Lsi2). Additionally, the imported Si can be deposited in plant leaves via silicification process using the Siliplant 1 (e.g., Slp1) protein. Functional homologs of these proteins have been reported in different food crops. Here, we performed a genome-wide analysis to identify different Si transporters and Slp1 homologs in the bioenergy crop poplar (Populus trichocarpa Torr. and A. Gray ex W. Hook). We identified one channel-type Si influx transporter (PtLsi1; Potri.017G083300), one Si efflux transporter (PtLsi2; Potri.012G144000) and two proteins like Slp1 (PtSlp1a; Potri.004G168600 and PtSlp1b; Potri.009G129900) in the P. trichocarpa genome. We found a unique sequence (KPKPPVFKPPPVPI) in PtSlp1a which is repeated six times. Repeated presence of this sequence in PtSlp1a indicates that this protein might be important for silicification processes in P. trichocarpa. The mutation profiles of different Si transporters in a P. trichocarpa genome-wide association study population identified significant and impactful mutations in Potri.004G168600 and Potri.009G129900. Using a publically accessible database (http://bar.utoronto.ca/eplant_poplar/), digital expression analysis of the putative Si transporters in P. trichocarpa found low to moderate expression in the anticipated tissues, such as roots and leaves. Subcellular localization analysis found that PtLsi1/PtLsi2 are localized in the plasma membrane, whereas PtSlp1a/PtSlp1b are found in the extracellular spaces. Protein–Protein interaction analysis of PtLsi1/PtLsi2 identified Delta-1-pyrroline-5-carboxylate synthase (P5CS) as one of the main interacting partners of PtLsi2, which plays a key role in proline biosynthesis. Proline is a well-known participant in biotic and abiotic stress tolerance in plants. These findings will reinforce future efforts to modify Si accumulation for enhancing plant stress tolerance and carbon sequestration in poplar.

Accuracy of various imaging methods for detecting misfit at the tooth-restoration interface in posterior teeth

Luciano Andrei Francio,Fernanda Evangelista Silva,Claudia Scigliano Valerio,Claudia Assunção e Alves Cardoso,Wellington Corrêa Jansen,Flávio Ricardo Manzi 대한영상치의학회 2018 Imaging Science in Dentistry Vol.48 No.2

Purpose: The present study aimed to evaluate which of the following imaging methods best assessed misfit at the tooth-restoration interface: (1) bitewing radiographs, both conventional and digital, performed using a photostimulable phosphor plate (PSP) and a charge-coupled device (CCD) system; (2) panoramic radiographs, both conventional and digital; and (3) cone-beam computed tomography (CBCT). Materials and Methods: Forty healthy human molars with class I cavities were selected and divided into 4 groups according to the restoration that was applied: composite resin, composite resin with liner material to simulate misfit, dental amalgam, and dental amalgam with liner material to simulate misfit. Radiography and tomography were performed using the various imaging methods, and the resulting images were analyzed by 2 calibrated radiologists. The true presence or absence of misfit corresponding to an area of radiolucency in regions subjacent to the esthetic and metal restorations was validated with microscopy. The data were analyzed using a receiver operating characteristic (ROC) curve, and the scores were compared using the Cohen kappa coefficient. Results: For bitewing images, the digital systems (CCD and PSP) showed a higher area under the ROC curve (AUROC) for the evaluation of resin restorations, while the conventional images exhibited a larger AUROC for the evaluation of amalgam restorations. Conventional and digital panoramic radiographs did not yield good results for the evaluation of resin and amalgam restorations (P<.05). CBCT images exhibited good results for resin restorations (P>.05), but showed no discriminatory ability for amalgam restorations (P<.05). Conclusion: Bitewing radiographs (conventional or digital) should be the method of choice when assessing dental restoration misfit.

Reference values for the cervical length measurement in the second trimester of pregnancy using the transvaginal ultrasound in a large Brazilian population

( Alberto Borges Peixoto ),( Taciana Mara Rodrigues Da Cunha Caldas ),( Ana Helena Bittencourt Alamy ),( Wellington P. Martins ),( Rafael Frederico Bruns ),( Edward Araujo Junior ) 대한산부인과학회 2016 Obstetrics & Gynecology Science Vol.59 No.4

To establish reference values for the cervical length (CL) measurement by transvaginal ultrasound between 20 and 24+6 weeks of gestation in a large Brazilian population. A retrospective cross-sectional study was performed with 996 singleton pregnancies. The CL measurement (mm) using the transvaginal ultrasound was obtained in a sagittal view and the calipers positioned to measure the linear distance between the triangular area of echodensity at the external os and the internal os. The median±standard deviation and ranges for the CL measurement (mm) was 37.0±10.7 (range, 8 to 51). CL measurement did not modify significantly with gestational age. The observed percentiles for the CL measurement (mm) considering all number case were the following: 5th, 28 mm; 50th, 37 mm; and 95th, 45 mm. Reference values for the CL measurement by transvaginal ultrasound between 20 and 24+6 weeks of gestation in a large heterogeneous Brazilian population were established.