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Li, Weixun,Choi, Tae-Woo,Ahnn, Joohong,Lee, Sun-Kyung Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.11
Regulator of calcineurin 1 (RCAN1) binds to calcineurin through the PxIxIT motif, which is evolutionarily conserved. SP repeat phosphorylation in RCAN1 is required for its complete function. The specific interaction between RCAN1 and calcineurin is critical for calcium/calmodulin-dependent regulation of calcineurin serine/threonine phosphatase activity. In this study, we investigated two available deletion rcan-1 mutants in Caenorhabditis elegans, which proceed differently for transcription and translation. We found that rcan-1 may be required for calcineurin activity and possess calcineurin-independent function in body growth and egg-laying behavior. In the genetic background of enhanced calcineurin activity, the rcan-1 mutant expressing a truncated RCAN-1 which retains the calcineurin-binding PxIxIT motif but misses SP repeats stimulated growth, while rcan-1 lack mutant resulted in hyperactive egg-laying suppression. These data suggest rcan-1 has unknown functions independent of calcineurin, and may be a stimulatory calcineurin regulator under certain circumstances.
Weixun Li,이선경,Jaya Bandyopadhyay,Hyun Sook Hwaang,Byung-Jae Park,조정훈,이진일,안주홍 한국분자세포생물학회 2012 Molecules and cells Vol.34 No.2
Thioredoxin reductase (TrxR) is a member of the pyridine nucleotide-disulfide reductase family, which mainly func-tions in the thioredoxin system. TrxR is found in all living organisms and exists in two major ubiquitous isoen-zymes in higher eukaryotic cells; One is cytosolic and the other mitochondrial. Mitochondrial TrxR functions to protect mitochondria from oxidative stress, where reactive oxidative species are mainly generated, while cytosolic TrxR plays a role to maintain optimal oxido-reductive status in cytosol. In this study, we report differential physiological functions of these two TrxRs in C. elegans. trxr-1, the cytosolic TrxR, is highly expressed in pharynx, vulva and intestine, whereas trxr-2, the mitochondrial TrxR, is mainly expressed in pharyngeal and body wall muscles. Deficiency of the non-selenoprotein trxr-2 caused defects in longevity and delayed development under stress conditions, while deletion mutation of the selenoprotein trxr-1 resulted in interference in acidification of lysosomal compartment in intestine. Interestingly, the acidification defect of trxr-1(jh143) deletion mutant was rescued, not only by selenocystein-containing wild type TRXR-1, but also cysteine-substituted mutant TRXR-1. Both trxr-1 and trxr-2 were up-regulated when worms were challenged by environmental stress such as heat shock. These results suggest that trxr-1 and trxr-2 function differently at organismal level presumably by their differential sub-cellular localization in C. elegans.
Time-varying Group Formation With Leader-following Control for Heterogeneous Multi-agent Systems
Xiangyang Du,Weixun Li,Jingyu Xiao,Zengqiang Chen 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.7
This paper studies time-varying group formation control for heterogeneous multi-agent systems (MAS). Two subgroups of heterogeneous MAS consisting of second-order dynamic and Euler-Lagrange (E-L) dynamic agents, three subgroups of heterogeneous MAS consisting of first-order, second-order dynamic and E-L dynamic agents are considered respectively. Firstly, through the assumption of the formation-tracking feasibility condition and the design of the formation compensation vectors in the controller, the time-varying formation control can be transformed into a consensus problem. Then, a distributed controller based on neighbor information is designed and sufficient conditions for time-varying formation control are obtained. The time-varying group formation problem of heterogeneous MAS is analyzed by Lyapunov stability theory and eigenvalue theory. Finally, two simulation results show that the proposed controller can realize the time-varying formation control of heterogeneous group MAS.
Sun-Kyung Lee,Weixun Li,Tae-Woo Choi,Joohong Ahnn 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.11
Regulator of calcineurin 1 (RCAN1) binds to calcineurin through the PxIxIT motif, which is evolutionarily con-served. SP repeat phosphorylation in RCAN1 is required for its complete function. The specific interaction between RCAN1 and calcineurin is critical for calcium/calmodulin-dependent regulation of calcineurin serine/threonine phosphatase activity. In this study, we investigated two available deletion rcan-1 mutants in Caenorhabditis elegans, which proceed differently for transcription and translation. We found that rcan-1 may be required for calcineurin activity and possess calcineurin-independent function in body growth and egg-laying behavior. In the genetic background of en-hanced calcineurin activity, the rcan-1 mutant expressing a truncated RCAN-1 which retains the calcineurin-binding PxIxIT motif but misses SP repeats stimulated growth, while rcan-1 lack mutant resulted in hyperactive egg-laying suppression. These data suggest rcan-1 has unknown functions independent of calcineurin, and may be a stimulatory calcineurin regulator under certain circumstances.