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RISS 인기검색어
- 검색키워드
- 저자 : Weibing Zhu (검색결과 4 건)
- 무료
- 기관 내 무료
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Weibing Zhu,Jingmin Xu,Yingchun Li 한국지질과학협의회 2017 Geosciences Journal Vol.21 No.5
In Shendong coalfield, severe support failure accidents caused by the dynamic pressure occurred frequently when longwall faces extracting the lower coal seam progress below the chamber coal pillars. These incidents largely threaten the personnel safety and regular operations. The rationale of the dynamic pressure has been investigated based on the movement law of the overlying strata. Experimental and numerical simulations of a longwall face in Shigetai coal mine agree well with the qualitative explanations. It is shown that the failure of the chamber coal pillars causes the sudden break and even rotation of the key strata, thereby leading to strong dynamic load that crushes the supports in the longwall face. Several guidelines have been proposed to prevent the occurrence of the dynamic pressure, the capability of which has been demonstrated by in situ practice in two longwall faces in Shendong coalfield.
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A study on the bearing effect of pier column backfilling in the goaf of a thin coal seam
Jianlin Xie,Weibing Zhu,JiaLin Xu,Jiahui Wen,Chuanzhen Liu 한국지질과학협의회 2016 Geosciences Journal Vol.20 No.3
The pier column backfilling method in the goaf of a thin coal seam introduced in this paper is the latest backfilling technology in China, which has the combined advantages of high efficiency and low cost. In order to fully verify the load bearing effect of this backfilling method, a comprehensive evaluation model which combined the actual measurement, numerical simulation and physical simulation is implemented in this paper. First, the stress bearing formula and backfilling volume rate of a pier column backfilling body is obtained by theory analysis. Then, through field monitoring, it was concluded that the bearing capacity when the backfilling body reached a stable state was similar to the results of theoretical calculation, and no obvious deformation occurred by observation the roadway deformation with the site. Finally, based on the drilling columnar and lithological parameters of the site, corresponding physical and numerical models were established and used to study the bearing effect of this backfilling method. It could be found that the stresses and displacements data that resulted from the simulation relatively confirmed data obtained from the site. After comprehension of above researches, it is concluded that the pier column backfilling method in a goaf has good bearing effect and a good economic benefit for mining thin coal seams.
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Research on the cone angle and clearance of main pump seal
Wang Heshun,Zhu Weibing,Huang Zepei,Zhang Chening,Zhang Junkai 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.7
For better film characteristics of the main pump seal (MPS), a theoretical calculation model was proposed based on the Reynolds equation. A case study with defined MPS was carried out, film stiffness was taken as the basic constraint condition, and the cone angle andclearance are two optimization targets. When the film stiffness reaches a maximum, the corresponding cone angle and clearance is theoptimal value. The results show that: (1) film stiffness increased and decreased with clearance and cone angle, respectively; (2) the optionalclearance was determined to be within a range of 2~8 μm at a cone angle of between 0.1~1.2'; (3) the maximum of film stiffness isinversely proportional to the cone angle (Clearance) approximately under the clearance (Cone angle) is fixed; (4) leakage is directly proportionalto the clearance to power three, and the clearance has greater influence on the amount of leakage than the cone angle. Theseresults provide a reliable theoretical justification for MPS-based designs including optimization method. It therefore forms a fundamentalbase for research and practical application.
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MiR-200c-3p aggravates gastric cell carcinoma via KLF6
Wang Ying,Lu Kaijuan,Li Weibing,Wang Zhigang,Ding Jing,Zhu Zeyu,Li Zhipeng 한국유전학회 2021 Genes & Genomics Vol.43 No.11
Background Gastric cell carcinoma (GCC) is a common and high-incidence malignant gastrointestinal cancer that seriously threatens human life and safety. Evidences suggest that microRNAs (miRNAs) exhibit an essential role in regulating the occurrence and development of GCC, while the efects and possible mechanisms remain to be further explored. Objective This study was designed to explore whether miR-200c-3p exerted its functional role in the growth and metastasis of GCC, and investigate the possible mechanisms. Methods The expression levels of miR-200c-3p in GCC tissues and cell lines were detected by qRT-PCR analysis. The functional role of miR-200c-3p in the viability, proliferation, migration and invasion of GCC cells were evaluated by CCK-8, EdU, wound healing and Transwell assays. In addition, the candidate targets of miR-200c-3p was predicted and confrmed by dual-luciferase reporter assay. Moreover, the relationship between miR-200c-3p and target (Krüppel like factor 6, KLF6) was assessed by qRT-PCR and western blot assays. Besides, the expression levels of KLF6 in GCC cells were determined by qRT-PCR and western blot assays. Furthermore, the role of KLF6 in the viability, proliferation, migration and invasion of GCC cells mediated with miR-200c-3p mimics was evaluated by CCK-8, EdU, wound healing and Transwell assays. Results In the present study, a new tumor promoting function of miR-200c-3p was disclosed in GCC. We found that the expression of miR-200c-3p was obviously increased in clinic GCC tissues and cell lines. In addition, down-regulation of miR-200c-3p suppressed cell viability, proliferation, migration, and invasion in GCC cells. Moreover, KLF6 was verifed as a direct target of miR-200c-3p by binding its 3’-UTR. Additionally, KLF6 was remarkably decreased and was negatively associated with the miR-200c-3p expression in GCC cell lines. Furthermore, over-expression of KLF6 retarded the efects of miR-200c-3p on the growth and metastasis of GCC cell lines. Conclusions MiR-200c-3p potentially played a tumor-promoting role in the occurrence and development of GCC, which may be achieved by targeting KLF6.
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