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Surgical treatment for hepatocellular carcinoma with bile duct invasion
Xu-guang Hu,Wei Mao,Sung Yeon Hong,Bong-Wan Kim,Wei-guang Xu,Hee-Jung Wang 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.90 No.3
Purpose: There is still some debate on surgical procedures for hepatocellular carcinoma (HCC) patients with bile duct tumor thrombi (BDTT, Ueda type 3 or 4). What is adequate extent of liver resection for curative treatment? Is extrahepatic bile duct resection mandatory for cure? The aim of this study is to answer these questions. Methods: Between February 1994 and December 2012, 877 consecutive HCC patients underwent hepatic resection at Ajou University Hospital. Thirty HCC patients (3.4%) with BDTT (Ueda type 3 or 4) were retrospective reviewed in this study. Results: In total, 20 patients enrolled in this study were divided into 2 groups: patients who underwent hemihepatectomy with extrahepatic bile duct resection (group 1, n = 10) and with only removal of BDTT (group 2, n = 10). The 1-, 3- and 5-year overall survival rates were 75.0%, 50.0%, and 27.8%, respectively. The 1-, 3-, and 5-year survival rates of group 1 were 100.0%, 80.0%, and 45.7%, and those of group 2 were 50.0%, 20.0%, and 10.0%, respectively (P = 0.014). The 1-, 3-, and 5-year recurrences free survival rates of group 1 were 90.0%, 70.0%, and 42.0%, and those of group 2 were 36.0%, 36.0%, and 0%, respectively (P = 0.014). Thrombectomy and infiltrative growth type (Ig) were found as independent prognostic factors for recurrence free survival by multivariate analysis. Thrombectomy, Ig, and high indocyanine green retention rate at 15 minutes were found as independent prognostic factors for overall survival by multivariate analysis. Conclusion: We suggest that the appropriate surgical procedure for icteric HCC patients should be comprised of ipsilateral hemihepatectomy with caudate lobectomy and extrahepatic bile duct resection.
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왕희정,Xu-Guang Hu,Wei Mao,박용근,Wei-Guang Xu,김봉완 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.5
Purpose: The systemic inflammation biomarker, Neutrophil-to-Lymphocyte Ratio (NLR), has been reported as one of the adverseprognostic factors for hepatocellular carcinoma (HCC) patient. The purpose of this study was to evaluate whether NLR could predictthe risk of recurrence and death for the HCC patient, according to Milan criteria after hepatectomy. Materials and Methods: Retrospective analysis was performed on a database of HCC patients who underwent hepatectomy betweenMarch 2001 and December 2011. The cutoff value of NLR was decided by receiver operating characteristic (ROC) curve analysis. Univariate and multivariate regression analyses were performed to identify predictive factors of recurrence and death. Results: A total of 213 patients were included in the present study. The median follow-up period was 48 months. One hundred andseven patients were experienced tumor recurrence; forty of them recurred within 12 months (early recurrence). NLR ≥1.505, albumin≤3.75 g/dL, microvascular invasion and high grade of cirrhosis were found to be independent factors for adverse recurrence-freesurvival in multivariate regression analysis. And NLR ≥1.945 was also found as a prognosis factor for early recurrence by univariateregression analysis. Conclusion: Elevated preoperative NLR can be easily obtained and reliable biomarker for assessing the tumor recurrence and earlyrecurrence of Milan criteria HCC after the initial hepatectomy.
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( Xu-guang Hu ),( Ingyu Kim ),( Sung Yeon Hong ),( Mao Wei ),( Bong-wan Kim ),( Hee-jung Wang ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Surgical resection has been the treatment of choice for hepatocellular carcinoma (HCC), and the overall survival was satisfied. However, the recurrence is a significant problem. The shortage of organ donors has led to a restricted indication for orthotropic liver transplantation for HCC. The aim of this study was to analyze the results of surgical treatment for HCC (≤2cm). Methods: From January 2005 to December 2013, 619 consecutive HCC patients underwent surgical treatment at our institution. 119 (20.8%) HCC patients who the diameter of tumor was less than 2 cm were retrospective. We excluded one case of incidental HCC and 4 cases hospital motality patients who were received liver transplantation. Finally, 114 HCC patients were enrolled in this study and they were divided into two groups by treatment procedure. One group is hepatectomy group (n=79), the other is transplantation group (n=35). Results: The median follow-up period was 40.5 months. Totally, 30 cases were experience tumor recurrence in the follow-up period, 29 of them were come from hepatectomy group, while only one case was from transplantation group. Figure 1 shows us the Treatment modalities for recurrent cases after initial hepatectomy. The 1, 3 and 5-year recurrence free survival rates of hepatectomy group were 85.8%, 68.3% and 50.9%, and those of transplantation group were 97.1%, 97.1% and 97.1%, respectively. (P=0.000) The 1, 3, and 5-year survival rates of hepatectomy group were 97.5%, 93.4% and 90.8%, and those of transplantation group were 100%, 96.9%, and 96.9%, respectively. (p=0.819) The cutoff value (38.5u/L) of serum ALT was detected by ROC cure (Area under the cure=0.709, P value=0.002) . We divided the hepatectomy group into two sub group: normal and elevated ALT group according the cutoff value. Elevated ALT group have worse disease free survival (P=0.005) and overall survival (p=0.225)(Firgure3). Figure 4 shows us that the overall survival of normal ALT group have a comparable overall survival to transplantation group, whereas the overall survival of elevated ALT group was worse than transplantation group (P=0.034).
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Three New 11,20-Epoxy-ent-kauranoids from Isodon rubescens
Xu Liu,Ji Zhou Wu,Rui Zhan,Wei Guang Wang,Xue Du,Yan Li,Peng Zhang,Jian Xin Pu,Han Dong Sun 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.12
Three rare and new 11,20-epoxy-ent-kaurane diterpenoids, named jianshirubesins D-F (1-3), along with one known analogue (4), were isolated from the aerial parts of Isodon rubescens. Their structures were established by analysis of spectroscopic data. Found in the MTT assay to evaluate the cytotoxicity of compounds 1, 2, and 4, only 1 could selectively inhibit certain cell lines from proliferating. In addition, a simple structure-activity relationship discussion might suggest a new bioactive moiety, different from the α,β-unsaturated ketone group.
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Guang Wei Li,Xiu Lin Chen,Yong Sun,Yu Xing Chen,Shi Cai Xu,Jun Xiang Wu 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.4
The ligand-binding function of odorant binding proteins (OBPs) that are expressed exclusively or enriched in antennae are well-studied, whilst the ligand binding properties of relatively low expressed OBPs in insect antennae are still unclear. Here, two low expressed GmolOBPs (namely GmolOBP12 and GmolOBP16) were cloned based on the antennal transcriptome of Grapholita molesta, and then their expression profiles and binding properties were investigated via real-time quantitative PCR (qRT-PCR) and fluorescence binding assays, respectively. Multiple sequence alignment and phylogenetic tree analyses displayed that both of GmolOBP12 and GmolOBP16 possessed the typical six-cysteine motifs unique to the classic OBPs subfamily and were classified as such. Although the abundance of transcripts of GmolOBP12 and GmolOBP16 were relatively low compared to that of many other OBPs in the antennal transcriptome of G. molesta, qRT-PCR results indicated that the transcript levels of GmolOBP12 and GmolOBP16 in antennae were significantly higher than those in other tissues. GmolOBP12 displayed higher expression level in male antennae than in female antennae, while the transcript level of GmolOBP16 in antennae was similar for both sexes. Both recombinant GmolOBP12 and GmolOBP16 exhibited strong binding affinities to the sex pheromone (Z)-8-dodecenyl alcohol and host-plant volatile pear ester. Besides, rGmolOBP12 showed outstanding binding affinities to (E)-2-hexenal, benzaldehyde, 1-hexanol, and (Z)-3-hexenyl acetate with K i values of 4.21, 6.81, 4.68 and 4.68 μM, respectively. rGmolOBP16 had moderate binding abilities with hexanal, decanal, 1-hexanol, methyl myristate and benzonitrile. We speculated that GmolOBP12 may have dual functions in recognition of green leaf volatiles and sex pheromone components and GmolOBP16 may participate in the detection of host-plant volatiles in chemoreception.
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Transplantation versus Hepatectomy for Hepatocellular Carcinoma 2 cm or Less Than 2 츠
( Xu-guang Hu ),( Hee-jung Wang ),( Bong-wan Kim ),( Mao Wei ),( Sung Yeon Hong ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Methods: From January 2005 to December 2013, 619 consecutive HCC patients underwent surgical treatment at our hospital. 119 (19.2%) patients, whose diameter of tumor was 2 cm or less than 2 cm, were included and they were divided into two groups by treatment procedure. One group is hepatectomy group (n=79), the other is transplantation group (n=40). The data were retrospective reviewed in this study. Results: The median follow-up period was 40 months. Totally, 30 cases experienced tumor recurrence in the follow-up period, 29 of them came from hepatectomy group, while only one case was from transplantation group. Figure 1 show us the treatment methods for recurrent cases after initial hepatectomy. The 1, 3 and 5-year recurrence free survival rates of hepatectomy group were 85.8%, 69.5% and 51.7%, and those of transplantation group were 97.2%, 97.2% and 97.2%, respectively. (P=0.0001) The 1, 3, and 5-year survival rates of hepatectomy group were 97.5%, 93.4% and 90.8%, and those of transplantation group were 90.0%, 87.3%, and 87.3%, respectively. (p=0.819) Conclusions: Our results show that transplantation could be a radical treatment for 2 cm or less than 2cm HCC.
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A Discovery of Low Hydraulic Resistance Channel Along Meridians
Wei-Bo Zhang,Yu-Ying Tian,Hong Li,Jia-He Tian,Ming-Fu Luo,Fa-Liang Xu,Guang-Jun Wang,Tao Huang,Yi-Hui Xu,Rui-Hong Wang 사단법인약침학회 2008 Journal of Acupuncture & Meridian Studies Vol.1 No.1
A hydro-mechanic model was put forward to study the fundamental nature of acupuncture meridians. The basic state of low hydraulic resistance was tested on humans and mini pigs using three methods. The first, a modified Guyton’s method, proved that there was lower hydraulic resistance on meridians compared with nonmeridians. The second scanning method involved a single pressure transducer that can find the lowest resistance point in tissue, and the third method used two transducers and provided a more stable measurement. Using the latter method, low hydraulic resistance points were found very close to low impedance points along meridians. The transmission of artificial interstitial fluid pressure waves was measured to examine their connection to the low resistance points, with the result that a good connection between the points was confirmed. This means the points form channels along the meridians that we refer to as low hydraulic resistance channels. The channel was imaged through isotopic tracing and a migration of isotope 99mTe could be found along the channel. The layer of the channel was detected by injecting Alcian blue and the track was found beneath the skin. All of the above experiments suggest the existence of a new type of channel in living tissues that has not yet been described in modern science, but coincides quite well with the Qi channel theory of traditional Chinese medicine. A hydro-mechanic model was put forward to study the fundamental nature of acupuncture meridians. The basic state of low hydraulic resistance was tested on humans and mini pigs using three methods. The first, a modified Guyton’s method, proved that there was lower hydraulic resistance on meridians compared with nonmeridians. The second scanning method involved a single pressure transducer that can find the lowest resistance point in tissue, and the third method used two transducers and provided a more stable measurement. Using the latter method, low hydraulic resistance points were found very close to low impedance points along meridians. The transmission of artificial interstitial fluid pressure waves was measured to examine their connection to the low resistance points, with the result that a good connection between the points was confirmed. This means the points form channels along the meridians that we refer to as low hydraulic resistance channels. The channel was imaged through isotopic tracing and a migration of isotope 99mTe could be found along the channel. The layer of the channel was detected by injecting Alcian blue and the track was found beneath the skin. All of the above experiments suggest the existence of a new type of channel in living tissues that has not yet been described in modern science, but coincides quite well with the Qi channel theory of traditional Chinese medicine.
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