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- 저자 : Wei-Jen Liao (검색결과 5 건)
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Loh, Tiing Jen,Moon, Heegyum,Cho, Sunghee,Jang, Hana,Liu, Yong Chao,Tai, Hongmei,Jung, Da-Woon,Williams, Darren R,Kim, Hey-Ran,Shin, Myung-Geun,Liao, D Joshua,Zhou, Jianhua,Shi, Wei,Zheng, Xuexiu,Shen National Hellenic Research Foundation 2015 ONCOLOGY REPORTS Vol.34 No.3
<P>CD44 is a transmembrane receptor for hyaluronic acid. CD44 pre-mRNA contains 19?exons, 9?of which are alternatively spliced. Among the CD44 spliced variants, the v4-7 variant, one of the v6?exon-containing isoforms that contains variable exon?4, 5, 6 and?7, confers metastatic potential to non-metastatic cells. Splicing of CD44 and the function of CD44 isoforms are different in breast cancer cells. hnRNP?A1 is a ubiquitously expressed protein with an inhibitory function in pre-mRNA splicing. We showed that CD44v6 isoform, which includes all of the v6-containing mRNA isoforms, had the highest expression level in non-metatatic breast cancer cells (MCF7) when compared to the level in metastatic breast cancer cells (MDA-MB-231) and normal breast cells (MCF10A). Furthermore we showed that hnRNP?A1 knockdown regulated splicing of CD44 differently in breast cancer cells. We showed here that CD44 isoform expression is completely different in MDA-MB-231 cells than that in MCF7 and MCF10A cells, whereas MCF7 and MCF10A cells had a similar expression pattern of CD44 isoforms. RT-PCR analysis of CD44v6 showed that MCF7 and MCF10A cells predominantly expressed the c5v6v7v8v9v10c6 isoform. However, in addition to this isoform, MDA-MB-231 cells also expressed the c5v6v8v9v10c6 and c5v6c6 isoforms. We also found that knockdown of hnRNP?A1 significantly reduced the expression of c5v6v7v8v9v10c6 and c5v6v8v9v10c6, and promoted the expression of c5v6c6. hnRNP?A1 knockdown significantly induced cell death. In addition, hnRNP?A1 knockdown induced a decrease in cell invasion in the MDA-MB-231 cells. Our results indicate that the knockdown of hnRNP A1 has a specific function on the splicing of CD44 in breast cancer cells.</P>
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A Methodology to Build a Groutability Formula via a Heuristic Algorithm
Chien-Lin Huang,Jen-Chen Fan,Kuo-Wei Liao,Tsung-Hsun Lien 대한토목학회 2013 KSCE JOURNAL OF CIVIL ENGINEERING Vol.17 No.1
The goal of this study is to provide a methodology to develop a groutability (N) formula of sandy silt soils using microfine cement grouts in a permeation grouting. Because the Fines Content (FC) of the sandy silt soils studied is relatively high, and the size of the grouts used is significantly smaller than the Portland cement, the existing empirical formulas cannot deliver a promising prediction of N. Support Vector Machines (SVMs) is an alternative tool used to predict N. However, SVMs do not provide an explicit formula,which creates an obstacle for practical engineers. Thus, a heuristic algorithm (the Tabu search, TS) was used to build the prediction formula. A total of 240 in-situ data samples were analyzed to ensure the accuracy of the proposed formula. The format of the existing empirical formula was adopted in the proposed TS-based formula. Four parameters were considered in our TS models: the effective soil particle size (D10), the soil particle size (D15), the water-to-cement ratio (w/c) and the FC. The prediction accuracy of the TSbased formula was approximately 94.17%, indicating that the proposed formula is a suitable tool. Because the proposed formula has a similar format to that of formulas that are typically used, the proposed approach can be implemented readily in practical engineering settings. Note that the proposed formula was only verified by the collected data samples, the suitability of applying the built formula to other conditions needs more investigation.
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Ching-Min Kuo,Wei-Jen Liao,Chun-Che Huang,Tsuo-Hung Lan,Ching-Heng Lin,Shun-Ping Wang,Cheng-Hung Lee,Ping-Wing Lui 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.4
Objective: The relationship of antipsychotics and the risk of refracture in treated patients is unclear. The aim of this study is to evaluate the association between prolonged antipsychotic and the incidences of bone fractures and refractures in schizophrenia. Methods: This is a retrospective nested case-control study using Taiwan National Health Insurance Research Database recorded from 2000 to 2005, with cases followed up to end of 2011. Total of 7,842 schizophrenic patients, 3,955 had developed bone fractures were compared with 3,887 control subjects matched in age, sex, and index date. Antipsychotic drug exposure was classified based on the drug type and medication duration. Conditional logistic regression analyses were performed. Odds ratio (OR) and confidence interval (CI) were calculated. Results: We found (after adjustments) higher risks of developing fractures under continued use of typical (OR = 1.70; 95% CI, 1.51−1.91) or atypical antipsychotics (OR = 1.43; 95% CI, 1.28−1.60) were found. Additionally, continued use typical (OR = 1.84; 95% CI, 1.35−2.50) or atypical antipsychotics (OR = 1.44; 95% CI, 1.06−1.95) was positively associated with refracture risks. Moreover, refractures were associated with continuous use of chlorpromazine (one typical antipsychotics, OR = 2.45; 95% CI, 1.14−5.25), and risperidone (OR = 1.48; 95% CI, 1.01−2.16) or zotepine (OR = 2.15; 95% CI, 1.06−4.36) (two atypical antipsychotics). Conclusion: Higher risks of bone fracture and refracture were found in schizophrenia under prolonged medication with typical or atypical antipsychotics. We therefore recommend that clinicians should pay more attention on bone density monitoring for patients using long-term antipsychotics.
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An autonomous Mobile Robot System based on Serverless Computing and Edge Computing
Tri Thong Tran,Yu-Chen Zhang,Wei-Tung Liao,Yu-Jen Lin,Ming-Chia Li,Huai-Sheng Huang 한국통신학회 2020 한국통신학회 APNOMS Vol.2020 No.09
Strengthen by Artificial Intelligence (AI) and complexly integrated sensors, an autonomous mobile robot (AMR) is extensively applied in coping with various human resources tasks in indoor office environments. However, implementing an AMR system from scratch needs a strong Electric Engineer background due to the complexity of robot-controlling. Besides, Communication between robot-server, sensor, and client-service also increases the difficulty and time-cost in AMR developing. In this paper, the AMR system we proposed aims to be implemented by people without a EE background, and we will achieve this by employing Robot Operating System. Besides, the AMR system should work independently but still capable of responding to human requests. We will demonstrate a serverless could structure that includes the client-side service and integrate the edge-computing, which in charge of the immediacy-demanding job.
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