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RISS 인기검색어
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- 저자 : Wanqi Zhu (검색결과 3 건)
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Lu Zhu,Jianxin Shi,Guochao Zhao,Dabing Zhang,Wanqi Liang 한국식물학회 2013 Journal of Plant Biology Vol.56 No.1
The tapetum of the anther locule encloses the malereproductive cells and plays a supportive role for normalpollen development. However, the underlying mechanismremains less understood. Previously, we identified a completerecessive male sterile mutant, post-meiotic deficient anther1(pda1), with abnormal postmeiotic tapetal development. Inthis study we comprehensively characterized pda1. Chemicalanalysis uncovered that pda1 anther had significant lowerlevels of cutin monomers and cuticular waxes. PDA1 geneencodes an ATP-binding cassette (ABC) half-transporter,namely OsABCG15, which is conserved from algae tohigher plants. In situ RNA hybridization assay showed thatPDA1 is strongly expressed in tapetal cells, and weakly inmicrospores during the anther development. Additionally,the expression of two pollen exine biosynthetic genesCYP704B2 and CYP703A3 was dramatically reduced inpda1 mutant anthers. Altogether, these observations suggestthat the tapetum-expressed ABC transporter PDA1 plays acrucial role in secreting lipidic precursors from the tapetumto developing microspores and the anther epidermis.
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Yi, Jakyung,Moon, Sunok,Lee, Yang-Seok,Zhu, Lu,Liang, Wanqi,Zhang, Dabing,Jung, Ki-Hong,An, Gynheung American Society of Plant Biologists 2016 Plant Physiology Vol.170 No.3
<P>After meiosis, tapetal cells in the innermost anther wall layer undergo program cell death (PCD)-triggered degradation. This step is essential for microspore development and pollen wall maturation. We identified a key gene, Defective Tapetum Cell Death 1 (DTC1), that controls this degeneration by modulating the dynamics of reactive oxygen species (ROS) during rice male reproduction. Mutants defective in DTC1 exhibit phenotypes of an enlarged tapetum and middle layer with delayed degeneration, causing male sterility. The gene is preferentially expressed in the tapetal cells during early anther development. In dtc1 anthers, expression of genes encoding secretory proteases or lipid transporters is significantly reduced, while transcripts of PCD regulatory genes, e.g. UDT1, TDR1, and EAT1/DTD, are not altered. Moreover, levels of DTC1 transcripts are diminished in udt1, tdr, and eat1 anthers. These results suggest that DTC1 functions downstream of those transcription factor genes and upstream of the genes encoding secretory proteins. DTC1 protein interacts with OsMT2b, a ROS scavenger. Whereas wild-type plants accumulate large amounts of ROS in their anthers at Stage 9 of development, those levels remain low during all stages of development in dtc1 anthers. These findings indicate that DTC1 is a key regulator for tapetum PCD by inhibiting ROS-scavenging activity.</P>
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Xiaoling Li,Ligang Xing,Yujun Zhang,Peng Xie,Wanqi Zhu,Xiangjiao Meng,Yinxia Wang,Lingling Kong,Hanxi Zhao,Jinming Yu 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.1
Acute radiation-induced esophagitis (ARIE) is among the most serious form of toxicities associated with definitive radiotherapy or chemoradiotherapy used for treatment of patients with esophageal cancer. Our preliminary phase I and II trials of lung cancer patients who received radiotherapy indicated epigallocatechin-3-gallate (EGCG) as a promising therapeutic option against ARIE. Therefore, we conducted a prospective phase II study to validate the efficacy and safety of EGCG in the treatment of ARIE. The patients who received chemoradiotherapy or definitive radiotherapy for treatment of esophageal cancer in the Shandong Cancer Hospital and Institute in China were enrolled for the present study. EGCG (440 μM) was administered with first onset of ARIE and then at weeks after final radiotherapy. The patients were monitored every week for dysphagia, Radiation Therapy Oncology Group (RTOG) score, and esophagitis-related pain. Moreover, tumor response and the effect on survival following the treatment were also evaluated. Comparison of the RTOG score in the first, second, third, fourth, fifth, and even sixth week after EGCG prescription and the first and second week after radiotherapy with baseline indicates a significant reduction. The tumor response rate was 86.3%. The overall survival rate in 1, 2, and 3 years was found to be 74.5%, 58%, and 40.5%. Oral administration of EGCG solution seems to be feasible for treating ARIE in patients with esophageal cancer who receive radiation therapy. EGCG might be an ARIE-reliever without compromising the efficacy of radiation therapy. A randomized study with a control group is needed for further evaluation.
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