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RISS 인기검색어
- 검색키워드
- 저자 : Guangyao Xiong (검색결과 4 건)
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Guangyao Xiong,Yanjiao Nie,Dehui Ji,Jing Li,Chunzhi Li,Wei Li,Yong Zhu,Honglin Luo,Yizao Wan 한국물리학회 2016 Current Applied Physics Vol.16 No.8
Microwave assisted sintering has attracted much attention due to the greatly reduced sintering time. In this work, for the first time, hydroxyapatite (HAp)-reinforced magnesium (Mg) composites were prepared by the microwave assisted sintering technique. The as-prepared HAp/Mg composites were characterized by mechanical and electrochemical tests, XRD analysis, and preliminary biological evaluation. Optical microscopy observation confirms the homogeneously distributed HAp particles in the Mg matrix. It is shown that the relative density of HAp/Mg composite with 10 wt% HAp can reach 96.5% after only 10 min microwave assisted sintering. Furthermore, the mechanical properties of HAp/Mg composites are significantly higher than those of pure Mg. The corrosion resistance of HAp/Mg composites evaluated by immersion and electrochemical measurements in simulated body fluid (SBF) at 37 C reveals significant improvement over pure Mg. It is demonstrated that the mechanical properties, corrosion resistance, and biological behavior can be properly controlled by adjusting HAp content.
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Guangyao Xiong,Yizao Wan,Honglin Luo,Chen Zhang,Yong Zhu 한국고분자학회 2015 Macromolecular Research Vol.23 No.8
Bacterial cellulose (BC) is considered a promising three-dimensional (3D) nanofibrous scaffold for tissue engineering. To further improve its biological behavior, BC scaffold was modified by the creation of macropores and the immobilization of collagen (COL) on the surface. The creation of macropores was performed by laser perforation technique and the immobilization of collagen was achieved by solution immersion and subsequent crosslinking. The asprepared macroporous BC/COL nanocomposite (denoted as mBC/COL) was characterized by SEM, FTIR, contact angle measurement, and dynamic mechanical analysis, and its cell behavior was evaluated by MTT assay. SEM and FTIR confirmed the presence of collagen coating and patterned macropores (300 μm). Although the presence of macropores and collagen reduced its storage modulus and hydrophilicity, mBC/COL exhibited sufficient stiffness and wettability. More importantly, preliminary cell studies demonstrated that mBC/COL exhibited improved biological activity over BC and BC/COL due to the co-existence of macropores and collagen.
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Self-assembled magnetic lamellar hydroxyapatite as an efficient nanovector for gene delivery
Guangyao Xiong,Yizao Wan,Guifu Zuo,Kaijing Ren,Honglin Luo 한국물리학회 2015 Current Applied Physics Vol.15 No.7
Magnetic lamellar hydroxyapatite (ML-HA) nanoparticles were synthesized by a template-assisted selfassembly process. The as-prepared ML-HA nanoparticles self-assembled under different conditions were characterized by XRD, TEM, cytotoxicity assessment, and DNA-loading and transfection efficiency measurements. We found that the structure and morphology of ML-HA were controlled by self-assembly conditions. The ML-HA synthesized in this work exhibited good biocompatibility. The DNA-loading capacity and z-potential of ML-HA were much lower in comparison to bare lamellar HA (L-HA) without magnetic nanoparticles. Despite that, the ML-HA with good lamellar structure showed 47% higher transfection efficiency than L-HA. Results suggested that the ordered lamellar structure is a key factor in controlling transfection efficiency and magnetization is an effective way of improving the transfection efficiency of lamellar HA. Mechanisms were proposed to interpret these experimental results. It is demonstrated that the ML-HA may be a promising gene vector to deliver DNA into the cells effectively and safely.
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Bacterial cellulose/graphene oxide nanocomposite as a novel drug delivery system
Honglin Luo,Haiyong Ao,Gen Li,Wei Li,Guangyao Xiong,Yong Zhu,Yizao Wan 한국물리학회 2017 Current Applied Physics Vol.17 No.2
Graphene-based nanocarriers not only possess large specific surface area but also prevent drugs from premature release outside the target cells. However, agglomeration in aqueous solution is a critical challenge. In this work, graphene oxide (GO) was uniformly embedded into the three-dimensional (3D) porous network of bacterial cellulose (BC) to form a novel BC/GO nanocomposite drug nanocarrier. For the first time, ibuprofen (IBU) was loaded onto the BC/GO nanocomposites. Scanning electron microscope (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) reveal the successful drug loading onto BC/GO nanocomposites. In vitro drug release studies indicate that the drug release of IBU@BC/GO follows a non-Fickian diffusion mechanism. Another important feature of this BC/GO nanocarrier is its better cell viability in comparison to BC. It is believed that this new nanocarrier is a potential choice for drug delivery system.
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