기종성 방광염 1예

마성권,나명윤,박종욱,고정희,염충호,김수완,김남호,최기철 全南大醫大 2001 전남의대학술지 Vol.37 No.2

Experimental and mechanism research on volatilization characteristics of HCl in desulfurization wastewater evaporation process using high temperature flue gas

Ma Shuangchen,Chai Jin,Wu Kai,Wan Zhongcheng,Xiang Yajun,Zhang Jingrui,Fan Zixuan 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.66 No.-

Due to the promulgation of “water pollution control action plan” in China, zero liquid discharge of desulfurization wastewater has become a new trend for water pollution control in power plants. The HCl volatilization in desulfurization wastewater evaporation process is the key problem that may influence the application of evaporation technology, so experiment was carried out in self-made experimental system. The effects of temperature, pH, Cl− concentration, total dissolved solids and main metal ions on HCl volatilization were explored. Results have shown that HCl volatilization increases respectively from 5.42% to 20.43% and 2.22% to 9.18% with the increasing temperature from 180 °C to 380 °C in two kinds of actual desulfurization wastewater evaporation process. When pH < 7, Cl− concentration is the main influencing factor on HCl volatilization; the higher Cl− concentration is, the higher HCl volatilization will be observed. While pH > 7, pH becomes the dominant factor, increasing pH will inhibit HCl volatilization; Mechanism of HCl volatilization was studied simultaneously by XRD and TGA. Gaseous HCl mainly comes from the combination of free H+ and Cl−, hydrolysis of Ca2+ and Mg2+ in liquid phase and hydrolysis of hydrate in high temperature solid phase; Ways to inhibit HCl volatilization in process were put forward according to the experimental results. The use of Ca(OH)2 to adjust the pH of desulfurization wastewater to 9.0–10.0 can inhibit HCl volatilization economically and efficiently. This study provides the key data for the application of flue gas evaporation technology under high temperature. The research results have important theoretical and practical values for the engineering practice of this technology.

Obovatol isolated from <i>Magnolia obovata</i> enhances pentobarbital-induced sleeping time: Possible involvement of GABA_A receptors/chloride channel activation

Ma, Hong,Jo, Young-Jun,Ma, Yuan,Hong, Jin-Tae,Kwon, Byoung-Mog,Oh, Ki-Wan Elsevier 2009 Phytomedicine Vol.16 No.4

<P><B>Abstract</B></P><P>This study aimed to investigate the effects of obovatol isolated from <I>Magnolia obovata</I> on pentobarbital-induced sleeping behaviors and to determine whether these effects were mediated by GABA<SUB>A</SUB> receptors/chloride channel activation, using a western blot technique and Cl<SUP>−</SUP> sensitive fluorescence probe. GABA<SUB>A</SUB> receptors subunits expression and chloride influx were investigated in cultured cerebellar granule cells. Obovatol (0.05, 0.1, and 0.2mg/kg) prolonged the sleeping time induced by pentobarbital (42mg/kg). In addition, obovatol (20 and 50μM) significantly increased Cl<SUP>−</SUP> influx in the primary cultured cerebellar granule cells. Moreover, obovatol increased the expression of GABA<SUB>A</SUB> receptor α-, β-, and γ-subunits. However, it had no effect on the abundance of the expression of glutamic acid decarboxylase (GAD), suggesting that obovatol might not activate GAD. These results suggest that obovatol potentiates pentobarbital-induced sleeping time through the GABA<SUB>A</SUB> receptors/chloride channel activation.</P>

Sanjoinine A Isolated from Zizyphi Spinosi Semen Augments Pentobarbital-Induced Sleeping Behaviors through the Modification of GABA-ergic Systems

Ma, Yuan,Han, Huishan,Eun, Jae Soon,Kim, Hyung-Chun,Hong, Jin-Tae,Oh, Ki-Wan Pharmaceutical Society of Japan 2007 Biological & pharmaceutical bulletin Vol.30 No.9

<P>Zizyphi Spinosi Semen (ZSS) has been widely used for the treatment of insomnia in oriental countries. This experiment was performed to investigate whether sanjoinine A, one of major alkaloid compounds of ZSS, has hypnotic effects and/or enhances pentobarbital-induced sleeping behaviors through the γ-aminobutyric acid (GABA)-ergic systems. Sanjoinine A itself did not induce sleeping at the higher dose used in this experiment. However, sanjoinine A prolonged sleeping time and reduced the sleeping latency induced by pentobarbital in a dose-dependent manner similar to muscimol, a GABA<SUB>A</SUB> receptor agonist. Sanjoinine A also increased sleeping rate and sleeping time when administered combined with pentobarbital at a sub-hypnotic dosage and showed synergistic effects with muscimol in potentiating sleeping onset and enhancing sleeping time induced by pentobarbital. In addition, both sanjoinine A and pentobarbital increased chloride influx in primary cultured cerebellar granule cells. Sanjoinine A also showed similar effects with muscimol in potentiating chloride influx inducing effects of low dose pentobarbital. Sanjoinine A decreased GABA<SUB>A</SUB> receptor α-subunit expression and increased γ-subunit expression, and had no effects on the abundance of β-subunits in primary cultured cerebellar granule cells, showing different subunit expression from pentobarbital. In addition, we found that sanjoinine A also enhanced expression of glutamic acid decarboxylase (GAD), but pentobarbital did not. In conclusion, sanjoinine A itself does not induce sleeping, but it augments pentobarbital-induced sleeping behaviors through the modification of GABA-ergic systems.</P>

Magnolol enhances pentobarbital-induced sleeping behaviors: possible involvement of GABAergic systems

Ma, Hong,Kim, Chung-Soo,Ma, Yuan,Nam, Sang-Yoon,Kim, Dong-Seon,Woo, Sung-Sick,Hong, Jin-Tae,Oh, Ki-Wan John Wiley Sons, Ltd. 2009 Phytotherapy research Vol.23 No.9

<P>This study was performed to investigate whether magnolol enhances pentobarbital-induced sleeping behaviors through the GABAergic systems. Magnolol prolonged the sleeping time induced by pentobarbital. In addition, magnolol increased chloride influx in primary cultured cerebellar granule cells. The expression of the GABA<SUB>A</SUB> receptor &agr;-subunit was increased selectively by magnolol, but magnolol had no effect on the abundance of &bgr;- or &ggr;-subunits. The expression of glutamic acid decarboxylase (GAD) was not influenced by magnolol. It is suggested that magnolol may enhance pentobarbital-induced sleeping behaviors through the activation of GABAergic systems. Copyright © 2009 John Wiley & Sons, Ltd.</P>

Altered Renal Expression of Aquaporin Water Channels and Sodium Transporters in Rats with Two-Kidney, One-Clip Hypertension

Ma, Seong Kwon,Bae, Eun Hui,Kim, In Jin,Choi, Chan,Lee, JongUn,Kim, Soo Wan S. Karger AG 2010 Kidney & blood pressure research Vol.32 No.6

<P><I>Aims:</I> To determine whether the renal regulation of aquaporin (AQP) water channels and sodium transporters are altered in 2-kidney, 1-clip (2K1C) hypertension. <I>Methods:</I> Male Sprague-Dawley rats were used. They were made 2K1C hypertensive for 1 week. The renal expression of AQPs and sodium transporters was determined by semiquantitative immunoblotting and immunohistochemistry. The activity of adenylyl cyclase was measured by stimulated generation of cAMP. <I>Results:</I> Systolic blood pressure was increased in 2K1C rats. Experimental rats revealed impaired urinary concentration in association with increased urine volume. Urinary sodium excretion also increased. The expression of AQP1-3 was decreased in the clipped kidney compared with the control kidney, whereas it was unchanged in the non-clipped kidney. The adenylyl cyclase activity provoked by arginine vasopressin, sodium fluoride or forskolin was blunted in the clipped kidney, but remained unaltered in the contralateral kidney. The expressions of the Na,K-ATPase α1-subunit, type 3 Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger, Na-K-2Cl cotransporter and epithelial sodium channels were decreased in the clipped kidney, while remaining unchanged in the non-clipped kidney. <I>Conclusion:</I> The downregulation of AQPs and major sodium transporters/channels in the clipped kidney may play a role in the urinary concentration defect and impaired sodium reabsorption in 2K1C hypertension.</P><P>Copyright © 2009 S. Karger AG, Basel</P>

Increased renal expression of nitric oxide synthase and atrial natriuretic peptide in rats with glycyrrhizic-acid-induced hypertension

Ma, Seong Kwon,Bae, Eun Hui,Kim, In Jin,Choi, Ki Chul,Kim, Suhn Hee,Lee, JongUn,Kim, Soo Wan John Wiley Sons, Ltd. 2009 Phytotherapy research Vol.23 No.2

<P>The present study aimed to examine whether there is an altered regulation of local hormonal systems in the kidney following the treatment of glycyrrhizic acid (GA), the active ingredient in licorice. Male Sprague-Dawley rats were treated with GA for 3 weeks. The expression of mineralocorticoid receptor (MR) was determined in the kidney by immunoblotting and real-time polymerase chain reaction (PCR). The protein expression of endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) was determined. The expression of atrial natriuretic peptide (ANP), natriuretic peptide receptor (NPR)-A and NPR-C was determined by real-time PCR. The activity of guanylyl cyclase was determined by the amount of cGMP generated in responses to sodium nitroprusside (SNP) or ANP. Following the GA treatment, systolic blood pressure was increased. The mRNA and protein expressions of MR were increased in the kidney. The protein expression of eNOS and iNOS was also increased. The expression of ANP mRNA was increased although that of NPR-A and NPR-C mRNA was not changed. The cGMP production provoked by either SNP or ANP was not changed. The increased expression of MR may contribute to GA-induced hypertension. The enhanced expression of NOS and ANP may play a compensatory role in GA-induced hypertension. Copyright © 2008 John Wiley & Sons, Ltd.</P>

ASESDP : An Efficient Service Discovery Protocol in Pervasive Computing Environments

Ma, Qianli,Liao, Minghong,Jiang, Shouxu,Hong, Wan-Pyo,Gao, Zhenguo The Korea Institute of Information and Commucation 2008 Journal of information and communication convergen Vol.6 No.4

Service discovery is the technology of finding needed services in networks, and a key point in pervasive computing environments. This paper presents a novel service discovery protocol: ASESDP(AIP and SRR Enhanced Service Discovery Protocol). In ASESDP, tow schemes are proposed to enhance its performance: AIP(Advertisement Information Piggybacked) and SRR(Shortest Reply Route). In AIP, parts of advertisement information are piggybacked in the service reply packet, which makes the advertisement information propagating along the reply path, and spreads its transmission area. In SRR, in order to reduce the service response time, the shortest reply route is chosen to forward the service reply packet to the source node sending the service request. With the theoretical analysis and Glomosim simulation results, it is verified that ASESDP can reduce the number of service request packets, save the response time, and improve the efficiency of service discovery.

Ginseng Extract Regulates the Alterations of Sleep Architecture and EEG Power Spectra in Restraint Stressed Rats

Ma, Yuan,Eun, Jae-Soon,Yang, Shulong,Lee, Kwang-Seung,Lee, Eun-Sil,Kim, Chung-Soo,Oh, Ki-Wan The Korean Society of Ginseng 2010 Journal of Ginseng Research Vol.34 No.1

The present investigation was conducted to evaluate the regulation of sleep architecture by the red ginseng water extract (RGE) in acutely and chronically restraint stressed rats. Adult rats were fitted with sleep.wake recording electrodes. Following post-surgical recovery, rats were extensively habituated for freely moving polygraphic recording conditions. Polygraphic signs of sleep-wake activities were recorded for 24 h after RGE administration and induction of stress and were analyzed to understand the regulation of sleep architecture. Acute stress decreased wakefulness and increased total sleep, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep in both the daytime and nighttime recording. RGE shortened the daytime NREM and REM sleep, without changing the wakefulness and total sleep. RGE increased nighttime wakefulness, and decreased total, NREM and REM sleep. Chronic stress increased wakefulness and decreased total sleep in the daytime recording, and increased REM and decreased NREM sleep in both the day and night time recording. RGE ameliorated chronic stress and induced alterations of REM and NREM sleep in the day and night time sleep architecture. Acute and chronic stress could also induce alternations in cortex electroencephalogram (EEG) recording during NREM, REM sleep and wakefulness. These findings suggest that RGE may modulate the sleep behavior in acutely and chronically stressed rats and the ameliorating effect of RGE on the sleep architecture may involve in modulation of $\alpha$-, $\theta$- and $\delta$- wave activities of the cortical EEG.

Therapeutic Effects of Ginseng on Psychotic Disorders

Ma, Yu-An,Eun, Jae-Soon,Oh, Ki-Wan The Korean Society of Ginseng 2007 Journal of Ginseng Research Vol.31 No.3

Ginseng, the root of Panax species, a well-known herbal medicine has been used as a traditional medicine for thousands of years and is now a popular and worldwide used natural medicine. Ginseng has been used primarily as a tonic to invigorate weak bodies to help the restoration of homeostasis in a wide range of pathological conditions such as cardiovascular diseases, cancer, immune deficiency and hepatotoxicity. Although conclusive clinical data in humans is still missing, recent research results have suggested that some of the active ingredients ginseng exert beneficial effects on central nervous system (CNS) disorders and neurodegenerative diseases, suggesting it could be used in treatment of psychotic disorders. Data from neural cell cultures and animal studies contribute to the understanding of these mechanisms that involve inhibitory effects on stress-induced corticosterone level increasing and modulating of neurontransmitters, reducing $Ca^{2+}$ over-influx, scavenging of free radicals and counteracting excitotoxicity. In this review, we focused on recently reported medicinal effects of ginseng and summarized the possibility of its applications on psychotic disorders.