http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Regulation of IL-18 expression by CRH in mouse microglial cells
Yang, Yoolhee,Hahm, Eunsil,Kim, Youngin,Kang, Jaeseung,Lee, Wangjae,Han, Innoc,Myung, Pyungkeun,Kang, Hyungsik,Park, Hyunjeong,Cho, Daeho 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10
Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-I8. Indeed, it was also found that CRH increased the generation of ROJ. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress.
Regulation of IL-18 expression by CRH in mouse microglial cells
Yang, Yoolhee,Hahm, Eunsil,Kim, Youngin,Kang, Jaeseung,Lee, Wangjae,Han, Innoc,Myung, Pyungkeun,Kang, Hyungsik,Park, Hyunjeong,Cho, Daeho 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8
Corticotropin Releasing Hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress.
Endogenous interleukin-l8 modulates immune escape of murine melanoma cells
Cho, Daeho,Kim, Youngin,Kang, Jaeseung,Hahm, Eunsil,Lee, Wangjae,Song, Hyunkeun,Pyun, Kwangho,Choi, Inpyo 이화여자대학교 세포신호전달연구센터 2001 고사리 세포신호전달 심포지움 Vol. No.3
It has been known that melanoma cells can suppress the immune system by the Fas ligand. The present study investigated whether interleukin(IL)-18, which can enhance Fas ligand expression, is produced by B16F10 melanoma cells and is involved in immune escape of tumor cells. Immunohistology, RT-PCR, intracellular FACS analysis, and immunoblotting demonstrated that melanoma cells express IL-18. In addition to IL-18, the IL-18 receptor was also detected in B16F10 melanoma cells, suggesting a role of this cytokine in regulating the functions of B16F10 melanoma cells. The functional effect of IL-18 on B16F10 melanoma cells was shown by reduction of Fas ligand expression in cells transfected with IL-18 antisense cDNA. In addition, the same treatments decreased intracellular reactive oxygen intermediate levels in B16F10 melanoma cells, indicating that IL-18 regulates reactive oxygen intermediate production. Furthermore, transfection of IL-18 antisense cDNA into melanoma cells increased the susceptibility of tumor cells to natural killer cells in vitro. When IL-18 antisense transfectants were implanted into syngeneic mice, severe reduction of tumor cell growth was observed. Taken together, these results demonstrate that IL-18 has a critical role as a survival factor for B16F10 melanoma cells.