Lidocaine, Thrombin, Epinephrine 의 항균효과

김진우,이동건,전혜선,김승준,김석찬,안중현,김치홍,권순석,김영균,김관형,문화식,신완식,송정섭,박성학 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

목적 : 기관지내시경 검사에서 흔히 사용되는 국소마취제인 lidocaine과 내시경시 지혈목적으로 사용되는 thrombin과 epinephrine이 각종 균주에 미치는 항균효과에 대해 알아보고자 하였다. 재료 및 방법 : 균주는 가톨릭대학교 성모병원에서 2004년 3월부터 2004년 9월까지 임상검체 에서 동정된 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 각각 42, 42, 42, 43주를 대상으로 하였다. Lidocaine, thrombin, epinephrine 감수성 검사는 National Committee for Clinical Laboratory Standards (NCCLS, 2002)의 기준에 따랐다. 결과 : Lidocaine은 S. aureus, S. pneumoniae, P. aeruginosa에서 MIC_(50), MIC_(90) 모두 20,000 ㎍/mL 이었다. K. pneumoniae는 각각 10,000 ㎍/mL이었다. Thrombin은 S. aureus와 P. aeruginosa에서 MIC50 500 lU/mL 과 MIC_(90) 500 IU/mL 이상이었고, K. pneumoniae에서는 MIC_(50)과 MIC_(90)이 모두 500 lU/mL이상이었으나 S. pneumoniae에서는 MIC_(50)과 MIC_(90)은 125 IU/mL이었다. Epinephrine은 K. pneumoniae, S. pneumoniae에 대한 MIC_(50), MIC_(90)가 모두 >500 ㎍/mL이었고, S. aureus와 P. aeruginosa에 대한 MIC_(50), MIC_(90)가 모두 500 ㎍/mL이었다. 결론 : 기관지 내시경 검사에서 흔히 쓰이는 lidocaine, thrombin, epinephrine 등의 약제들이 호흡기 질환의 흔한 병원균인 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 균주들에 대해 항균 효과가 있을 수 있어 세균배양검사에 영향을 미칠 수 있겠다. Background : We performed this stody to find out about antimicrobial effect of lidocaine which is commonly used local anesthetic, and thrombin and epinephrine used for hemostasis during bronchoscopic procedures. Materials and Methods : The microorganisms that were cultured from specimens obtained during bronchoscopy were Staphylococcus aureus (n=42), Streptococcus pneumoniae (n=42), Klebsiella pneumoniae (n=42), and Pseudomonas aeruginosa (n=43) collected from St. Mary's Hospital, from March to Sep 2004 were used for susceptibity testing. Susceptibility to lidocaine, thrombin, and epinephrine were tested according to the National Committee for Clinical Laboratory Standards. Result : MIC_(50) and MIC_(90) of lidocaine for S. aureus, S. pneumoniae, P. aeruginosa were all 20,000 ㎍/mL and that for K. pneumoniae were 10,000 ㎍/mL. MIC_(50) and MIC_(90) of thrombin for both S. aureus and P. aeruginosa was 500 IU/mL and above 500 IU/mL, respectively; that for K. pneumoniae were all above 500 IU/mL and for S. pneumoniae they were 125 IU/mL, MIC_(50) and MIC_(90) of epinephrine for K. pneumoniae and S. pneumoniae were above 500 ㎍/mL; that for S. aureus and P. aeruginosa were 500 ㎍/mL. Conclusion : We observed possible antimicrobial effect of lidocaine, thrombin, and epinephrine in vitro against pathogens such as S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa, which are common respiratory microorganisms. The use of these agants could affect the result of bacterial culture.

순천향대학교의 연구년제도 개선에 관한 연구

탁충습,김완섭,김완종,김형기,남해선,한현각 순천향대학교 사회과학연구소 1999 순천향 사회과학연구 Vol.4 No.2

This study was done for the purpose of making an improved provision for sabbatical year program of the Soonchunhyang university. We made a comparison, between the provision for sabbatical year of Soonchunhyang university and those of other 16 universities in Korea, and proposed a new rule for sabbatical year program. The main features of the reformed plan are as follows. 1) Diversification of sabbatical year program based on a period of time and contents into two categories : research fellowship and reduction of the lecture time for duty per semester. 2) More detailed description of the purpose for sabbatical year program. 3) Relief of the qualification for application. 4) More strict prescription to the number of faculties for sabbatical year. 5) More definite prescription to the faculty's obligations. To be more progressive and competitive in 21st century for Soonchunhyang university, new approaches to program for faculty retraining including the sabbatical year rule are needed.

PBT에 의한 얕은기초의 지지력 및 침하량 산정연구

심태섭,기완서,주승완,김선학 朝鮮大學校 建設技術硏究所 2002 建設技術硏究 Vol.22 No.1

A stable and economical bearing force estmate and the upper load condition and foundation ground characteristics are very important in a case of designing shallow foundation. A typicial field test method which get the coefficient of subgrade reaction to estmate bearing capacity of the earthand sand ground foundation and settlement of the soil and rock foundation with most direct method of the field test methods to estimate bearing capacity, is plate bearing test(PBT). So this study refer's to the calculation characteristics of the bearing capacity and settlement according to plate bearing method of the A field and B field which is practiced in the soil of weathered gneiss and soil reclamation ground, and refers to the reasonable settlement calculation method and bearing capacity estmate and safety examination method suitable to the soil of wethered rock and soil reclamation ground according to the plate bearing test result when we examine the structure safety of same design term by awllowable bearing capacity calculation in the point of view of bearing capacity and settlement. Therefore in the methods to determine yield bearing capacity that is applied to allowable bearing capacity calculation when we design shallow foundation and examine safety by plate bearing test, P-S analysis, logP-logS analysis and logP-S analysis are proper methods and it is proper to examine safety by the point of bearing capacity in the soilground to be able t o find the yield point in the Load-Settlement behavior curve.

다짐도에 따른 화강풍화토의 역학적 특성

심태섭,기완서,주승완,김선학 朝鮮大學校 建設技術硏究所 2002 建設技術硏究 Vol.22 No.1

In this study do we collect the Wethered Granite Soil of Gwang-ju Pung -am district and Youm-ju-dong Gwang-ju world cup stadium construction field and identify physical character according to basic physical test and summerged the sample of 85% degree of compaction in the dry side and wet side in a water tank for ten days on the basis of the sample of 80%, 85%, 90% degree of compaction and Optimum Moisture Ratio in the Optimum Moisture Ratio state in order to exam permeability and compression character of the Weathered Granite Soil according to the compaction state of retaining wall, abutment bankfill banking. We perform falling head permeability test and them standard compaction test and calculate coefficient of permeability and consolidation constant according to the test result. We have a mind to clear permeability and compression character of the Weathered Granite Soil of this study area according to relation curve of the calculated coefficient of permeability, consolidation constant and void ratio, degree of compaction. Therefore compression constant, according to the compaction energy of Optimum Moisture Ratio, is in inverse proportion linearally in the Weathered Granite Soil of WGS-1 and WGS-2 and coefficient of permeability increase directly in a range of void ratio e=0.627∼0.779. e=0.6.57∼0.800.

강우시 불포화 성토사면의 안정해석

심태섭,기완서,김선학,최순범 朝鮮大學校 建設技術硏究所 2005 建設技術硏究 Vol.25 No.1

This study conducted the indoor slope model test which reproduces the rainfall after building up the artificial slope by considering the construction condition of the actual slope in order to understand the characteristics of the change of the quantitative value such as the pore water pressure, dangerous rainfall volume etc, in accordance with the superior seepage of the unsaturated banking slope in the time of rainfall. With this result. the change of the pore water pressure caused by the rainfall seepage, the estimation of time for the slope degradation and of the dangerous rainfall volume, the change of the seepage line, the characteristics of the change in safety rate by using the simplified Janbu's method (1968) have been analyzed and studied. The abstract for this study is as follows: 1. Since the soil within the slope is in the unsaturated state in the early period after the rainfall started, it is started at the pore water pressure of the negative value(-) in the measuring point around the outer layer and of the positive value(+) in the deep area. As the rainfall permeates into the slope, it become saturated, therefore, the pore water pressure also increases which lead to the degradation. After that, it tends to be gradually diminished. The pore water pressure had shown relatively considerable increase right before the degradation, and 50~150 minutes before the slope degradation happens, it had shown sharp increase. 2. The safety rate is sharply decreased when reached the slope layer after being started its activity at the slope line area; the time to the complete degradation of the slope layer by being the 1.0 for the safety rate after the degradation at the slope line area started is displayed short as the rainfall intensity strengthens, and longer as the slope inclination becomes gentler. Likewise, the time to the complete degradation from the slope line to the slope layer is relatively short for the slope built by the 8M than by the one built by the SW.

예체능 심화과정 학생들의 기능 변화에 대한 연구

이완섭,김춘선,김정희 춘천교육대학교 예체능교육연구소 1996 예체능교육연구 Vol.1 No.-

VOQL : 시각적 객체지향 질의어

조완섭,김정희 충북대학교 컴퓨터 정보통신 연구소 1998 컴퓨터정보통신연구 Vol.6 No.2

객체지향 데이터베이스를 위한 시각적 질의어(Visual query language)의 설계에서 복잡한 질의조건을 간단하고도 직관적으로 표현할 수 있도록 지원하는 것이 중요한 연구과제가 되고 있다. 본 논문에서는 시각적 객체지향 질의어인 VOQL(Visual Object Query Language)을 제안한다. VOQL은 그래프와 밴다이어그램을 결합한 시각적 표현 기법을 사용하여 객체지향 데이터베이스의 스키마(schema)와 질의어를 하나의 통일된 시각적 표시법으로 표현하며, 객체지향 질의어에 포함된 다양한 객체지향 특성도 간단한 시각적 표시법을 이용하여 표현한다. VOQL의 가장 큰 특징은 기존의 시각적 객체지향 질의어들에 비하여 간단하고 직관적인 구문과 의미를 가지며, 뛰어난 질의 표현력을 가진다는 점이다. Expressing complex query conditions in a concise and intuitive way has been a challenge in the design of visual object-oriented query languages. We propose a visual query language called VOQL (Visual Object-oriented Query Language) for object-oriented databases. By employing the visual notation of graph and Venn diagram, the database schema and the advanced features of object-oriented queries such as multi-valued path expressions and quantifiers can be represented in a simply way. VOQL has such good features as simple and intuitive syntax, well-defined semantics, and excellent expressive power of object-oriented queries compared with previous visual object-oriented query languages.

Agent에 근거한 생산시스템 관리체계 : agent oriented SCM을 중심으로 focuse on the agent oriented SCM

엄완섭,임상환,윤만영,김영훈 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-

Recently, in the competitive environments, every company recognizes the importance of the control architecture for production system. Manufacturing has been evolving over the years as different needs and technologies arise. Information systems have become the nerve center of most manufacturing system. The Supply Chain is a worldwide network of suppliers, factories, warehouses, distribution centers, and retailers through which raw materials are acquired, transformed, and delivered to customers. Partnership quality has been considered important to optimize performance of Supply Chain Management. But the dynamics of the enterprise and the market make this difficult, for example, materials do not arrive on time, production facilities fail, workers are ill, customers change or cancel order, and so forth, causing deviations from the plan. In this paper, we develop a control architecture for production system. Then, using the simulation technique with Arena Professional Edition, we proposes a effective evaluation method for production systems.

강우시 침투영향을 고려한 사면안정해석

심태섭,기완서,김선학,최순범 朝鮮大學校 建設技術硏究所 2007 建設技術硏究 Vol.27 No.2

Most of current slope safety analyses consider only the effect of the rise of underground water level. However, because the infiltration of surface water into the ground is believed to have significant effects on slope stability, the present study performed slope safety analysis in case of the rise of underground water level, the infiltration of surface water, and both resulting from rainfall, and examined their effects. For this study, we selected Slope A and B, at which slope failure had happened due to rainfall, and made slope safety analysis in consideration of the fall of wetting front and the rise of underground water level resulting from rainfall. Based on the results of the analysis, we made comparative analysis on the relation between the effect of infiltration on rainfall and the stability of the slopes and proposed a desirable slope safety analysis method. The conclusions of this study are as follows. 1. In slope safety analysis in consideration of the effect of infiltration resulting from rainfall, the variation of safety factor was different depending on whether to consider the fall of wetting front, the rise of underground water level. or both. 2. The decrease of the slope safety factor caused by the fall of wetting front on rainfall was somewhat faster than that caused by the rise of underground water level. This suggests that slope failure caused by rainfall is affected more by the fall of wetting front than by the rise of underground water level. 3. When both the fall of wetting front and the rise of underground water level were considered at the same time, the slope safety factor decreased faster than when either the fall of wetting front or the rise of underground water level was considered. Accordingly, it is considered desirable to consider both the fall of wetting front and the rise of underground water level in slope safety analysis that takes into account the effect of infiltration resulting from rainfall.

교육대학교 대학원 예체능 교육과정에관한 연구

이완섭,김정희,유원 춘천교육대학교 예체능교육연구소 1987 예체능교육연구 Vol.2 No.-