Challenges of Endoscopic Management of Pancreaticobiliary Complications in Surgically Altered Gastrointestinal Anatomy

Tin Moe Wai,Eun Young Kim 대한소화기내시경학회 2016 Clinical Endoscopy Vol.49 No.6

Pancreaticobiliary complications following various surgical procedures, including liver transplantation, are not uncommon and areimportant causes of morbidity and mortality. Therapeutic endoscopy plays a substantial role in these patients and can help to avoid theneed for reoperation. However, the endoscopic approach in patients with surgically altered gastrointestinal (GI) anatomy is technicallychallenging because of the diffculty in entering the enteral limb to reach the target orifice to manage pancreaticobiliary complications. Additional procedural complexity is due to the need of special devices and accessories to obtain successful cannulation and absenceof an elevator in forward-viewing endoscopes, which is frequently used in this situation. Once bilioenteric anastomosis is reached, thetechnical success rates achieved in expert hands approach those of patients with intact GI anatomy. The success of endoscopic therapyin patients with surgically altered GI anatomy depends on multiple factors, including the expertise of the endoscopist, understandingof postoperative anatomic changes, and the availability of suitable scopes and accessories for endoscopic management. In this issueof Clinical Endoscopy, the focused review series deals with pancreatobiliary endoscopy in altered GI anatomy such as bilioentericanastomosis and post-gastrectomy.

Identification of lead inhibitors targeting influenza A virus nucleoprotein through surface plasmon resonance screening

Chun-Yeung Lo,Sze-Ting Choi,Olive Tin-Wai Li,Jacky Chi-Ki Ngo,David Chi-Cheong Wan,Leo Lit-Man Poon,Pang-Chui Shaw1 한국구조생물학회 2015 Biodesign Vol.3 No.3

Currently, many strains of influenza A virus have developed resistance against anti-influenza drugs, and it is essential to find new chemicals to combat this virus. The viral nucleoprotein (NP) is a major component of the ribonucleoprotein (RNP) complex for the transcription and replication of the virus. In this study, we have employed surface plasmon resonance direct binding screening on the influenza A NP and found a hit compound 16 that can subdue influenza RNP activities. Subsequently, two analogs (compounds 55 & 58) from compound 16 were identified which inhibit RNP activities of various influenza A subtypes and viral growth at micromolar levels. These analogs were also shown to directly interact with NP, with KD 12.0±1.25 and 41.6±1.93 μM respectively by surface plasmon resonance assay.

Study on Treatment Planning for the Prostate in Proton Therapy with Oxygen Enhancement Ratio Effect

Yoo Seung Hoon,Geng Hui,Lam Wai Wang,Kong Chi Wah,Yang Bin,Chiu Tin Lok,Wu Po Man,Cheung Kin Yin,Yu Siu Ki,Shin Dongho,Min Byung Jun 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.77 No.7

The purpose of this study was to investigate the oxygen enhancement ratio (OER) effects on treatment planning for a hypoxic prostate tumor with proton scanning beams. Two different OER-based dose calculation models (the average model and the voxel model) were investigated by using hypoxic tumor models in this simulation study. For the hypoxic tumor model, an oxygen distribution with a range of 2.4-9.4 mmHg was used according to the clinical data. The results given by the average model and the voxel model were compared for 50% and 90% tumor control probabilities with variations in the hypoxic tumor volume and fractionation. Comparison between the treatment plans with OER-based higher predicted dose and with the conventional prescription dose was conducted to investigate the organ-at-risk (OAR) doses for the prostate case. The average model showed a higher calculated dose than the voxel model. The voxel model with a 50% control probability showed good agreement with the current prescription dose. The OER values of the average model ranged from 1.05 to 1.25, which were applied to the whole tumor volume in treatment planning. The voxel-model-based OERs were higher (1.50-1.75) than those of average model, and these OERs should be applied only for the hypoxic boost region. Regarding treatment plans, the doses of the rectum and the bladder were reduced to the tolerable range V80Gy (volume receiving equal to or greater than 80Gy) < 15% and V75Gy (volume receiving equal to or greater than 75Gy) < 15% respectively after an optimization, but the maximum dose to femoral heads was higher than 50 Gy. In conclusion, we investigated the possible ranges of the OER (1.3-1.8) for proton-beam treatment of prostate cases. A dose escalation of up to about 1.8 times can be applied for the small hypoxic region. This result, which was obtained using a model study, should be verified through clinical experiment.

Molecular Assessment of Artemisinin Resistance Markers, Polymorphisms in the K13 Propeller, and a Multidrug-Resistance Gene in the Eastern and Western Border Areas of Myanmar

Nyunt, Myat Htut,Hlaing, Thaung,Oo, Htet Wai,Tin-Oo, Lu-Lu Kyaw,Phway, Hnin Phyu,Wang, Bo,Zaw, Ni Ni,Han, Soe Soe,Tun, Thurein,San, Kyaw Kyaw,Kyaw, Myat Phone,Han, Eun-Taek Oxford University Press 2015 Clinical infectious diseases Vol.60 No.8

<P>K13 mutations were significantly associated with day 3 parasitaemia, emphasizing the importance of K13 surveillance. Low prevalence of K13 mutations and absence of day 3 positive cases indicate that artemisinin resistance may not have spread to the western Myanmar border region.</P><P><B><I>Background.</I></B> As K13 propeller mutations have been recently reported to serve as molecular markers, assessment of K13 propeller polymorphisms in multidrug-resistant gene in isolates from Myanmar, especially the eastern and western border areas, is crucial if we are to understand the spread of artemisinin resistance.</P><P><B><I>Methods.</I></B> A 3-day surveillance study was conducted in the eastern and western border areas in Myanmar, and K13 propeller and <I>Plasmodium falciparum</I> multidrug resistance-associated protein 1 (<I>pfmrp1</I>) mutations were analyzed.</P><P><B><I>Results.</I></B> Among the 1761 suspected malaria cases screened, a total of 42 uncomplicated falciparum cases from the eastern border and 49 from the western border were subjected to 3 days of surveillance after artemether-lumefantrine treatment. No parasitemic case showing positivity on day 3 was noted from the western border, but 26.2% (11/42) of cases were positive in the eastern border. Although we found no marked difference in the prevalence of the <I>pfmrp1</I> mutation in the eastern and western borders (36% vs 31%, respectively), K13 mutations were more frequent in the eastern border area (where the 3-day persistent cases were detected; 48% vs 14%). C580Y, M476I, A481V, N458Y, R539T, and R516Y accounted for 68.9% of all K13 mutations significantly associated with day 3 parasitaemia.</P><P><B><I>Conclusions.</I></B> The K13 mutations were significantly associated with day 3 parasitaemia, emphasizing the importance of K13 surveillance. The low prevalence of K13 mutations and the absence of day 3 parasitaemic cases indicate that artemisinin resistance may not have spread to the western Myanmar border region. Although analysis of multiple K13 mutations is challenging, it should be done at various sentinel sites in Myanmar.</P>

Laser resurfacing in acne scarring: a review

Lee Cheuk Hung,Lee Kar Wai Alvin,Chan Kwin Wah,Lam Kar Wai Phoebe,Wong Tin Hau 대한미용의학회 2022 대한미용의학회지 Vol.6 No.1

Scarring can complicate acne vulgaris and lead to considerable psychosocial implications. Resurfacing and collagen regeneration treatments for acne scars include cryotherapy, chemical peeling, lasers and lights, and radiofrequency. Lasers have become popular among these options. A range of lasers with varying designs, wavelengths, and fractional technologies have become available as treatment choices for acne scars. This review compares the efficacy and adverse effects of these treatments. This is a literature review to determine whether the use of a combination of laser treatments yields superior outcomes compared to a single-device method in the management of acne scars. Our literature review revealed that patient factors, including Fitzpatrick skin phenotype and acne scar subtype, are essential determinants of outcome success in acne treatment with laser. Evidence suggests that ablative CO2 and Er:YAG lasers provide the best curative effects on acne scars in all skin types. Both non-fractional and fractional techniques can effectively treat atrophic acne scars. However, when using a pulse-dye laser to treat hypertrophic scars, the outcomes are variable. Potential complications of ablative lasers include acne flares, infections, and scarring.

Trends in the Incidence of 15 Common Cancers in Hong Kong, 1983-2008

Xie, Wen-Chuan,Chan, Man-Him,Mak, Kei-Choi,Chan, Wai-Tin,He, Miao Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Background: The objective of this study WAS to describe cancer incidence rates and trends among THE Hong Kong population for the period 1983-2008. Methods: Incident cases and population data from 1983 to 2008 were obtained from the Hong Kong Cancer Registry and the Census and Statistics Department, respectively. Agestandardized incidence rates (ASIR) were estimated and joinpoint regression was applied to detect significant changes in cancer morbidity. Results: For all cancers combined, the ASIR showed declining trends (1.37% in men, 0.94% in women), this also being the case for cancers of lung, liver, nasopharynx, stomach, bladder, oesophagus for both genders and cervix cancer for women. With cancer of thyroid, prostate, male colorectal, corpus uteri, ovary and female breast cancer an increase was evident throughout the period. The incidence for leukemia showed a stable trend since early 1990s, following an earlier decrease. Conclusion: Although overall cancer incidence rates and certain cancers showed declining trends, incidence trends for colorectal, thyroid and sex-related cancers continue to rise. These trends in cancer morbidity can be used as an important resource to plan and develop effective programs aimed at the control and prevention of the spread of cancer amongst the Hong Kong population. It is particularly useful in allowing projection of future burdens on the society with the increase in certain cancer incidences.

Serotyping and antibiotic sensitivity of Escherichia coli isolated from colibacillosis infected pig farms

Min Maung Cho,Latt Latt Tun,Soe Soe Wai,Kyaw San Linn,May Thet Hnin Oo,Myint Thein,Tin Tin Myaing 대한수의학회 2009 대한수의학회 학술대회발표집 Vol.2009 No.-