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RISS 인기검색어
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- 저자 : Uma-Mageswary Mageswaran (검색결과 2 건)
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Probiotic Improves Skin Oxidation, Elasticity, and Structural Properties in Aging Rats
Boon-Kiat Lee,Pei Xu,Uma-Mageswary Mageswaran,Woo-Sik Jeong,Engku Ismail Engku-Husna,Kadir Muhammad-Nashriq,Svetoslav Dimitrov Todorov,Guoxia Liu,Yong-Ha Park,Siti Nurma Hanim Hadie,Min-Tze Liong 한국식품영양과학회 2023 Preventive Nutrition and Food Science Vol.28 No.3
Skin aging, which affects all living organisms, is associated with oxidative stress. Probiotics exhibit antioxidant properties by producing reactive metabolites that counter oxidative stress. We hypothesized that Limosilactobacillus fermentum USM 4189 (LF 4189) has antioxidative properties and may prevent skin aging. In the present study, we used a D-galactose senescence-induced rat model to evaluate the potential antioxidative capability of LF 4189. The results indicated that rats administered LF 4189 exhibited increased plasma antioxidative activity (P=0.004), lipid peroxidation capacity (P=0.007), and skin elasticity compared with untreated aged rats (P=0.005). LF 4189 prevented telomere length shortening (P<0.05), indicating the potential to prevent senescence. A higher apoptotic activity was observed in old rats compared with young rats, whereas LF 4189 reduced the expression of four antioxidative enzyme genes that function as radical scavengers (all P<0.05), suggesting that the LF 4189 group had a reduced need to scavenge free radicals. Our findings indicate the potential of probiotics, such as LF 4189, as an anti-aging dietary intervention with antioxidant potential to improve skin health.
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Constipation anti-aging effects by dairy-based lactic acid bacteria
Mohamad Hafis Jaafar,Pei Xu,Uma-Mageswary Mageswaran,Shandra-Devi Balasubramaniam,Maheswaran Solayappan,Jia-Jie Woon,Cindy Shuan Ju Teh,Svetoslav Dimitrov Todorov,Yong-Ha Park,Guoxia Liu,Min-Tze Liong 한국축산학회 2024 한국축산학회지 Vol.66 No.1
Constipation, which refers to difficulties in defecation and infrequent bowel movement in emptying the gastrointestinal system that ultimately produces hardened fecal matters, is a health concern in livestock and aging animals. The present study aimed to evaluate the potential effects of dairy-isolated lactic acid bacteria (LAB) strains to alleviate constipation as an alternative therapeutic intervention for constipation treatment in the aging model. Rats were aged via daily subcutaneous injection of D-galactose (600 mg/body weight [kg]), prior to induction of constipation via oral administration of loperamide hydrochloride (5 mg/body weight [kg]). LAB strains (L. fermentum USM 4189 or L. plantarum USM 4187) were administered daily via oral gavage (1 × 10 Log CFU/day) while the control group received sterile saline. Aged rats as shown with shorter telomere lengths exhibited increased fecal bulk and soften fecal upon administration of LAB strains amid constipation as observed using the Bristol Stool Chart, accompanied by a higher fecal moisture content as compared to the control (p < 0.05). Fecal water-soluble metabolite profiles showed a reduced concentration of threonine upon administration of LAB strains compared to the control (p < 0.05). Histopathological analysis also showed that the administration of LAB strains contributed to a higher colonic goblet cell count as compared to the control (p < 0.05). The present study illustrates the potential of dairy-sourced LAB strains as probiotics to ameliorate the adverse effect of constipation amid aging, and as a potential dietary intervention strategy for dairy foods including yogurt and cheese.
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