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- 저자 : U. Ullmann (검색결과 1 건)
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U. Ullmann,J. Metzner,C. Schulz,J. Perkins,B. Leuenberger 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.3
Commercial Coenzyme Q10 (CoQ10, ubiquinone) formulations are often of poor intestinal absorption. We investigated the bioavailability of DSM Nutritional Products Ltd. (Kaiseraugst, Switzerland) CoQ10 10% TG/P (all-Q??), a new tablet-grade formulation, with CoQ10 Q-Gel?? Softsules?? based on the Bio-Solv?? technology (Tishcon Corp., Salisbury, MD; marketed by Epic4Health™, Smithtown, NY) and Q-SorB?? (Nature’s Bounty™, Bohemia, NY). Twelve healthy male subjects participated in a randomized, three-period crossover bioequivalence study. Plasma CoQ10 was determined from pre-dose until 36 hours. To compare bioavailability, corrected maximum concentration (Cmax) and area under the curve from 0 to 14 hours [AUC(0-14 h)] were assessed and tested for bioequivalence. The bioequivalence ranges of 0.8–1.25 hour g/mL for AUC(0-14 h) and 0.75–1.33 g/mL for Cmax were applied. In summary, the kinetic profiles of all CoQ10 preparations revealed a one-peak plasma concentration–time course. Highest Cmax values were seen after Q-Gel application, whereas time to Cmax was nearly identical across all treatments. The AUC(0-14 h) values were highest for Q-Gel, narrowly followed by all-Q. The tests for bioequivalence showed a bioequivalence between Q-Gel and all-Q, and both preparations were found to have better bioavailability properties than Q-SorB. Although all-Q and Q-Gel have equivalent bioavailability properties, all-Q can be directly used in tablets, while this is not the case for Q-Gel or other similar forms.
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