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Nomura,Tsuyoshi,Suzuki,Motoyuki 嶺南大學校 環境問題硏究所 1995 環境硏究 Vol.15 No.1
Porous membrane of poly(tetrafluoroethylene)(PTFE) was formed on the surface of porous ceramic tubes by means of heat treatment of the PTFE particles deposit layer prepared by filtering PTFE microparticles emulsified in aqueous phase. By means of inert gas permeation, pore size was determined and compared with scanning electron micrograph observation. Also rejection measurement of aqueous dextran solutions of wide range of molecular weights showed the consistent result regarding the pore size. Since the membrane prepared by this method is stable and has unique features derived from PTFE, it is expected that the membrane has interesting applications in the field of water treatment.
Goto, Tsuyoshi,Hirata, Mariko,Aoki, Yumeko,Iwase, Mari,Takahashi, Haruya,Kim, Minji,Li, Yongjia,Jheng, Huei-Fen,Nomura, Wataru,Takahashi, Nobuyuki,Kim, Chu-Sook,Yu, Rina,Seno, Shigeto,Matsuda, Hideo,A American Society for Biochemistry and Molecular Bi 2017 The Journal of biological chemistry Vol.292 No.22
<P>Obesity causes excess fat accumulation in white adipose tissues (WAT) and also in other insulin-responsive organs such as the skeletal muscle, increasing the risk for insulin resistance, which can lead to obesity-related metabolic disorders. Peroxisome proliferator-activated receptor-alpha (PPAR alpha) is a master regulator of fatty acid oxidation whose activator is known to improve hyperlipidemia. However, the molecular mechanisms underlying PPAR alpha activator-mediated reduction in adiposity and improvement of metabolic disorders are largely unknown. In this study we investigated the effects of PPAR alpha agonist (fenofibrate) on glucose metabolism dysfunction in obese mice. Fenofibrate treatment reduced adiposity and attenuated obesity-induced dysfunctions of glucose metabolism in obese mice fed a high-fat diet. However, fenofibrate treatment did not improve glucose metabolism in lipodystrophic A-Zip/F1 mice, suggesting that adipose tissue is important for the fenofibrate-mediated amelioration of glucose metabolism, although skeletal muscle actions could not be completely excluded. Moreover, we investigated the role of the hepatokine fibroblast growth factor 21 (FGF21), which regulates energy metabolism in adipose tissue. In WAT of WT mice, but not of FGF21-deficient mice, fenofibrate enhanced the expression of genes related to brown adipocyte functions, such as Ucp1, Pgc1a, and Cpt1b. Fenofibrate increased energy expenditure and attenuated obesity, whole body insulin resistance, and adipocyte dysfunctions in WAT in high-fat-diet-fed WT mice but not in FGF21-defi-the fenofibrate-mediated improvement of whole body glucose metabolism in obese mice via the amelioration of WAT dysfunctions.</P>
Topology optimization for design of segmented permanent magnet arrays with ferromagnetic materials
Lee, Jaewook,Yoon, Minho,Nomura, Tsuyoshi,Dede, Ercan M. Elsevier 2018 Journal of magnetism and magnetic materials Vol.449 No.-
<P><B>Abstract</B></P> <P>This paper presents multi-material topology optimization for the co-design of permanent magnet segments and iron material. Specifically, a co-design methodology is proposed to find an optimal border of permanent magnet segments, a pattern of magnetization directions, and an iron shape. A material interpolation scheme is proposed for material property representation among air, permanent magnet, and iron materials. In this scheme, the permanent magnet strength and permeability are controlled by density design variables, and permanent magnet magnetization directions are controlled by angle design variables. In addition, a scheme to penalize intermediate magnetization direction is proposed to achieve segmented permanent magnet arrays with discrete magnetization directions. In this scheme, permanent magnet strength is controlled depending on magnetization direction, and consequently the final permanent magnet design converges into permanent magnet segments having target discrete directions. To validate the effectiveness of the proposed approach, three design examples are provided. The examples include the design of a dipole Halbach cylinder, magnetic system with arbitrarily-shaped cavity, and multi-objective problem resembling a magnetic refrigeration device.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A co-design method of magnet segment and iron is proposed using topology optimization. </LI> <LI> A material interpolation scheme is proposed for multi-material representation. </LI> <LI> A penalization scheme is proposed to achieve segmented magnet arrays. </LI> <LI> The effectiveness of proposed design method is validated in three optimization examples. </LI> </UL> </P>
Lee, Jaewook,Kim, Dongjin,Nomura, Tsuyoshi,Dede, Ercan M.,Yoo, Jeonghoon Elsevier 2018 COMPOSITE STRUCTURES -BARKING THEN OXFORD- Vol.201 No.-
<P><B>Abstract</B></P> <P>This paper presents a topology optimization method for the sequential design of material layout and fiber orientation in functionally graded fiber-reinforced composite structures. Specifically, the proposed method can find the optimal structural layout of matrix and fiber materials together with optimal discrete fiber orientations. In this method, an orientation design variable in the Cartesian coordinate system is employed with a conventional density design variable. The orientation design variable controls not only the fiber orientation, but also fiber volume fraction. The fiber volume fraction control can be used to relax the orientation design problem and simultaneously design a functionally graded structural layout of fiber material. To avoid intermediate fiber orientations and achieve discrete fiber orientation design, a penalization scheme is applied to the orientation design variable. For solving the optimization problem which involves multiple design variables such as the density variable, fiber orientation variable, and target discrete orientation set, a three-step sequential optimization procedure is proposed. In this procedure, the result for each step provides the isotropic design, continuous fiber orientation design, and functionally graded discrete orientation design, respectively. To validate the effectiveness of the proposed approach, numerical examples for structural compliance minimization and compliant mechanism design are provided.</P>