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Tomoko Ogawa,Noriko Hanamura,Masako Yamashita,Hiroko Kimura,Minori Ito,Takashi Nakamura,Yumi Kashikura,Yuki Nohara,Aya Noro 한국유방암학회 2012 Journal of breast cancer Vol.15 No.4
We introduce a method combining two oncoplastic techniques for breast-conserving reconstruction. The procedure is as follows: first, an extended glandular flap is made by undermining the breast from both the skin and the pectoralis fascia to the upper edge of the breast at the subclavicular area. After modeling the breast mound with the extended glandular flap, an inframammary adipofascial flap is made. The flap is reflected back to the breast area remodeled using the extended glandular flap. After reshaping the breast, the inframammary line is then re-shaped. This method is indicated for patients with breast cancer in the outer portion of the breast, who have small dense breasts, and have undergone a large excision of about 40% of their breast volume. We treated four patients, all of whom had either excellent or good cosmetic results with no fat necrosis.
Tomoko Ogawa,Noriko Hanamura,Masako Yamashita,Minori Ito,Hiroko Kimura,Takashi Nakamura,Yumi Kashikura,Yuki Nohara,Aya Noro 한국유방암학회 2013 Journal of breast cancer Vol.16 No.2
An abdominal advancement flap (AAF) is a flap that pulls the elevated abdominal skin up and creates the shape of the inferior portion of the breast by making a neo-inframammary fold. Seven patients underwent remodeling using an AAF or a method combining an AAF with other volume displacement techniques after partial mastectomy. The excision volume ranged from 15% to 35%. AAF with only mobilization of the gland flaps was performed in two cases, with lateral mammoplasty in one case, with the round block technique (RBT) in one case, with a modified RBT in one case, and with medial mammoplasty in two cases. Although one patient treated with a RBT had a partial blood-flow insufficiency of the nipple-areola complex, it improved with conservative treatment. The cosmetic results were found to be excellent in three cases, good in three, and fair in one case.
Inhibitory Effect of Honeybee-Collected Pollen on Mast Cell Degranulation In Vivo and In Vitro
Yasuko Ishikawa,Tomoko Tokura,Nobuhiro Nakano,Mutsuko Hara,Fran?is Niyonsaba,Hiroko Ushio,Yuji Yamamoto,Tadahiro Tadokoro,Ko Okumura,Hideoki Ogawa 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1
Bee-collected pollen (bee pollen [BP]) has been used as a folk medicine for centuries against various diseases,including allergy. There is no study elucidating how BP exerts such an anti-allergic effect. Since mast cells play a central rolein the pathogenesis of various allergic diseases, we investigated the effect of BP on mast cell activation elicited by the Fc im-munoglobulin E (IgE) receptor (Fc.RI)-mediated pathways. The in vivo effect of orally administered BP on cutaneous mastcell activation was examined by passive cutaneous anaphylaxis reaction. In vitromast cell degranulation and IgE binding tomast cells and the status of protein tyrosine phosphorylation were examined using bone marrow-derived mast cells. Daily oraladministration of BP to mice significantly reduced the cutaneous mast cell activation elicited by IgE and specific antigens.BP also reduced in vitromast cell degranulation and tumor necrosis factor-. production by inhibiting IgE binding to Fc.RIon mast cells. The inhibitory effect of BP on mast cell degranulation by preventing IgE binding was confirmed by the re-duced levels of protein tyrosine phosphorylation, which occurred as downstream events in activated mast cells via Fc.RI.These results first revealed that the anti-allergic action of BP was exerted by inhibiting the Fc.RI-mediated activation of mastcells, which plays important roles, not only in the early phase, but also in the late phase of allergic reactions.
A Case of Intractable Suspected Perilymph Fistula with Severe Depression
Fumiyuki Goto,Naoki Oishi,Tomoko Tsutsumi,Kaoru Ogawa 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.4
A 68-year-old woman presented dizziness whenever she put her finger into the right ear and also complained of water-streaming tinnitus, which indicated she would have been suffering from perilymph fistula. An exploratory tympanotomy was conducted. Leakage of perilymph from the round window was suspected, although the cochlin-tomoprotein (CTP) results were negative. After the procedure, the patient’s finger-induced dizziness, tinnitus, and vertigo spells disappeared completely. However, her dizzy symptom did not improve. The patient also complained of general fatigue, weight loss, and insomnia, which led us to suspect comorbid depression. Antidepressants and vestibular rehabilitation treatment resulted in a significant improvement in her dizziness. Although it is not apparent whether the patient had a perilymph fistula, this case demonstrates the importance of evaluating not only physical symptoms but also psychological comorbidity, especially when the physical symptoms are intractable despite treatment.
Takashi Nonaka,Takaomi Kessoku,Yuji Ogawa,Shogo Yanagisawa,Tadahiko Shiba,Takashi Sakaguchi,Kazuhiro Atsukawa,Hisao Takahashi,Yusuke Sekino,Hiroshi Iida,Hiroki Endo,Yasunari Sakamoto,Tomoko Koide,Hiro 대한소화기 기능성질환∙운동학회 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.1
Background/Aims The aim of this study was to examine the convenience of the quality of life and utility evaluation survey technology (QUEST) questionnaire and the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) questionnaire as self-assessment diagnostic instrument. Methods This was a two-way crossover study conducted over 6 weeks from September 2010 to November 2010. The subjects were 60 consecutive patients admitted to the Hiratsuka city hospital with a gastrointestinal condition, regardless of the coexistence of heartburn. They were assigned to fill in both the QUEST and FSSG questionnaires in random order. We analyzed the time taken to complete the questionnaires, whether subjects asked any questions as they filled in the questionnaire, and the questionnaire scores. Results Comparison of the QUEST and the FSSG revealed significant differences in the completion time (196.5 vs. 97.5 seconds, respectively; P < 0.0001) and in whether subjects asked any questions (37 vs. 15 subjects, respectively; P < 0.0001). Completion time in QUEST scores of ≥ 4 was lower than < 4 (170.5 vs. 214.0 seconds, respectively; P = 0.022), and the QUEST score was significantly higher without questions than with question (3 vs. 1 points, respectively; P = 0.025). Conclusions This study revealed that the FSSG questionnaire may be easier for Japanese subjects to complete than the QUEST questionnaire.
Yuki Nohara,Noriko Hanamura,Hisamitsu Zaha,Hiroko Kimura,Yumi Kashikura,Takashi Nakamura,Aya Noro,Nao Imai,Mai Shibusawa,Tomoko Ogawa 한국유방암학회 2015 Journal of breast cancer Vol.18 No.1
Purpose: Although various strategies have been reported, thereare no defined criteria for cosmetic evaluation methods afterbreast-conserving surgery (BCS). Since Asians tend to havesmaller breasts, indistinct inframammary folds, and conspicuousscars, differences in the cosmetic results are expected. So weexamined two subjective methods and one objective method todetermine the differences, and elements necessary for a cosmeticevaluation after BCS. Methods: Frontal photographs of 190Japanese were evaluated using the Harris scale (Harris) and theevaluation method proposed by the Japanese Breast Cancer SocietySawai group (Sawai group) as the subjective methods, andthe Breast Cancer Conservation Treatment cosmetic results(BCCT.core) as the objective method, respectively. In order to examinethe necessary elements for developing a new ideal method,100 out of 190 were selected and assessed separately by sixraters using both the Harris and modified Sawai group methodsin the observer assessment. The correlation between the twomethods was examined using the Spearman rank-correlation coefficient. Results: The results of the BCCT.core and the other twomethods were clearly different. In the observer assessment, theconsensuses of the six raters were evaluated as follows: 27, 27,26, and 20 cases were evaluated as “excellent,” “good,” “fair,”and “poor,” respectively. For the Spearman rank-correlation coefficient,values higher than 0.7 indicated a strong correlation, asseen by the values of 0.909 for the breast shape and 0.345 forthe scar. The breast shape accounted for the most significantpart of the evaluation, and the scar had very little correlation. Conclusion:In this study, we recognized a clear difference betweenthe subjective and objective evaluation methods, and identifiedthe necessary elements for cosmetic evaluation. We would like tocontinue developing an ideal cosmetic evaluation that is similar tosubjective one and is independent from raters.