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Research on Fluid Analysis Simulator for Elastic Oscillating Fin of Biomimetic Underwater Robots
Tomokazu Nakamura,Ikuo Yamamoto 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This paper describes about researchon fluid analysis simulator for elastic oscillating fin of biomimeticunderwater robots. Authors has been researching biomimetic underwater vehicle such as flapping wing type. In suchsystem, new concept of fluid analysis simulator is required because of the unique fluid characteristics of elasticoscillating fin. First of all, this paper shows basic characteristics of flapping wing type underwater vehicle as typicalcase of elastic oscillating fin. Second of all, it shows theoretical problem of conventional fluid analysis simulator, andthen, also proposes new concept of fluid analysis simulator for elastic oscillating fin to solve this problem.
Tomokazu Sazuka,Naoki Nihei,Kazuyoshi Nakamura,Shinichi Sakamoto,Satoshi Fukasawa,Atsushi Komaru,Takeshi Ueda,Tatsuo Igarashi,Tomohiko Ichikawa 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.3
Purpose: Single-agent interferon (IFN) is no longer regarded as a standard option for first-line systemic treatment of metastatic renal cell carcinoma (RCC) in Western countries. However, some patients with favorable-risk RCC may still achieve complete and long-lasting remission in response to IFN treatment. The present study compared favorable-risk Japanese patients with metastatic RCC Japanese patients who had been treated with IFN or tyrosine kinase inhibitor (TKI) therapy as a first-line systemic therapy. Materials and Methods: From 1995 to 2014, a total of 48 patients with favorable risk as defined by the Memorial Sloan Kettering Cancer Center criteria who did not receive adjuvant systemic therapy were retrospectively enrolled in this study. We assessed the tumor response rate, progression-free survival (PFS), and overall survival (OS). Results: The objective response rate for first-line therapy was 29% in the IFN group and 47% in the TKI group, but this difference did not reach the level of statistical significance. Median OS for IFN and TKI was 71 and 47 months, respectively (p=0.014). Median first-line PFS for IFN and TKI was 20 and 16 months, respectively (no significant difference). First-line IFN therapy did not prove inferior to TKI therapy in terms of OS according to metastatic sites. Conclusions: IFN is associated with a survival benefit in Japanese patients with favorable-risk metastatic RCC in the era of targeted therapy. Further prospective study is needed.
Yijie Guo,Tomokazu Fukuda,Shuichi Nakamura,Lanlan Bai,Jun Xu,Kengo Kuroda,Rintaro Tomioka,Hiroshi Yoneyama,Emiko Isogai 아세아·태평양축산학회 2015 Animal Bioscience Vol.28 No.2
Leptospiral lipopolysaccharide (L-LPS) has shown potency in activating toll-like receptor 2 (TLR2) in pig fibroblasts (PEFs_NCC1), and causes the expression of proinflammatory cytokines. However, the stimulation by L-LPS was weak eliciting the function of TLR2 sufficiently in pig innate immunity responses during Leptospira infection. In this study, the immune response of pig embryonic fibroblast cell line (PEFs_SV40) was investigated and was found to be the high immune response, thus TLR2 is the predominate receptor of L-LPS in pig cells. Further, we found a strategy using the antibody against L-LPS, to prevent L-LPS interaction with TLR2 in pig cells which could impact on immune activation.
Access Control with OpenID on the Web
Tadashi SHIROMA,Tetsuya HIGA,Tomokazu NAGATA,Yuji TANIGUCHI,Shiro TAMAKI,Morikazu NAKAMURA 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
In recent years, Single Sign-On for the Web is demanded highly and OpenID was proposed. OpenID is usually used as a method for verifying the identifier of users. By contrast, we use OpenID as a method for proving the attributes or knowledge of users. In this article, we suggest an access control method using OpenID with the optional factors of the users on the Web.
Guo, Yijie,Fukuda, Tomokazu,Nakamura, Shuichi,Bai, Lanlan,Xu, Jun,Kuroda, Kengo,Tomioka, Rintaro,Yoneyama, Hiroshi,Isogai, Emiko Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.2
Leptospiral lipopolysaccharide (L-LPS) has shown potency in activating toll-like receptor 2 (TLR2) in pig fibroblasts (PEFs_NCC1), and causes the expression of proinflammatory cytokines. However, the stimulation by L-LPS was weak eliciting the function of TLR2 sufficiently in pig innate immunity responses during Leptospira infection. In this study, the immune response of pig embryonic fibroblast cell line (PEFs_SV40) was investigated and was found to be the high immune response, thus TLR2 is the predominate receptor of L-LPS in pig cells. Further, we found a strategy using the antibody against L-LPS, to prevent L-LPS interaction with TLR2 in pig cells which could impact on immune activation.
Research on network system of unmanned flying observation robot
Naohiro Inagawa,Ikuo Yamamoto,Tomokazu Nakamura 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This paper describes about network system of un-manned flying observation robot which can be used to survey disaster area and transmit real time video image to distanced headquarter. In addition, I performed the field experiment that assumed the disaster spot.
Anti-Cancer Effects of Green Tea by Either Anti- or Pro-Oxidative Mechanisms
Hayakawa, Sumio,Saito, Kieko,Miyoshi, Noriyuki,Ohishi, Tomokazu,Oishi, Yumiko,Miyoshi, Mamoru,Nakamura, Yoriyuki Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Tea derived from the leaves and buds of Camellia sinensis (Theaceae) is consumed worldwide. Green tea contains various components with specific health-promoting effects, and is believed to exert protective effects against diseases including cancer, diabetes and hepatitis, as well as obesity. Of the various tea components, the polyphenol catechins have been the subject of extensive investigation and among the catechins, (-)-epigallocatechin gallate has the strongest bioactivity in most cases. Our research group has postulated that hepatocyte nuclear factor-$4{\alpha}$, sterol regulatory element-binding proteins, and tumor necrosis factor-${\alpha}$ are targets of green tea constituents including (-)-epigallocatechin gallate for their anti-diabetes, anti-obesity, and anti-hepatitis effects, respectively. Published papers were reviewed to determine whether the observed changes in these factors can be correlated with anti-cancer effects of green tea. Two major action mechanisms of (-)-epigallocatechin gallate have been proposed; one associated with its anti-oxidative properties and the other with its pro-oxidative activity. When reactive oxygen species are assumed to be involved, our findings that (-)-epigallocatechin gallate downregulated hepatocyte nuclear factor-$4{\alpha}$, sterol regulatory element-binding proteins, and tumor necrosis factor-${\alpha}$ may explain the anti-cancer effect of green tea as well. However, further studies are required to elucidate which determinant directs (-)-epigallocatechin gallate action as an anti-oxidant or a pro-oxidant for favorable activity.