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In vitro immunoregulatory role of recombinant Ancylostoma ceylanicum calreticulin
Tingting Zhuang,Asmaa M.I. Abuzeid,Xiaoyu Chen,Shilan Zhu,Guoqing Li 대한기생충학ㆍ열대의학회 2024 The Korean Journal of Parasitology Vol.62 No.1
Ancylostoma ceylanicum is a zoonotic soil-derived nematode that parasitizes the intestines of humans and animals (dogs and cats), leading to malnutrition and iron-deficiencyanemia. Helminth parasites secrete calreticulin (CRT), which regulates or blocks thehost’s immune response. However, no data on A. ceylanicum calreticulin (Ace-CRT) areavailable. We investigated the biological function of recombinant Ace-CRT (rAce-CRT). rAce-CRT showed reliable antigenicity and stimulated the proliferation of mouse splenocytes and canine peripheral blood mononuclear cells. Quantitative reverse-transcriptionPCR assays revealed that rAce-CRT primarily promoted the expression of T helper 2 cytokines, particularly IL-13, in canine peripheral blood lymphocytes. rAce-CRT inhibitedcomplement-mediated sheep erythrocyte hemolysis in vitro. Our findings indicate thatAce-CRT plays an immunomodulatory role and may be a promising candidate moleculefor a hookworm vaccine.
Junhai Wang,Weipeng Zhuang,Tingting Yan,Wenfeng Liang,Ting Li,Lixiu Zhang,Xiaoyi Wei 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.100 No.-
Herein, copper perrhenate (Cu(ReO4)2) was synthesized using a micro-emulsion method and adhered tographene (Gr) using an ultrasonic process. Then, the as-prepared Cu(ReO4)2/Gr composite was added intothe synthetic oil as a lubricant additive with the help of ionic liquid to achieve enhanced dispersionstability within the base oil. The tribological performances of the Cu(ReO4)2/Gr additive wereinvestigated using four-ball tests and the ball-on-disk reciprocating configuration under varioustemperatures. The potential lubrication mechanisms of the Cu(ReO4)2/Gr additive were performed usinga series of characterization methods including XRD, Raman, SEM-EDS, TEM, DSC/TG, and XPS. The resultsof four-ball tests at room temperature indicated that the Cu(ReO4)2/Gr additive could substantiallyimprove the tribological performances of the base oil. The smallest coefficient of friction (COF) and wearscar diameter (WSD) values were 0.068 and 495 mm, respectively, when 0.05 wt% of Cu(ReO4)2/Gr wasadded. Additionally, the graphene accelerated friction-induced heat transfer, which led to decreasedfriction and wear. The results of reciprocating friction experiments at elevated temperatures revealedthat the Cu(ReO4)2/Gr additive had excellent friction-reduction properties when the temperature washigh. This could be attributed to the generation of a protective layer containing tribo-oxides from thealloy, some residual carbides and copper perrhenate induced by friction heat and stress. This protectivelayer was uniformly and stably covered on the worn surface, which could effectively alleviate directcontact between the rubbing pair.