Ultrasound-Guided Radiofrequency Ablation in Tertiary Hyperparathyroidism: A Prospective Study

Deng Erya,Jiang Tingting,Chai Huihui,Weng Ning,He Hongfeng,Zhang Zhengxian,Peng Chengzhong,Yue Wenwen,Xu Huixiong 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.3

Objective: To prospectively evaluate the outcomes of ultrasound (US)-guided radiofrequency ablation (RFA) in tertiary hyperparathyroidism (THPT). Materials and Methods: Patients with THPT underwent RFA between September 2017 and January 2022. Laboratory parameters, including serum intact parathyroid hormone (iPTH) levels, were monitored for 48 months after RFA and compared with the levels at baseline. Complications related to RFA and changes in hyperparathyroidism-related clinical symptoms were recorded before and after RFA. Results: A total of 42 patients with THPT were recruited for this study. Ultimately, 36 patients with renal failure and 2 patients who underwent successful renal transplantation (male:female, 17:21; median age, 54.5 years) were enrolled. The follow-up time was 21.5 ± 19.0 months in the 36 patients with renal failure. In these 36 patients, iPTH levels were significantly decreased to 261.1 pg/mL at 48 months compared with the baseline value of 1284.9 pg/mL (P = 0.012). Persistent hyperparathyroidism, defined as iPTH levels maintained at > 585.0 pg/mL for 6 months after treatment, occurred in 4.0% of patients (1/25). Recurrent hyperparathyroidism, defined as iPTH levels > 585.0 pg/mL after 6 months, were 4.0% (1/25) and 0.0% (0/9) at 6 months and 4 years after treatment, respectively. In two patients with THPT after successful renal transplantation, iPTH decreased from the baseline value of 242.5 and 115.9 pg/mL to 171.0 and 62.0 pg/mL at 6 months after treatment. All complications resolved within 6 months of ablation without medical intervention, except in 10.5% (4/38) patients with permanent hypocalcemia. The overall symptom recovery rate was 58.8% (10/17). The severity scores for bone pain, arthralgia, and itchy skin associated with hyperparathyroidism improved after treatment (P < 0.05). Conclusion: US-guided RFA is an effective and safe alternative to surgery in the treatment of patients with TPTH and improves hyperparathyroidism-related clinical symptoms.

Primary Invasive Mucinous Adenocarcinoma of the Lung: Prognostic Value of CT Imaging Features Combined with Clinical Factors

Wang Tingting,Yang Yang,Liu Xinyue,Deng Jiajun,Wu Junqi,Hou Likun,Wu Chunyan,She Yunlang,Sun Xiwen,Xie Dong,Chen Chang 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.4

Objective: To investigate the association between CT imaging features and survival outcomes in patients with primary invasive mucinous adenocarcinoma (IMA). Materials and Methods: Preoperative CT image findings were consecutively evaluated in 317 patients with resected IMA from January 2011 to December 2015. The association between CT features and long-term survival were assessed by univariate analysis. The independent prognostic factors were identified by the multivariate Cox regression analyses. The survival comparison of IMA patients was investigated using the Kaplan-Meier method and propensity scores. Furthermore, the prognostic impact of CT features was assessed based on different imaging subtypes, and the results were adjusted using the Bonferroni method. Results: The median follow-up time was 52.8 months; the 5-year disease-free survival (DFS) and overall survival rates of resected IMAs were 68.5% and 77.6%, respectively. The univariate analyses of all IMA patients demonstrated that 15 CT imaging features, in addition to the clinicopathologic characteristics, significantly correlated with the recurrence or death of IMA patients. The multivariable analysis revealed that five of them, including imaging subtype (p = 0.002), spiculation (p < 0.001), tumor density (p = 0.008), air bronchogram (p < 0.001), emphysema (p < 0.001), and location (p = 0.029) were independent prognostic factors. The subgroup analysis demonstrated that pneumonic-type IMA had a significantly worse prognosis than solitary-type IMA. Moreover, for solitary-type IMAs, the most independent CT imaging biomarkers were air bronchogram and emphysema with an adjusted p value less than 0.05; for pneumonic-type IMA, the tumors with mixed consolidation and ground-glass opacity were associated with a longer DFS (adjusted p = 0.012). Conclusion: CT imaging features characteristic of IMA may provide prognostic information and individual risk assessment in addition to the recognized clinical predictors.

Wave propagation analysis of the ball in the handball’s game

Yongyong Wang,Qixia Jia,Tingting Deng,Mostafa Habibi,Sanaa Al-Kikani,H. Elhosiny Ali 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.85 No.6

It is a recent attraction to the mechanical scientists to investigate state of wave propagation, buckling and vibration in the sport balls to observe the importance of different parameters on the performance of the players and the quality of game. Therefore, in the present study, we aim to investigate the wave propagation in handball game ball in term of mass of the ball and geometrical parameters wit incorporation of the viscoelastic effects of the ball material into account. In this regard, the ball is modeled using thick shell structure and classical elasticity models is utilized to obtain the equation of motion via Hamilton’s principle. The displacement field of the ball model is obtained using first order shear deformation theory. The resultant equations are solved with the aid of generalized differential quadrature method. The results show that mass of the ball and viscoelastic coefficient have considerable influence on the state of wave propagation in the ball shell structure.

Molecular characterization of chicken infectious anaemia virus in Guangxi Province, southern China, from 2018 to 2020

Minxiu Zhang,Xianwen Deng,Zhixun Xie,Yanfang Zhang,Zhiqin Xie,Liji Xie,Sisi Luo,Qing Fan,Tingting Zeng,Jiaoling Huang,Sheng Wang 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.5

Background: Chicken anemia virus (CAV) causes chicken infectious anemia, which results in immunosuppression; the virus has spread widely in chicken flocks in China. Objectives: The aim of this study was to understand recent CAV genetic evolution in chicken flocks in Guangxi Province, southern China. Methods: In total, 350 liver samples were collected from eight commercial broiler chicken farms in Guangxi Province in southern China from 2018 to 2020. CAV was detected by conventional PCR, and twenty CAV complete genomes were amplified and used for the phylogenetic analysis and recombination analysis. Results: The overall CAV-positive rate was 17.1%. The genetic analysis revealed that 84 CAVs were distributed in groups A, B, C (subgroups C1-C3) and D. In total, 30 of 47 Chinese CAV sequences from 2005-2020 belong to subgroup C3, including 15 CAVs from this study. There were some specific mutation sites among the intergenotypes in the VP1 protein. The amino acids at position 394Q in the VP1 protein of 20 CAV strains were consistent with the characteristics of a highly pathogenic strain. GX1904B was a putative recombinant. Conclusions: Subgroup C3 was the dominant genotype in Guangxi Province from 2018–2020. The 20 CAV strains in this study might be virulent according to the amino acid residue analysis. These data help improve our understanding of the epidemiological trends of CAV in southern China.

Simultaneous Single-Position Oblique Lateral Interbody Fusion Combined With Unilateral Percutaneous Pedicle Screw Fixation for Single-Level Lumbar Tuberculosis: A 3-Year Retrospective Comparative Study

Jinyue He,Jiezhong Deng,Yusheng Yang,Tingting Zheng,Fei Luo,Jianzhong Xu,Zehua Zhang 대한척추신경외과학회 2023 Neurospine Vol.20 No.4

Objective: To illustrate a simultaneous single-position oblique lateral interbody fusion (SPOLIF) combined with unilateral percutaneous pedicle screw fixation in treating single-level lumbar tuberculosis, compared with posterior-only approach in clinical and radiographic evaluations. Methods: Consecutive patients who had undergone surgeries for single-level lumbar tuberculosis from January 2018 to December 2020 were retrospectively reviewed. The patients included were divided into SP-OLIF and posterior-only groups according to surgical methods applied, with follow-up for at least 36 months. Outcomes included estimated blood loss, operative time, and complications for safety evaluation; visual analogue scale (VAS), Oswestry Disability Index (ODI) for efficacy evaluation; erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) for evaluating tuberculosis activity; x-ray and computed tomography scan were used for radiographic evaluation. Results: A total of 136 patients had been enrolled in the study (60 for SP-OLIF and 76 for Posterior-only). The median operative time, blood loss, and hospital stay in SP-OLIF group were significantly less, with a lower complication rate. Meanwhile, the SP-OLIF group showed substantially lower VAS in 1 and 7 days and decreased ODI in the first month postoperatively, without significant difference afterward. Similarly, the median CRP and ESR in SP-OLIF group were significantly lower in 3 and 7 days postoperatively. All indicators had reduced to normal after 3 months. No recurrence had been reported throughout the whole follow-up. Conclusion: SP-OLIF was an efficient minimally invasive protocol for single-level lumbar tuberculosis, facilitating earlier clinical improvement, with decreased blood loss, operative time and hospital stay compared with posterior-only approach.

Degrees of Freedom of Two-Cluster MIMO Multiway Relay Interference Channels Using Blind Interference Neutralization

( Bowei Zhang ),( Wenjiang Feng ),( Tingting Dong ),( Yina Deng ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.1

In this paper, we investigate the degrees of freedom (DoF) of a two-cluster multiple-input multiple-output (MIMO) multiway relay interference channel (mRIC), where there are two relays and two users per cluster. In this channel, users within the same cluster exchange messages among themselves with the help of two relays. We first obtain the DoF upper bound of the considered MIMO mRIC based on cut-set bound. Then, we propose a novel transmission strategy, blind interference neutralization (BIN), to approach the DoF upper bound. This new method utilizes the overheard information at two relays and focuses on the beamforming matrix designs at two relays so that the channel state information (CSI) at users is not required. Through theoretical analysis and numerical simulations, we show that the DoF upper bound can be obtained by using the BIN scheme. From simulation results, we show that the proposed BIN scheme can provide significant performance gain over the conventional time division multiple access (TDMA) scheme in terms of DoF. In addition, we show that the BIN scheme is a superior approach to the existing signal space alignment (SSA) schemes for the considered mRIC.