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Nguyen Duc Thuan,Nguyen Dang Ton 대한파킨슨병및이상운동질환학회 2022 Journal Of Movement Disorders Vol.15 No.2
Domperidone, a peripheral and central dopamine receptor antagonist with gastroprokinetic and antiemetic effects, is a widely prescribed medication in clinical practice. This agent presents very low rates of extrapyramidal side effects due to its negligible penetration through the blood–brain barrier (BBB)
Analysing Productivity in Vietnamese Seafood Processing Firms: A Control Function Approach
NGUYEN, Van,TRAN, Thuan Duc,MAI, Thanh Khac Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.2
This study aims to estimate the production function and total factor productivity (TFP) of Vietnamese seafood processing firms. At the same time, the study analyses the impact of internal factors of firms and the quality of economic institutions on the TFP of the Vietnamese seafood processing industry. The study uses the Function Control (FC) approach in TFP estimation and the Feasible Generalized Least Squares (FGLS) regression model in the analysis of factors affecting TFP. The study was carried out on the census data of enterprises of the Vietnamese seafood processing industry collected by the Vietnamese General Statistics Office and Provincial Competitiveness Index data of Vietnam Chamber of Commerce and Industry in the period from 2013 to 2018. Estimated results from the models show that: i) Vietnamese seafood processing firms are, currently, mainly labor-intensive, the TFP contribution and output is only about 2.258. ii) Factors such as the firm's age, firm's size, and the firm's ownership affect TFP. In which, firms that have few numbers of years of operation, small and medium firms, and private firms have low TFP. iii) Institutional quality and the provincial business environment have a positive impact on the TFP of Vietnamese seafood processing firms in this period.
Mechanical Design of Robot Head with Human-like Emotions
Nguyen Khac Toan,Le Duc Thuan,Le Bao Long,Nguyen Truong Thinh 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
One of the fields that has detonated lately dependent on the AI platform is humanoid robots. The facial expressions of robots, then again, are getting less and less attention. The design of a robot head that communicates a wide range of human-like expressions is described in this paper. The eye-eyelid, lip-jaw, and neck were the three main parts of the robot head under investigation. Mechanical structure of human head such as number of degrees of freedom, size, ability of joints, and major muscle groups to create movements in each part are determined based on anatomy. Then, facial expressions are analyzed dependent on AUs to find out reasonable control points. The mechanical structures of each part were designed to try to replicate the movement and expression as closely as expected. Additionally, proportions, sizes, distances of the designs, such as CoP-CoP, tr-n, n-sn, and so on, must closely resemble those of a human head. The robot head in this article is designed and modeled on an Asian human head. The result of the design, the head section is made up of three mechanisms connected by a shaft that runs through the entire head. Through the experimental process, the robot head can perform 6 of the basic expressions and movements like a real human head.
Phi Duc Long,Dao Thi Loi,To Minh Manh,Nguyen Thanh Binh,Nguyen Duy Cuong,Gautret Philippe,Hoang Van Thuan 대한의학회 2023 Journal of Korean medical science Vol.38 No.49
Geographical and racial factors constitute important distinctions between Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C), but no study has been conducted in Vietnam. Forty-one children with KD from January 2018 to July 2020 and 42 with KD/MIS-C from August 2020 to December 2022 were included in this study. Of the patients, 52.3% were aged between 12 and 35 months. Only two were aged over 5 years, and both were belong to the KD/MIS-C group. A 59.5% of the patients were male. Apart from fever, all symptoms tended to be more frequent in patients with KD/MIS-C. The prevalence of diffuse skin rash, hand and foot edema or erythema and gastrointestinal signs was significantly higher in patients hospitalized with KD/MIS-C. There was no significant difference in laboratory findings between the two groups. Coronary artery dilation was more frequently observed in patients with KD/MIS-C compared to those with KD (40.5% vs. 14.6%, P = 0.009).
How Leader Characteristics and Leader Member Exchange Lead to Social Capital and Job Performance
TRAN, Duc-Thuan,LEE, Li-Yueh,NGUYEN, Phuoc-Thien,SRISITTIRATKUL, Wethima Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.1
The study aims to verify the relationship between leaders' personality traits in leader - member exchange (LMX), and job performance. Hierarchical Regression Analysis was used to examines (a) how leaders' personality traits and LMX affect the influence of social capital on job performance and organizational citizenship behavior; (b) how perceived organization support (POS) can moderate the influences of LMX on social capital, in turn impacting job performance and OCB. Responses are employees in the service industry in Thailand, which consisted of 236 independent samples in 77 groups. Each group included at least one leader and 1-5 followers. The results show that there is a significant relationship between leader's personality traits, LMX and social capital. Leader with the higher level of conscientious, and agreeableness can always create good relations with their followers. The level of LMX are also related to social capital and both of these influence OCB and job performance. The moderating effect of perceived organizational support is also significant that POS can amplify the influence of LMX on social capital. Finally, the research findings show that perceived organizational support is one of the moderating factors in LMX exchanges. Followers perceived organizational support can amplify the influence of LMX on social capital.
Tu Anh Do,Mang Tia,Thuan Huu Nguyen,Tuyet Thi Hoang,Tam Duc Tran 대한토목학회 2022 KSCE Journal of Civil Engineering Vol.26 No.1
Three-dimensional finite element (FE) thermal and stress models were created to compute the temperature evolution, thermal stress and potential of cracking in a segmental concrete box girder segment during construction. User-defined subroutines were developed in the ANSYS program to activate the degree of hydration-dependent heat rate and material properties, and creep behavior in the thermal and stress calculations. The developed FE model was verified with experimental measurements of a concrete cube. Adiabatic temperature rise, together with compressive strength and splitting tensile strength for a high-strength concrete mix typically used in construction of box girders were tested and incorporated in the subroutines. The effect of casting time and placement season (summer and winter), initial concrete temperature change, and insulation on the risk of cracking in a cast-in-situ box girder segment at early ages was investigated using the proposed model. The results indicate that the temperature difference between the segment’s middle and the gate corner is very large leading to a high cracking risk. Use of an insulation material such as blankets along with casting concrete at the nighttime would significantly lessen the thermal tensile stress and thus could reduce cracking risk in the segment.
Vo Minh Hoang Do,Long Giang Bach,Diem-Huong Nguyen Tran,Van Du Cao,Thi Nhu Quynh Nguyen,Duc Thuan Hoang,Van Cuong Ngo,Dai Hai Nguyen,Thai Thanh Hoang Thi 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.2
Polyamidoamine (PAMAM) dendrimer is emerging as an effective nanocarrier for delivering anticancer drugs. Still, unmodified PAMAM dendrimer is hardly used in vivo because of unsatisfied drug release, high tendency of interfering with cellular membranes, and rapid clearance by reticuloendothelial system. In this study, low generation polyamidoamine (PAMAM) dendrimer G3.0 is developed and surface modified with methoxypolyethylene glycol (PAMAM G3.0-mPEG) to overcome its limitations. Specifically, PAMAM G3.0 conjugated with mPEG at different ratios are investigated to effectively eliminate its charge-associated toxicity, in which PAMAM G3.0-mPEG- 8 is chosen for oxaliplatin (OX) loading. Results reveal that OX-loaded PAMAM G3.0-mPEG-8 has desirable size, good entrapment efficiency, and sustained release with minimum drug leakage. In addition, Resazurin assay indicates that the toxicity of loaded OX is reduced as compared to free drug but still maintain substantially anticancer activity on HeLa cells, suggesting the potential application of PAMAM G3.0-mPEG-8 for OX delivery in cancer therapy.
Huan, Le Cong,Tran, Phuong-Thao,Phuong, Cao Viet,Duc, Phan Huy,Anh, Duong Tien,Hai, Pham The,Huong, Le Thi Thu,Thuan, Nguyen Thi,Lee, Hye Jin,Park, Eun Jae,Kang, Jong Soon,Linh, Nguyen Phuong,Hieu, Tr Elsevier 2019 Bioorganic chemistry Vol.92 No.-
<P><B>Abstract</B></P> <P>In search for novel small molecules with antitumor cytotoxicity via activating procaspase-3, we have designed and synthesized three series of novel (E)-<I>N</I>′-benzylidene-4-oxoquinazolin-3(4<I>H</I>)-yl)acetohydrazides (<B>5a-j, 6a-h,</B> and <B>7a-h)</B>. On the phenyl ring ò the benzylidene part, three different substituents, including 2-OH-4-OCH<SUB>3</SUB>, 4-OCH<SUB>3</SUB>, and 4-N(CH<SUB>3</SUB>)<SUB>2</SUB>, were introduced, respectively. Biological evaluation showed that the acetohydrazides in series <B>5a-j</B>, in which the phenyl ring of the benzylidene part was substituted by 2-OH-4-OCH<SUB>3</SUB> substituent, exhibited potent cytotoxicity against three human cancer cell lines (SW620, colon; PC-3, prostate; NCI-H23, lung). Most of the compounds, in this series, especially compounds <B>5c, 5b</B> and <B>5h,</B> also significantly activated caspase-3 activity. Among these, compound <B>5c</B> displayed 1.61-fold more potent than PAC-1 as caspase-3 activator. Cell cycle analysis showed that compounds <B>5b</B>, <B>5c</B>, and <B>5h</B> significantly arrested the cell cycle in G1 phase. Further apoptotic studies also demonstrated compounds <B>5b</B>, <B>5c</B>, and <B>5h</B> as strong apoptotic cell death inducers. The docking simulation studies showed that these compounds could activate procaspase <I>via</I> chelating Zn<SUP>2+</SUP> ion bound to the allosteric site of the zymogen.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel (<I>E</I>)-<I>N</I>′-benzylidene-2-(4-oxoquinazolin-<I>3(4H)-yl</I>)acetohydrazides were synthesized. </LI> <LI> The acetohydrazides <B>5a-i</B> exhibited potent cytotoxicity against three human cancer cell lines. </LI> <LI> A number of cytotoxic compounds exhibited good caspase activation activity. </LI> <LI> The cytotoxic compounds were shown to arrest cells at G1 phase. </LI> <LI> The cytotoxic compounds were shown as strong apoptotic inducers. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
The first years of liver transplantation: experiences at a single center
Phu Hong Pham,Nghia Phuoc Phan,Viet Doan Khac Tran,Viet Quoc Dang,Thuan Duc Nguyen,Long Cong Duy Tran,Bac Hoang Nguyen 대한이식학회 2022 Korean Journal of Transplantation Vol.36 No.2
Background: The aim of this study was to analyze the first stages of progress in liver transplantation (LT) at a single center in Vietnam. Methods: This study analyzed data from patients and donors who participated in the LT program between August 2018 and December 2021 at University Medical Center, Ho Chi Minh City. Study measures included any difficulties encountered, as well as the post- LT outcomes for living donor LT (LDLT) and deceased donor LT (DDLT). The chi-square test and Kaplan Meier survival analysis were used to test the factors that influenced the outcomes. Results: A total of 18 adult recipients with LT (LDLT, n=16; DDLT, n=2) were included (mean age, 55.2±2.6 years; male, 88.9%). The most common post-LT complications were middle hepatic venous stenosis (20%) and graft rejection (22.2%). These compli- cations were observed in LDLT patients. For DDLT, graft rejection (50%) was the only complication recorded. The survival rates for recipients at 3 months, 6 months, and 1 year were 100%, 88.9%, and 88.9%, respectively. The LDs had their right livers without the middle hepatic veins harvested, and biliary leakage (6.25%) was the only complica- tion observed. There were no deaths among recipients or LDs during the operations or hospital stays. Conclusions: This study provides key details about the process of LT, and these positive outcomes support LT as an important therapy for end-stage liver disease and early he- patocellular carcinomas.