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      • Comparison of Effects of Hemoglobin Levels Upon Tumor Response among Cervical Carcinoma Patients Undergoing Accelerated Hyperfractionated Radiotherapy versus Cisplatin Chemoradiotherapy

        Thakur, Priyanka,Seam, Rajeev Kumar,Gupta, Manoj Kumar,Rastogi, Madhup,Gupta, Manish,Bhattacharyya, Tapesh,Sharma, Mukesh,Revannasiddaiah, Swaroop Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10

        Purpose: Blood hemoglobin levels are known to influence response to radiotherapy. This retrospective analysis compared the effect of hemoglobin levels upon response to radiation among patients treated with radiation alone (by accelerated hyperfractionated radiotherapy) versus those treated with concurrent cisplatin chemoradiotherapy. Materials and Methods: Among patients treated for locally advanced carcinoma of the cervix (LACC) during 2009-10, a total of 60 fulfilled the eligibility criteria. In this time frame, external beam radiotherapy was delivered with either concurrent chemoradiotherapy (CRT, n=31) (45Gy over 25 fractions, with weekly cisplatin at 40mg/m2), or with accelerated hyperfractionated radiotherapy (AHRT, n=29) (20Gy over 10 daily fractions over the first two weeks, followed by 30Gy over 20 fractions over the next two weeks, with two fractions of 1.5Gy per day, without the use of chemotherapy). Mean weekly hemoglobin (MWH) levels of all patients were calculated as the arithmetic means of weekly recorded blood hemoglobin levels. As per MWH, patients in both of the AHRT or the CRT groups were classified into two subgroups-those with MWH between 10-10.9g/dL, or with MWH>11g/dL. Complete response (CR) to external beam RT phase (prior to brachytherapy) was declared after clinical examinations and computed tomography. The CR rate was noted for both MWH sub-groups within each of the AHRT and CRT groups. Results: Within the AHRT group, patients with MWH>11g/dL had a much better CR rate in comparison to those with MWH:10-10.9g/dL (80% vs. 21.1%) which was statistically significant (p 0.0045). Within the CRT group, there was no significant difference in the outcomes within the MWH>11g/dL and MWH:10-10.9g/dL sub-groups (CR rates of 80% vs. 61.9%, p=0.4285). Conclusions: The importance of maintaining a minimum hemoglobin level of 11g/dL during RT is much greater for patients treated with RT alone, than for patients treated with concurrent chemoradiotherapy. Enhanced haemoglobin levels during RT may to an extent negate the ill-effects that may otherwise arise due to non-use of concurrent chemotherapy.

      • SCOPUSKCI등재

        A New Perspective to Stable Marriage Problem in Profit Maximization of Matrimonial Websites

        Bhatnagar, Aniket,Gambhir, Varun,Thakur, Manish Kumar Korea Information Processing Society 2018 Journal of information processing systems Vol.14 No.4

        For many years, matching in a bipartite graph has been widely used in various assignment problems, such as stable marriage problem (SMP). As an application of bipartite matching, the problem of stable marriage is defined over equally sized sets of men and women to identify a stable matching in which each person is assigned a partner of opposite gender according to their preferences. The classical SMP proposed by Gale and Shapley uses preference lists for each individual (men and women) which are infeasible in real world applications for a large populace of men and women such as matrimonial websites. In this paper, we have proposed an enhancement to the SMP by computing a weighted score for the users registered at matrimonial websites. The proposed enhancement has been formulated into profit maximization of matrimonial websites in terms of their ability to provide a suitable match for the users. The proposed formulation to maximize the profits of matrimonial websites leads to a combinatorial optimization problem. We have proposed greedy and genetic algorithm based approaches to solve the proposed optimization problem. We have shown that the proposed genetic algorithm based approaches outperform the existing Gale-Shapley algorithm on the dataset crawled from matrimonial websites.

      • KCI등재

        A New Perspective to Stable Marriage Problem in Profit Maximization of Matrimonial Websites

        ( Aniket Bhatnagar ),( Varun Gambhir ),( Manish Kumar Thakur ) 한국정보처리학회 2018 Journal of information processing systems Vol.14 No.4

        For many years, matching in a bipartite graph has been widely used in various assignment problems, such as stable marriage problem (SMP). As an application of bipartite matching, the problem of stable marriage is defined over equally sized sets of men and women to identify a stable matching in which each person is assigned a partner of opposite gender according to their preferences. The classical SMP proposed by Gale and Shapley uses preference lists for each individual (men and women) which are infeasible in real world applications for a large populace of men and women such as matrimonial websites. In this paper, we have proposed an enhancement to the SMP by computing a weighted score for the users registered at matrimonial websites. The proposed enhancement has been formulated into profit maximization of matrimonial websites in terms of their ability to provide a suitable match for the users. The proposed formulation to maximize the profits of matrimonial websites leads to a combinatorial optimization problem. We have proposed greedy and genetic algorithm based approaches to solve the proposed optimization problem. We have shown that the proposed genetic algorithm based approaches outperform the existing Gale-Shapley algorithm on the dataset crawled from matrimonial websites.

      • KCI등재

        A Modern Automatic Bus Transfer Scheme

        Tarlochan S. Sidhu,Vinayagam Balamourougan,Manish Thakur,Bogdan Kasztenny 대한전기학회 2005 International Journal of Control, Automation, and Vol.3 No.2

        The proliferation of technology has made global conduction of business increasingly dependent upon the availability of reliable power. As a result, alternate power systems are being installed and expanded to protect the broadening scope of critical electrical loads. Bus transfer restores designated critical loads to an alternate source when utility derived service becomes inadequate or goes out of service due to any contingency. This paper describes the practices, requirements and implementation of bus transfer of motor loads to an alternate source of power. A new high-speed automatic bus transfer scheme is proposed which includes the development of a new algorithm for determining the type of bus transfer required and the realization of the scheme by using modem protection devices and intra-substation communication facilities.

      • SCIESCOPUSKCI등재

        A Modern Automatic Bus Transfer Scheme

        Sidhu Tarlochan S.,Balamourougan Vinayagam,Thakur Manish,Kasztenny Bogdan Institute of Control 2005 International Journal of Control, Automation, and Vol.3 No.S

        The proliferation of technology has made global conduction of business increasingly dependent upon the availability of reliable power. As a result, alternate power systems are being installed and expanded to protect the broadening scope of critical electrical loads. Bus transfer restores designated critical loads to an alternate source when utility derived service becomes inadequate or goes out of service due to any contingency. This paper describes the practices, requirements and implementation of bus transfer of motor loads to an alternate source of power. A new high-speed automatic bus transfer scheme is proposed which includes the development of a new algorithm for determining the type of bus transfer required and the realization of the scheme by using modem protection devices and intra-substation communication facilities.

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