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Xi-yuan Zheng,Chang-hong Wang,Zi-jia Zhang,Gui-xin Chou,Tao Wu,Xue-mei Cheng,Zheng-tao Wang 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.9
Acetylcholinesterase inhibitors (AChEIs) currently form the basis of the newest drugs available for the treatment of Alzheimer's disease. For the aim of screening effective AChEIs, the methanol extracts of the seeds of genus Peganum were found to show significant inhibitory activity of acetylcholinesterase enzyme (AChE) using an in vitro TLC-bioautographic assay. In further studies to seed of P. nigellastrum Bunge, activity-guided fractionation led to the isolation of two new alkaloids nigellastrine Ⅰ (9) and nigellastrine Ⅱ (10), and along with eight known alkaloids, vasicinone (1), vasicine (2), harmine (3), deoxyvasicinone (4), deoxyvasicine (5), harmaline (6), harmol (7), harman (8), in which harmol and harman were first isolated from species P. nigellastrum Bunge. As active constituents, all compounds showed good inhibitory activities against AChE. The results of in vitro semi-quality TLC-bioautographic assay showed that harmine, harmaline and harmol displayed a similar AChE inhibitive activities comparing to galanthamine. These results indicated that these alkaloids in P. nigellastrum Bunge could be a potent class of AChEIs.
Xing-Xi Gao,Jun-Hua Wu,Da-Hua Shi,Yun-Xi Chen,Jiang-Tao Cui,Yu-Rong Wang,Chun-Ping Jiang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.8
The aim of this study was to investigate the effects of tectorigenin on chemically induced liver fibrosis in rats. Liver fibrosis was induced in rats with carbon tetrachloride, a diet high in fat, cholesterol and alcohol in the drinking water. Our results indicate that tectorigenin treatment significantly inhibited the increases in the activities of alanine aminotransferase (ALT),aspartate aminotransferase (AST) and the increases in the serum levels of hyaluronate (HA), laminin (LN) and procollagen III N-terminal peptide (PIIIP); tectorigenin treatment also significantly inhibited the increases in the amount of collagen in the livers of the fibrogenic rats. Chemically induced liver fibrosis caused a drop in the serum albumin concentration and a decrease in the ratio of albumin to globulin (A/G). Tectorigenin caused a remarkable increase at a dose of 30 mg/kg, but only a slight increase at the lower doses. Tectorigenin was also able to inhibit the increase in the liver lipid peroxidation (LPO), as well as the decrease in the activities of liver superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), caused by liver fibrosis. In addition, we present a related metabolic profile determined, using a 1H NMR spectroscopy and multivariate pattern recognition techniques. The results were consistent with the pathological examination, liver function analysis and liver fibrosis marker analysis. Furthermore, tectorigenin does not cause acute toxicity.
The role of WRKY47 gene in regulating selenium tolerance in Arabidopsis thaliana
Xi Wu,Manzhi Tao,Yun Meng,Xiangyu Zhu,Liangwen Qian,Alia Shah,Wei Wang,Shuqing Cao 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.1
Selenium stress has a serious impact on the growth of plants. However, the available understanding on the mechanism of Se stress response is still insufficient. In this study, we found that the WRKY47 gene plays an important role in maintaining Se homeostasis and tolerance in Arabidopsis thaliana. Expression of WRKY47 is induced by Se stress. The wrky47 mutants are sensitive to Se stress, and this sensitivity is associated with a decrease in the transcription levels of Se-detoxify genes HMT1 and HMT3. Surprisingly, the WRKY47-overexpression lines also showed increased sensitivity to Se stress and had increased Se content; this correlates to an increase in the transcription level of Se-uptake gene PHT1;4 but not Se-detoxify genes HMT1 and HMT3. Our results suggest that gain- and loss-of-function mutations in WRKY47 enhance the sensitivity of A. thaliana plants to Se stress through different mechanisms.
The Top-K QoS-aware Paths Discovery for Source Routing in SDN
( Xi Chen ),( Junlei Wu ),( Tao Wu ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.6
Source routing is the routing scheme that arranges the whole path from source to target at the origin node that may suit the requirements from the upper layer applications’ perspective. The centralized control in SDN (Software-Defined Networking) networks enables the awareness of the global topology at the controller. Therefore, augmented source routing schemes can be designed to achieve various purposes. This paper proposes a source routing scheme that conducts the top-K QoS-aware paths discovery in SDN. First, the novel non-invasive QoS over LLDP scheme is designed to collect QoS information based on LLDP in a piggyback fashion. Then, variations of the KSP (K Shortest Paths) algorithm are derived to find the unconstrained/constrained top-K ranked paths with regard to individual/overall path costs, reflecting the Quality of Service. The experiment results show that the proposed scheme can efficiently collect the QoS information and find the top-K paths. Also, the performance of our scheme is applicable in QoS-sensitive application scenarios compared with previous works.
중국 Changzhou댐의 방수로 운용에 따른 어류밀도와 분포에 관한 음향조사
( Xi Chang Tan ),강명희 ( Myoung Hee Kang ),( Jiang Ping Tao ),( Xin Hui Li ),( Dao Ming Huang ) 한국수산과학회(구 한국수산학회) 2011 한국수산과학회지 Vol.44 No.4
Hydroacoustic surveys were performed to clarify the density and spatial distribution of fish upstream and downstream of Changzhou Dam in the Pearl River, China, with regard to the condition of the spillways. Fish were densely distributed in the forebay of the upstream dam and the average fish density was 0.22 individuals/㎥ under open spillways on 24 June 2010, but when the spillways were closed on 25 June 2010, the fish in the upstream dam dispersed and the average fish density decreased to 0.007 individuals/㎥. Meanwhile, the average fish density in the downstream region was 0.28 individuals/㎥ before the spillway was opened on 24 May 2010, but it decreased to 0.08 individuals/㎥ on 26 June, just after the spillway was closed. The vertical distribution of fish upstream of the dam was not consistent. The target strength (TS) of fish upstream of the dam was larger than that of fish in the downstream region, although the distribution of TS was similar between the upstream and downstream regions. Therefore, we concluded that while numerous fish could swim to the upstream region while the spillways were open, closed spillways obstructed fish migrating upward from the downstream region.
Xi Zeng,Shi-ming Ji,Ming-sheng Jin,Da-peng Tan,Jue-hui Li,Wen-tao Zeng 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.
In order to improve material removal rate of laser hardening workpiece and also make machining tool suitable for free-form surface,a new method based on the softness consolidation abrasives (SCA) is put forward, which means the abrasives are consolidated onthe outer layer of pneumatic wheel to achieve the softness-machining. Binder selecting test shows that acidic silicone is proved tosuit for consolidating particles in cutting process. Combined with robot, the machining system has been established. The machiningeffects of SCA are investigated when it faces with workpiece of different hardness. According to the Preston predicted model, thesimulation results of stress and velocity are proven by analysis of average roughness in the contact region. The contrastive machiningexperimental results show that SCA can supply high cutting stress for material removal and fit for freeform surface’s machining byself-adjustment of flexible body.