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- 저자 : Takuya Nomura (검색결과 3 건)
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Absorption of Orally Administered Hyaluronan
Mamoru Kimura,Takuya Maeshima,Takumi Kubota,Hitoshi Kurihara,Yasunobu Masuda,Yoshihiro Nomura 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.12
Hyaluronan (HA) has been utilized as a supplement. However, the absorption of orally administrated HA remains controversial. The degradation and absorption of HA in the intestine were investigated in this study. HA excretion into the feces, degradation in the intestinal tract, absorption through the large intestine, and translocation to the blood and skin were examined. HA administered orally was not detected in rat feces. HA was degraded by cecal content, but not by artificial gastric juice and intestinal juice. Oligosaccharide HA passed through excised large intestine sacs. Furthermore, disaccharides, tetrasaccharides, and polysaccharides HA were distributed to the skin of rats following oral administration of high molecular weight HA (300 kDa). The results of the study suggest that orally administered HA is degraded to oligosaccharides by intestinal bacteria, and oligosaccharide HA is absorbed in the large intestine and is subsequently distributed throughout the tissues, including the skin.
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Deposition Profile Control of Carbon Films on the Surface of Fine Structures using Plasma CVD
Kzunori Koga,Takuya Nomura,Masaharu Shiratani,Yuichi Setsuhara,Makoto Sekine,Masaru Hori 한국표면공학회 2010 한국표면공학회 학술발표회 초록집 Vol.2010 No.11
Deposition profile of DLC and a-C:H films in trenches is one of the concerns to realize coatings on patterned substrates. We have succeeded in controlling deposition profile of Cu in trenches for nano-fabrications, and have realized sub-conformal, conformal and anisotropic deposition. We are applying the deposition profile control method to carbon films in trenches. Deposition rate increases with decreasing the substrate temperature, because carbon etching rate by H atoms decreases with decreasing the substrate temperature. Deposition rate on sidewall and that on bottom decrease with increasing aspect ratio, while deposition rate on top little depends on the aspect ratio. The results suggest that the deposition profile can be controlled by changing deposition condition.
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Katsuyoshi Ando,Mikihiro Fujiya,Yoshiki Nomura,Yuhei Inaba,Yuuya Sugiyama,Takuya Iwama,Masami Ijiri,Keitaro Takahashi,Kazuyuki Tanaka,Aki Sakatani,Nobuhiro Ueno,Shin Kashima,Kentaro Moriichi,Yusuke Mi 대한장연구학회 2018 Intestinal Research Vol.16 No.3
Background/Aims: Venous thromboembolism (VTE) is a major extraintestinal manifestation in inflammatory bowel disease (IBD), regarded as an independent risk factor for VTE according to reports from Western countries. However, the incidence and risk factors of VTE in Asian IBD patients are not fully understood. We aimed to reveal the incidence and risk factors of VTE in Japanese IBD inpatients. Methods: The incidence of VTE in inpatients with IBD (n=340), gastrointestinal cancers (n=557), and other gastrointestinal diseases (n=569) treated at our hospital from 2009 to 2013 was retrospectively investigated. The characteristics and laboratory data of IBD inpatients with and without VTE were compared in univariate and multivariate analyses. Clinical courses of VTE in IBD were surveyed. Results: VTE was detected in 7.1% of IBD inpatients, significantly higher than in gastrointestinal cancer inpatients (2.5%) and inpatients with other gastrointestinal diseases (0.88%). The incidence of VTE in ulcerative colitis (UC) patients (16.7%) was much higher than that in those with Crohn’s disease (3.6%). In the univariate analysis, the risk factors were an older age, central venous catheter, prednisolone, surgery, low serum albumin, high serum C-reactive protein and D-dimer. According to a multivariate analysis, >50 years of age and surgery were the only risk factors. The in-hospital mortality rate of IBD inpatients with VTE was 4.2%. Conclusions: The incidence of VTE with IBD, especially UC, was found to be high compared with other digestive disease, which was almost equivalent to that of Western countries. The efficacy of prophylaxis needs to be investigated in Asian IBD patients.
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