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- 저자 : Takayuki Kimura (검색결과 9 건)
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Takayuki Morita,Mitsuhiro Kimura 보안공학연구지원센터 2015 International Journal of Software Engineering and Vol.9 No.2
As our goal, we are interested in estimating the degree of software reliability based on software development project data. It is widely-known that several software development attributes which are measured can be used to evaluate and predict software reliability/quality via multi-variable analyses. In this article, we focus on the data treatment method which is needed prior to the software reliability assessment, since the software development data sets often include missing data. This paper discusses the method of data preparation against missing data and their effectiveness by using the Random Forest as a multi-variable analysis.
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Photooxidation of alcohols by a porphyrin/quinone/TEMPO system
Nagasawa, Takayuki,Allakhverdiev, Suleyman I.,Kimura, Yoshifumi,Nagata, Toshi Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.2
Photooxidation of alcohols to the corresponding aldehydes with a porphyrin/quinone/TEMPO (TEMPO = 2,2,6,6-tetramethyl-1-piperidinyloxy free radical) system is described. This photoreaction is a combination of a photoinduced electron transfer from the porphyrin to the quinone and a TEMPO-catalyzed oxidation of alcohols triggered by one electron oxidation. The rates of oxidation were in the order of benzylic $\approx$ allylic > primary $\gg$ secondary, which is consistent with the intermediacy of the oxoammonium cation derived from TEMPO. Examination of the initial rates suggested that the reaction proceeded via the triplet excited state of the zinc porphyrin. The dependence of initial rates on the oxidation potentials of the porphyrin showed a characteristic bell shape, which is caused by two competitive factors, the efficiency of photoinduced electron transfer and the equilibrium of electron exchange between the porphyrin cation radical and TEMPO. The potential significance of this reaction in photosynthetic model chemistry is briefly discussed.
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Emi Ishikawa,Takayuki Hojo,Makiko Shibuya,Takahito Teshirogi,Keiji Hashimoto,Yukifumi Kimura,Toshiaki Fujisawa 대한치과마취과학회 2023 Journal of Dental Anesthesia and Pain Medicine Vol.23 No.1
Background: A high incidence (40–73%) of postoperative nausea and vomiting (PONV) has been reported following orthognathic surgery, and various risk factors have been associated with it. Identifying PONV risk factors based on initial onset time will help establish preventive measures. This study aimed to identify factors that are significantly related to PONV based on the initial onset time after orthognathic surgery. Methods: This study included 590 patients who underwent orthognathic surgery. Multivariate logistic regression analysis was performed to identify the risk factors that are significantly related to PONV. The objective variables were classified into three categories: no PONV, early PONV (initial onset time: 0–2 h after anesthesia), and late PONV (initial onset time: 2–24 h after anesthesia). The explanatory variables included relevant risk factors for PONV, as considered in previous studies. Results: Total intravenous anesthesia with propofol was a significant depressant factor for early PONV (adjusted odds ratio [aOR] = 0.340, 95% confidence interval [CI] = 0.209–0.555) and late PONV (aOR = 0.535, 95% CI = 0.352–0.814). The administration of a combination of intraoperative antiemetics (vs. no administration) significantly reduced the risk of early PONV (aOR = 0.464, 95% CI = 0.230–0.961). Female sex and young age were significant risk factors for late PONV (aOR = 1.492, 95% CI = 1.170–1.925 and unit aOR = 1.033, 95% CI = 1.010–1.057, respectively). Conclusion: We identified factors that are significantly related to PONV based on the initial onset time after orthognathic surgery. Total intravenous anesthesia with propofol significantly reduced the risk of PONV not only in the early period (0–2 h after anesthesia) but also in the late period (2–24 h after anesthesia).
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( Hirofumi Nakayama ),( Yasuyuki Kimura ),( Takayuki Shimaoka ),( Ryoichi Furuta ),( Ichiro Hiura ) 한국폐기물자원순환학회(구 한국폐기물학회) 2017 한국폐기물자원순환학회 심포지움 Vol.2017 No.1
Radioactive materials were widely spread as a result of a nuclear accident at the Tokyo Electric Power Company Fukushima Daiichi Nuclear Power Plant initiated by the 2011 Tohoku Earthquake, which occurred on March 11. Radioactive decontamination work for the same is still underway. At the temporary storage sites, decontamination wastes are stored in flexible containers and gas-permeable waterproof sheets are used for capping to cover the waste. However, currently, 6 years after the accident, several capping sheets are being reported as damaged, raising concerns about the contamination of surrounding environment because of rain leaking through the capping sheet. Large puddles formed on top of the capping sheets are the main cause for their damage. The reported damages include tears in the capping sheet materials and separation of joints caused by the tension generated by the puddles. More than 1000 temporary storage sites have been constructed and more than 100,000 mountains have been built. At these sites, it is necessary to monitor the puddles formed on the capping sheets and inspect the resulting damages. Although visual inspection of temporary storage sites is currently being conducted approximately once a month, the number of temporary storage sites is vast and conducting inspection by climbing on degraded capping sheets involves a risk in terms of the safety of the workers. Therefore, this study investigates a monitoring method to locate a site with a high probability of damages on the capping sheets via measurement of the strain generated by the puddles on the sheets and using a drone to photograph and analyze the temporary storage sites. This study generated 3D models via SfM analysis of the images photographed by drones and aimed to develop a method to estimate the damage endangered area by estimating the stress and strain distribution with FEM using the coordinate data of the point groups forming the 3D models as the input data. The results of this study are as follows: Strain and stress generated by the puddles are concentrated at the edges of the puddles. For mock temporary storage site, we were able to confirm a strain of approximately 20% and stress of 9 MPa measured by adhering a strain gauge to the capping sheet. This is five times greater than 1.75 MPa, the self-standard value of the capping sheet strength set by the Japan Water Sealing Association, and therefore, monitoring of the sheet is considered to be of utmost importance. There was an increase in the strain and stress values near the vicinity of the puddle center; however, they were only about half of the values at the edges. Strain and stress distribution for mock temporary storage sites were calculated via FEM analysis. Because the measured results and the analytically calculated values were consistent in terms of the location and the degree of strain, we can infer that there is a constant validity and believe that it is possible to apply this to an actual site. The method developed in this study was applied for the detection of damage endangered area at an actual temporary storage site for decontamination waste in Fukushima. Concentration of the strain and stress near the top of the slope at the edge of the temporary storage site was confirmed and the strain value was recorded up to a maximum of 4%, while a maximum of 1.8 MPa was attained for the stress. These values slightly exceed 1.75 MPa, which is the self-standard tensile strength set by the Japan Water Sealing Association.
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Methemoglobinemia caused by a low dose of prilocaine during general anesthesia
Shibuya, Makiko,Hojo, Takayuki,Hase, Yuri,Kimura, Yukifumi,Fujisawa, Toshiaki The Korean Dental Society of Anesthsiology 2021 Journal of Dental Anesthesia and Pain Medicine Vol.21 No.4
Methemoglobinemia is a blood disorder in which an abnormal amount of methemoglobin is produced, and prilocaine is one of the drugs that can cause this disorder. The maximum recommended dose of prilocaine is 8 mg/kg. We report a case of methemoglobinemia caused by the administration of 4.2 mg/kg of prilocaine without other methemoglobinemia-inducing drugs during general anesthesia. A 17-year-old girl with hyperthyroidism and anemia was scheduled to undergo maxillary sinus floor elevation and tooth extraction. The patient's peripheral oxygen saturation (SpO<sub>2</sub>) decreased from 100% at arrival to 95% after receiving prilocaine with felypressin following induction of general anesthesia. However, the fraction of inspired oxygen was 0.6. Blood gas analysis showed that the methemoglobin level was 3.8% (normal level, 1%-2%), fractional oxygen saturation was 93.9%, partial pressure of oxygen was 327 mmHg, and arterial oxygen saturation was 97.6%. After administration of 1 mg/kg of methylene blue, her SpO<sub>2</sub> improved gradually to 99%, and the methemoglobin value decreased to 1.2%. When using prilocaine as a local anesthetic, it is important to be aware that methemoglobinemia may occur even at doses much lower than the maximum recommended dose.
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Seiji Mabuchi,Kenichirou Morishige,Takayuki Enomoto,Tadashi Kimura 대한부인종양학회 2010 Journal of Gynecologic Oncology Vol.21 No.2
Objective: The aim of this study is to evaluate the efficacy of carboplatin-paclitaxel (TC) as an initial treatment in patients with the International Federation of Gynecology and Obstetrics (FIGO) stage IVb cervical cancer. Methods: We retrospectively reviewed seven patients with stage IVb cervical cancer who have been primarily treated with TC. The activity and the toxicity were evaluated. Response rate was the main endpoint. Results: Overall, the treatment of TC was well tolerated. The overall response rate was 71.4% (2 complete response, 3partial response). Although grade 3-4 hematologic toxicities were observed in 3 out of 7 patients (42.8%), no patients experienced grade 3-4 non-hematologic toxicities. When we combined our present results with the previous reports,the overall response rate of TC is 63.6%. Conclusion: TC is active and well tolerated in patients FIGO stage IVb cervical cancer. This combination may be considered as an initial treatment regimen in this patient population.
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Emi Ishikawa,Makiko Shibuya,Ayako Yokoyama,Takayuki Hojo,Yukifumi Kimura,Toshiaki Fujisawa 대한치과마취과학회 2023 Journal of Dental Anesthesia and Pain Medicine Vol.23 No.2
We provided general anesthesia management to a patient with advanced atrioventricular block, which was discovered in the remote period after open-heart surgery. A 21-year-old man with Noonan syndrome was scheduled to undergo excision of a median intramandibular tumor. At 2 months of age, the patient underwent endocardial repair for congenital heart disease. During our preoperative examination, an atrioventricular block was detected, which had not been previously noted. Emergency drugs were administered, and a transcutaneous pacemaker was placed. During anesthesia induction, mask ventilation was easy, and intubation was performed smoothly using a video laryngoscope. The transcutaneous pacemaker was activated in demand mode at a pacing rate of 50 cycles/min approximately throughout the anesthesia time, and the hemodynamic status remained stable. The effect of intraoperatively administered atropine was brief, lasting only a few seconds. Although body movements due to thoracoabdominal muscle spasm were observed during pacemaker activation, they did not interfere with surgery. In postoperative patients with congenital heart disease, an atrioventricular block may be identified in the remote period, and preoperative evaluation should be based on this possibility. In addition, during anesthesia management, it is important to prepare multiple measures to maintain hemodynamic status.
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Eiji Kondo,Tsutomu Tabata,Nao Suzuki,Daisuke Aoki,Hideaki Yahata,Yoshio Kotera,Osamu Tokuyama,Keiichi Fujiwara,Eizo Kimura,Fumitoshi Terauchi,Toshiyuki Sumi,Aikou Okamoto,Nobuo Yaegashi,Takayuki Enomo 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.6
Objective: In this study we sought to investigate the clinical factors that affect post progression survival (PPS) in patients with recurrent or persistent clear cell carcinoma (CCC). We utilized the JGOG3017/Gynecological Cancer InterGroup data to compare paclitaxel pluscarboplatin (TC) and irinotecan plus cisplatin (CPT-P) in the treatment of stages I to IV CCC. Methods: We enrolled 166 patients with recurrent or persistent CCC and assessed the impactof variables, including platinum sensitivity, treatment arm, crossover chemotherapy, primarystage, residual tumor at primary surgery, performance status, ethnicity, and tumor reductionsurgery at recurrence on the median of PPS in patients with recurrent or persistent CCC. Results: A total of 77 patients received TC, and 89 patients received CPT-P. The median PPSfor patients with platinum-resistant disease was 10.9 months, compared with 18.8 monthsfor patients with platinum-sensitive disease (hazard ratio [HR]=1.88; 95% confidence interval[CI]=1.30–2.72; log-rank p<0.001). In the multivariate analysis, the platinum sensitivity(resistant vs. sensitivity; HR=1.60; p=0.027) and primary stage (p=0.009) were identified asindependent predictors of prognosis factors for PPS in recurrent or persistent CCC. Conclusions: Our findings revealed that platinum sensitivity and primary stage are clinicalfactors that significantly affect PPS in patients with recurrent or persistent CCC as well as other histologic subtypes of ovarian cancer. PPS in patients with recurrent CCC shouldestablish the basis for future clinical trials in this population.
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