좀비 드라마의 부권 서사: <워킹 데드>의 남성성과 부성 분석

김태형 ( Kim¸ Taehyung ) 대한영어영문학회 2021 영어영문학연구 Vol.47 No.2

The research examines the logic of the patriarchal society that runs throughout the narrative of the television series The Walking Dead. Males in the zombified world often strike out the living dead through violence, which affects people’s sometimes unethical and deadly behaviors toward other human beings. The family and community also take advantage of such masculine violence for their survival. The protagonist of the series, Rick Grimes, becomes the head of the family and survivor group by eliminating or winning over competitors for the name of the father. Rick’s son, Carl, stands up for his biological father among other father figures, supporting Rick’s patrilineal system. Women in the community need toughness and masculinity to adapt to the changed circumstances; mother figures in Rick’s family die providing house work, which is especially undervalued in a zombie apocalypse. Carl has to decide not between his mother and his father in an Oedipal triad but between fathers as a consequence of his mother’s absence. The logic of patriarchy takes up the main narrative of the series, and the longing for the missing Rick ultimately proves the father’s symbolic authority in his absence. (Kunsan National University)

Spectrum of somatic mutation dynamics in chronic myeloid leukemia following tyrosine kinase inhibitor therapy

Kim, TaeHyung,Tyndel, Marc S.,Kim, Hyeoung Joon,Ahn, Jae-Sook,Choi, Seung Hyun,Park, Hee Jeong,Kim, Yeo-kyeoung,Kim, Soo Young,Lipton, Jeffrey H.,Zhang, Zhaolei,Kim, Dennis (Dong Hwan) American Society of Hematology 2017 Blood Vol. No.

<P>Somatic mutations commonly detected in a variety of myeloid neoplasms have not been systematically investigated in chronic myeloid leukemia (CML). We performed targeted deep sequencing on a total of 300 serial samples from 100 CML patients; 37 patients carried mutations. Sixteen of these had evidence of mutations originating from preleukemic clones. Using unsupervised hierarchical clustering, we identified 5 distinct patterns of mutation dynamics arising following tyrosine kinase inhibitor (TKI) therapy. This study demonstrates that patterns of mutation acquisition, persistence, and clearance vary but have a number of interesting correlations with clinical outcomes. Mutation burden often persisted despite successful TKI response (pattern 1), providing indirect evidence that these mutations also originated from preleukemic mutations, whereas patients exhibiting mutation clearance (pattern 3) showed mixed clinical outcomes. Unsurprisingly, patients acquiring new mutations during treatment failed TKI therapy (pattern 2). These patterns show that CML mutation dynamics following TKI therapy are markedly distinct from other myeloid neoplasms. In summary, clinical implications of mutation profiles and dynamics in CML should be interpreted with caution.</P>

Exome sequencing reveals <i>DNMT3A</i> and <i>ASXL1</i> variants associate with progression of chronic myeloid leukemia after tyrosine kinase inhibitor therapy

Kim, TaeHyung,Tyndel, Marc S.,Zhang, Zhaolei,Ahn, Jaesook,Choi, Seunghyun,Szardenings, Michael,Lipton, Jeffrey H.,Kim, Hyeoung-Joon,Kim Dong Hwan, Dennis Elsevier 2017 Leukemia research Vol.59 No.-

<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>The development of tyrosine kinase inhibitors (TKIs) has significantly improved the treatment of chronic myeloid leukemia (CML). However, approximately one third of patients are resistant to TKI and/or progress to advanced disease stages. TKI therapy failure has a well-known association with <I>ABL1</I> kinase domain (KD) mutations, but only around half of TKI non-responders have detectable <I>ABL1</I> KD mutations.</P> <P><B>Method</B></P> <P>We attempt to identify genetic markers associated with TKI therapy failure in 13 patients (5 resistant, 8 progressed) without <I>ABL1</I> KD mutations using whole-exome sequencing.</P> <P><B>Results</B></P> <P>In 6 patients, we detected mutations in 6 genes commonly mutated in other myeloid neoplasms: <I>ABL1</I>, <I>ASXL1</I>, <I>DNMT3A</I>, <I>IDH1</I>, <I>SETBP1</I>, and <I>TP63</I>. We then used targeted deep sequencing to validate our finding in an independent cohort consisting of 100 CML patients with varying drug responses (74 responsive, 18 resistant, and 8 progressed patients). Mutations in genes associated with epigenetic regulations such as <I>DNMT3A</I> and <I>ASXL1</I> seem to play an important role in the pathogenesis of CML progression and TKI-resistance independent of <I>ABL1</I> KD mutations.</P> <P><B>Conclusion</B></P> <P>This study suggests the involvement of other somatic mutations in the development of TKI resistant progression to advanced disease stages in CML, particularly in patients lacking <I>ABL1</I> KD mutations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Acquisition of somatic mutation is associated with TKI therapy failure and progression in CML patients. </LI> <LI> Exome sequencing revealed mutations in 6 genes: <I>ABL1, ASXL1, DNMT3A, IDH1, SETBP1,</I> and <I>TP63.</I> </LI> <LI> Somatic mutations is responsible for TKI resistance esp. lacking <I>ABL1</I> KD mutations. </LI> </UL> </P>

A Decision-Making Framework to Evaluate Traffic Control Strategies on Freeway Work Zone

Taehyung Kim,Taehyeong Kim,Hyoungsoo Kim 보안공학연구지원센터 2013 International Journal of Control and Automation Vol.6 No.2

Interplay between Crystal Structure and Photoluminescence Properties of β-Ca₃SiO₄Cl₂:Eu²⁺

Kim, Tae-Gon,Kim, Taehyung,Kim, Jaegyeom,Kim, Seung-Joo,Im, Seoung-Jae American Chemical Society 2014 The Journal of Physical Chemistry Part C Vol.118 No.23

<P>The crystal structure of β-Ca<SUB>3</SUB>SiO<SUB>4</SUB>Cl<SUB>2</SUB> was determined by the <I>ab initio</I> structure determination method based on the synchrotron powder XRD data for the first time, and the luminescence properties of a Eu<SUP>2+</SUP>-doped β-Ca<SUB>3</SUB>SiO<SUB>4</SUB>Cl<SUB>2</SUB> phosphor were characterized. β-Ca<SUB>3</SUB>SiO<SUB>4</SUB>Cl<SUB>2</SUB> was found to be monoclinic (space group <I>P</I>2<SUB>1</SUB>/<I>c</I>) with the lattice parameters, <I>a</I> = 5.91234(1) Å, <I>b</I> = 10.20128(1) Å, <I>c</I> = 10.98866(1) Å, β = 90.3423(1)°. This structure can be considered as an intergrowth structure built up from alternating stacks of two layered sublattices, <SUB>∞</SUB><SUP>2</SUP>[Ca<SUB>2</SUB>SiO<SUB>4</SUB>] and <SUB>∞</SUB><SUP>2</SUP>[CaCl<SUB>2</SUB>], along the [100] direction. In this structure, the Ca atoms occupy three crystallographically distinct sites: Ca1O<SUB>4</SUB>Cl<SUB>3</SUB>, Ca2O<SUB>5</SUB>Cl<SUB>2</SUB>, and Ca3O<SUB>3</SUB>Cl<SUB>4</SUB>. The photoluminescence of the Eu<SUP>2+</SUP>-doped Ca<SUB>3</SUB>SiO<SUB>4</SUB>Cl<SUB>2</SUB> phosphor excited at 450 nm blue light shows the 150 nm wide-band emission peaked at 635 nm with about 70% quantum efficiency. The photoluminescence properties, such as centroid shifts, crystal-field splitting, and Stokes shifts, were correlated with the crystal structure through the calculation of shared-electron populations reflecting the bond covalency between Ca and O/Cl. Effects of doping concentrations on the luminescence spectra and temperature stability were also discussed based on the inhomogeneous energy transfer property determined by the structural geometric factor.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2014/jpccck.2014.118.issue-23/jp5002379/production/images/medium/jp-2014-002379_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp5002379'>ACS Electronic Supporting Info</A></P>

Study on the radiological characteristics of metal infilled filaments for three-dimensional printing according to the infill rate and pattern

Kim Taehyung,Kim Jeongun,Kim Engchan 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.81 No.11

Three-dimensional (3D) printing technology has been widely used to fabricate customized phantom for patients. High-density structures, such as bone, are not easy to reproduce with regular flaments and require high-density materials. In this study, we use polylactic acid+ (PLA+) flaments and fve metal flaments (bronze, copper, aluminum, iron, and tungsten) containing metal powder to investigate variations in the Hounsfeld unit (HU) values refected in computed tomography images under flament and printing output conditions. Samples were produced to verify the element composition using each flament, and scanning electron microscopy–energy dispersive spectroscopy (SEM–EDS) analyses were performed. The variations of HU values according to the infll patterns were verifed using PLA+, and six flaments were used to verify the variation in HU values according to the infll rate. SEM–EDS analysis shows that all flaments contain C and O elements in common and account for the largest proportion. In the case of metal flaments, additional elements were observed: Cu (1.77%) in bronze, Na (0.45%) and Al (4.48%) in aluminum, Ca (0.7%) and Fe (2.54%) in iron, and W (1.61%) in tungsten. Linearity was confrmed according to the infll rates using various infll patterns. The results showed high linearity of 0.99 or higher in the determination coefcient (R-squared; R2 ) of most patterns. However, in the case of the full honeycomb (R2=0.8825) and fast honeycomb (R2=0.9606) patterns, HU values increased rapidly or gradually at a certain infll rate, indicating a relatively low determination coefcient. The measurement of the variation in HU value according to the type of flament and the degree of flling showed that the higher the degree of flling, regardless of the type of flament, the higher the HU value. For a 100% fll ratio, the average HU value of the cube output to each flament was measured diferently at−28.7, 526.3, 70.1,−32.3, and 3061 HU for PLA+, bronze, copper, iron, and tungsten, respectively. This study will help express various HU values using 3D printing. Moreover, metal flaments will positively afect reproducing dense anatomical structures, such as bones, which have been difcult to express in previous studies.

비소성 황토 혼입률에 따른 콘크리트의고온 역학적 특성 평가를 위한 초음파법 검토

김태형(Taehyung Kim),김원창(Wonchang Kim),정기신(Keesin Jeong),김규용(Gyuyong Kim),이태규(Taegyu Lee) 한국화재소방학회 2023 한국화재소방학회논문지 Vol.37 No.2

본드코팅에 따른 열차폐코팅의 박리수명 평가

김태형(Taehyung Kim),안종기(Jongkee Ahn),신동익(Dongick Shin),김기태(Kitae Kim),정연길(Yeon-Gil Jung),김동훈(Donghoon Kim) 한국추진공학회 2015 한국추진공학회 학술대회논문집 Vol.2015 No.5

가스터빈 부품을 고온의 환경에서 보호하기 위하여 표면에 열차폐코팅을 한다. 열차폐코팅의 증착에는 다양한 방법이 적용되지만 일반적으로 APS와 EB-PVD법을 적용한다. 본 연구에서는 APS와 EB-PVD법을 이용하여 열차폐코팅을 하였을 때 본드코팅 공정에 따라 열피로 및 열충격시 코팅의 박리수명을 평가하였다. 이를 위해 본드 코팅은 APS, HVOF, LPPS를 각 열차폐코팅에 적용하고 두께를 변화하면서 평가를 진행하였다. 평가 결과 APS법을 이용하여 열차폐코팅을 실시한 경우에는 본드 코팅에도 APS를 적용하였을 때 가장 긴 수명을 나타낸 반면 EB-PVD를 적용하였을 때는 LPPS를 이용하여 본드코팅을 실시하였을 때 가장 긴 수명을 나타내었다. 본 연구를 통하여 각 열차폐코팅에 적합한 본드 코팅 선정에 가이드를 제시할 수 있었다. TBC(Thermal Barrier Coating) is applied for protection of high temperature components in gas turbine engine from high temperature environment. Generally APS and EB-PVD are applied. In this research, APS and EB-PVD TBC’s delamination life was evaluated using thermal-shock and thermal fatigue test. For evaluation, specimens are prepared with various bond coating(APS, HVOF and LPPS) and top coating(APS and EB-PVD). In results, APS top coating showed longest delamination life with APS bond coat and EB-PVD top coating showed longest life with LPPS bond coat. It’s possible to design the appropriate TBC architecture with results from this research.

Criticality Safety Analysis on Dry Storage Module (DSM) With PWR Spent Nuclear Fuel

Kiyoung Kim,Donghee Lee,Sunghwan Chung,Taehyung Na,Taehyeon Kim,Yongdeog Kim,Yunsik Kim 한국방사성폐기물학회 2021 한국방사성폐기물학회 학술논문요약집 Vol.2021 No.11

도로 성토 시 인근 구조물에 각변위기준 적용에 있어 계측시스템의 한계성

김태형(Taehyung Kim),김동인(Dongin Kim),김윤태(Yuntae Kim),유상호(Sangho You),정용은(Youngeun Jung),김성웅(Sungwoung Kim) 한국지반환경공학회 2014 한국지반환경공학회논문집 Vol.15 No.1

부등침하로 인한 각변위는 구조물의 안정성과 사용성에 영향을 미치는 중요한 요소 중 하나이다. 실무에서는 현재 Bjerrum이 제안한 각변위기준이 널리 사용되고 있다. 하지만 현재 도로 성토 현장에서 적용하고 있는 계측시스템은 구조물의 각변위를 적합하게 나타내지 못하고 있다. 이와 같은 문제는 충분하지 못한 계측 수, 부정확한 계측기 설치, 계측된 자료의 해석에 있어 각변위 기본개념의 잘못된 이해 등과 관련이 된다. 본 연구에서 도로 성토 현장에서 얻어진 데이터의 분석을 통해 이와 같은 문제점을 규명하였다. 도로 성토 현장에서 적용할 수 있는 자동화된 상대변위 계측시스템이라는 개선된 계측시스템을 제안하였다. Angular distortion due to differential settlement is one of the critical factors which influences on the stability and serviceability of a structure. The angular distortion criterion proposed by Bjerrum is generally used in practice. However, the measurement system used in field especially a road embankment site did not properly represent the angular distortion of a structure. The problem was related to the shortage and not proper installation of measurement gauges, and the incorrect understanding of the basic concept of angular distortion in interpretation of measurement data. These things were reveled by analyzing the measured data in the road embankment site. An improved measurement system has been suggested as a so-called “relative displacement measurement system” between columns with automatic measurement.