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- 저자 : Sym (검색결과 46 건)
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Sym, Sun Jin,Ryu, Min-Hee,Lee, Jae-Lyun,Chang, Heung Moon,Kim, Tae-Won,Kim, Hee Cheol,Kim, Ki Hun,Yook, Jeong Hwan,Kim, Byung Sik,Kang, Yoon-Koo Wiley Subscription Services, Inc., A Wiley Company 2008 Journal of surgical oncology Vol.98 No.1
<B>Background</B><P>We investigated the role of surgical intervention for advanced GIST after imatinib.</P><B>Methods</B><P>Among 256 patients treated with imatinib for advanced GIST, the medical records of the 34 patients who underwent surgery of residual tumors after imatinib treatment were reviewed.</P><B>Results</B><P>Surgery was performed on 24 patients with responsive disease (RD) after imatinib, on 3 with focal progressive disease (FP), and on 7 with generalized progressive disease (GP). All gross tumors were completely resected in 19/24 (79%), 1/3 (33%), and 1/7 (14%) patients, respectively. Disease status at surgery was associated with prognosis after surgery; with a median follow-up of 25.7 months, the median progression-free survival of patients resected for RD, FP, and GP were 27.8 months (95% CI, 17.8–37.8 months), 5.1 months (95% CI, 4.7–5.6 months), and 3.3 months (95% CI, 2.7–3.9 months), respectively (P < 0.001). Median overall survival was not reached in patients resected for RD, and was 22.5 months (95% CI, 1.4–43.0 months) and 23.5 months (95% CI, 3.0–43.9) for patients resected for FP and GP, respectively (P < 0.001).</P><B>Conclusion</B><P>Surgical resection of tumors responsive to imatinib may be beneficial in patients with advanced GIST. Debulking surgery, however, is not recommended for patients who have already developed imatinib resistance. J. Surg. Oncol. 2008;98:27–33. © 2008 Wiley-Liss, Inc.</P>
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Sym, Sun Jin,Ryu, Min-Hee,Lee, Jae-Lyun,Chang, Heung Moon,Kim, Tae Won,Lee, Sung Sook,Lee, Jung Shin,Kang, Yoon-Koo Lippincott Williams Wilkins, Inc. 2008 American journal of clinical oncology: cancer clin Vol.31 No.2
OBJECTIVES:: We retrospectively assessed the combination of biweekly irinotecan with 5-fluorouracil (5-FU), and leucovorin (LV) as salvage chemotherapy in patients with advanced gastric cancer (AGC) previously treated with fluoropyrimidine (F), platinum (P), and taxane (T). METHODS:: Between October 2003 and February 2006, all 131 patients with AGC were treated with irinotecan (150 mg/m on day 1), along with either FOLFIRI-1 (ie, LV (20 mg/m bolus) before 5-FU (1000 mg/m continuous infusion over 6-hour) on days 1–2), or FOLFIRI-2 (ie, LV (20 mg/m bolus) before 5-FU (400 mg/m bolus) followed by 22-hour continuous infusion of 600 mg/m on days 1–2), or FOLFIRI-3 (ie, 5-FU (400 mg/m bolus) followed by 46-hour continuous infusion of 2400 mg/m 5-FU and 100 mg/m LV). Cycles were repeated every 2 weeks. RESULTS:: The median age of the patients was 52 years (range, 19–70 years). Patients received a median of 4 cycles of chemotherapy (range, 1–21 cycles). Of the 97 patients with measurable disease, 1 (1.0%) achieved a complete response, and 11 (11.3%) achieved partial responses, making the overall response rate 12.3%. The median time to progression (TTP) was 2.2 months (95% CI, 1.9–2.6 months) and the median overall survival (OS) was 6.2 months (95% CI, 5.6–6.9 months). Good performance status (P = 0.046), fewer metastatic sites (P < 0.001), and longer time to progression of previous chemotherapy (P = 0.006) were independent prognostic factors affecting OS. OS was longer with the FOLFIRI-1 regimen but not with statistical significance (P = 0.064). The treatments were generally well tolerated. CONCLUSIONS:: In actual clinical practice, biweekly irinotecan with 5-FU and LV had modest activity and tolerability in AGC patients previously treated with F, P, and T.
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카나비노이드 수용체 활성화 및 TRPV1 억제를 통한 arachidonoyl-serotonin (AA-5-HT)의 진통 효과
심은진(Eunjin Sym),심원식(Won-Sik Shim) 대한약학회 2021 약학회지 Vol.65 No.4
Pain is a noxious sensation caused by tissue damage, which can severely interfere with a person’s quality of life. Although numerous analgesics are available for eradicating pain, there remain limitations in terms of safety and efficacy. This review focuses on arachidonoyl-serotonin (AA-5-HT) − an endogenous lipid with a putative antinociceptive effect. After detailed investigation, previous studies have revealed that AA-5-HT can stimulate the cannabinoid system, which results in the inhibition of pain sensation. Moreover, AA-5-HT can inhibit the action of TRPV1, which is a nonselective cation channel that mediates pain signals in the nervous system. This dual effect makes AA-5-HT a potentially safe and potent analgesic. This review summarizes the roles of the cannabinoid system and TRPV1 in pain sensation, and the function of AA-5-HT in pain modulation.
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심선진 ( Sun Jin Sym ) 대한내과학회 2015 대한내과학회지 Vol.89 No.5
Metastatic bladder cancer is generally incurable, with a median survival of 14 to 15 months under a modern chemotherapy regimen. Cisplatin-based chemotherapy, including the combination regimens methotrexate-vinblastine-doxorubicin-cisplatin and gemcitabine-cisplatin, are the standard first-line therapy. Despite response rates of 40% to 60% achieved, most patients’ cancers progress after about 8 months. Second-line single agents have only marginal efficacy after cisplatin-based treatment failure, with objective response rates of 5% to 20% and a median progression-free survival of only 3 to 4 months. Moreover, there is little evidence that second-line systemic treatment can substantially improve overall survival or quality of life. Agents targeting growth, survival, and proliferation pathways have been added to cytotoxic therapy with limited added benefits to date. Drugs that modulate the host immune response to cancer-associated antigens, including immunologic checkpoint blockade by antibodies against programmed cell death protein-1 or its ligands, appear promising, and multiple new therapeutic approaches are being pursued. In addition, the receptor tyrosine kinase/Ras pathway and the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of the rapamycin pathway represent potential therapeutic targets for advanced disease, and novel agents are in development. (Korean J Med 2015,89:515-521)
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John Donne 과 韓龍雲 : 詩想과 그 表現法의 比較 A Comparison of Their Poetic Ideas and Expressions
沈明鎬 韓國比較文學會 1986 比較文學 Vol.11 No.-
Although there lies a space of three centuries and the cultural difference of West and East between John Donne, the 17th century English metaphysical poet, and Han Yongun, the present century Korean poet, their poetic ideas and expressions are strikingly similar and even very close to each other. Both of them led a life also similar in many ways to each other, for example, they were born in a comparatively rich family, educated early, and they traveled abroad when young and became priests in their middle age and devoted themselves to religion. On the other hand, Han might have been influenced, one may imagine, from Donne, be it ever so little, through his possible reading of foreign poets during the period when he was editing a Buddhist magazine called Yusin (Thinking Spirit). Otherwise, Donne's indirect influence might have reached Han through an Indian poet Rabindranath Tagore who may have been exposed to the 17th century metaphysical poets while studying in England and whose poetry Han certainly read with much interest. However, all this supposition from the writer's private mind carries no support of concrete evidence as yet from definite sources and the present thesis does not aim to achieve it. Instead, the writer who has strongly been drawn to their likeness has simply made an attempt to see how their poetic ideas are similar and in what similar ways these ideas are expressed in their poetic works. The result may briefly be summarized: First of all, their poetry relies heavily upon what may be termed Dialectic Logic and Metaphysical Conceit, which are indeed essential to their mode of expression and the use of which are similar between the two poets. Secondly, there are in their poetry other distinctive and similar qualities such as paradox, hypobole, metaphor, and simile. Both Donne and Han deal with the agony of lovers' leave-taking in many of their poems and they reach a similar awakening that in true love parting is only of their flesh and their souls never know each other's absence. However, in the philosophy of lovers' leavetaking, Han goes further and asserts that between lovers parting is inevitable and essential and it is greater than death. To conclude, George Williamson once said, "In fact, the study of Baudelaire is a preparation that no one should neglect who would get the most out of Donne," but the writer would like to add that the study of any one of the two poets, Donne and Han, must be beneficial to the better understanding of the other.
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沈明鎬 서울大學校 語學硏究所 1976 應用 言語學 Vol.8 No.1
The current teaching of College English has not yet seen any substantial improvement in its methodology as well as in its administration. Some private universities have launched pilot projects with a view to reforming the teaching of College English for the past years, and they certainly have succeeded in it to some extent. National universities including Seoul National University and many other private universities, however, still fall far behind in this field of teaching College English with little or no effort whatever to discover problem areas and provide their solutions. Consequently, it may be deduced that these universities waste an abundance of man power, time and money. The present research therefore has made an initial, overall survey of the system, administration and the actual teaching processes of College English course at Seoul National University as a case study as mentioned in the research plan. It has further examined and analysed the major problems discovered during the course of the survey and has supported them with reliable data collected through a statistical approach. The current teaching practice of College English, which usually provides a single uniform course maintaining a fixed academic standard for average freshmen, is both inefficient and unprofitable, Hundreds of students enrolled in the College English course are either learning little or just loafing because they are in effect unable to pursue College English due to their poor competence or else to their command of English that is even higher than the College English standards. In either case, no partial adjustment or improvement of the current system of teaching College English can be a solution. From the conclusions drawn from the process of examination and analysis, the present research has therefore strongly proposed a tripartite system of teaching College English as a positive measure for the reformation of the College English course, Accordingly, the College English, each distinct in academic standard but linked together in a step by step progress. The first channel is, quite obviously, for those freshmen whose English ability is so poor that they can hardly pursue the College English course currently taught. The second channel, which is an equivalent to the current College English course, is for those who are well qualified to start with College English. The third channel is for those whose command of English is recogninizably higher than the College English standard. The present research has also suggested that the ultimate solution for all the problems of College English inevitably calls for an amendment of the system of university entrance examination currently adopted.
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