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The effect of LAMA and LABA on lung function in bronchiectasis patients
( Suyeon Lee ),( Yeon Mok Oh ),( Sei Won Lee ),( Jae Seung Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Bronchiectasis is a chronic lung disease characterized by coughing, sputum, and repeated bronchial infections with permanent bronchial dilatation. One of the treatment goal for bronchiectasis is maintaining or improving lung function. In practice, long-acting muscarinic antagonist (LAMA) or beta-agonist (LABA) inhaled bronchodilators are often used to treat bronchiectasis, but there is very low evidence to recommend their use. So the aim of this study is to evaluate the effectiveness of LAMA or LABA in bronchiectasis patients by comparing lung function before and after LAMA or LABA treatment. Methods: This study was a retrospective, observational study comparing lung function, before and after LAMA or LABA treatment. We analyzed the data of 230 bronchiectasis patients who were treated with LAMA or LABA for at least one month without any history of asthma or cigarette smoking. We similarly analyzed the data of 97 patients, after excluding those treated with antibiotics, steroids, or mucolytics. We identified the factors relating to the increase in FEV1 values after the treatment of LAMA or LABA with linear regression analysis. Results: Of 230 patients, 32.5% were male, and the median age was 60 years. Mean FEV1 was 53.5% of predicted value. After treatment with LAMA or LABA, we found improvement of FEV1 (P<0.001). The mean change in FEV1 was 5%±8.9% of the predicted value. After excluding the patients treated with antibiotics, steroids or mucolytics, we also found improvement of FEV1 (P<0.001), with a mean change of 5.7%±7.8%. The factors relating to the increase in FEV1 were mMRC dyspnea grade and baseline FEV1 value. The lower the mMRC dyspnea grade, the greater the change of FEV1 (P=0.005); the lower the baseline FEV1 value, the greater the change of FEV1 (P=0.0001). Conclusions: LAMA or LABA treatment might improve lung function in bronchiectasis patients.
Suyeon Lee,Eun Young Shin,Dawoon Jang,Seungjoo Choi,Hyeju Park,Jeongho Kim,Sungjin Park 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.9
Degradation of organic pollutants is an important research area to solve environmental issues. Metal-free carbon nitride (C3N4) materials have a great potential as cost-effective and environment-friendly photocatalysts for this purpose. Herein, we develop a route to produce mesoporous C3N4 materials and investigate their photocatalytic performance for degrading rhodamine B (RhB). The mesoporous materials are generated through the self-assembly of melamine and cyanuric acid during high-temperature pyrolysis. The materials show excellent photocatalytic activities for RhB degradation under the irradiation of visible light. They possess higher surface areas, better adsorption ability of visible light and longer lifetimes of the photoexcited electrons than common C3N4 sample. These aspects are the reasons for the excellent photocatalytic performance.
Lee, Jihyoun,Kim, Sungwon,Kang, Eunyoung,Park, Suyeon,Kim, Zisun,Lee, Min Hyuk 한국유방암학회 2017 Journal of breast cancer Vol.20 No.2
<P>Lack of awareness, the stigma of carrying a genetic mutation, and economic factors are barriers to acceptance of <I>BRCA</I> genetic testing or appropriate risk management. We aimed to investigate the influence of Angelina Jolie's announcement of her medical experience and also health insurance reimbursement for <I>BRCA</I> gene testing on practice patterns for hereditary breast and ovarian cancer (HBOC). A survey regarding changes in practice patterns for HBOC before and after the announcement was conducted online. The rate of <I>BRCA</I> gene testing was obtained from the National Health Insurance Review and Assessment Service database. From May to August 2016, 70 physicians responded to the survey. Genetic testing recommendations and prophylactic management were increased after the announcement. Risk-reducing salpingo-oophorectomy and contralateral prophylactic mastectomy was significantly increased in <I>BRCA</I> carriers with breast cancer. The <I>BRCA</I> testing rate increased annually. Health insurance and a celebrity announcement were associated with increased genetic testing.</P>
Lee, Suyeon,Han, Hye Seong,Seong, Dong Gi The Korean Society for Composite Materials 2022 Composites research Vol.35 No.3
Owing to advantages of polymeric materials for hydrogen tank liner like light-weight property and high specific strength, polymer based composites have gained much attention. Despite of many benefits, polymeric materials for fuel cell tank cause problems which is critical to applications as low gas barrier property, and poor processability when adding fillers. For these reasons, improving gas barrier property of polymer composites is required to study for expanding application fields. This work presents impermeable polymer nanocomposites by introducing thin barrier coating using layer by layer (LBL) deposition method. Also, bi-layered and quad-layered nanocomposites were fabricated and compared for identifying relationship between deposition step and gas barrier property. Reduction in gas permeability was observed without interrupting mechanical property and processability. It is discussed that proper coating conditions were suggested when different coating materials and deposition steps were applied. We investigated morphology, gas barrier property and mechanical properties of fabricated nanocomposites by FE-SEM, Oxygen permeation analyzer, UTM, respectively. In addition, we revealed the mechanism of barrier performance of LBL coating using materials which have high aspect ratio.