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Sung, Kyoung,Kim, Ji Yong,Lee, Yeoun Joo,Hwang, Eun Ha,Park, Jae Hong The Korean Society of Pediatric Gastroenterology 2014 Pediatric gastroenterology, hepatology & nutrition Vol.17 No.3
Purpose: The etiology of acute gastroenteritis (AGE) has changed since the introduction of the rotavirus vaccination. The aim of this study was to clarify which common pathogens, both bacterial and viral, are currently causing AGE in infants. Methods: Infants with acute diarrhea were enrolled. We tested for 10 bacterial pathogens and five viral pathogens in stool specimens collected from infants with AGE. The clinical symptoms such as vomiting, mucoid or bloody diarrhea, dehydration, irritability, and poor oral intake were recorded, and laboratory data such as white blood cell count and C-reactive protein were collected. The clinical and laboratory data for the cases with bacterial pathogens and the cases with viral pathogens were compared. Results: Of 41 total infants, 21 (51.2%) were positive for at least one pathogen. Seventeen cases (41.5%) were positive for bacterial pathogens and seven cases (17.1%) were positive for viral pathogens. Staphylococcus aureus (13 cases, 31.7%) and Clostridium perfringens (four cases, 9.8%) were common bacterial pathogens. Norovirus (five cases, 12.2%) was the most common viral pathogen. Fever and respiratory symptoms were common in the isolated viral infection group (p=0.023 and 0.044, respectively), whereas other clinical and laboratory data were indistinguishable between the groups. Conclusion: In our study, S. aureus (41.5%) and norovirus (12.2%) were the most common bacterial and viral pathogens, respectively, among infants with AGE.
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HisCoM-GGI: Software for Hierarchical Structural Component Analysis of Gene-Gene Interactions
Choi, Sungkyoung,Lee, Sungyoung,Park, Taesung Korea Genome Organization 2018 Genomics & informatics Vol.16 No.4
Gene-gene interaction (GGI) analysis is known to play an important role in explaining missing heritability. Many previous studies have already proposed software to analyze GGI, but most methods focus on a binary phenotype in a case-control design. In this study, we developed "Hierarchical structural CoMponent analysis of Gene-Gene Interactions" (HisCoM-GGI) software for GGI analysis with a continuous phenotype. The HisCoM-GGI method considers hierarchical structural relationships between genes and single nucleotide polymorphisms (SNPs), enabling both gene-level and SNP-level interaction analysis in a single model. Furthermore, this software accepts various types of genomic data and supports data management and multithreading to improve the efficiency of genome-wide association study data analysis. We expect that HisCoM-GGI software will provide advanced accessibility to researchers in genetic interaction studies and a more effective way to understand biological mechanisms of complex diseases.
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FARVAT: a family-based rare variant association test
Choi, Sungkyoung,Lee, Sungyoung,Cichon, Sven,Nö,then, Markus M.,Lange, Christoph,Park, Taesung,Won, Sungho Oxford University Press 2014 Bioinformatics Vol.30 No.22
<P>Motivation: Individuals in each family are genetically more homogeneous than unrelated individuals, and family-based designs are often recommended for the analysis of rare variants. However, despite the importance of family-based samples analysis, few statistical methods for rare variant association analysis are available. Results: In this report, we propose a FAmily-based Rare Variant Association Test (FARVAT). FARVAT is based on the quasi-likelihood of whole families, and is statistically and computationally efficient for the extended families. FARVAT assumed that families were ascertained with the disease status of family members, and incorporation of the estimated genetic relationship matrix to the proposed method provided robustness under the presence of the population substructure. Depending on the choice of working matrix, our method could be a burden test or a variance component test, and could be extended to the SKAT-O-type statistic. FARVAT was implemented in C+ +, and application of the proposed method to schizophrenia data and simulated data for GAW17 illustrated its practical importance.</P>
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The Scope of Practice for Registered Nurses in 64 South Korean Laws
Choi, Sungkyoung,Jang, Seung Gyeong,Lee, Won 한국간호과학회 2019 Journal of Korean Academy of Nursing Vol.49 No.6
Purpose: The role of registered nurses is expanding in scope as the healthcare paradigm shifts from acute, hospital-based care to community and population-based care. Given this paradigm shift, this study explores the legal aspects of the role of a registered nurse. Methods: We used document analysis for extracting laws and legal orders related to nursing from the entirety of Korean law. Using textualism approach, we examined the contents utilizing a framework that was developed based on the role classification of community nurses by Clark in this study. Results: A total of 119 items related to nursing were derived from 64 laws. Of these, 71.4 % can be performed by people in multiple types of occupations including nurses. As a result of analyzing required qualifications, 45.4% of 119 items required additional qualifications besides registered nurse license. Analysis of workplace and activity type demonstrated that 26.1% of the 119 items were related to medical institutions, with nurses performing mostly “Client-oriented role.” More than half (68.9%) were non-medical institutions, with nurses performing mostly “Delivery-oriented role.” Some, however, did not stipulate the nurse’s roles clearly. Conclusion: Therefore, to match the enhanced scope and responsibilities of registered nurses and to appropriately recognize, guide, and hold these nurses accountable, laws and policy must reflect these changes. In doing so, these updated laws and policies will ultimately serve as a basis for improving the quality and safety of nursing services.
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신문 텍스트에 나타난 한국어 헤지 표현의 사용 양상 연구
도성경 ( Sungkyoung Do ),진송수 ( Songsoo Jin ) 이중언어학회 2018 이중언어학 Vol.70 No.-
The purpose of this study is to conceptualize Korean hedging expressions from newspaper editorials and suggest strategies for teaching Korean hedging expressions to academic Korean learners. Since newspaper articles are written in a logical manner, they are widely used for reading and writing education. However, there are not a lot of studies that focus on newspaper editorials in Korean language education research. Yet, analyzing characteristics of a genre, such as the structure of a text and its style, should be studied. Therefore, in this study, we emphasize the use of hedging expressions, which reveal genre-specific features of newspaper editorials. We focus on hedges, which are expressions that speakers or writers use to soften the impact of their claims. First, we investigate the frequency of how often Korean hedging expressions are used in newspaper editorials. Then, we classify a list of Korean hedging expressions based on the degree of judgment. After that, we propose the usage of Korean hedging expressions through examples. In conclusion, we suggest a list of Korean hedging expressions with examples that can be applied in Korean language education for Korean learners. (Ewha Womans University)
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Risk Prediction Using Genome-Wide Association Studies on Type 2 Diabetes
Choi, Sungkyoung,Bae, Sunghwan,Park, Taesung Korea Genome Organization 2016 Genomics & informatics Vol.14 No.4
The success of genome-wide association studies (GWASs) has enabled us to improve risk assessment and provide novel genetic variants for diagnosis, prevention, and treatment. However, most variants discovered by GWASs have been reported to have very small effect sizes on complex human diseases, which has been a big hurdle in building risk prediction models. Recently, many statistical approaches based on penalized regression have been developed to solve the "large p and small n" problem. In this report, we evaluated the performance of several statistical methods for predicting a binary trait: stepwise logistic regression (SLR), least absolute shrinkage and selection operator (LASSO), and Elastic-Net (EN). We first built a prediction model by combining variable selection and prediction methods for type 2 diabetes using Affymetrix Genome-Wide Human SNP Array 5.0 from the Korean Association Resource project. We assessed the risk prediction performance using area under the receiver operating characteristic curve (AUC) for the internal and external validation datasets. In the internal validation, SLR-LASSO and SLR-EN tended to yield more accurate predictions than other combinations. During the external validation, the SLR-SLR and SLR-EN combinations achieved the highest AUC of 0.726. We propose these combinations as a potentially powerful risk prediction model for type 2 diabetes.
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안성경(Ahn, SungKyoung) 한양법학회 2010 漢陽法學 Vol.31 No.-
On the last 15 August 2008, President Lee Myung-bak proposed the so-called “green growth” concept, which is a economic and environmental harmony, and balance. Since then, the concept of green growth is being used routinely in our lives, I think it is a problem. This Article is intend to criticize a use of the “green growth”, proposes to use the “sustainable development” which is a strategic concept that is combination of economic development and environmental protection from the theoretical and practical perspective. This article in order to achieve these objectives are being claimed by the government to clean up the green growth Theory (Ⅱ), the existing claims in the general persistence will organize the sustainable development theory (Ⅲ). Under this base, in terms of green growth conceptual and theoretical aspects and practical aspects after reviewing the “green growth” concept than the concept of “sustainable development” and the vague and abstract, theoretical, and practical perspective, the concept of the problem is will argue(Ⅳ). Finally, by discussing and writing more (Ⅴ). The concept of green growth requires interpretation. Even though using of the expression of green growth is familiar to researchers, the concept of green growth is abstract and vague in actual. We need to consider another expression, “sustainable development”. “Sustainable development” and “green growth”, both are in the same level in concept, however “sustainable development” is used worldwide and for a long time and more popular. By the government's line of view, the economic development and environmental protection are two sections in consideration of the concept of green growth. On the contrary, the concept of sustainable development, economic development, environmental protection and social justice are three elements to the content. Therefore, in the concept of sustainable development, social justice between the layers of social justice, between generations and between international communities is essential and must to be premised. On the contrary, the concept of green growth seems to neglect the social justice element. In addition, the concept of green growth is still incomplete as a strategic concept for environmental policy. The concept of green growth is the uncertain theoretical and practical issues. That is causing the problem. Finally, the “Low Carbon, Green Growth Act” as enacted into Law, “Sustainable Development Act” to refine this legislation changing its nature that relatively larger to carry out the policy up to the top of the law resulted in a logical contradiction, resulted in the confusion legislation.
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