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      • Thermodynamic Modeling of Miscibility Gap in the Al-In System

        Kim, Sung Sik Research Institute of Science and Technology HONGI 2005 Hongik Journal of Science and Technology Vol.9 No.-

        A thermodynamic modeling of phase diagram in the binary Al-In system was described using the Gibbs free energies of the phases. The subregular solution model was applied to describe the liquid phase in the present system. Using the experimental miscibility gap data in the literature, the interaction parameters in the excess Gibbs free energy expression of liquid phase were obtained as A^(0) = 39.8874 - 0.0192T and A^(1)= 2.5464 + 0.0008T (kJ/mol). With these parameters, the miscibility gap was regenerated. The present result was compared and discussed with other experimental and assessed data available in the literature.

      • KCI등재

        수학자 보재 이상설(李相卨)의 근대자연과학 수용 -『백승호초(百勝胡艸)』를 중심으로-

        이상구 ( Sang Gu Lee ),박종윤 ( Chong Yun Park ),김채식 ( Chae Sik Kim ),이재화 ( Jae Hwa Lee ) 한국수학교육학회 2013 수학교육논문집 Vol.27 No.4

        본 논문은 한국 근대수학교육의 아버지 이상설(李相卨, 1870-1917)이 자연과학―물리학―에 기여한 내용을 다루고있다. 이상설은 ?수리(數理)?를 쓴 시기를 전후하여, 같은 시기에 붓으로 총 8면에 걸쳐 『백승호초(百勝胡艸)』라는이름의 고전물리학 원고를 써서 남겼다. 분석결과 이 책의 원전은 1879년에 동경제대 의학부 교재로 발간된 『물리학(物理學)』이다. 이상설은 『백승호초』에서 먼저 개념을 정의하고, 일상에서 나타난 대표적 현상을 선록하여 한문으로번역하였고, 『물리학』의 전체 분량에서도 특히 ‘통유성(通有性)’에 중점을 두고 설명하였다. 동양에서 서양의 수리과학이 들어와야만 말할 수 있는 ‘질량보존의 법칙’, ‘타성(惰性, 관성)’과 같은 고전물리학의 중요개념을 포함하는 내용이 19세기 말에 이미 이 책에 소개된 것으로 보아 이상설은 당대의 다른 저술에서 보기 힘들 정도로 당시 일반물리학의 최고수준의 원서를 통해 최신 정보를 수용하고 전파하기 위하여 노력하였음을 볼 수 있다. Sang-Seol Lee(1870-1917) wrote a manuscript BaekSeungHoCho(百勝胡艸) in the late 19th century. BaekSeungHo-Cho was transcribed in classical Chinese from the 1879 Japanese book Physics(物理學) by Teizo Ihimori (1851-1916). Sang-Seol Lee, a famous independence activist, is also called Father of the Modern Mathematics Education of Korea,because of his early contribution to the modern mathematics education in the 19th century. In this paper, we introduce contents of his manuscript BaekSeungHoCho for the first time and discuss the significance of this book. Also, we show his constribution on the introduction to modern physics in the late 19th century Korea.

      • KCI등재후보

        Effect of Developmental Lead Exposure on the Expression of Hippocampal NMDA Receptor Subunit mRNA

        Kim, Tae-Wan,Chung, In-Sung,Bae, Jae-Hoon,Shin, Dong-Hoon,Lee, Mi-Young,Kim, Joon-Sik 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

        목적: in vivo 및 vitro에서 해마 신경세포의 발생단계별 NMDA 수용체 아단위 mRNA 발현에 대한 연 폭로 영향을 알아보고자 하였다. 방법: 흰쥐 해마 신경세포의 발생단계별 NMDA 수용체 NR2A, NR2B 아단위 mRNA 발현에 대한 연의 영향은 정상군과 연 폭로군의 출생 후 7일, 14일, 22일 흰쥐의 해마에서 in situ hybridization으로 mRNA 발현 정도를 densitometer로 측정하여 비교하였고, 연과 NMDA 의 세포독성은 해마 신경세포 일차배양 후 도립현미경을 이용한 형태학적인 관찰과 LDH 활성도를 이용하여 측정하였다. 결과: 연 과 NMDA 에 의한 세포독성에 대한 in vitro 실험에서 형태학적 소견과 LDH 활성도에서 해마 미성숙 신경세포와 성숙 신경세포사이의 차이가 있었으므로, 연과 NMDA 독성효과는 해마 신경세포의 발달 단계에 따라 차이가 있다. 정상군의 해마에서의 NR2A mRNA 발현은 출생 후 연령이 증가함에 따라 점진적으로 증가하였으나, NR2B mRNA 발현은 출생 후 연령이 증가함에 따라 점진적으로 증가하였으나 NR2B mRNA 발현은 연령의 증가에 따른 변화가 없었다. 연 폭로에 희한 NR2A mRNA 발현은 유의하게 감소하였으나(p<0.05), NR2B mRNA 발현은 변화가 나타나지 않았다. 만성적 연 폭로는 NR2A를 포함하는 NMDA 수용체를 감소시킬 수 있음을 알 수 있다. 결론: 연은 해마신경세포의 발생단계에서 NMDA 수용체 아단위 특히 NR2A mRNA 발현의 변화를 야기하여 시냅스 신호 전달에 영향을 나타냄을 알 수 있었다. Hippocampus

      • KCI등재

        한국 근대수학교육의 아버지 이상설(李相卨)이 쓴 19세기 근대화학 강의록 『화학계몽초(化學啓蒙抄)』

        Son, Yongkeun,Kim, Chae Sik,Lee, Sang-Gu,Lee, Jae Hwa 강원경기수학회 2012 한국수학논문집 Vol.20 No.4

        본 원고는 한국 근대 수학교육의 아버지 이상설(李相卨, 1870-1917)이 자연과학-화학-에 기여한 내용을 다루고 있다. 이상설은 "수리(數理)"를 쓴 시기를 전후하여, 같은 시기에 붓으로 총 46쪽에 달하는 "화학계몽초(化學啓蒙抄)"를 필사하였다. 분석해 본 결과 그 원전은 영국인 H. E. Roscoe(羅斯科, 1833-1915)가 1876년 발간한 Science Primers: Chemistry를 영국인 선교사 Joseph Edkins(艾約瑟, 1823-1905)가 번역하여 1886년에 간행한 "화학계몽(化學啓蒙)"으로 "서학계몽(西學啓蒙)" 16종 가운데 하나이다. Sang-Seol LEE wrote a manuscript HwaHakGyeMongCho(化學啓蒙抄) in the late 19th century. HwaHakGyeMongCho was transcribed from Science Primers: Chemistry (written by H. E. Roscoe), which is translated into Chinese by Joseph Edkins in 1886. LEE did not copy original writing exactly, but he understood the contents of each chapter and sections, then summarized and edited them in his caligraphic writing. In this paper, we introduce the contents for the first time and discuss the significance of this book.

      • KCI등재

        예비체육교사의 패럴림픽에 대한 이해도 비교 연구

        김상두(Sang Doo Kim),김준석(Jun Sik Kim) 한국사회체육학회 2014 한국사회체육학회지 Vol.0 No.57

        The purpose of this study is to find out the level of understanding for pre-service physical-education teachers about the Paralympics and the differences between physical education majors and adapted physical education majors. For the purpose of the survey, a distinct difference between the groups on a survey has been identified. The survey material used for this study with a modification is based on Yeon-Sook Ko, Kyung-Sook Kim``s modified survey(2005) that scale analysis of disability attitude factor, which DFS(Disability Factor Scale) invented by Siller(1983) and translated by Jong-Nam Lee(1994), was used as a reference. For this study, collected 380 papers of information was updated and SPSS 18.0 program was used for its analysis with significant level of 5 percent or below. The frequency analysis has been conducted to figure out the subject``s general features, and t-test which is mean difference analysis and One-Way ANOVA have been conducted to see the awareness of the Paralympics. These tests were also used to verify differences between the two groups differentiated by major. The result are as followed. First, male have better understanding toward Paralympics than female do. However, none of statistical significance-difference was found. Second, the level of understanding toward Paralympics for all graders shows no sign of statistical significance-difference. Third, overall, adapted physical education majors have decent level of understanding toward Paralympics and the gap created from the fact, that whether he/she took adapted physical education classes, was shown. Fourth, a group with experience of volunteering turned out to have high level of understanding toward Paralympics and statistical significance-difference was found. It is shown that the differences about understanding toward Paralympics between the groups exist and pre-service physical-education teachers have lower level of understanding toward Paralympics compared to adapted physical-education majors. Fifth, the understanding level of pre-service physical-education teachers indicates areal gap and classes taken. In this study, a survey has been developed to find out the understanding level of Paralympics, which is one of the major events, for pre-service physical-education teachers and the differences between the groups have been identified. In this study which is to develop a survey as base line data to vitalize , it is suggested as followed. First, due to the fact that pre-service physical-education teachers were the subject for this study, an additionalstudy for a group of teachers who are currently working in the field should be made. Second, this study is only for major events of disabled for Paralympics. Later on, hence, study including morefeatures is a mandatory, such as various games, domestic sports festival for the people with handicapped. Third, due to this study is focused on pre-service physical education teacher, later, research which is forspecial education teacher should be needed for their better physical education service.

      • KCI등재후보

        월남 이상재의 체육사상 연구

        김성수(Kim Sung-Soo),엄정식(Um Jung-Sik) 한국체육과학회 2003 한국체육과학회지 Vol.12 No.1

        Wolnam was a devout Christian and an activist for independence and civil rights. as well as journalist. He developed a nationalist movement within the YMCA and boosted the Korean spirit through his sense of humor and wit when the country was under Japanese colonial rule. Wolnam the bay it attaches importance in objection and before improving the traditional education method which one makes a public official unbiased view the nation participates namely. to go without question the young and old, who the possibility of being educated is from equal opportunity inside of education frequently. the strenuous efforts must accomplish presented an education method in crane line agreement. Like this Wolnam, the arrival point of education thought mindㆍspiritㆍbody becoming the Trinity, was a volition thing which prepares a harmonious personality it shows personally. Wolnam's YMCA peculiar whole man thought, namely spiritㆍmindㆍbody it receives an impression even in balance human being vocal thought and spirit with only mind it considers seriously and body it disregards the place where it conquers a hitherto Confucianism fixed idea to lead, it became. This is one revolution. Is like this the thought which is narrow-minded slants with one piece knows mindㆍspiritㆍbody the thing and the thinker public opinion which the body which attempt a fortune development with the artificial flower (mind) in it thinks specially in one minutes to be forever remembered, route it wishes. The wolnarn sees the transference powerful enemy asserted the change of the recognition from the feudal society against a physical Education in the converter in the modem time civic society the thing that our country physical Education development it has a big history value. With this together Wolnam as only our country modem time thinker the bay it knows from practice width of modem time physical Education with development of physical Education thought it is thought a big contribution with the fact that height must come to be evaluated as one person.

      • KCI등재

        Assessment of In Vitro Assay System for Thyroid HormoneDisruptors Using Rat Pituitary GH3 Cells

        Hee Jin Kim1,Hae Young Park1,Jeonga Kim1,Il Hyun Kang2,Tae Sung Kim2,Soon Young Han2,Tae Seok Kang2,Kui Lea Park2,Hyung Sik Kim1 한국독성학회 2006 Toxicological Research Vol.22 No.4

        The development of in vitro assays has been recommended to screening and test-ing the potential endocrine disruptors (EDs). These assay systems focus only on identifying thethe thyroid hormone (TH) disruptors. The aim of this study was to evaluate a test system to detectTH disruptors using rat pituitary tumor GH3 cells. The test system is based on the TH-dependentincrease in growth rate. As expected, L-3,5,3-triiodothyronine (T3) markedly induced a morphologicalchange in GH 3 cells from flattened fibroblastic types to rounded or spindle-shaped types. T3 stimu-lated GH3 cell growth in a dose-dependent manner with the maximum growth-stimulating effect9 M. In addition, T3 increased the release of growth hor-mone and prolactin into the medium of the GH3 cells culture. Using this assay system, the TH-dis-rupting activities of bisphenol A (BPA) and its related compounds were examined. BPA,dimethylbisphenol A (DMBPA), and TCI-EP significantly enhanced the growth of GH3 cells in therange of 1 × 10-5M to 1 × 10-6M concentrations. In conclusion, this in vitro assay system might bestandardization before it can be used as a broad-based screening tool.

      • SCIESCOPUSKCI등재

        Protective effect of Korean Red Ginseng against FK506-induced damage in LLC-PK1 cells

        Dahae Lee,Ki Sung Kang,Jae Sik Yu,Jung-Yoon Woo,Gwi Seo Hwang,Dae-Woon Eom,Seung-Hoon Baek,Hye Lim Lee,Ki Hyun Kim,Noriko Yamabe 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.3

        Background: Compound FK506 is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and inflammatory response mediated by FK506 limit its usefulness. In this study, the protective effect of Korean Red Ginseng (KRG) against FK506-induced damage in LLC-PK1 pig kidney epithelial cells was investigated. Methods: LLC-PK1 cells were exposed to FK506 with KRG and cell viability was measured. Western blotting and RT-PCR analyses evaluated protein expression of MAPKs, caspase-3, and KIM-1. TLR-4 gene expression was assessed. Caspase-3 activities were also determined. The number of apoptotic cells was measured using an image-based cytometric assay. Results: The reduction in LLC-PK1 cell viability by 60mM FK506 was recovered by KRG cotreatment in a dose-dependent manner. The phosphorylation of p38, p44/42 MAPKs (ERK), KIM-1, cleaved caspase-3, and TLR-4 mRNA expression was increased markedly in LLC-PK1 cells treated with 60mM FK506. However, with the exception of p-ERK, elevated levels of p-p38, KIM-1, cleaved caspase-3, and TLR-4 mRNA expression were significantly decreased after cotreatment with KRG. Activity level of caspase-3 was also attenuated by KRG cotreatment. Moreover, image-based cytometric assay showed that apoptotic cell death was increased by 60mM FK506 treatment, whereas it was decreased after cotreatment with KRG. Conclusion: Taken together, these results suggest that the molecular mechanism of KRG in the FK506-induced nephrotoxicity may lead to the development of an adjuvant for the inhibition of adverse effect FK506 in the kidney.

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