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Hong, Sung-Yu,Chung, Kwang-Hoe,You, Hea-Jung,Choi, Ik-Hwa,Chae, Mi-Jin,Han, Ja-Young,Jung, Ok-Jai,Kang, Soo-Jung,Ryu, Chung-Kyu 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14
A series of 6-arylamino-5-chloro-benzimidazole-4,7-diones were synthesized and tested for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. Among them, 6-arylamino-5-chloro-2-methyl-benzimidazole-4j,7-diones exhibitied potent antiproliferative activity. Benzimidanole-4,7-dione 2c activated SAPK/JNK signaling pathway in the RAoSMCs.
( Hong-joon Shin ),( Jae-kyeong Lee ),( Hyung-joo Oh ),( Min-seok Kim ),( Bo Gun Kho ),( Ha Young Park ),( Tae-ok Kim ),( Cheol-kyu Park ),( Yong-soo Kwon ),( In-jae Oh ),( Yu-il Kim ),( Sung-chul Lim 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Cryptogenic organizing pneumonia (COP) is idiopathic interstitial pneumonia characterized on imaging by multifocal ground glass opacities and/or consolidation. COP is similar to bacterial or viral pneumonia in clinical and radiologic features, therefore, it is necessary to differentiate between COP and pneumonia. Krebs von den Lungen-6 (KL-6) has been proposed as a diagnostic biomarker for differentiating interstitial pneumonia. This study was to evaluate the usefulness of serum KL-6 in the diagnosis of COP by comparing serum KL-6 in COP and pneumonia patients. Methods We retrospectively reviewed patients who measured serum KL-6 from January 2020 to July 2020. COP was defined as idiopathic, presence of typical chest CT features, and elevation of lymphocyte in bronchoalveolar lavage fluid and/or pathological findings for COP on transbronchial lung biopsy. Results Total of 47 patients were enrolled in the study, 19 for COP and 28 for pneumonia, respectively. Eleven patients were diagnosed with COP by transbronchial lung biopsy. The mean age was 71.0 in COP and 68.7 in pneumonia. Female was predominant in COP (63.2% vs. 28.6%; P = 0.019). The mean values for white blood cells (WBC) and C-reactive protein (CRP) were significantly higher in pneumonia than in COP (WBC: 12896 vs. 7721/uL; P = 0.004, CRP: 12.6 vs. 3.1 mg/dL; P < 0.000). The mean value for serum KL-6 was significantly higher in COP than in pneumonia (1047 vs. 436 U/mL; P = 0.010). Receiver operating characteristic curve for diagnosis of COP showed the area under the curve of serum KL-6 was 0.812. When the cut-off value of serum KL-6 was 450 U/mL, sensitivity was 73.7% and specificity was 67.9%, respectively. Conclusion: These Results suggest that serum KL-6 is a useful diagnostic marker for COP.
Poster Session 1 : Role of carboxy-terminus of p23 in the regulation of its physiological functions
( Sang Hyeok Woo ),( Sung Kwan An ),( Hyeon Ok Jin ),( Hyung Chahn Lee ),( Sung Keum Seo ),( Doo Hyun Yoo ),( Chang Hun Rhee ),( Seok Il Hong ),( In Chul Park ) 한국생화학분자생물학회 (구 한국생화학회) 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-
A Study on Symbolism of Graffiti
Hong, Ki-hyeon,Lee, Choon-hee,Shin, Sang-ok The Costume Culture Association Department of Clot 1998 Fashion, industry and education Vol.1 No.1
In the postmodern society, graffiti style involves various symbolism according to interpreters because of different ways of decoding signs. This study analyzes the graffiti style as symbolism of nonlinguistic communication media and examines variety, phenomenon and symbolisms of graffiti on their casual attire from the point of semiological view and refers to many graffiti works in each country. As a result. German and korean graffiti-figured costumes have common signifiance as follows. First, they induce the application of DIY technique, expand awareness of participation, and lead tired-of mass-production consumers to the role of positive sign-producer. Second, they notify participation in environmental protection. Third, they stress a leisure activity with the pleasure of making something. Fourth, they premise that even the same text can produce various signifie according to context, and be interpreted and communicated by receivers. Fifth, unlike previous graffiti which had protestation as humor and wit shown in figures and colors, it tells that the sign is changed according to time and space.
Colon Transit Time May Predict Inadequate Bowel Preparation in Patients With Chronic Constipation
( Hong Jun Park ),( Myeong Hun Chae ),( Hyun Soo Kim ),( Jae Woo Kim ),( Moon Young Kim ),( Soon Koo Baik ),( Sang Ok Kwon ),( Hee Man Kim ),( Kyong Joo Lee ) 대한장연구학회 2015 Intestinal Research Vol.13 No.4
Background/Aims: We evaluated whether colonic transit time (CTT) can predict the degree of bowel preparation in patients with chronic constipation undergoing scheduled colonoscopy in order to assist in the development of better bowel preparation strategies for these patients. Methods: We analyzed the records of 160 patients with chronic constipation from March 2007 to November 2012. We enrolled patients who had undergone a CTT test followed by colonoscopy. We defined patients with a CTT ≥30 hours as the slow transit time (STT) group, and patients with a CTT <30 hours as the normal transit time (NTT) group. Boston Bowel Preparation Scale (BBPS) scores were compared between the STT and NTT groups. Results: Of 160 patients with chronic constipation, 82 (51%) were included in the STT group and 78 (49%) were included in the NTT group. Patients with a BBPS score of <6 were more prevalent in the STT group than in the NTT group (31.7% vs. 10.3%, P=0.001). Multivariate analysis showed that slow CTT was an independent predictor of inadequate bowel preparation (odds ratio, 0.261; 95% confidence interval, 0.107-0.634; P=0.003). The best CTT cut-off value for predicting inadequate bowel preparation in patients with chronic constipation was 37 hours, as determined by receiver operator characteristic (ROC) curve analysis (area under the ROC curve: 0.676, specificity: 0.735, sensitivity: 0.643). Conclusions: Patients with chronic constipation and a CTT >30 hours were at risk for inadequate bowel preparation. CTT measured prior to colonoscopy could be useful for developing individualized strategies for bowel preparation in patients with slow CTT, as these patients are likely to have inadequate bowel preparation. (Intest Res 2015;13:339-345)
Sung-Kug Park,Meehye Kim,You Sub Sho,So Young Chung,Soojung Hu,Jong Ok Lee,Moo Ki Hong,Myung Chul Kim,Ju Seop Kang,Ok Hwa Jhee 한국식품과학회 2007 Food Science and Biotechnology Vol.16 No.6
The microbiological and chemical identification of antibiotic residues was attempted for livestock and seafood products including pork (n=34), beef (n=34), chicken (n=32), flatfish (n=37), armorclad rockfish (n=36), and sea bream (n=27). The meat (n=100) and seafood (n=100) samples were collected from 9 markets in 5 major Korean cities. Antibiotic substances were identified from the classes of tetracyclines, macrolides, penicillins, aminoglycosides, polyethers, peptides, sulfonamides, quinolones, chlorampenicols, and novobiocins using a microbiological assay, the Charm II test and high performance liquid chromatography (HPLC) with ultra violet (UV) and fluorescence detectors. The results showed that 2 tetracyclines (oxytetracycline and tetracycline) and 3 quinolones (ciprofloxacin, norfloxacin, and enrofloxacin) were detected in 4 samples of flatfish among all 100 seafood samples tested. No antibiotic residues were detected in the 100 livestock product samples tested. The amounts (min-max, mg/kg) of the residual antibiotics were as follows; tetracycline 0.78-0.85, oxytetracycline 0.49-0.74, ciprofloxacin 0.09-0.83, norfloxacin 0.01-0.21, enrofloxacin 0.12-2.98. These data indicate that the total detection rate of antibiotics in livestock and seafood products was approximately 2%.
Hong, Sun-Mi,Jeon, Sang-Ok,Seo, Jo-Eun,Chun, Kyeung-Hwa,Oh, Dong-Ho,Choi, Young Wook,Lee, Do Ik,Jeong, Seong Hoon,Kang, Jae Seon,Lee, Sangkil Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.11
Compound K (CK) was formulated as polymeric micelles (PM) using Pluronic$^{(R)}$ F-127 to enhance the oral absorption of CK, an intestinal bacterial metabolite of ginseng protopanaxadiol saponin. The physicochemical properties of Ck-loaded PM were characterized and an in vitro transport study using the Caco-2 cell system as well as an in vivo pharmacokinetic study using SD rats was carried out. The hydrodynamic mean particle size of CK-loaded PM (CK-PM) was $254{\pm}23.45nm$ after rehydration and the drug loading efficiency was ca. 99.9%. The FT-IR spectroscopy, X-ray diffraction, differential scanning calorimetry and scanning electron microscopy data supported the presence of a new solid phase in the PM. The $P_{app}$ value of in vitro Caco-2 cell permeation of CK-PM and the oral absorption of CK was enhanced about 1.2-fold and 2.6-fold compared to CK suspension, respectively, showing that the present PM formulation enabled an enhancement of oral CK absorption.