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뇌수막종에 대한 고식적 방사선 치료 : 7예 치험보고 Experience of 7 Cases
이창훈,윤상민,이승훈,김종현 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.12
Meningiomas had long been considered radioresistant and therefore the role of radiation therapy in its treatment remains controversial. Lately, however, most of the retrospective analysis of meningiomas indicates that radiation therapy does show some degree of beneficial effects not only for malignant but also for benign meningiomas with the advanced technology and increased amount of radiation therapy, the rate of growth of tumor had been successfully slowed and local recurrence rate is also reduced following subtotal resection. We have performed conventional high dose radiation therapy on 7 cases of meningiomas (four cases of meningotheliomatous meningiomas, and three cases of malignant meningiomas). Of the 7 cases, the residual mass of 6 had decreased in size and neurological improvement was also evident. However, the 7th case resulted in complicated hydrocephalus. These cases are presented and the effect of conventional radiation therapy is discussed together with the review of literatures.
재발한 희돌기 교세포종에 대한 BCNU-CDDP 연속정주 화학요법
윤상민,이창훈,이승훈,송재욱,김종현 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.3
Eight patients with recurrent oligodendroglioma were treated with 1.3-bis(2-chloroethyl) nitrosourea(BCNU) and CDDP continuous infusion chemotherapy. They were 5 with benign oligodendrogliomas and 3 with anaplastic oligodendrogliomas. All the recurrent tumors had been treated with surgery and radiotherapy. Four patients had already received chemotherapy with ACNU. Seven of them showed response to continuous infusion chemotherapy. The time from the response to progression was 15 to 67 weeks. No severe complication of the chemotherapy was found. In conclusion, BCNU-CDDP continuous infusion chemotherapy is an effective treatment modality in recurrent oligodendrogliomas.
실험적 백서 9L Gliosarcoma 뇌종양 모델 개발
김종현,이승훈,이창훈,윤상민 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.5
Experimental brain tumor model is essential for the development of new therapeutic modalities of brain tumors and evaluation of efficacy of each therapeutic variety. Authors developed experimental rat brain tumor model with 9L and C6 cell line in Fisher rat using stereotactic method. We tried to determine the tumor occurrence rate, the ideal time for secondary experiment using this brain tumor model. and the duration between the onset of neurological signs and the time of expiration. We performed autoradiography for each cell line to evaluate the reliance of the tumor model. We could make good tumor model in all the cases of experiment and expect to use it in another extension of experiment.
두개강내로 전이된 Adenoid Cystic Carcinoma 2례 : 증례보고 Report of Two Cases
송재욱,윤상민,이창훈,장지수,이승훈,조경자,강신광 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10
The authors describe two cases of unusual intracranial metastatic adenoid cystic carcinomas. A 42-year-old woman had a right pariental epidural metastatic mass. presumed hematogenous. spread from a primary tumor in the parotid gland. In second case, a 32-year-old man had a intracranial metastatic adenoid cystic carcinoma mimicking calcified psammomatous meningioma on CT scans. We present these unusual cases with a review of relevant literature and a discussion of possible pathogenesis.
척수로 전이된 후두엽 다형성 교아세포종 : 증례보고 A Case Report
윤상민,송재욱,이창훈,조경자,김종현,이승훈 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.3
The tendency of glioblastoma to metastasize to the cerebrospinal fluid(CSF) is well documented, reaching approximately 20% in autopsy series. Nevertheless, clinical symptoms from spinal seeding seem to be infrequent or are at least rarely diagnosed. The authors report a case of 41-year old female patient with a cerebral glioblastoma multiform who developed paraplegia due to a pathologically confirmed spinal matastasis.
He, Xi-Biao,Kim, Mirang,Kim, Seon-Young,Yi, Sang-Hoon,Rhee, Yong-Hee,Kim, Taeho,Lee, Eun-Hye,Park, Chang-Hwan,Dixit, Shilpy,Harrison, Fiona E,Lee, Sang-Hun AlphaMed Press 2015 Stem Cells Vol.33 No.4
<P>Intracellular Vitamin C (VC) is maintained at high levels in the developing brain by the activity of sodium-dependent VC transporter 2 (Svct2), suggesting specific VC functions in brain development. A role of VC as a cofactor for Fe(II)-2-oxoglutarate-dependent dioxygenases has recently been suggested. We show that VC supplementation in neural stem cell cultures derived from embryonic midbrains greatly enhanced differentiation toward midbrain-type dopamine (mDA) neurons, the neuronal subtype associated with Parkinson's disease. VC induced gain of 5-hydroxymethylcytosine (5hmC) and loss of H3K27m3 in DA phenotype gene promoters, which are catalyzed by Tet1 and Jmjd3, respectively. Consequently, VC enhanced DA phenotype gene transcriptions in the progenitors by Nurr1, a transcription factor critical for mDA neuron development, to be more accessible to the gene promoters. Further mechanism studies including Tet1 and Jmjd3 knockdown/inhibition experiments revealed that both the 5hmC and H3K27m3 changes, specifically in the progenitor cells, are indispensible for the VC-mediated mDA neuron differentiation. We finally show that in Svct2 knockout mouse embryos, mDA neuron formation in the developing midbrain decreased along with the 5hmC/H3k27m3 changes. These findings together indicate an epigenetic role of VC in midbrain DA neuron development. Stem Cells2015;33:1320-1332</P>