The effects of BRL-50481 on ovalbumin-induced asthmatic lung infl ammation exacerbated by co-exposure to Asian sand dust in the murine model

Hong Jo Kim,Jin Yong Song,Tae Il Park,Won Seok Choi,Jong Heon Kim,Oh Seong Kwon,Ji-Yun Lee 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.1

Asian sand dust (ASD), which mainly originatesin China and Mongolia in the spring and blows into Korea,can exacerbate respiratory and immunological diseases. This study aims to observe eff ects of co-exposure to ASD onovalbumin (OVA)-induced asthmatic lung infl ammation andof treatment with a phosphodiesterase 7 (PDE7) inhibitor ina mouse model. The challenge with OVA increased airwayhyperresponsiveness (AHR) and infl ammatory cell infi ltrationinto the lung tissue. Interleukin (IL)-13, tumor necrosisfactor-alpha, monocyte-protein-1, mucin, and antigen-specific IgE and IgG1 production increased in mouse serum. The co-exposure of ASD signifi cantly exacerbated theseeff ects in this asthma model. Notably, the administration ofa PDE7 inhibitor, BRL-50481 (BRL), signifi cantly reducedAHR, infi ltration of infl ammatory cells into the lungs, andthe levels of type 2 T helper cell-related cytokines, antigenspecific immunoglobulins, and mucin. Thus, the administrationof BRL ameliorated OVA-induced allergic asthmaticresponses exacerbated by co-exposure to ASD. This studysuggests that PDE7 inhibition can be a therapeutic strategyfor infl ammatory lung diseases and asthma via the regulation of T lymphocytes and reduction of IL-13, and, consequently,mucin production.

Induction of IL-lα mRNA Expression by 17β-Estradiol in Normal Human Keratinocytes

( Chuluundorj Delgertsetseg ),( Seok Beom Hong ),( Young Il Kim ),( Nack In Kim ) 대한피부과학회 2004 Annals of Dermatology Vol.16 No.4

광고 대행사와 제작사의 사회연결망 분석 : 광고 대행사의 소유형태와 규모가 거래관계에 미친 영향

홍석민,윤태일,이기홍 한국방송광고공사 2005 광고연구 Vol.0 No.66

이 연구는 광고시장개방이 한국 광고산업에 실질적으로 미치는 영향을 규명하기 위해서, 2002년 산업자료를 바탕으로 대행사와 방송광고 제작사 사이의 거래연결망을 분석해보았다. 특히 사회연결망 분석(Social Network Analysis; SNA)의 틀을 원용하여, 광고 대행사의 소유형태(다국적 대행사 대 국내 대행사) 및 규모(상위권 대행사 대 중위권 대행사)에 따라 연결망에 차이가 있는가를 통계적으로 검증해 보았다. 분석결과 다국적 대행사가 국내 대행사보다, 그리고 상위권 대행사가 중위권 대행사보다 거래연결망의 구조 자체가 더 밀도가 높고 다양하여 효율적인 것으로 나타났다. 또, 이들 대행사의 중앙성(centrality) 지표가 높아 제작사와의 거래연결망에서 더 중심적인 위치를 차지하는 것으로 밝혀졌다. 특히 중앙성 지표에 대한 대행사의 소유형태와 규모 사이의 상호작용 효과는 연결정도 중앙성, 사이 중앙성, 위세 중앙성 3가지 지표 모두에서 나타났다. 또 중앙성 지표가 높은 대행사일수록 방송매출액, 순위, 종업원 수, 1인당 취급액 등의 기업성과 관련 지표에서도 우수성을 나타냈다. 이러한 분석결과에 대한 이론적 실무적 함의와 국내 광고산업의 경쟁력 제고를 위한 제언사항을 논의했다. Prior studies regarding Korea’s advertising industry have almost exclusively examined practitioners’ perceptions of changes in the advertising industry as global advertising agencies launched business in Korea. This study on Korea’s advertising market, however, used a unprecedented approach by looking into the relationship between advertising agencies and advertising production companies through the framework of social network analysis. It tested if there existed significant difference by ownership(global vs. local) and size(the largest 10 agencies vs. the rest) in maintaining business networks. Results from this study indicate that the global advertising agencies show stronger network density and centrality, more diversification, and more efficiency than the local advertising agencies in terms of inter-organizational relationship. Additionally, the interaction effect existed between the ownership and the size of advertising agencies by centrality index. Finally, the higher centrality index among agencies is, the higher billing and ranking are. The end of the paper offers further theoretical and practical implications of the analyses and suggestions to improve Korean advertising agencies’ business performance.

사람 위선암에서 cathepsin L의 발현증가

홍원선,홍석일,박인철,손영숙,정훈용,양석균,김해련,민영일 울산대학교 의과대학 1996 울산의대학술지 Vol.5 No.1

cathepsin L은 lysosomal cysteine 단백분해효소로서 기저막(basement membrane)과 세포외기질(extracellular matrix)을 파괴하여 암세포의 침윤과 전이에 중요한 역할을 하는 물질로 알려져 있다. 이러한 cathepsin L에 대한 mRNA 발현도를 5개의 사람 위선암(gastric adenocarcinoma) 세포주와 5명의 위선암 환자에서 채취한 조직에서 방사능으로 표지된 cathepsin L특이 cDNA를 사용한 Northern blot법으로 측정하였다. 위암의 전이병소에서 수립한 세포주인 SNU-5, SNU-16, MKN-45와 Kato Ⅲ에서는 cathepsin L mRNA가 발현되었으나 원발병소에서 수립한 AGS 세포주에서는 mRNA의 발현이 관찰되지 않았다. 5명의 위암 환자에서는 원발병소, 전이가 확인된 임파절 및 암 근처 정상 위점막에서 각각 조직을 채취하여 cathepsin L mRNA의 발현을 측정하였다. 원발병소와 전이병소에서는 모두 cathepsin L mRNA가 발현되었으나 정상 위점막조직에서는 전예에서 mRNA 발현이 관찰되지 않았다. 한편 mRNA의 발현도는 1예에서는 전이병소가 원발병소에 비해 높았으나, 2예에서는 전이병소에서 발현도가 낮았으며, 나머지 2예에서는 원발병소와 전이병소 사이에 차이가 없어, 원발병소와 전이병소 사이에 mRNA의 발현도의 일관성 있는 경향은 관찰되지 않았다. 이상의 결과는 cathepsin L은 위암의 발생과 진행에 있어 암세포의 침윤과 전이를 촉진하는 것 이외에 또 다른 역할을 할 가능성을 시사하고 있다고 사료된다. Cathepsin L, a lysosomal cysteine protease, is known to play an important role in cancer invasion and metastasis by degrading the components of basement membrane and extracellular matrix. The mRNA expression of cathepsin L was determined by Northern blot analysis using a radiolabeled cDNA specific for cathepsin L in five human gastric adenocarcinoma cell lines and five surgical specimens of primary gastric adenocarcinomas, their metastatic lymph nodes and matched adjacent normal mucosae. The mRNA of cathepsin L was expressed in all of the four cell lines established from the metastatic sites, SNU-5, SNU-16, MKN-45 and Kato Ⅲ, while not detected in one cell line established from the primary site, AGS. The mRNA was expressed in all of the five primary and five metastatic cancer specimens tested, while it was not detected in all matched normal mucosae. The intensities of the mRNA expressions, however, did not show the consistent pattern between primary sites and metastatic lymph nodes. These results suggest that cathepsin L may have the other function in addition to facilitation of the invasion and metastasis during the development and progression of stomach cancer.

전자 도서관과 교육 분야 응용

홍기천,오일석 全北大學校 敎育大學院 2000 敎育論叢 Vol.20 No.-

The construction and usage of digital library are rapidly increasing all over the world. This paper introduces the concept of digital library and describes the present state of national library, private library, and university library in Korea. Additionally the library of Chonbuk national university is presented in detail. Finally we discuss how digital library can be used in the educational field.

급성 A형 간염에 병발한 급성신부전 2 례

홍수민;박경식;박일권;손형래;구호석;고행일 인제대학교 2011 仁濟醫學 Vol.32 No.-

Hepatitis A is a mild, self-limiting disease of the liver, critical complications of which, such as acute kidney injury, are rare. Two cases of patients with acute hepatitis A who had an acute renal failure complication are reported herein. The first case is that of a 30-year-old man who showed up at the author’s hospital complaining of fever and myalgia. His laboratory tests upon his admission showed 9,520 lU/L of aspartate transaminase, 5,600 lU/L of alanine transaminase, 31.9 mg/dL of blood urea nitrogen, and 5.5 mg/dL of creatinine, and he was positive for the Anti-HAV IgM antibody. Upon his admission, supportive treatment was started, which included fluid therapy. The laboratory tests on the next day showed 53 mg/dL of blood urea nitrogen, 9.9 mg/dL of creatinine, and lower urine output per day. Renal replacement therapy was performed only once. A renal biopsy was performed and the result was Acute Tubular Necrosis (ATN). The patient recovered from acute renal failure without sequela. In the second case, a 35-year-old man complained of fever and abdominal pain. His laboratory tests upon his admission showed 8,570 lU/L of aspartate transaminase, 4,510 lU/L of alanine transaminase, 16 mg/dL of blood urea nitrogen, and 1.19 mg/dL of creatinine, and he was positive for the Anti-HAV IgM antibody. He experienced acute renal failure and recovered after two-time renal replacement therapy. The result of the renal biopsy was Acute Tubular Necrosis and C1q nephropathy.

단구간에너지와 변곡점 평가에 의한 음성의 천이구간 특징추출

최일홍,장승관,김창석 명지대학교 대학원 1997 대학원논문집 Vol.1 No.-

This paper proposed a discriminating method by estimating the turning points and the average magnitude energy in speech signal. This method solved a problem of zero-crossing rate. Transient samples before signal does not reach steady state from the beginning point are discriminated and also features of transient data are estimated by this method. As results that carried out with speech signals, it was found that even through speech samples included in D.C level, the beginning and end point of the speech signals was exactly discriminated by this method, a length of transient period and a short time energy and frequency features were extracted from transient samples and these parameters were compared to each spoken words.

粉末法을 爲한 多重度 因子

徐日煥,秋錦洪,李珍昊,林星秀,柳保盈,朴晶蘭,金憲俊,成百石,李正秀,金文執 충남대학교 자연과학연구소 1993 忠南科學硏究誌 Vol.20 No.1

The multiplicity factor, which may be defined as the number of different planes in a form having identical interplanar spacing and identical intensity, is tabulated here for eleven Laue groups on the basis of their symmetries.

Xanthomonas sp. EPS-1의 Exopolysaccharide생산을 위한 무기염류의 영향

박석규,손봉수,이상원,서권일,김홍출 순천대학교 기초과학연구소 1995 基礎科學硏究誌 Vol.6 No.-

For the production of high viscosity exopolysaccharide from Xanthomonas sp. EPS-1 which isolated and identified from soils, optimum concentration of inorganic salts were investigated : 0.2% KH_2PO_4, 0.05% MgSO_4·7H_2O, 0.3% NaCl, 0.005% CaCO_3, 0.007% FeSO_4·7H_2O, 0.005% MnSO_4·7H_2O. When EPS-1 strain was cultivated at 30℃ for 72 hours in a jar fermentor (impeller speed 300 rpm, aeration rate 3 vvm, 2 liter), polymer content, product rate and yield(Y_p/s) was 18.4g/ℓ, 0.26g/ℓ/h and 37%, respectively.

디스크 시스템의 설계를 위한 모의 실험에 대한 연구

장윤석,김홍일,김국보 대진대학교 1994 大眞論叢 Vol.2 No.-

I/O subsystems, especially, disk systems are the most important aspect at computer system performance for recent high-performance computer systems. But development of new d s k system consumes very high costs, it performed by simulation, in general. This paper researches accurate disk modeling techniques for basis of accurate simulation, and implements the disk model, and proves the modelled disk can be executed with small deviation, compares with real disk system, by trace-driven simulation The simulation program can widely be used for basic tool to develope new disk systems.