Imazethapyr 유도체의 제초활성에 미치는 3-(N-methyl-N-(X)-치환-phenylaminooxoacetyl) group의 영향

성낙도,김현재,장해성,김대황 충남대학교 생물공학연구소 1993 생물공학연구지 Vol.3 No.-

새로운 25종의 Imazethapyr 유도체, (2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3-(N-methyl-N-(X)치환 -phenylaminooxoacetyl)-5-methylpyridine)들을 합성하여 치환기(X) 변화에 따른 발아 전 후, 피(Echinochla crus-galli.)의 제초활성에 미치는 3-(N-methyl-N-(X)치환 -phenylaminoozoacetyl) group의 영향을 검토한 바, 발아 전보다 발아 후의 제초활성에 더 큰 영향을 미침을 알 수 있었다. 발아 후의 제초활성은 X-치환기의 전자밀게 효과와 입체상수(E_s)에 의존적이었으며 가장 큰 제초활성을 나타내는 화합물로는 bulky(E_s<O)하고 전자밀게 (б<O)가 치환된 화합물, 15(4-t-butyl group)와 20(3,5-dimethyl group)이었다. 그리고 높은 제초활성을 나타낼 것으로 예상되는 화합물의 조건들이 검토되었다. (1993년 9월 18일 접수, 1993년 9월 22일 수리). New twenty five Imazethapyr derivatives, [2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3-(N-methyl-N-X(sub.)-phenylaminooxoacetyl)-5-methylpyridine] were synthesized. and The quantitative structure activity relationships (QSARs) between their post-emergence herbicidal activity(pI_50) values in vivo against Barnyard grass (Echinochloa crus-galli) and physicochemical parameters of substituents(X) of 3-(N-methyl-N-X(sub.)-phenylaminoo-xoacetyl) group have been studied. From the basis on the findings, in case of post-emergence, the activities were dependent on the steric constant(E_s<θ)and electron donating (o<O) effect by subsitituents(X) of 3-(N-methyl-N-X(sub.)phenylaminooxacetyl) group. Therefore, The most effective compound, 15 (4-t-butyl group) and 20 (3,5-dimethyl group) were examined in this study. And the conditions on the compounds predicted to show higher herbicidal activity were also discussed.

담도폐색 흰쥐에서 Phenobarbital과 Choloc Acid 투여가 Heptic Microsomal Cytochrome P-450과 2-AAF의 Hydroxylation에 미치는 영향

김복희,홍영숙,성낙응 梨花女子大學校 醫科大學 醫科學硏究所 1981 EMJ (Ewha medical journal) Vol.4 No.3

In cholestatic rats, effects of phenobarbital or cholic acid on hepatic microsomal cytochrome p-450 and b_5 were investigated. The total contents of both cytochrome p-450 and cytochrome b_5 were decreased after bile duct ligation and the administration of estradiol. When cholic acid or phenobarbital was adminstrated in cholestatic rats, the decrease of cytochrome p-450 was prevented. The effects of cholic acid or phenobarbital on both ring-hydroxylation and N-hydroxylation of AAF in cholestatic rat hepatic microsomal fraction were studied. N-hydroxylation of AAF in bile duct ligated rat liver microsomes was reduced by 34%, but ring-hydroxylation was increased by 51%. In estradiol administrated rat, both ring-hydroxylation and N-hydroxylation of AAD was increased by 20 to 25%. In cholic acid administration, both ring-hydroxylation and N-hydroxylation was increased by about 10%. N-hydroxylation of AAF in phenobarbital treated rats was reduced more than ring-hydroxylation was reduced compared to the bile duct ligated group. Estradiol treated group which administrated with cholic acid or phenobarbital exhibited inhibited effects of N-hydroxylation.

Comparison of output power of InGaN laser diodes for different Al compositions in the AlGaN n-cladding layer

Ryu, H. Y.,Ha, K. H.,Son, J. K.,Paek, H. S.,Sung, Y. J.,Kim, K. S.,Kim, H. K.,Park, Y.,Lee, S. N.,Nam, O. H. American Institute of Physics 2009 JOURNAL OF APPLIED PHYSICS - Vol.105 No.10

Imazapyr 유도체의 제초활성에 미치는 3 - ( N - methyl - N ( X ) - 치환 - Phenylaminooxoacetyl ) Group 의 영향

성낙도(N . D . Sung),유택승(T . S . Ryu),장해성(H . S . Chang),김대황(D . W . Kim) 한국응용생명화학회 1994 Applied Biological Chemistry (Appl Biol Chem) Vol.37 No.6

New seventeen imazapyr derivatives, 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3-(N-methyl-N-X(sub.)-phenylaminooxoacetyl)pyridine, 6 were synthesized and their pre-emergence herbicidal activity(pI_(50) in vivo against Corn (Zea mays L.) and Pigweed (Amaranthus viridis L.) were studied by the pot test under paddly conditions. (quantitative structure activity relationships (QSARs) were analyzed using the physicochemical parameters of substituent(X) on the phenyl ring of 3-(N-methyl-N-X(sub.)-phenylaminooxoacetyl) group and regression analysis. The herbicidal activities were related to the steric effect of X-substituent. The effect was rationalized by paraholic function of MR and L₁, where the optimal values were MR=5.56 (Zea mays L.) and L₁=3.34 Å (Amaranthus viridis L.). Among them, 2,5-difluoro substituted compound, 6i showed good herbicidal activity against Pigweed with excellent tolerance to Corn.

Imazethapyr 유도체의 제초활성에 미치는 3 - ( N - methyl - N - ( X ) - 치환 - phenylaminooxoacetyl ) group 의 영향

성낙도(N . D . Sung),김현재(H . J . Kim),장해성(H . S . Chang),김대황(D . W . Kim) 한국응용생명화학회 1993 Applied Biological Chemistry (Appl Biol Chem) Vol.36 No.5

New twenty five Imazethapyr derivatives, [2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3-(N-methyl-N-X(sub.)-phenylaminooxoacetyl)-5-methylpyridine] were synthesized. and The quantitative structure activity relationships (QSARs) between their post-emergence herbicidal activity(pI_(50)) values in vivo against Barnyard grass (Echinochloa crus-galli) and physicochemical parameters of substituents(X) of 3-(N-methyl-N-X(sub.)-phenylaminooxoacetyl) group have been studied. From the basis on the findings, in case of post-emergence, the activities were dependent on the steric constant(E_s$lt;0) and electron donating (σ$lt;0) effect by subsitituents(X) of 3-(N-methyl-N-X(sub.)phenylaminooxoacetyl) group. Therefore, The most effective compound, 15 (4-t-butyl group) and 20 (3,5-dimethyl group) were examined in this study. And the conditions on the compounds predicted to show higher herbicidal activity were also discussed.

Lactic acid bacteria directly degrade N-nitrosodimethylamine and increase the nitrite-scavenging ability in kimchi

Kim, S.H.,Kang, K.H.,Kim, S.H.,Lee, S.,Lee, S.H.,Ha, E.S.,Sung, N.J.,Kim, J.G.,Chung, M.J. Butterworths ; Taylor Francis ; Elsevier Science 2017 FOOD CONTROL Vol.71 No.-

<P>To investigate whether lactic acid bacteria (LAB) play a role in reducing the concentrations of N-nitrosodimethylamine (NDMA) and its precursors during kimchi production, experimental kimchi prepared with added Lactobacillus sakei, Lactobacillus curvatus, and Lactobacillus brevis was periodically monitored for 20 days to analyze the concentrations of NDMA, nitrite, dimethylamine (DMA), nitrate, and biogenic amines. LAB species in MRS broth with and without NDMA or NaNO2 were grown and NDMA and nitrite concentrations studied. The amounts of NDMA, nitrite, DMA, nitrate, and biogenic amines remaining in the LAB-fortified kimchi decreased significantly relative to that of the control kimchi. The effects of L. sakei and L curvatus on the reduction of NDMA concentration in kimchi were higher than that of L. brevis. These LAB species might be indirectly reducing the amounts of NDMA in LAB-fortified kimchi by inhibiting the formation of NDMA precursors originating from kimchi. Interestingly, LAB were found to directly degrade NDMA during culture in MRS broth containing NDMA. (C) 2016 Elsevier Ltd. All rights reserved.</P>

Breath hydrogen and methane are associated with intestinal symptoms in patients with chronic pancreatitis

Kim, D.B.,Paik, C.N.,Sung, H.J.,Chung, W.C.,Lee, K.M.,Yang, J.M.,Choi, M.G. Karger 2015 PANCREATOLOGY Vol.15 No.5

Backgrounds: The bacterial overgrowth might be associated with chronic pancreatitis. This study was to evaluate the prevalence and characteristics of small intestinal bacterial overgrowth (SIBO) in patients with chronic pancreatitis. Methods: 36 patients with chronic pancreatitis and 49 healthy controls undergoing the hydrogen (H<SUB>2</SUB>)-methane (CH<SUB>4</SUB>) lactulose breath test (LBT) were reviewed. The LBT positivity (+) indicating the presence of SIBO, gas types, bowel symptom questionnaire, laboratory and radiologic results were surveyed. The LBT+ was (1) an increase in the breath H<SUB>2</SUB> (≥20 ppm) or CH<SUB>4</SUB> (≥10 ppm) over the baseline or (2) a baseline H<SUB>2</SUB> (≥20 ppm) or CH<SUB>4</SUB> (≥10 ppm) within 90 min after lactulose load. Results: LBT+ was significantly higher in the patients (17/36) than in controls (1¾9) (47.2% vs. 26.5%, P < 0.05). During LBT, the H<SUB>2</SUB> levels between 0 and 105 min were significantly higher in patients than in controls. Among LBT+ patients, 11 (64.7%), 1 (5.9%), 5 (29.4%) were in the LBT (H<SUB>2</SUB>)+, (CH<SUB>4</SUB>)+, (mixed)+ groups, respectively. The LBT+ group had significantly higher scores of flatus than those of the LBT- group. Considering the subtypes of LBT, the LBT (mixed)+ group had higher symptom scores of significance or tendency in hard stool, strain, urgency, and flatus than LBT- group The laboratory and radiologic features were not significantly different between LBT+ and LBT- groups. Conclusions: SIBO is common in patients in chronic pancreatitis. Especially, excretions of mixed H<SUB>2</SUB> and CH<SUB>4</SUB> appear to be related with deterioration of intestinal symptoms.

일개 면지역주민의 년도별 보건지소 이용실태에 관한 고찰 : 경기도 남양주군 수동면; 1976-1980 Su-Dong Myun, Nam Yang-Ju Gun, Kyung-Gi Do

민동원,성낙순,안백화,하은희 이화여자대학교 의과대학 1985 梨花醫學誌 Vol.- No.17

In order to know about the trend of utilization of Health Subcenter in Su-Dong community, a study was carried out through analyzing the reports on the status of out-patients in Su-Dong Health Subcenter during 5 years from 1976 to 1980, and following results were obtained. 1) Population of Su-Dong Myun was changed from 5,424 in 1975 to 5,211 in 1979. 2) The annual utilization rate of Health Subcenter of Su-Dong Myun showed decreasing tendency from 803.3 in 1976 to 700.6 in 1980 per 1,000 population. 3) In terms of annual utilization rate by age group, the highest group is 0-4 age group and the lowest group is 15-24 age group every year. 4) The average visiting time per case to Health subcenter showed 1.75 times in 1978, 1.69 times in 1979 and 1.60 times in 1980. 5) In terms of utilization rate of Su-Dong Health Subcenter by Ries, the highest rate was shown in Ribsouk 2 Rie and the lowest in Gidoon. 6) The 5 major diseases cared in Health Subcenter were as follows : Diseases of the Respiratory System, Diseases of the Digestive System, Diseases of the Skin and Subcutaneous Tissue, Accident, Poisoning and Violence, and Diseases of the Nervous System and Sense Organs in the year of 1976∼1980. 7) Annual average medical fee per first visiting was increased such as 405(￦) in 1976, 653(￦) in 1977, 1,090(￦) in 1978, 1,650(￦) in 1979 and 1,970(￦) in 1980. And annual average medical fee per case was also increased such as 923(￦) in 1977, 1,450(￦) in 1978, 2,540(￦) in 1979 and 2,990(￦) in 1980.

RFID를 이용한 실시간 수질정보 관리 운영 시스템 개발

정양재,정병길,성낙창,강헌찬,강대성 東亞大學校 環境問題硏究所 2005 硏究報告 Vol.27 No.1

In this paper, an inspector measures the quality of water in contaminated place or anticipated place of pollution, or extracts polluted water and inspects the quality of water at an inspecting office by existing method of the quality of water analysis. These existing methods of the quality of water analysis are difficult to measure the quality of water with real time and they have some limits to measure the quality of water precisely. In this paper, to solve this problem, we propose a new method of the quality of water pollution measurement using a measuring instrument and RFID(Radio Frequency Identification). The whole system is processing automatically and through the real time analysis or monitoring, a supervisor processes analysis, measurement and supervision effectively.

몇가지 사료 첨가제가 계란의 특정성분에 미치는 영향

성기승,윤칠석,이남형,한찬규,이복희 한국축산학회 2000 한국축산학회지 Vol.42 No.1

The experiment was conducted to determine the effects of various commercial feed additives on specific components in shell egg and to develop a new type of brand egg. Forty-four week old ISA Brown layers were randomly assigned to 8 treatments. Hens of each treatment were 300 and treatment was replicated 3 times. Experimental period was 10 weeks. The 8 treatments were as follows: astarich^ⓡ 2%(B), astarich^ⓡ 5%(C), chitin+chitosan 2%(D), omega-3 powder 2%(E), pyrogreen 1%(F), greenpia 0.2%(G), hydrogenated soy oil 3%(H) and commercial layer feed(A). Eggs were collected at day 0, 7, 14, 40 and 70 for chemical analyses. Chemical analyses were done for vitamins A and E, cholesterol and fatty acid profile of egg yolks. During the experimental period, the contents of vitamin A increased overall. Astarich^ⓡ 5%(C) group showed the highest amounts of vitamin A (11.14±3.93 ㎍/g yolk) whereas commercial layer feed goup(A) showed the lowest amounts of vitamin A(8.65±1.97 ㎍/g yolk). Vitamin E contents were significantly different among treatments at day 7, 40, and 70 (p$lt;0.05). Mean value of vitamin E (99.66±8.30 ㎍/g yolk) was the highest in omega-3(E) group and the lowest in pyrogreen (F) group (53.49±11.36 ㎍/g yolk). Yolk cholesterol contents tended to increase, although the fluctuation existed somewhat depending on the day of measurement. The highest value of yolk cholesterol(11.71±0.50㎎/g yolk) was observed in astarich^ⓡ 2%(B) group and the Lowest value(9.45±2.32㎎/g yolk) in pyrogreen (F) group. The mean compositions of yolk fatty acids during the experimental period were 37.3∼39.6% for saturated fatty acids(SFA), 39.3∼41.3% for monounsaturated fatty acids(MUFA), 16.2∼18.9% for omega-6 fatty acids and 2.20∼5.36% for omega-3 fatty acids. In general, the concentrations of SFA and omega-6 fatty acids decreased, while those of MUFA tended to increase. On the other hand, eicosapentaenoic acid(C_(20:5) ω6, EPA) and docosapentaenoic acid(C_(22:5) ω3, DPA) were detected only in astarich^ⓡ 5%(B) and omega-3(E) groups where the docosahexaenoic acid(C_(22:6) ω3, DHA) concentration was over twice higher than those of other group. The study proved both astarich^ⓡ and omega-3 powder were suitable to produce brand eggs specially high in certain components.