Alcohol extract of Geum Chung Cho alleviates alcohol-induced short-term memory impairment in gerbils

Han-Sam Cho,Tae-Woon Kim,Sang-Seo Park,Mal-Soon Shin,Jae-Min Lee,Eun-Sang Ji,Chang-Ju Kim 한국운동재활학회 2015 한국운동재활학회 학술대회 Vol.2015 No.10

Chronic ethanol consumption leads to memory impairment and also induces brain damage. The hippocampus has been particularly regarded as a possible target organ of alcoholic intoxication, since this structure plays a prominent function in memory processes. Cordyceps has been used as a traditional medicine in Asian countries for a long time. Different types of Cordyceps extract were reported to have various pharmacological activities including anti-tumor, anti-inflammatory, anti-viral, and immune modulatory effects. Guem Chung Cho is an artificial cultivated Cordyceps, and was supplied from GCordy (Seoul, Korea). Ethanol extract of Cordycep (50 g) was made by rotary evaporate, and resulting powder 8.29 g was obtained (yield 17%). In the present study, we investigated the effects of ethanol extract of Geum Chung Cho on short-term memory, cell proliferation and apoptosis in the hippocampus of ethanol-treated gerbils. The gerbils were divided into 5 groups (n = 10 in each group): Control group, alcohol-treated group, alcohol-treated and 0.001 mg/kg Geum Chung Cho-applied group, alcohol-treated and 0.01 mg/kg Geum Chung Cho-applied group, and alcohol-treated and 0.1 mg/kg Geum Chung Cho-applied group. Gerbils in the alcohol-treated groups were orally administered ethanol (1 g/kg) once a day for 2 weeks. Gerbils in the Guem Chung Cho-applied groups were orally administered Guem Chung Cho extract at each dosage 1 hour before ethanol consumption. Our results revealed that consumption of alcohol for 2 weeks deteriorated short-term memory, induced apoptosis, and inhibited cell proliferation, and reduced expressions of brain-derived neurotrophic (BDNF) and tyrosine kinase B (TrkB). However, Guem Chung Cho treatment alleviated alcohol-induced short-term memory impairment through enhancing cell proliferation and BDNF expression with inhibiting apoptosis in the hippocampus. Guem Chung Cho showed maximum effects at 0.1 mg/kg. Based on these results, alcohol extract of Guem Chung Cho may provide therapeutic value for the treatment of chronic alcohol-inducted brain injury. This study was supported by GCordy company.

The Influence of AH-26 and Zinc Oxide-Eugenol Root Canal Sealer on the Shear Bond Strength of Composite Resin to Dentin

Cho, Ju-Yeon,Jin, Myoung-Uk,Kim, Young-Kyung,Kim, Sung Kyo 大韓齒科保存學會 2006 Restorative Dentistry & Endodontics Vol.31 No.3

AH-26 근관실러가 상아질에 대한 복합레진의 전단결합강도에 미치는 영향을 평가하기 위하여 144개의 발거된 대구치를 실린더형의 몰드에 매식한 다음 치관부의 상아질 표면을 노출시킨 후 편평하게 연마하고 AH-26을 도포한 군, ZOE paste를 도포한 군 및 실러를 도포하지 않은 대조군으로 나누어 One-step 상아질 접착제를 처리한 후에 Charisma (Heraeus Kulzer, Germany) 복합레진을 적용하고 광중합시켰다. 시편을 분리하여 37℃ 항온조에 24시간 보관후 Instron test machine (Model 4202, Instron Corp., USA)을 이용하여 시편의 전단 결합 강도를 측정하고 one-way ANOVA 및 Tukey's studentized rank test로 통계 분석하였다. AH-26 근관실러로 처리한 군과 대조군은 ZOE 근관실러 처리군에 비해 유의하게 놓은 접착강도를 나타내었다 (p<0.05). AH-26 근관실러 처리군과 아무 처리하지 않은 대조군 사이에는 결합강도에 있어 유의한 차이를 나타내지 않았다 (p>0.05). 본 연구의 조건에서는 ZOE 근관실러는 상아질에 대한 복합레진의 전단결합강도를 저하시키는 반면 AH-26 근관실러는 유의한 영향을 미치지는 않는 것으로 보인다. 따라서 임상에서 근관실러로 AH-26을 사용한 근관충전 후에는 즉시 복합레진 코어를 해 주어도 결합력에 저해가 없을 것으로 여겨진다. The purpose of this study was to evaluate the influence of the AH-26 root canal sealer on the shear bond strength of composite resin to dentin. One hundred and forty four (144) extracted, sound human molars were used. After embedding in a cylindrical mold, the occlusal part of the anatomical crown was cut away and trimmed in order to create a flat dentin surface. The teeth were randomly divided into three groups; the AH-26 sealer was applied to the AH-26 group, and zinc-oxide eugenol (ZOE) paste was applied to the ZOE group. The dentin surface of the control group did not receive any sealer. A mount jig was placed against the surface of the teeth and the One-step dentin bonding agent was applied after acid etching. Charisma composite resin was packed into the mold and light cured. After polymerization, the alignment tube and mold were removed and the specimens were placed in distilled water at 37℃ for twenty four hours. The shear bond strength was measured by an Instron testing machine. The data for each group were subjected to one-way ANOVA and Tukey's studentized rank test so as to make comparisons between the groups. The AH-26 group and the control group showed significantly higher shear bond strength than the ZOE group (p<0.05). There were no significant differences between the AH-26 group and the control one (p>0.05). Under the conditions of this study, the AH-26 root canal sealer did not seem to affect the shear bond strength of the composite resin to dentin while the ZOE sealer did. Therefore, there may be no decrease in bond strength when the composite resin core is built up immediately after a canal filling with AH-26 as a root canal sealer.

흰쥐의 신경병증성 통증에 대한경피신경전기자극과 미세전류신경근자극

이윤주,이충휘,조상현,임중우,남택상 大韓再活醫學會 1999 Annals of Rehabilitation Medicine Vol.23 No.3

부하분산 및 결함허용을 제공하는 CORBA 기반 원격 회의 시스템 설계

성재철,임주혁,장우혁,조찬윤,최항묵 인제대학교 1999 仁濟論叢 Vol.15 No.1

인터넷 및 통신 기술의 발달에 따라 원격 회의 시스템이나 원격 교육, 가상 대학과 같은 응용에 대한 연구가 활발히 진행되고 있다. 이와 판은 시스템에 기존의 중앙 집중 방식을 사용할 경우에는 서버측의 부하가 모두 집중되어 전체 시스템에 영향을 미치게 될 수 있으므로 분산 시스템을 이용한 연구가 활발히 진행되고 있다. 본 논문에서는 이미지나 텍스트-파일과 같은 자료를 필요로 하는 원격 회의 시스템을 설계하고 Factory 객체와 관계형 통합 데이터 베이스를 이용하여 동적 부하 분산과 동적 결함 허용을 제공하는 시스템을 제안한다. As the technigues of the Interned and Communication are developed, the study about its applications such as Remote Conference system, Remote Education and Cyber University are lively progressing. When the centralized method is applied to those kinds of system mentioned above, the load is mostly occurred in the server side anaitcauas bad effect to the whole system. So the Study about an application such as Remote Conference system, Remote Education and Cyber University is considering using the distributed system. In this paper I would like design a Remote Conference System is soogetled, which needs sub data like images, text files and givers dynamic load balance and dynamic fault tolerance using Factory object and Relational Integrated Data Base.

電子商去來와 著作權 : 라이센스계약과 知的財産法의 충돌 A Conflict of License Contract and the Intellectual Property Law

조성종,전일주 진주산업대학교 2001 論文集 Vol.40 No.-

The relationship between contract and intellectual property about the future of copyright in the information industries on the electronic commerce(for example a software transaction on the Internet), it often appears as if some believe that we are facing an impending big bang as the fields of copyright and contract(for example a "shrink-wrap" contract) head toward some unclearly defined, but inevitably cataclysmic conflict. The fields of contract and intellectual property law have always co-existed, not only peacefully, but in an aggressive interaction between ordinarily consistent and mutually supportive fields. Modern efforts to tailor contract themes to fit the digital information era and the commerce it yields follow that great tradition. This study aims at understanding the scope of protection for intellectual property and effectiveness of unilateral form license contract. The Contents are as follow : Ⅰ. Introduction Ⅱ. Scope of protection for intellectual property Ⅲ. Effectiveness of unilateral form license contract Ⅳ. Conclusion

莞島近海의 海洋環境에 관한 硏究

曺炷煥,金成根 조선대학교 기초과학연구소 1994 自然科學硏究 Vol.17 No.1

The results from investigation for the physical, chemical and biological marine environments during the period from February 1989 to November 1990 in the Wando coastal areas are as follows: 1. The water temperature appeared high in proportion to a amount of diural sun rays and air temperature. 2. The salinity appeared differently every season by a amount of precipitation. 3. The distribution of pH was settled, and the degree of acidity apperared relatively high in the area where the river waters flows. 4. The dissolved oxygen was low in summer season, but high in winter. 5. The distribution of the chemical oxygen demand was distributed irregularly every season. 6. The suspended materials appeared remarkably high on St.1 in 1990. 7. The concentration of the phosphate-phosphorous is higher in river waters than in sea waters, and the phosphate-phosphorous in sea waters was mostly flowed from lands. 8. The concentration of the dissolved inorganic nitrogen appeared high in autumn when nitrite-nitrogen and nitrate-nitrogen is more concentrated. 9. The relative relationship between phosphate-phosphorous and dissolved inorganic nitrogen appeared higher comparatively in 1990 than in 1989. After all. our investigation suggests that the physical, chemical character brings about an abnormal variation of the marine ecosystem, and obstructs the birth and breeding of the submarine livings. Therefore, we must draw up divers shemes for the preservation of the quality of coast water, and concentrate our efforts on doing away with factors of all marine pollution which spread rapidly in proportion to the industrial development.

한국 서해 경기만 조간대 퇴적층의 퇴적물 특성과 층서

조주환,김영성,임동일 조선대학교 사범대학 부설 교과교육연구소 2001 敎科敎育硏究 Vol.4 No.1

경기만 반월 조간대 퇴적분지의 퇴적 층서를 밝히기 위해 2지점에서 평균 20m에 달하는 심부시추를 실시하였다. 시추된 퇴적물은 퇴적환경과 경계면의 특성에 의해 크게 2개의 퇴적단위 UnitⅠ과 UnitⅡ로 구분된다. UnitⅠ은 5-10m의 두꺼운 니질 퇴적물로 구성되며, 현세 해침기간동안 점이적인 해수면 상승과 힘께 형성된 현세 니질 조간대 퇴적층으로 해석된다. 기반암을 부정합적으로 피복하고 있는 퇴적단위 UnitⅡ는 두께가 최대 10m에 달하며, 조립의 자갈과 모래로 구성된다. 조립의 사질 퇴적물은 동해의 사구에 비하여 원마도가 낮고, 서해의 대륙붕 퇴적물보다는 높은 원마도를 나타낸다. 이러한 결과들은 UnitⅡ 퇴적물이 다소 강한 유수 작용에 의한 하천 퇴적물임을 제시한다. 결론적으로 생물 파편의 부재, 역사질의 조립한 퇴적물 조직, 쇄설성 입자의 형태 특성 그리고 층서 위치 등을 고려할 때 퇴적단위 UnitⅡ는 현세 해침이전 최대빙하기(LGM)동안 퇴적된 육성의 하천 퇴적물로 해석된다. To elucidate the stratigraphy of Banweol tital-flat deposits, Kyunggi Bay, western coast of Korea, two boreholes, up to 20 m in thickness, were taken using a well-unilized deep-drilling equipment. On the basis of depositional enviornment and erosional boundary, these deepdrilled borehole sediments can be divided into two sedimentary units(UnitⅠ and UnitⅡ). UnitⅠ reaches up to 10 m in thickness and consists mainly of mud and silt sediments with mean grain size of 7-9 phi. This unit is interpreted as a typical intertidal-flat deposition accumulated during mid-to-late Holocence sea-level rise. Beneath the Holocence tidal-flat mud(UnitⅠ) are very coarse-grained sandy sediments (UnitⅡ) woth approximately 10 m thick. Roundness in UnitⅡ sediments is lower than those of relict shelf sediments. Considering the texture, grain shape, stratigraphic position, and absence of biogenic materials, UnitⅡ might be accumulated under the active hydrodynamic condition of the fluvial enviornment during sea-level lowstand, possibly last glacial maximum(LGM).

다중 제어루프에 의한 자기부상용 DC-DC 전원장치에 관한 연구

조주현,조정민,전기영,이상집,이승환,오봉환,이훈구,한경희 明知大學校 産業技術硏究所 2004 産業技術硏究所論文集 Vol.23 No.-

The author present a modified multi-loop algorithm including feedforward for controlling a 55kW step down chopper in the power supply of Maglev. The control law for the duty cycle consists of three terms. The first is the feedforward term which compensates for variations in the input voltage. The second term consists of the difference between the slowly moving inductor current and output current. The third term consists of proportional and integral terms involving the perturbation in the output voltage. This perturvation is derived by subtracting the desired output voltage from the actual output voltage. The proportional and integral action stabilizes the system and minimizes output voltage error. In order to verify the validity of the proposed multi-loop controller, simulation study was tried using Matlab simulink.

저작권보호에 관한 연구 : 인터넷상의 저작권을 중심으로

조성종,전일주 진주산업대학교 2002 論文集 Vol.41 No.-

By now, most everyone is familiar with the Internet and the World Wide Web and has at least sent a few e­mails or reviewed a number of web site. The Internet makes it extraordinarily easy to copy data. Copying or distributing of materials on the Internet, without the owner's consent, could result in copyright infringement. This study aims at understanding the protection of copyright, desiring to remove the distortions and impediments in the Internet, and taking into account the needs to promote effective and adequate protection of copyright.

노인에서 넘어짐의 원인과 예방

조상현,이현주 연세대학교 보건과학연구소 2002 보건과학논집 Vol.12 No.-