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Sung Hyuk Heo,이은혜,박현희,Bum Joon Kim,Hyo Chul Youn,Young Seo Kim,Hyun Young Kim,Seong-Ho Koh,장대일 대한뇌졸중학회 2018 Journal of stroke Vol.20 No.1
Background and Purpose Carotid plaques are a strong risk factor for ischemic stroke, and plaquerupture poses an even higher risk. Although many studies have investigated the pathogenicmechanisms of carotid plaque formation, few have studied the differences in molecular mechanisms underlying the rupture and non-rupture of carotid plaques. In addition, since early diagnosis and treatment of carotid plaque rupture are critical for the prevention of ischemic stroke, many studies have sought to identify the important target molecules involved in the rupture. However, a target molecule critical in symptomatic ruptured plaques is yet to be identified. Methods A total of 79 carotid plaques were consecutively collected, and microscopically divided into ruptured and non-ruptured groups. Quantitative polymerase chain reaction array, proteomics, and immunohistochemistry were performed to compare the differences in molecular mechanisms between ruptured and non-ruptured plaques. Enzyme-linked immunosorbent assay was used to measure the differences in ATP-binding cassette subfamily A member 1 (ABCA1) levels in the serum. Results The expression of several mRNAs and proteins, including ABCA1, was higher in ruptured plaques than non-ruptured plaques. In contrast, the expression of other proteins, including β-actin, was lower in ruptured plaques than non-ruptured plaques. The increased expression of ABCA1 was consistent across several experiments, ABCA1 was positive only in the serum of patients with symptomatic ruptured plaques. Conclusions This study introduces a plausible molecular mechanism underlying carotid plaquerupture, suggesting that ABCA1 plays a role in symptomatic rupture. Further study of ABCA1 is needed to confirm this hypothesis.
Transient Global Amnesia with Transient Ischemic Attack in the Habenular Nucleus
Heo, Sung Hyuk,Park, Key Chung,Yoon, Sung Sang,Ahn, Tea Beom,Chang, Dae Il,Chung, Kyung Cheon 경희대학교 2006 慶熙醫學 Vol.22 No.1
일과성 전기억상실증은 최근 확산강조 자기공명영상에서 관찰되는 해마의 허혈성 변화로 가장 많이 보고되어 있으나 그 기전은 아직까지 명확히 밝혀져 있지 않다. 우리는 기억과 학습의 중요한 기능을 하는 것으로 알려진 고삐핵의 일과성허혈발작에 의한 일과성 전기억상실증을 경험하여 보고하는 바이다. 환자는 증상발현 7시간과 96시간 이후에 연속적으로 확산강조 자기공명영상을 시행하였고, 처음 영상에서 나타난 고삐핵의 매우 작은 고신호강도 병변이 이후 영상에서는 관찰되지 않았다. The TGA can be produced by the small and discrete thalamic structure like habenular nucleus that is thought to be related with the cholinergic network for learning and memory in the central nervous system.
Hyuk Sung Yoon,In-Lee Choi,Jae-Yun Heo,Ju Young Kim,Su Jeong Han,Ho-Min Kang 한국원예학회 2018 원예과학기술지 Vol.36 No.5
The purpose of this study was to determine how asparagus spear qualities are affected by hot water immersion (HWT) and modified atmosphere packaging (MAP) pre-treatments. Asparagus spears were treated either with different durations of HWT or packed with 10,000 cc/m²·day·atm oxygen transmission rate (OTR) film as the MAP treatment, and then stored at 4°C until the final storage day. Respiration and ethylene production rates in asparagus increased after HWT, with 8 and 16 min treatments having the most effect on these parameters. Fresh weight loss was less than 0.3% with all treatments. Gas composition (i.e., C₂H₄, CO₂, and O₂) within the packaging was not significant among all treatments during storage. The MAP and HWT treatments made no difference not only in fresh weight but also in gas composition. Microbial growth (i.e., total aerobic bacteria, yeast, mold, and E. coli) was lower with the 2 and 4 min treatments than with the other treatments. Electrolyte leakage was less in the control, 2 min, and 4 min treatments compared to the 8 and 16 min treatments. The hue angle and total chlorophyll values, which are associated with yellowing, remained constant at the 2 and 4 min treatments compared to the other treatments, which did not have maintained values. Asparagine content accumulated in the control, 2 and 4 min treatments, whereas the 8 and 16 min treatments showed a decrease in asparagine content. Stem firmness was similar to pre-storage measurements with the 4 min treatment. Stem length for all of the treatments was slightly increased before storage regardless of HWT duration. Asparagus off-odor and visual qualities were the best with 4 min treatment compared to the other treatments. Consequently, HWT for 2-4 min and MAP Pre-treatments were effective in maintaining the measured qualities among the treatment and control groups. In contrast, HWT for more than 8 min offset any beneficial heat-treatment effects for long-term storage; as indicated by tissue softening at the stem tip, which resulted in secondary damages that included microorganism infection and deterioration of visual quality in the vegetables.
A quadrupolar two-photon fluorescent probe for <i>in vivo</i> imaging of amyloid-β plaques
Heo, Cheol Ho,Sarkar, Avik Ranjan,Baik, Sung Hoon,Jung, Tae Sung,Kim, Jeong Jin,Kang, Hyuk,Mook-Jung, Inhee,Kim, Hwan Myung Royal Society of Chemistry 2016 Chemical Science Vol.7 No.7
<▼1><P>A quadrupolar two-photon fluorescent probe for <I>in vivo</I> imaging of amyloid-β plaques is reported.</P></▼1><▼2><P>The formation of beta amyloid (Aβ) plaques in specific brain regions is one of the early pathological hallmarks of Alzheimer's disease (AD). To enable the early detection of AD and related applications, a method for real-time, clear 3D visualization of Aβ plaques <I>in vivo</I> is highly desirable. Two-photon microscopy (TPM) which utilizes two near-infrared photons is an attractive tool for such applications. However, this technique needs a sensitive and photostable two-photon (TP) probe possessing bright TP exited fluorescence to impart high signal-to-noise (S/N) visualization of Aβ plaques. Herein, we report a quadrupolar TP fluorescent probe (<B>QAD1</B>) having large TP action cross section (<I>Φδ</I><SUB>max</SUB> = 420 GM) and its application for <I>in vivo</I> TPM imaging of Aβ plaques. This probe, designed with a centrosymmetric D–A–D motif with a cyclic conjugating bridge and solubilizing unit, displays bright TP excited fluorescence, appreciable water solubility, robust photostability, and high sensitivity and selectivity for Aβ plaques. Using the real-time TPM imaging of transgenic 5XFAD mice after intravenous injection of <B>QAD1</B>, we show that this probe readily enters the blood brain barrier and provides high S/N ratio images of individual Aβ plaques <I>in vivo</I>. We also used <B>QAD1</B> in dual-color TPM imaging for 3D visualization of Aβ plaques along with blood vessels and cerebral amyloid angiopathy (CAA) inside living mouse brains. These findings demonstrate that this probe will be useful in biomedical applications including early diagnosis and treatments of AD.</P></▼2>
Heo, Jin Hyuck,Im, Sang Hyuk,Kim, Hi-jung,Boix, Pablo P.,Lee, Suk Joong,Seok, Sang Il,Mora-Seró,, Ivá,n,Bisquert, Juan American Chemical Society 2012 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.116 No.39
<P>The Sb<SUB>2</SUB>S<SUB>3</SUB>-sensitized photoelectrochemical cells (Sb<SUB>2</SUB>S<SUB>3</SUB>–SPECs) in cobalt electrolyte were fabricated by depositing Sb<SUB>2</SUB>S<SUB>3</SUB> on the macroporous TiO<SUB>2</SUB> nanorods electrodes and consecutively spin-coating P3HT (Poly-3-hexylthiophene) interlayer to relieve the mass transport problem at vicinity of Sb<SUB>2</SUB>S<SUB>3</SUB> and cobalt redox couples and reduce the backward recombination. Through the introduction of P3HT interlayer, we could greatly enhance the power conversion efficiency of Sb<SUB>2</SUB>S<SUB>3</SUB>–SPEC to 4.2% at 1 sun illumination, whereas the Sb<SUB>2</SUB>S<SUB>3</SUB>–SPEC without P3HT interlayer exhibits 3.2% of device efficiency. The electrochemical impedance analysis let us know that the improved device performance was mainly attributed to the reduced backward recombination building up the higher open circuit voltage.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2012/jpccck.2012.116.issue-39/jp305150s/production/images/medium/jp-2012-05150s_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp305150s'>ACS Electronic Supporting Info</A></P>
Heo, Jin Hyuck,Lee, Seung-Chul,Jung, Su-Kyo,Kwon, O-Pil,Im, Sang Hyuk The Royal Society of Chemistry 2017 Journal of materials chemistry. A, Materials for e Vol.5 No.39
<▼1><P>Highly efficient and thermally stable inverted MAPbI3 and FAPbI3−xBr<I>x</I> perovskite planar solar cells are demonstrated by using a <I>N</I>,<I>N</I>′-bis(phenylmethyl)naphthalene-1,4,5,8-tetracarboxylicdiimide (NDI-PM)-based electron transporting material (ETM) instead of a conventional PCBM-based ETM.</P></▼1><▼2><P>Highly efficient and thermally stable inverted CH3NH3PbI3 (MAPbI3) and HC(NH2)2PbI3−xBrx (FAPbI3−xBrx) perovskite planar solar cells are demonstrated by using a <I>N</I>,<I>N</I>′-bis(phenylmethyl)naphthalene-1,4,5,8-tetracarboxylic diimide (NDI-PM)-based electron transporting material (ETM) instead of a conventional fullerene-based phenyl-C61-butyric acid methyl ester (PCBM) ETM. The MAPbI3 and FAPbI3−xBrx devices with the NDI-PM-based ETM exhibit 18.4% and 19.6% power conversion efficiency under an illumination of 1 Sun (100 mW cm<SUP>−2</SUP>), respectively, which are comparable to the efficiency of PCBM ETM-based ones (18.9% and 20.0%). The improved thermal stability of NDI-based perovskite solar cells is attributed to much stronger hydrogen bonds in the NDI-PM molecular crystals than the PCBM crystals.</P></▼2>
Heo, Jin Hyuck,Shin, Dong Hee,Song, Dae Ho,Kim, Do Hun,Lee, Sang Jin,Im, Sang Hyuk The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.18
<P>Super-flexible bis(trifluoromethanesulfonyl)-amide (TFSA)-doped graphene transparent conducting electrode (GR TCE)-based FAPbI3 − xBrx perovskite solar cells with 18.9% power conversion efficiency (PCE) for a rigid device and 18.3% for a flexible one are demonstrated because the TFSA-doped GR TCE reveals high conductivity and high transmittance. The unencapsulated TFSA-doped GR TCE-based cell maintained ∼95% of its initial PCE under a continuous light soaking of 1 Sun at 60 °C/30% relative humidity for 1000 h. In addition, the TFSA-doped GR TCE-based flexible perovskite solar cells show excellent bending stabilities, maintaining PCEs of ∼85, ∼75, and ∼35% of their original values after 5000 bending cycles, at <I>R</I> = 12, 8, and 4 mm, respectively.</P>