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Papaverine이 저분극된 토끼 유두근의 수축력과 활동전압에 미치는 영향
임인자,조성일,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.3
In Partially deppolarized, isolated papillary muscle from rabbit heart, the effect of papaverine on contractile force and calcium mediated slow action potential was investigated. Results were as follows; 1. Papaverine induced the negative inotropic effect dose-dependently in the majority of preparations, although some preparations showed the opposite namely positive inotropic response. The significant correlation was found between the degree of depression in tension and increase that of in drug concentration. 2. The contractile force depressed by papaverine was restored by calcium(4 mM). 3. In partially depolarized papillary muscle, papaverine reduced slightly both action potential amplitude and upstroke velocity (dV/dt_max). The duration of action potential (duration of 90% repolarization) was also increased by papaverine in a dose-dependent manner. 4. The resting membrane potential was not altered in low concentrations (10^-7∼5X 10^-6M) of papaverine, however, it was significantly decreased in high concentration (10^-5∼5X 10^-5M) of the drug. The slightly increased overshoot potential was also observed in the above at high concentration range. From these results, it is suggested that in papillary muscle of rabbit heart, inhibitory effect of papaverine on the contractility may be attributable to its antagonistic action on the calcium current rather than its inhibitory effect on the phosphodiesterase activity. The local anesthetic property of the drug may also contribute to the papaverine induced decreases in both contractile force and upstroke velocity. The prolongation of action potential duration brought by papaverine appears to be induced not by increase in calcium currents but by a decrease in K^+ conductance.
조태웅,민영돈,김경종,정권율,강성인,류소연,임성철 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.1
Obturator hernia is a rare pelvic hernia, occuring most frequently in elderly, extra-thin or debilitated women. Because of the anatomic character of the obturator foramen and the nonspecific symptoms in the presence of the hernia, the risk of strangulation of the herniated bowel is high, which leads to high morbidity and mortality rate. The authors experienced an unusual case of left obturator hernia with strangulation of the small bowel in an 80-year old female. The hernia was diagnosed by abdomino-pelvic computed tomography (CT) scan. Through the lower midline transperitoneal approach, resecting the strangulated small bowel, the hernia sac was ligated and the obturator foramen was repaired using adjacent broad ligament. We report these findings with a brief review of the literature.
송근영,강길,박정희,김경종,민영돈,박치영,임성철 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2
Gastric small cell carcinoma(SCC) is defined as poorly-differentiated neuroendocrine tumor of the stomach, and their morphologic and biologic features arc similar to those of the lung. It is known that this tumor has poor prognosis even in early pathologic stage, It acounts for only 3% of all gastrointestinal SCC. that has been reported only 33 cases outside and 6 cases inside of the comitiy. Most of these reports are related to advanced gastric SCC. as pathologic stage IIIb or IV. This report describes a case of early gastric SCC. pathologic stage Ib.
The rice RING E3 ligase OsHIR1 participates in positive regulation of arsenic and cadmium uptake
Sung Don Lim,Jin Gyu Hwang,Cheol Seong Jang 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
The metalloid arsenic (As) and the hevy metal cadmium (Cd) are ubiquitously found at low concentrations in the earth, while high concentrations of the both elements in soil and crop are severe dangerous to human health. We have tried to retrieve RING E3 ligase gene, which is believed to regulate substrate proteins in As or Cd uptake via ubiquitin 26S proteasome pathway, related to inhibit metal ion transport system. A total of 48 rice RING E3 ligases were randomly selected and then conducted semi-quantitative RT-PCR for their expression patterns as exposed to As and Cd treatments. We discovered one gene, Oryza sativa heavy metal induced RING E3 ligase 1 (OsHIR1) that was significantly up-regulated against both treatments. A total of 31 positive interaction clones with OsHIR1 were screened depending on their strong α-galactosidase activity via yeast-two hybrid screen. Bimolecular fluorescence complementation analysis evidenced that the OsHIR1 protein was clearly interacted with each of six partner protein including aquaporin tonoplast intrinsic protein 4;1 (OsTIP4;1) in the plasma membrane. Protein degradation assay showed that OsHIR1 strongly degraded the protein level of OsTIP4;1 via ubiquitin 26S proteasome system. Heterogeneous overexpression of OsHIR1 in Arabidopsis showed As- and Cd-insensitive phenotype. In addition, the transgenic plant showed low levels of As and Cd accumulation than the control plant in leaf and root. Here, we report the novel finding that OsHIR1 E3 ligase positively regulates OsTIP4;1 related to As and Cd uptake.