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- 저자 : Suk-Won Chae (검색결과 315 건)
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Achieving tolerant CO<sub>2</sub> electro-reduction catalyst in real water matrix
Won, Da Hye,Shin, Hyeyoung,Chung, Min Wook,Jung, Hyejin,Chae, Keun Hwa,Oh, Hyung-Suk,Hwang, Yun Jeong,Min, Byoung Koun Elsevier 2019 Applied Catalysis B Vol.258 No.-
<P><B>Abstract</B></P> <P>In order to achieve practical application of electrochemical CO<SUB>2</SUB> conversion technologies, the development of durable catalyst in real water matrix is essential because the use of catalysts only showing high performance within a well-refined environment cannot guarantee their feasibility in realistic conditions. Here, we report a design strategy for a catalyst, which shows excellent tolerance to deactivation factors, using a carbon-based material under more practical condition implemented by real tap water. Screening analyses on various components in tap water elucidated that the impurity group, which can be deposited on the catalyst surface and impede the active sites, such as copper, zinc, and especially iron are the main factors responsible for deactivation. Based on these findings, the structural modified nitrogen-doped carbon nanotube (denoted as ball mill N-CNT) was adopted as a catalyst design to secure durability. Consequently, the ball mill N-CNT revealed tolerance to the disclosed deactivation factors and showed stable performance during unprecedented long-time of 120 h in tap water media.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Electro-reduction of CO<SUB>2</SUB> was performed in real water matrix (tap water) conditions. </LI> <LI> Iron was found to be the most detrimental element in silver catalyzed CO<SUB>2</SUB> electro-reduction. </LI> <LI> Nitrogen doped carbon based material was designed to be a stable model catalyst in real water. </LI> <LI> Stable performance was tested for an unprecedented long-time of 120 h in tap water media. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Won, Hye Sung,Maeng, Lee So,Chae, Hiun Suk,Kim, Hyung Keun,Cho, Young Suk,Kang, Jin-Hyoung,Jang, Hong Seok,Ryu, Mi-Ryeong The Korean Society of Gastroenterology; the Korean 2012 Gut and Liver Vol.6 No.2
<P><B>Background/Aims</B></P><P>The purpose of this study was to investigate the malignant potential of aberrant crypt foci (ACF) by measuring the multiplicity of crypts and lectin expression in the early and late stages of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis.</P><P><B>Methods</B></P><P>Six-week-old Wistar rats were injected subcutaneously with DMH for 27 weeks. We classified ACF according to the number of crypts per ACF as a few crypts (≤3 crypts, FC ACF) or numerous crypts (≥4 crypts, NC ACF). Immunohistochemistry was used to evaluate lectin expression.</P><P><B>Results</B></P><P>In the early stage, FC ACF (590/1,902, 31.0%) occurred more frequently than NC ACF (35/449, 7.8%); whereas in the late stage, NC ACF (176/449, 39.2%) occurred more frequently than FC ACF (324/1,902, 17.0%). The number of ACF peaked at 15 to 20 weeks. The ratio of NC/FC ACF increased gradually during carcinogenesis. The expression of both UEA1 and PNA was higher in NC ACF than FC ACF. Lectin expression increased in the late stage compared with the early stage.</P><P><B>Conclusions</B></P><P>The expression of lectin was higher in NC ACF and ACF in the late stage. Therefore, ACF with higher multiplicities in the late stage may have more malignant potential in DMH-induced colon carcinogenesis.</P>
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Won-Seok Chae,Chun-Nam Cha,Chang-Yeul Yoo,Suk Kim,Hu-Jang Lee 한국예방수의학회 2018 예방수의학회지 Vol.42 No.1
Highly pathogenic avian influenza virus (HPAIV) damages vital organs and tissues, frequently leading to death in birds, and causes serious economic losses in the poultry industry. In addition, HPAIV can infect humans and other mammals, often with fatal outcomes. In this study, the virucidal efficacy of Clean-Zone??, which contains citric acid, malic acid and phosphoric acid, against avian influenza virus (AIV, H9N2) was investigated. Virucidal efficacy was determined by examining the viability of AIV after contact with the disinfectant in the allantoic membrane of chicken embryos. The disinfectant and AIV were reacted under hard water (HW) and organic matter suspension (OM) condition. AIV was inactivated with 200- and 50-fold dilutions of the disinfectant under HW and OM conditions, respectively. As the disinfectant, Clean-Zone??, has a virucidal efficacy against AIV, it can be used to prevent the spread of animal viral diseases.
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Chae, Sun Young,Ahn, Sei Hyun,Kim, Sung-Bae,Han, Sangwon,Lee, Suk Hyun,Oh, Seung Jun,Lee, Sang Ju,Kim, Hee Jeong,Ko, Beom Seok,Lee, Jong Won,Son, Byung Ho,Kim, Jisun,Ahn, Jin-Hee,Jung, Kyung Hae,Kim, Elsevier 2019 LANCET ONCOLOGY Vol.20 No.4
<P><B>Summary</B></P> <P><B>Background</B></P> <P>A biopsy of first recurrence or metastatic disease is recommended to re-evaluate oestrogen receptor status in patients with breast cancer and to select appropriate treatment. However, retesting for oestrogen receptor status with rebiopsy is not always feasible, depending on lesion location and the risk associated with biopsy, and in these cases clinicians continue to treat patients according to the oestrogen receptor status of the primary tumour. Consequently suboptimal therapy might be offered to these patients. We assessed the diagnostic accuracy and safety of 16α-[<SUP>18</SUP>F]fluoro-17β-oestradiol (<SUP>18</SUP>F-FES) PET-CT to assess oestrogen receptor status in patients with recurrent or metastatic breast cancer.</P> <P><B>Methods</B></P> <P>We did a prospective cohort study at the Asan Medical Center, Seoul, South Korea. Eligible patients had breast cancer, with first recurrence or metastatic disease at presentation, were 19 years or older, and had an Eastern Cooperative Oncology Group performance status of 0–2. The primary objective was to show the agreement between qualitative <SUP>18</SUP>F-FES PET-CT interpretation and the results of oestrogen receptor expression by immunohistochemical assay, a non-reference standard test. Whole-body <SUP>18</SUP>F-FES PET-CT imaging was done after intravenous injection of 111–222 MBq of <SUP>18</SUP>F-FES, with dosing primarily determined by radiation dosimetry analysis. <SUP>18</SUP>F-FES uptake above background intensity was interpreted as positive. Efficacy was assessed in all patients with histologically confirmed recurrent or metastatic breast cancer who received <SUP>18</SUP>F-FES and had PET-CT images available (intention-to-diagnose analysis), and safety was assessed in all patients who received <SUP>18</SUP>F-FES. This study is registered with ClinicalTrials.gov, number NCT01986569.</P> <P><B>Findings</B></P> <P>Between Nov 27, 2013, and Nov 10, 2016, 93 patients were enrolled. Of the 85 patients included in the efficacy analysis, 47 (55%) were oestrogen receptor-positive and 38 (45%) were oestrogen receptor-negative. Positive status percent agreement between the <SUP>18</SUP>F-FES PET-CT results and oestrogen receptor status by immunohistochemical assay was 76·6% (95% CI 62·0–87·7) and the negative status percent agreement was 100·0% (90·8–100·0). Patients who were oestrogen receptor-positive and had a positive <SUP>18</SUP>F-FES PET-CT result had a significantly higher progesterone receptor expression than those who were oestrogen receptor-positive and had a negative <SUP>18</SUP>F-FES PET-CT result (23 [68%] of 34 patients <I>vs</I> 0 of 11 patients; p<0·0001). The most common adverse event was procedural pain in nine (10%) of 90 patients injected with <SUP>18</SUP>F-FES. No adverse events were related to the study drug except injection site pain in one (1%) patient. No serious adverse events were recorded.</P> <P><B>Interpretation</B></P> <P>The high negative percent agreement between <SUP>18</SUP>F-FES PET-CT and oestrogen receptor status by immunohistochemical assay in this cohort suggests that positive <SUP>18</SUP>F-FES uptake by recurrent or metastatic oestrogen receptor-positive breast cancer lesions could be an alternative to oestrogen receptor assays in this setting. Staging assessment should include <SUP>18</SUP>F-FES PET-CT when retesting oestrogen receptor status is not feasible.</P> <P><B>Funding</B></P> <P>Asan Institute for Life Sciences, Ministry of Health and Welfare, South Korea.</P>
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Won Sung Min,Lee Na Young,Oh Ki-Kwang,Gupta Haripriya,Sharma Satya Priya,Kim Kyung Hwan,Kim Byoung Kook,Joung Hyun Chae,Jeong Jin Ju,Ganesan Raja,Han Sang Hak,Yoon Sang Jun,Kim Dong Joon,Suk Ki Tae 한국미생물학회 2023 The journal of microbiology Vol.61 No.2
The progression and exacerbation of liver fibrosis are closely related to the gut microbiome. It is hypothesized that some probiotics may slow the progression of liver fibrosis. In human stool analysis [healthy group (n = 44) and cirrhosis group (n = 18)], difference in Lactobacillus genus between healthy group and cirrhosis group was observed. Based on human data, preventive and therapeutic effect of probiotics Lactobacillus lactis and L. rhamnosus was evaluated by using four mice fibrosis models. L. lactis and L. rhamnosus were supplied to 3,5-diethoxycarbonyl-1,4-dihydrocollidine or carbon tetrachloride-induced liver fibrosis C57BL/6 mouse model. Serum biochemical measurements, tissue staining, and mRNA expression in the liver were evaluated. The microbiome was analyzed in mouse cecal contents. In the mouse model, the effects of Lactobacillus in preventing and treating liver fibrosis were different for each microbe species. In case of L. lactis, all models showed preventive and therapeutic effects against liver fibrosis. In microbiome analysis in mouse models administered Lactobacillus, migration and changes in the ratio and composition of the gut microbial community were confirmed. L. lactis and L. rhamnosus showed preventive and therapeutic effects on the progression of liver fibrosis, suggesting that Lactobacillus intake may be a useful strategy for prevention and treatment.
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Won-Suk Chae,Chang-Yeul Yoo,Eun-Kee Park,Suk Kim,Hu-Jang Lee 한국예방수의학회 2019 예방수의학회지 Vol.43 No.4
The present study evaluated the repellent activity and the improvements in egg production and mortality rate on laying hens infested with poultry red mites (PRM) administered with a mixture of Korean traditional herbal methanolic extracts (CHE, Foeniculum vulgare : Sophora flavescens : Cinnamomum cassia : Glycyrrhiza glabra = 1:1:1:1, w/w/w/w). PRM numbers per laying hens in CHE-0.5 administered with CHE 0.5 kg/ton feed were significantly decreased compared to those in Non-CHE (control) during overall experimental periods (1st week post-treatment, p<0.05; 2nd week post-treatment, p<0.01; 3rd-4th week post-treatment, p<0.001). In CHE-1.0 administered with CHE 1.0 kg/ton feed, PRM numbers were significantly decreased compared to those in Non-CHE during the whole experimental periods (1st week post-treatment, p<0.01; 2nd-4th week post-treatment, p<0.001). After administration of CHE for 4 weeks, egg production and mortality rate in CHE-0.5 and CHE-1.0 were significantly improved compared to those in Non-CHE (p<0.05). In addition, hematological and blood biochemical parameters in all CHE-treated groups were insignificantly different compared to those in Non-CHE. This study showed that CHE (0.5 and 1.0 kg/ton feed) had a repellent activity on PRM in laying hens and effects on the improvement in egg production and mortality rate of laying hen. CHE could be an effective and safe candidate for the control of PRM and the improvement in egg production and mortality rate of laying hens.
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Effect of Ion-Pair Formation with Bile Salts on the In Vitro Cellular Transport of Berberine
Chae, Hye-Won,Kim, In-Wha,Jin, Hyo-Eon,Kim, Dae-Duk,Chung, Suk-Jae,Shim, Chang-Koo 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.1
The objective of this study was to examine the effect of ion-pair complexation with endogenous bile salts on the transport of a quarternary ammonium organic cationic (OC) drug, berberine, across the Caco-2 and LLC-PK1 cell monolayers. The basolateral-to-apical (BL-AP) transport of berberine in Caco-2 cells was temperature dependent and 10-fold higher than that of the apical-to-basolateral (AP-BL) transport. Similar results were observed for the transport of berberine across the LLC-PK1 cells. Moreover, the BL-AP transport in the Caco-2 cells was significantly reduced by the cis-presence of P-glycoprotein (P-gp) inhibitors such as cyclosporine A, verapamil, and digoxin. These results suggest that an efflux transporter, probably P-gp, is involved in the Caco-2 cell transport. The $K_m$ and $V_{max}$ values for the carrier-mediated transport were estimated to be 83.4 mM and 7640 pmole/h/$cm^2$, respectively. The apparent partition coefficient (APC) of berberine between n-octanol and a phosphate buffer (pH 7.4) was increased by the presence of an organic anion (OA), taurodeoxycholate (TDC, a bile salt), suggesting the formation of a lipophilic ion-pair complex between an OC (berberine) and an OA (TDC). Despite the ion-pair complexation, however, the BL-AP transport of berberine across the Caco-2 and LLC-PK1 cells was not altered by the cis-presence of bile salts or the rat bile juice. This is consistent with the reportedly unaltered secretory transport of a quarternary ammonium compound, tributylmethylammonium (TBuMA), across the Caco-2 cell monolayers in the cis-presence of bile salts or the rat bile juice, but not with our previous report in which the secretory transport of TBuMA across the LLC-PK1 cell was increased in the cis-presence of TDC. Therefore, the effect of ion-pair formation with the bile components or bile salts on the secretory transport of OCs appears to depend on the molecular properties of OCs (e.g., molecular weight, lipophilicity and affinity to relevant transporters) and the characteristics of cell strains (e.g., expression and contribution of responsible transporters to the transport).
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