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Ophthalmological manifestations in patients with Leigh syndrome
Han, Jinu,Lee, Young-Mock,Kim, Sang Myung,Han, So Young,Lee, Jong Bok,Han, Sueng-Han British Medical Association 2015 British journal of ophthalmology Vol.99 No.4
<P><B>Background</B></P><P>To describe the ophthalmological manifestations in patients with childhood onset Leigh syndrome (LS) and investigate the correlation between genotypes and phenotypes in patients with LS.</P><P><B>Methods</B></P><P>Childhood onset LS was clinically and enzymatically confirmed in a total of 63 patients. Among them, 44 patients who underwent ophthalmologic consultation were included in this study. Patients with LS underwent genotyping for the whole genome of mitochondrial DNA and SURF1 mutations. The clinical demographic and ophthalmologic phenotypes were compared between the good prognosis group and the poor prognosis group.</P><P><B>Results</B></P><P>Strabismus (40.9%) was the most frequently observed ophthalmologic manifestation, followed by pigmentary retinopathy (22.5%), optic atrophy (22.5%), ptosis (15.9%), and nystagmus (13.6%). Thirteen patients were exotropes and five patients were esotropes. The mean exodeviation was 29.6±12.5 prism dioptres (PD) and the mean esodeviation was 24.0±8.9 PD. All patients with esotropia reported disease onset at <1 year old. Among 26 patients older than 4 years, eight (30.8%) patients had better than 0.4 in the best eye was noted. Eyelid ptosis was a main presenting sign in four patients (9.1%). Among these patients, two patients had m.13513G>A mutation in the <I>MT-ND5</I> gene. Age at onset was 2.47±2.06 years in the good prognosis group and 0.92±0.98 years in the poor prognosis group (p=0.002). Serum lactate peak concentration was 3.23±1.36 mmol/L in the good prognosis group and 4.54±2.31 mmol/L in the poor prognosis group (p=0.051).</P><P><B>Conclusions</B></P><P>LS is a group of mitochondrial disorders with variable ophthalmologic manifestations, the most frequent being strabismus in this study. Ptosis could be an initial sign in patients with LS and these patients can be easily misdiagnosed as having juvenile myasthenia gravis.</P>
Retinal Nerve Fiber Layer Thickness is Decreased in Patients With Hematologic Malignancy
Han, Jinu,Kim, Ji Hyun,Yoo, Hanna,Han, Sueng-Han,Hong, Samin,Seong, Gong Je,Kim, Chan Yun Wolters Kluwer Health, Inc. All rights reserved. 2016 Journal of glaucoma Vol.25 No.3
<P>Purpose: To investigate whether retinal nerve fiber layer (RNFL) thickness is decreased in patients with hematologic malignancy using optical coherence tomography (OCT). Patients and Methods: This prospective, observational cross-sectional study included 65 eyes from 34 patients with hematologic malignancy and 72 healthy control eyes. OCT-measured RNFL thickness parameters (average, 4 quadrants, and 12 clock-hour thickness) and RNFL defect in red-free photo were compared between patients with hematologic malignancy and controls. Results: Among average, quadrant, and clock-hour map, the only 11-o'clock RNFL in patients with hematologic malignancy was statistically thinner than in controls (P=0.021). The RNFL defect was detected in 21/65 (32.3%) patients with hematologic malignancy and in 5/72 (6.9%) controls (P<0.001). In patients with hematologic malignancy, the mean RNFL thickness was significantly lower in the severe and moderate anemia groups compared with the mild anemia group (P=0.011). In the generalized estimating equations model, the mean hemoglobin level was associated with RNFL thickness while correcting for inter-eye correlation, age, and refraction error (coefficient=3.685, P=0.006). Conclusions: The RNFL defect was frequently observed, and the RNFL was thinner in severe anemic patients with hematologic malignancy. These results suggest that chronic anemia may be a factor of RNFL loss.</P>
전한별(Han Byeol Jeon),한승희(Sueng Hee Han),윤린(Rin Yun),김종만(Jong Man Kim),원종필(Jong Pil Won) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.5
The burning of fossil fuels is source of the incomplete combustion gas of CO and Nox, which occurs the global warming. Many international efforts have been done to prevent this global warming problem. The oxy-fuel combustion has emerged as one of the solutions to decrease the incomplete combustion gas. The Oxy-fuel combustion shows the about 30% energy savings compared to the normal air combustion, and the combustion products are only H₂O and CO₂. The basic design data for air heater was obtained by an experiments with the pure oxygen for combustion, and the heat transfer area of the air heater was calculated by using the data. The optimum tube array of the air heater was determined by using the commercial CFO program.
한승훈 ( Sueng Hun Han ),임순길 ( Soon Gill Lim ),박재우,김정수 ( Jung Soo Kim ),김판수 ( Pan Soo Kim ),오병진 ( Byung Jin Oh ) 대한무도학회 2011 대한무도학회지 Vol.13 No.2
본 연구는 최대 운동 후 산소 농도를 달리한 회복법이 생리적 피로 요인에 미치는 영향을 알아보기 위해 남자유도선수 10명 대상으로 탈진적인 유산소운동을 실시 후 1차 실험에 대기산소 농도와 같은 21%, 2차 실험에 30%, 3차 실험에 90%의 고농도산소를 15분씩 섭취 시켜 안정시, 운동후, 회복 30분, 회복 90분에 혈중산소농도, 혈압, 젖산, 암모니아를 검사한 결과 혈중산소포화는 산소 농도 30%와 90% 집단이 21%집단에 비해 회복 90분더 높은 혈중산소포화도를 보였으나 유의한 차이는 검증할 수 없으며, 수축기 혈압과 이완기 혈압 모두 산소농도를 21%, 30%, 90%로 달리 하여 섭취한 결과 유의한 차이는 검증 할 수 없었다. 젖산은 회복 30분에 산소농도 90%집단이 21%와 30%집단 보다 낮으나 집단간 유의한 차이는 검증할 수 없으나, 집단과 시기 간에 상호작용은 있는 것으로 나타났다. 암모니아는 최대운동 후 산소농도를 21%, 30%, 90%로 달리 하여 섭취한 결과 유의한 차이는 검증 할 수 없었다. 최대운동 후 휴식시 섭취하는 고농도 산소는 젖산에서 나타난 집단과 시가간의 상호작용을 나타내었으나, 산소농도차이에 따른 혈중산소농도, 혈압, 암모니아의 유의한 차이는 발견할 수 없었다. 이러한 원인으로는 평소 고강도 훈련을 실시하는 유도선수들임으로 신체 에너지 보유량이나 회복능력이 빠른 점과 본 연구에서 측정한 혈중산소농도, 혈압, 젖산, 암모니아는 운동 후 빠른 대사가 이루어져 유용한 변화를 검증 할 수 없었을 것으로 생각되어진다. In this study, blood oxygen concentration, blood pressure, lactic acid, and ammonia are investigated at the states of stable, after performing exercise, recovery for 30 minutes, and recovery for 90 minutes by applying highly concentrated oxygen of 21% as the same as atmosphere oxygen concentration in the first experiment, 30% for the second experiment, and 90% for the third experiment after performing exhaustive aerobic exercises for the subjects, 10 male Judo players, in order to investigate the influence of a recovery method that varies oxygen concentrations after completing maximum exercise. In the results of this investigation, although the groups that apply oxygen concentrations of 30% and 90% represent higher blood oxygen saturation than the group, which applies oxygen concentration of 21%, for the recovery for 90 minutes, it is not possible to verify their significant differences. Also, it is difficult to verify the significant difference in the blood oxygen saturation according to the change in oxygen concentrations, such as 21%, 30%, and 90%, for systolic and diastolic blood pressures. In the case of the lactic acid, although the group that applies oxygen concentration of 90% shows lower oxygen concentration than the groups that apply oxygen concentrations of 21% and 30% for the recovery for 30 minutes, it is not possible to verify a significant difference between groups. However, there are some interactions between the groups and the times. In the ammonia, it is difficult to verify the significant difference in taking oxygen by varying its concentrations, such as 21%, 30%, and 90%, after performing maximum exercise. In addition, there are no significant differences in oxygen intake concentrations at a recovery period after performing maximum exercise as well as blood oxygen concentration, blood pressure, lactic acid, and ammonia. The results are due to the fact that Judo players have a high physical energy level and a fast recovery rate because they have high intensity training in their normal times. In addition, it is considered that the verification of the significant change in some factors measured in this study, such as blood oxygen concentration, blood pressure, lactic acid, and ammonia, is difficult because such factors represent fast metabolism after performing exercise.