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- 저자 : Steven J.T. Jackson (검색결과 2 건)
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Steven J.T. Jackson,Keith W. Singletary,Laura L. Murphy,Richard C. Venema,Andrew J. Young 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.1
Phytonutrients have rapidly emerged as natural food chemicals possessing multifaceted biological actions thatmay support beneficial health outcomes. Among the vast array of phytonutrients currently being studied, sulforaphane, curcumin, quercetin, and resveratrol have been frequently reported to stimulate the expression of endogenous detoxification enzymes and may thereby facilitate the neutralization of otherwise harmful environmental agents. Some of these same phytonutrients, however, have also been implicated in disrupting normal cell proliferation and hence may possess toxic properties in and of themselves. In this study, we characterize the respective minimum threshold concentrations of the aforementioned phytonutrients in Hepa1c1c7 cells that stimulate NAD(P)H:quinone oxidoreductase (NQO1), a key enzyme in the hepatic neutralization of menadione, other biological oxidants, and some environmental carcinogens. Moreover, our findings demonstrate that relatively low concentrations of either sulforaphane or curcumin significantly (P < .05) increase NQO1 protein expression and activity without triggering G2/M cell cycle arrest or mitotic catastrophe. The minimal quercetin concentration inducing NQO1, however, was 100-fold higher than that which disrupted mitosis. Also, while resveratrol modestly stimulated NQO1, the minimally effective resveratrol concentration concomitantly induced evidence of cellular apoptosis. Taken together, these findings indicate that only particular phytonutrients are likely efficacious in upregulating NQO1 activity without also leading to hepatic cytotoxicity.
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Reaping What You Sow : Agriculture PAC Punishment Over the China Trade Vote
David J. Jackson,Steven T. Engel 한국공공정책학회 2005 공공정책연구 Vol.19 No.-
Business PACs are thought likely to follow safe strategies with regard to their direct campaign contributions and to seek to develop long-term relationships with powerful members of Congress whose voting records support the interests of the PACs. Both of these traditional approaches, believed to be prevalent among business PACs (the access and electoral/ideological strategies), share the common characteristic of deep interest in the voting records of members of Congress. While access to the powerful is important, it is unlikely agribusiness PACs would give large contributions to members who consistently oppose their preferences on important legislation.
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