http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Sunmi,Eom, Soyong,Kim, Hai-Joong,Lee, Jeong Jae,Choi, Gyuyeon,Choi, Sooran,Kim, Sungjoo,Kim, Su Young,Cho, Geumjoon,Kim, Young Don,Suh, Eunsook,Kim, Sung Koo,Kim, Seunghyo,Kim, Gun-Ha,Moon, Hyo-B Elsevier 2018 Science of the Total Environment Vol.624 No.-
<P><B>Abstract</B></P> <P>Exposure of the developing fetus and infants to toxic substances can cause serious lifelong health consequences. Several chemicals have been associated with adverse neurodevelopmental disorders in the early life stages of humans. However, most epidemiological studies have focused on a limited number of chemicals, and hence may exclude important chemicals from consideration or result in conclusions built on associations by chance. In the present study, we investigated the chemical exposure profile of the women, and associated these with the early neurodevelopmental performance of their offspring at 13–24months of age. The chemicals assessed include four phthalates, bisphenol A, three heavy metals, 19 polychlorinated biphenyls (PCBs), 19 organochlorine pesticides, and 19 polybrominated diphenyl ethers, which were measured from urine, whole blood, serum, and/or breastmilk of the pregnant or lactating women. For neurodevelopmental performance, the Bayley Scales of Infant Development-II (BSID-II), Social Maturity Scale (SMS), and Child Behavior Checklist (CBCL) were measured from a total of 140 toddlers. Among the measured chemicals, monoethyl phthalate (MEP) in maternal urine was significantly associated with early mental, psychomotor, and social development. In addition, breast milk di-ethylhexyl phthalate (DEHP) metabolite and blood lead concentrations were inversely associated with mental and psychomotor development indices, respectively. Maternal blood PCB153, heavy metals, and urinary MEP levels were also higher among the children with behavioral problems, as indicated by the CBCL range. Taken together, maternal exposure to several EDCs such as PCBs and DEHP was associated with adverse neurodevelopmental performances among the children aged 1–2years. Confirmation of these association in larger populations, as well as longer-term consequences of such exposure warrant further investigation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Prenatal Hg, Pb, BPA, or DEP exposures were associated with neurodevelopmental delay. </LI> <LI> DEHP exposure through lactation showed negative association with mental index. </LI> <LI> Prenatal Hg, DEP, or PCB exposures showed positive associations on CBCL scores. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Sunmi,Lee, Jangwoo,Park, Jeongim,Kim, Hai-Joong,Cho, Geum Joon,Kim, Gun-Ha,Eun, So-Hee,Lee, Jeong Jae,Choi, Gyuyeon,Suh, Eunsook,Choi, Sooran,Kim, Sungjoo,Kim, Sung Koo,Kim, Young Don,Kim, Su You Elsevier 2017 The Science of the total environment Vol.607 No.-
<P><B>Abstract</B></P> <P>Phthalates are important group of endocrine disruptors. Infants and young children are susceptible to phthalate exposure. However, information on the phthalate exposure during the early stages of life is very limited. This study was conducted to understand the temporal trend of exposure to major phthalates among infants of Korea during the first 15months after birth, and to estimate associated risks. A total of 286 urine samples were collected from 171 children at 3, 9, 12, or 15months of age, with 77 children sampled for two or more times. Four phthalates, i.e., di(2-ethylhexyl) phthalate (DEHP), di-isobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP), and diethyl phthalate (DEP) were chosen, and their major metabolites were analyzed in the urine. The DEHP metabolites were detected in 100% of the urine samples at relatively higher levels compared to those reported in other countries. The levels of mono-ethyl phthalate (MEP) were generally lower. Urinary concentrations of most phthalate metabolites, especially DEHP metabolites, increased as children grew older. Intra-class correlation coefficients (ICCs) calculated for DEHP metabolites over time were high (0.7–0.8), suggesting persistence of consistent exposure sources during this sensitive period of life. Hazard quotient (HQ) and hazard index (HI) were calculated from daily intake estimates divided by recommended toxicity thresholds. Among the study population, 4, 16, and 26% of the children showed HI >1 at 9, 12, and 15months of age, respectively. DEHP exposure explained most of the risk estimates. Considering vulnerability of young children to endocrine disruption, efforts to identify sources of exposure and to develop appropriate mitigation options are warranted.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Multiple urines were collected at 3, 9, 12, or 15months of age from 171 children. </LI> <LI> High intra-individual correlation and age-dependent increase were observed. </LI> <LI> Up to 26% of children showed hazard index >1 by exposure to target phthalates. </LI> <LI> Estimated risks are mostly due to the exposure to DEHP and DnBP. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Jin Hee,Park, Hyunkyung,Lee, Jangwoo,Cho, Geumjoon,Choi, Sooran,Choi, Gyuyeon,Kim, Su Young,Eun, So-Hee,Suh, Eunsook,Kim, Sung Koo,Kim, Hai-Joong,Kim, Gun-Ha,Lee, Jeong Jae,Kim, Young Don,Eom, So BMJ Publishing Group 2016 Journal of epidemiology & community health Vol.70 No.5
<P><B>Background</B></P><P>Several studies have suggested potential links of phthalates to obesity in children and adults. Limited evidence, however, has been available for the relations between diethylhexyl phthalate (DEHP) and obesity-related markers or body mass change in early life.</P><P><B>Methods</B></P><P>128 healthy pregnant women were recruited and, after delivery, their newborns’ first urine and umbilical cord blood samples were collected. We measured urinary levels of two DEHP metabolites, mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP). We also measured the levels of leptin, total cholesterol and triglyceride (TG) in cord serum, and used them along with weight, length, head circumference and ponderal index (PI, 100 g/cm<SUP>3</SUP>) at birth, as obesity-related markers, and estimated the relations between DEHP metabolites and obesity-related markers using generalised linear models. For the evaluation of body mass increase by early life DEHP exposure, body mass index (BMI) z-score change during 3 months after birth by DEHP metabolites in the first urine samples of the newborns were evaluated using logistic regression.</P><P><B>Results</B></P><P>DEHP exposure was associated with decrease of PI and increase of TG (PI, β=−0.11, p=0.070 and TG, β=0.14, p=0.027), especially for boys (PI, β=−0.13, p=0.021; and TG, β=0.19, p=0.025). Moreover, DEHP exposure was positively associated with body mass increase during 3 months after birth (change of BMI z-scores, OR=4.35, p=0.025).</P><P><B>Conclusions</B></P><P>Our findings suggest that DEHP exposure may affect body mass change in early life through changes of obesity-related markers.</P>
Kim, Johanna Inyang,Yun, Je-Yeon,Park, Heyeon,Park, Suk-Young,Ahn, Youngsheen,Lee, Hansol,Kim, Tae-Kwon,Yoon, Sooran,Lee, Young-Joon,Oh, Sohee,Denninger, John W,Kim, Bung-Nyun,Kim, Jeong-Hyun JMIR Publications 2018 Journal of medical Internet research Vol.20 No.10
<P><B>Background</B></P><P>Videoconferencing-based treatments have shown great potential in increasing engagement and compliance by decreasing the barriers of time and distance. In general, employees tend to experience a lot of stress, but find it difficult to visit a clinic during office hours.</P><P><B>Objective</B></P><P>The purpose of this study was to investigate the effectiveness of a mobile videoconference-based intervention for stress reduction and resilience enhancement in employees.</P><P><B>Methods</B></P><P>In total, 81 participants were randomly allocated to one of the three conditions: mobile videoconferencing, in-person, and self-care; of these, 72 completed the study. All participants underwent assessment via self-reported questionnaires before, immediately after, and 1 month after the intervention. Intervention lasted for 4 weeks and consisted of elements of cognitive behavioral therapy, positive psychology, and meditation. Changes in clinical variables regarding stress and resilience across time were compared between treatment conditions.</P><P><B>Results</B></P><P>There were significant condition × time effects on variables measuring perceived stress, resilience, emotional labor, and sleep, demonstrating significantly differential effects across time according to treatment condition. Moreover, there were significant effects of condition on perceived stress and occupational stress. There were no significant differences in any variable between the mobile videoconferencing and in-person conditions at 1 month after the intervention.</P><P><B>Conclusions</B></P><P>Results indicate that both mobile videoconferencing and in-person interventions were comparably effective in decreasing stress and enhancing resilience. Further studies with a larger sample size and a longer follow-up period are warranted to investigate the long-term effect of mobile videoconferencing interventions.</P><P><B>Trial Registration</B></P><P>ClinicalTrials.gov identifier NCT03256682; https://clinicaltrials.gov/ct2/show/NCT03256682 (Archived by WebCite at http://www.webcitation.org/71W77bwnR)</P>
Kim, Sunmi,Park, Jeongim,Kim, Hai-Joong,Lee, Jeong Jae,Choi, Gyuyeon,Choi, Sooran,Kim, Sungjoo,Kim, Su Young,Lee, Duk Hee,Moon, Hyo-Bang,Kim, Sungkyoon,Choi, Kyungho American Chemical Society 2015 Environmental science & technology Vol.49 No.13
<P>Exposure to several persistent organic pollutants (POPs) has been linked to alteration of lipid metabolism. Adipokines, such as leptin and adiponectin, are hormones that play roles in lipid metabolism, and have been suggested as markers of health effects that may lead to obesity. To date, only serum adipokines have been associated with POPs exposure. In the present study, for the first time, the associations between leptin and adiponectin in breast milk, and several POPs in serum were investigated among 82 lactating Korean women between 25 and 46 years of age. Breast milk adipokines are important because adipokine intake of infant through breastfeeding may influence the growth of infants. The median concentrations of leptin and adiponectin in skimmed milk of the Korean lactating women were 17.9 ng/L and 16.5 μg/L, respectively. Leptin concentrations in breast milk were negatively associated with ∑hexachlorohexane (HCH), oxychlordane, ∑chlordane, or 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB 153) levels in maternal serum. Linear relationships between adiponectin and POPs concentrations were not observed, however, nonmonotonic relationship which showed generally positive associations was suggested for <I>p</I>,<I>p</I>′-dichlorodiphenyltrichloroethane (DDT) and ∑chlordane in quartile analysis. Our observations show that POPs at the current level of exposure may be associated with the alteration of lipid metabolism among lactating women. Implication of adipokine transfer to breastfed infants is of concern and deserves further investigation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/esthag/2015/esthag.2015.49.issue-13/acs.est.5b00520/production/images/medium/es-2015-00520t_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/es5b00520'>ACS Electronic Supporting Info</A></P>