갱년기 여성의 호르몬 대치 요법에 대한 수용율

이임순,장진영,이정재,이순곤,이권해,이해혁,김승형 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Purpose: We have evaluated the compliance of hormone replacement therapy. Method: There are 185 climacteric women who are divided into three groups (Group I, Group II, Group III). Group I is given conjugated equine estrogen(CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate(MPA, 5mg, day 1-12). Group II is given conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 2.5mg, day 1-30), Group III is given only conjugated equine estrogen(CEE, 0.625mg, day 1-30). Results: 1) The compliance rate of hormone replacement therapy during three months is 77.9% including each Group I : 77.7%, Group Ⅱ : 76.1%, Group Ⅲ :80.4%. 2) The compliance rate of hormone replacement therapy during six months is 60.7% including each Group Ⅰ:52.9%, Group Ⅱ: 56.4%, Group Ⅲ: 79.5%. 3) The compliance rate of hormone replacement therapy during nine months is 49.7% including each Group Ⅰ: 45.5%, Group Ⅱ:41.7%, Group Ⅲ: 64.3%. 4) The compliance rate of hormone replacement therapy during a year is 44.4% including each Group Ⅰ: 40.2%, Group Ⅱ:35.3%, Group Ⅲ: 59.5%. Conclusion : It is vital that we maximize compliance if patients are to receive the full benefits from hormone replacement therapy. We think that physicians who prescribe hormone replacement therapy for climacteric women should enough explain the purpose, risks, and side effect of treatment for maximizing compliance of hormone replacement therapy.

정신분열증과 우울증의 지각결핍의 비교

이수형,송경의,이형영,하형욱 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.4

정신분열증 환자의 지각결핍을 타 질환군과 비교해 보기 위하여 1983.6.1부터 동년 8월 31일 까지 전남의 대병원 정신과 외래에 다니는 우울증 환자 20명 국립나주정신병원에 입원한 정신분열증 환자 20명을 임의 선택하여 Garner의 모형을 이용 카드 분류를 시행하고 그 자료를 토대로 수정분류시간, 공제지수, 비율지수 등을 산출하여 변량분석한 결과 다음과 같은 결론을 얻었다. 1. 양 군의 수정시간을 변량 분석한 결과 유의한 차이를 발견할 수 없었다. 2. 공제지수와 비율지수를 변량분석한 결과 과다성 분류와 여과분류에서는 공제지수와 비율지수에서 아무런 유의차가 없었다. 3. 주사분류에서는 공제지수 비교에서 1% 수준에서 비율지수 비교에서 5% 수준으로 우울증의 분류시간이 긴 것으로 나타났다. 이상의 결과를 살펴볼 때 여과기능의 결함이라는 지각결핍은 정신분열증의 고유한 장애가 아닐 수도 있겠다. The perception of stimuli with two dimensions (size and figure) was investigated using Garners card sorting method into schizophrenic and depressive patients. The comparison of three performance indices (redundancy, filltering, scanning) between two study groups revealed that 1) the analysis of variance of the corrected time shows no significant difference between two groups, 2) in redundancy and filtering sorting the subtractive and ratio indices show no significant difference between two groups, 3) in scanning sorting the depressive group shows significantly longer sorting time than schizophrenic group(p<0.01 in subtractive index, p>0.05 in ratio index). The above findings suggest that the previously known perceptual deficit(mainly filtering deficit) may not be specific only to schizophrenia.

지역사회 정신의학 전공의 교육과정 실태조사

홍진표,황순찬,이영문,이선형,신나리,이종일,박종익,장동원,정인원 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1

Objectives : There is a increasing need to recruit and retain more psychiatrists who can plan and implement organized programs to work with chronic mentally ill patients in community settings. The aim of study is to discover what training is currently in place to prepare psychiatrist for work in "community" or "public" settings. Methods : Survey questionnaires were mailed to 85 residency training directors and 10 leaders of community mental health in 2005. Response rate was 75%. Results : Academic seminar about community mental health were not administered to residents in 63% of training hospitals. Forty one out of 64 training hospitals had community mental health rotation programs, Community mental health center (50%) and day hospital (36%) were the most common type of programs. Few general hospital had affiliation with community mental health programs. The amount of time for clinical rotation varied from less than three months part time to 6 months fulltime, with most frequent form of one day per week for three month in second or third year of psychiatry residents. Conclusion : Further steps are needed to improve residency training curricula and to encourage well qualified psychiatrist to choose careers in community psychiatry.

폐폴리우레탄 폼을 이용한 유출유 흡수

이현구,김형순 한국공업화학회 2003 응용화학 Vol.7 No.1

This study investigate the effectiveness of rigid and flexible waste polyurethane foams for oil spills clean up. For the two types of the waste foams used as a sorbent, rigid sandwich panel foam and high density auto seat foam were selected, respectively. The sorption test of the above foams were performed in different types of petroleum products, and in the presence and absence of water as well. Finally, the same experiments were carried out in simulated seawater bath in order to estimate that actual sorption properties in the sea. In the case of rigid polyurethane foam, the sorption properties that the sorbent materials had, were poorer as compared with the flexible foam except floating ability, which showed good sorption properties not only in floating ability, but also in initial sorption rate and maximum sorption capacity.

마이크로 컴퓨터를 이용한 과학교육 실험 학습방안에 관한 연구(1) : 정량적 연속변화법을 이용한 화학 양론의 학습

이대형,신순임 春川敎育大學 1990 論文集 Vol.30 No.-

肝吸蟲成蟲의 白鼠 腹腔內 注入에 關한 實驗的 硏究

李純炯 중앙대학교 의과대학 의과학연구소 1979 中央醫大誌 Vol.4 No.1

The present experimental study was undertaken to observe the chronological changes of the pathological findings of the liver when fifty adult worms of Clonorchis sinensis were inoculated to each rat intraperitoneally. The pathological changes of the liver were investigated by conventional microscopy in the 5 groups, each group consisted of 5 rats, classified by the duration of observation period, i. e., 4, 10, 28, 56 and 180 days. The results obtained were summarized as follows. 1. Histopatologically the liver failed to show any parasitic worm inside the intrahepatic biliary system. However, multiple well formed egg-containing granulomas were present along the liver capsule. The worms recovered on the surface of the liver capsule were degenerated and necrotized. 2. Portal widening and focal phlebitis together with vascular dilatation were most common features seen in the liver. Occasionally, focal necrosis was also observed. 3. The bile duct in the liver showed mild dilatation of the lumen, epithelial of lining epithelium and periductal small round cell infiltration. Neither adenomatous hyperplasia nor portal fibrosis was seen in the whole experimental group.

夏眠이 만손住血吸蟲 感染 Biomphalaria glabrata에 미치는 影響

李純炯,宋哲鏞 중앙대학교 의과대학 의과학연구소 1975 中央醫大誌 Vol.1 No.1

To elucidate the changes and differences in Schistosoma mansoni infected snails, Biomphalaria glabrata, during the process of estivation, the growth rate, survival rate, and histopathological findings were observed during the 22 weeks experimental period. Two groups of snails, each group consisted of 36 snails, were used for the present experiment. One group of snails carrying S. mansoni infection (Group Ⅱ) was underwent 18 weeks of estivation while other group of S. mansoni infected snails was applied as control group (Group Ⅰ) and reared in the water. The results obtained were as follows: 1. The growth rates (increase in shall diameter and wet weight) of estivating snails (Group Ⅱ) were consistently lower than those of their control snails (Group Ⅰ) kept in water. 2. The growth rates rose rapidly when the estivating snails were put into water for 4 weeks, after 18 weeks of estivation. No shedding of cercariae was observed among those exposed, estivating snails, when they were put into water again. 3. The survival rate of estivating snails (Group Ⅱ) was lower than their control (Group Ⅰ) from the beginning to 13th week of experiment, but since then they showed little difference. 4. The histopathological changes were observed in the hepatopancreas, ovotestes, seminal vesicle, kidney and restal ridge of above snails which belong to both Group Ⅰ and Group Ⅱ. In general, the reduction of parenchyme and degenerative pictures were prominently observed during the estivation (Group Ⅱ), whereas destructive and degenerative pictures by the compression of invaded cercariae were monitored in control snails (Group Ⅰ).

島山 安昌浩의 理想村 建設 運動 : 새마을運動과 관련하여

李淳珩 제주대학 1975 논문집 Vol.7 No.1

Dosan Ahn Chang-ho was a politician who had devoted his life to the independence movement of the people under the oppression of Japan. He was a thinker who had great ability in administration and idea of national salvation for the permanent prosperity of the Korean people. Especially he was a man of thought and practice with all his heart to national education in Korea. He thought that powerlessness of the people had caused the country to fall and that it was impossible for our nation to become independent and prosperous without power. Therefore to develop the fundamental power of the people and to strive for unity is to build his independence movement. He evolved the political struggle since the year of 1907 with Shin Min Society, Kuk Min Society of the Korean people in America and the Provisional Government in China, and he organized the Young Korean Academy, Heung Sa Dan for training talents necessary to the independence. He established educational facilities, Dae Sung ScHool and undertook activities of the national renovation through education. Particularily he felt keenly the necessity of the fundamental idea of national salvation and built many times the independence movement base ill foreign countries. It was a long term plan preparing for the independence struggle with military of officers' training school. It was for building up the economic and educational base of compatriots in foreign countries and for leading the almost permanent safe life in the Shelter regions where independence patriots were roaming. Here, he would train the national power through education in many fields, training talents, economy, military, art and science. This was called the Model Village, fundamental base of the independence movement. He tried to carry out the plan centering around China, front North Manchuria to Wha-book and Wha-Nam in China as the proposed site. In 1932, he was arrested by the Japanese police, and built the model villages near P'yang to renovate Korea but they didn't come true. But first of all the Model Village movement was the half permanent base of life of compatriots in foreign countries, secondary it was the training base of talents, thirdly it was an educational movement of the local plan which they tried to extend accross the nation to form the modern rural community. He built up the comportable model village combined with social various functions, and he tried to renovate Korea. From the keynote of the comportable Model Village it is in touch with the Saemaul Movement. It was the cultivation movement for developing social various fields to train the leadership which is necessary to the village community with building up the collective village aiming at the development of education and economy. So we can say that the SaeMaul Movement is the realization of the idea of the Model Village. The Saemaul Movement rests on three bases of spiritual development of the people, the betterment of living attitude, industralization through the economic and social development to lead the national and cultural life. On the contrary the Model Village Movement was the social education movement to extend effectively, which people with the sane and sound mind, as the conscious factor of the people (spirit development), cooperate with each other, going through the rational farming and vocational life (economy development), and rational life showing that community enjoys culturally sense of welfare (social development). Especially the kernel of the Model Village was for training men of ability in the vocational schools. He prospected the new history creation by renovating human spirit and human attitude with the rational reconstruction or social development. He took a serious view of human factors by developing history rather than by changing poltical and social organization. Then it will be his excellent methodology, and coincide with the position of scholars who have discussed modernization and social development, stressing on human factor by developing society. Therefore the Model Village Movement, social development movement which has attached importance to talents training will be high estimated now. It will be developed and succeeded to the Saemaul Movement, which is the idea of promoting the country in our history.

^14C-Lactate를 利用한 肝吸蟲의 自記放射法的 硏究

李喆性,李純炯 중앙대학교 의과대학 의과학연구소 1977 中央醫大誌 Vol.2 No.1

The distribution of the exogenous ^14C-lactate by chinese liverfluke Clonorchis sinensis was investigated by autoradiography. The radioactive substance, Sodium DL-lactate-1-^14C (specific activity 20-40mCi/mM), was obtained from Radiochemical Center, England and this labeled compound was dissolved in Tyrode solution at the concentration of 2.5μCi/ml. This solution was designated as incubation medium. Twenty worms of healthy fluke were incubated in 25 ml Erlenmeyer flask with 10ml of incubation medium. This flask was maintained for 1 hour in Dubnoff shaking incubator at 37℃. After incubation, the flukes were rapidly removed from the flask and freed of exteranl radioactivity by a series of washing in cold Tyrode solution. These flukes were fixed in 10% formalin, dehydrated and embedded in paraffin, and were sectioned at the thickness of 5 microns. Then the specimen mounted slides were covered with Kodak AR-10 stripping film and were exposed for 30 days in cold dark room. After the exposure, the autoradiographs were developed in Kodark D-19 and fixed in Kodark acid fixer. Autoradiographs were then stained with hematoxylin and brought to microscopy. The autoradiographs of C. sinensis showed that there were apparent densities of black silver grains derived from ^14C-lactate in regard to various anatomical structures of the worm. The highest densities of black grains were found in the seminal vesicle and spermatic ducts, subparenchymal cells, pharynx, intestinal epithelium, vitellaria and ovary. Moderate amount of radioactivity was also monitored in the tegument, oral sucker, ventral sucker, intestinal contents, and testes. A week concentration of silver grains can be seen in the reticular tissue, uterus and eggs, spermatheca and the content of seminal vesicle. The possible reasons for the appearance of radioactive substance in respective organs and tissues of this fluke were discussed.

난소적출과 에스트로젠 투여가 백서의 하악골 구조에 미치는 영향

이형순,홍성규,김정기 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.1

본 실험은 폐경기 골다공증 여성의 교정치료에서 일어날 수 있는 하악골의 구조의 변화와 에스트로젠 투여 효과를 추정하기 위한 연구의 일환으로 난소를 적출한 군과 에스트로젠 투여 및 비투여군으로 분류하고 미세방사선사진으로 하악골을 촬영하여 이의 골 면적을 측정하고 조직 변화를 관찰하였다. 생후 4개월된 Sprauge-Dawley계 백서 50마리를 난소적출(OVE)군, 난소적출 후 에스트로젠 투여(OVE-EST)군, sham operation 시행후 에스트로젠 투여(EST)군으로 분류하여 각군을 수술후, 5주, 6주, 7주째 희생시켜 하악골을 적출한 후 좌측 하악골은 비탈회표본으로 제작하여 미세방사선사진을 통해 해면골을 관찰하고 면적을 측정하였으며 우측 하악골은 탈회표본으로 제작하여 병리조직학적인 소견을 관찰하여 다음 과 같은 결과를 얻었다. 1. 하악골의 전체골면적에 대한 피적골의 비율분석에서 OVE군, OVE-EST군, EST군 모두에서 통계적으로 유의한 변화가 없었다. 2. OVE군은 대조군에 비해 5, 6, 7주째로 갈수록 골수강의 비율이 증가하였는데(p<0.05), 백서의 난소제거가 하악골에서도 골소주를 소실시켜 골수강을 확장시켰다. 3. OVE-EST군은 5주째는 골수강의 비율이 약간 증가되어 있었으나 점차 감소하여 7주째에 유의하게 적었고(p<0.05), EST군은 6주째부터 골수강의 비율이 현저히 감소되었는데 (p<0.05), 에스트로젠이 골수강의 크기를 감소시키는 효과가 있음을 알수 있었다. 4. 미세방사선사진과 병리조직학적 소견상 OVE군에서 골수강들의 크기가 확정되었고 파골세포들이 불규칙한 변연부에서 다수 관찰된 반면, OVE-EST군은 점점 치밀해지는 골소주들로 골수강이 작아지는 양상을 나타냈고, EST군에서는 풍부하고 치밀한 골소주들로 골수강들의 크기가 작아졌다. The purpose of this study was to evaluate the changes of cancellous and cortical bone and the effect of estrogen in ovariectomized rats. Fifty female rats, 250gm in body weight, were divided into three groups : ovariectomized group(OVE), ovariectomized and estrogen-injected group(OVE-EST), and sham operated and estrogen-injected group(EST). Bilateral ovariectomy was performed at the onset of the experiment. In OVE-EST group and EST group, estrogen was injected 50μg/kg B. W. every other days from 3 weeks after surgery to sacrifice. Each five rats were sacrificed after 5, 6, 7 weeks. One side of mandibular body was radiographed with a soft x-ray apparatus(Hitex Co., Ltd., Japan ). Thereafter the obtained microradiographs were used for the morphometric analysis using a Image analyzer. The morphometric analysis was performed for parameters such as total bone area. cortex bone area and medullary bone area. The other side of the mandibular bone was decalcified and embedded in paraffin as using a general method. The specimens were sectioned and stained with Mallory`s anilline blue and observed light microscopically. The results were as follows. 1. In all groups, the proportion of cortex to total bone area was not significantly different. 2. In ovariectomized(OVE) group, the proportion of marrow cavity to medullary bone area increased significantly from 5 to 7 weeks (p<0.05). In ovariectomized and estrogen-injected(OVE-EST) group, it decreased significantly at 7 weeks, and in estrogen-injected(EST) group, it decreased significantly from 6 weeks(p<0.05). 3. Microradiogram and histopathologic findings revealed that marrow cavity was enlarged and osteoclasts were observed around irregular bone surface in OVE group. In OVE-EST group, the size of marrow cavity at 7 weeks was similar to that of control group. In EST group, as dense trabecular bone increased from 5 to 7 weeks, marrow cavity decreased.