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유방암에서 종양의 크기와 액와림프절 전이의 상관성을 근거로 한 액와림프절 절제술의 생략
송근영,조현진,김권천 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2
Purpose: The aim of this study is evaluation of the relations between axillary lymph node status and tumor size, and then applied the omission criteria of axillary lymph node dissection in early breast cancer. Materials and Methods: We reviewed 110 patients underwent radical mastectomy and axillary lymph node dissection in breast cancer at Chosun university Hospital between Feb. 1996 and Mar. 2003. We evaluated the correlations between clinicopathologic factors, axillary lymph node status, and presence of metastasis. Results: Correlations between clinicopathologic factors and axillary lymph node status were statistically significant (p=0.01). Correlation between locoregional metastasis and distant metastasis and axillary lymph node status was significant (p=0.03). Results from the number of histologically-positive lymph nodes were significant (p=0.02) as that of lymph node status. Conclusions: The rate of axillary lymph node metastasis in Tla breast cancer is minute. And, preoperative evaluations and postoperative routine radiation therapy can control the axillary lymph node metastasis in Tla breast cancer. So, omission of the axillary lymph node dissection in Tla breast cancer may be considerable.
사람폐암세포주 (PC-14)에서 Cyclosporin A에 의한 Adriamycin 내성의 극복
김영환,홍원선,송재관,강윤구,이진오,강태웅,김건열,한용철 대한내과학회 1990 대한내과학회지 Vol.38 No.3
Cyclosporin A and verapamil were tested using MTT assay to evalute the modification effect on the resistance to adriamycin in a human lung cancer cell line(PC-14) and its resistant subline(PC-14/A). PC-14/A was derived by the continuous exposure of PC-14 to incremental concentrations of adriamycin. PC-14/A was 2.5 times more resistant to adriamycin in terms of ICso than PC-14. Cyclosporin A alone, at a concentration of 2.5㎍/㎖, inhibited the growth of PC-14 to 68.3%. 2.5㎍/ ㎖ and 5.0㎍/㎖ of cyclosporin A showed an increase in the cytotoxicity of adriamycin (p<0.01) with 5.0㎍/㎖ being greater than 2.5㎍/㎖(p<0.01). Excluding the direct cytotoxic effect, however, cyclosporin A did not increase in the sensitivity of PC-14 to adriamycin but only showed an additional cytotoxic effect with adriamycin. Verapamil (up to 6.0㎍/㎖) did not inhibit the growth of PC-14. 3.0㎍/㎖ of verapamil did not increase the cytotoxic effect of adriamycin. The combination of cyclosporin A and verapamil with adriamycin enhanced the cytotoxicity of adriamycin, but the result was similar to that of cyclosporin A with adriamycin. 5.0㎍/㎖ of cyclosporin A modified the adriamycin resistance of PC-14/A(SR, 3.2). However, 3.0㎍/㎖ of verapamil did not significantly reverse the adriamycin resistance of PC-14/A. The modified effect of the combination of 5.0㎍/㎖ of cyclosporin A and 3.0㎍/㎖ of verapamil was similar to that of 5.0㎍/㎖ of cyclosporin A alone in PC-14/A. These results demonstrate that cyclosporin A has an additional cytotoxic effect with adriamycin in PC-14 and PC-14/A and has overcome the acquired resistance to adriamycin in PC-14/A. They also suggest that cyclospoin A may have the therapeutic potential in the treatment of human lung cancer.
Stress Analysis of an Underground Steel Pipeline Considering Corrosion Defect
Weon-Keun Song,Jong-Woo Rhee 한국강구조학회 2006 International Journal of Steel Structures Vol.6 No.3
This paper examines a problem in the interaction betwen a soil medium that experiences frost heave and thaw settlementconsidering a corrosion pit on a pipe wal. The comparative analysis of the theory and the actual performances was valuablein that it established a level of confidence in the aplication of the introduced theory to the field. The numerical results showthe influence of frost heave and thaw settlement of a granite soil medium on a temperature-dependent stress field on a wallof a pipeline buried in South Korea.
Chang Weon Song,Mi Young You,Damin Lee,Hyoung Seok Mun,Seohan Kim,Pung Keun Song 한국표면공학회 2020 한국표면공학회지 Vol.53 No.5
The change of the deposition behavior of diamond through a pretreatment process of the base metal prior to diamond deposition using HFCVD was investigated. To improve the specific surface area of the base material, sanding was performed using sandblasting first, and chemical etching treatment was performed to further improve the uniform specific surface area. Chemical etching was performed by immersing the base material in HCl solutions with various etching time. Thereafter, seeding was performed by immersing the sanded and etched base material in a diamond seeding solution. Diamond deposition according to all pretreatment conditions was performed under the same conditions. Methane was used as the carbon source and hydrogen was used as the reaction gas. The most optimal conditions were found by analyzing the improvement of the specific surface area and uniformity, and the optimal diamond seeding solution concentration and immersion time were also obtained for the diamond particle seeding method. As a result, the sandblasted base material was immersed in 20% HCl for 60 minutes at 100 °C and chemically etched, and then immersed in a diamond seeding solution of 5 g/L and seeded using ultrasonic waves for 30 minutes. It was possible to obtain optimized economical diamond film growth rates.