Comparable oncologic outcome of minimally invasive pancreaticoduodenectomy for common bile duct cancer compared with open pancreaticoduodenectomy: A propensity score matched analysis

Kyungchul LEE,Woohyung LEE,Yejong PARK,Jae Woo KWON,Eunsung JUN,Ki Byung SONG,Jae Hoon LEE,Seo Young PARK,Song Cheol KIM 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.-

Cushing syndrome with acute kidney injury due to ureteral stones in a 6-year-old boy

Song Kyungchul,권아름,Suh Junghwan,Choi Han Saem,채현욱,김호성 대한소아내분비학회 2020 Annals of Pediatirc Endocrinology & Metabolism Vol.25 No.4

Cushing syndrome (CS) is rare in children. The clinical presentation of CS varies according to extent and duration of glucocorticoid excess, and urolithiasis is a common complication. We report the first case of a patient with CS associated with acute kidney injury (AKI) due to urolithiasis. A 6-year-old boy presented to the Emergency Department with seizure. On physical examination, he had clinical features of CS and high blood pressure. Brain computed tomography (CT) suggested posterior reversible encephalopathy syndrome due to hypertension. On evaluation of hypertension, laboratory tests suggested adrenocortical tumor, but abdominal CT suggested pheochromocytoma. During further evaluation, his condition deteriorated with AKI due to bilateral ureteral stones, for which the patient underwent continuous renal replacement therapy in the intensive care unit. After controlling hypercortisolism with etomidate and performing ureteral stent indwelling, an adrenal mass was resected and histologically confirmed as an adrenocortical adenoma. We review the clinical manifestations, diagnosis, and management of CS associated with urolithiasis and AKI. Early recognition and careful monitoring of urolithiasis in CS patients are important to avoid severe complications of urolithiasis.

Nonalcoholic fatty liver disease and insulin resistance in children

Kyungchul Song,Ho-Seong Kim,Hyun Wook Chae 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.12

Nonalcoholic fatty liver disease (NAFLD), a spectrum of liver diseases characterized by excessive fat accumulation, is the leading cause of chronic liver disease. The global prevalence of NAFLD is increasing in both adults and children. In Korea, the prevalence of pediatric NAFLD increased from 8.2% in 2009 to 12.1% in 2018 according to a national surveillance study. Forearly screening of pediatric NAFLD, laboratory tests including aspartate aminotransferase and alanine aminotransferase; biomarkers including hepatic steatosis index, triglyceride glucose index, and fibrosis-4 index; and imaging studies including ultrasonography and magnetic resonance imaging are required. Insulin resistance plays a major role in the pathogenesis of NAFLD, which promotes insulin resistance. Thus, the association between NAFLD and insulin resistance, diabetes mellitus, and metabolic syndrome has been reported in many studies. This review addresses issues related to the epidemiology and investigation of NAFLD as well as the association between NAFLD and insulin resistance and metabolic syndrome with focus on pediatric NAFLD

Testing Conditional Independence: Martingale Transforms and Bootstrap 1

Kyungchul Song 한국계량경제학회 2007 한국계량경제학회 학술대회 논문집 Vol.2007 No.2

This paper investigates the problem of testing conditional independence of Y and Z given (X) for some 2 R d ; for a parametric function ( ): First, this paper proposes several classes of asymptotic pivotal tests that are based on Rosenblatt transforms and establishes that against certain alternatives of generic nature, a martingale transform can be employed to improve the asymptotic power of the tests in terms of limiting Pitman e¢ ciency. The martingale transform applied here is extremely simple, causing almost zero additional computational cost. Second, this paper proposes wild bootstrap procedures applied to Rosenblatt transform-based tests and Rosenblatt-martingale transform-based tests. Third, this paper …nds that even when one knows exactly the conditional distribution functions used in the test statistics, using their nonparametric estimators improves the asymptotic power in terms of limiting Pitman e¢ ciency. Lastly, the …nite sample performances of the proposed tests are compared via a Monte Carlo simulation study.

Functional conservation of polo kinases in both budding yeast and human

Song Sukgil,Lee Chong-kil,Chung Yoen Bok,Hong Jin Tae,Sung Heyran,Han Kyungchul 대한약학회 2004 大韓藥學會 總會 및 學術大會 Vol.2004 No.2

급경사지방재를 위한 급경사지정보 및 지하공간정보 DB 구축과 활용 방안 연구

이경철(Kyungchul Lee),장용구(Yonggu Jang),송지혜(Jihye Song),강인준(Injoon Kang) 한국지반환경공학회 2014 한국지반환경공학회논문집 Vol.15 No.7

최근 우면산 산사태, 춘천지역 산사태, 황령산 터널 입구 산사태 등 국내의 급경사지 붕괴에 따른 사고가 빈번히 발생하고 있으며, 그 규모가 점차 커지고 있는 추세이다. 또한 이에 따른 인명?재산피해가 증가하고 있다. 이에 따라 소방방재청에서는 급경사지 방재를 위한 DB 구축을 통하여 급경사지 붕괴 예측 및 신속한 대응체계 구축을 위한 급경사지 통합관제시스템 구축을 추진하고 있다. 급경사지 방재와 관련된 정보로는 급경사지 일제조사서를 기반으로 한 사면정보와 지반, 지질 등의 지하공간정보가 있으며, 이 중 국가재난관리시스템을 통한 텍스트 기반의 간단한 급경사지 정보 외 나머지 정보는 구축되어 있지 않아 급경사지 방재DB 구축이 매우 시급한 실정이다. 따라서 본 연구에서는 급경사지 방재 DB 구축방법과 활용방안을 제시하였다. 급경사지 방재DB 중 급경사지 일제조사서 기반의 사면 DB는 기존 일제조사서의 문제점 분석을 개선한 급경사지 일제조사서를 기반으로 하는 웹 급경사지 입력시스템을 통한 DB 구축방법을 제시하였으며, 지하공간정보의 경우 국토교통부(국토지반정보 통합 DB 센터)와 소방방재청(국가지진방재 통합정보시스템) 사이의 지하공간정보 실시간 연계체계로 관리되는 지진방재용 지하공간정보 중 급경사지 부분의 지하공간정보 DB 구축방법을 제시하였다. 또한 급경사지 방재 DB의 활용방안은 현재 소방방재청에서 구축 중인 U-IT기반의 급경사지 통합관리시스템, 급경사지 붕괴 위험도 판단시스템 등으로의 활용방안을 제시하였다. Recently, a great number of natural disasters have more frequently happened than the past. The National Emergency Management Agency of Korea has made preparation for the integrated management system of steep slope lands. There is information based on the steep slope inspection sheets and the underground spatial information related to the prevention against steep slope disasters. Nevertheless, building a complete DB System to prevent the hazards and secure the safeties should be urgently dealt with. It is mainly because the information of the National Disaster Management System is restricted to the text-based brief data. Therefore, the purpose of this study is to suggest the method as to building steep slope DB system for disaster prevention and maximizing the availabilities. This study shows the way of building a web-based DB system having its root in the steep slope inspection sheets. The method of establishing the ideal DB system that has liaisons between the Ministry of Land, Infrastructure and Transport and the National Emergency Management Agency is discussed in this study. Furthermore the optimization of DB utilization will assist the various integrated steep slope management systems based on U-IT which are ongoing projects.

급경사지 방재 및 관리를 위한 급경사지정보 통합관리시스템 개발

이경철(Kyungchul Lee),장용구(Yonggu Jang),송지혜(Jihye Song),강인준(Injoon Kang) 한국지반환경공학회 2014 한국지반환경공학회논문집 Vol.15 No.9

현재 소방방재청에서는 국가재난관리시스템(NDMS, National Disaster Management System)을 운영 중에 있으나 급경사지 정보의 입력 및 관리를 위한 기능이 단순한 DB 입력?관리 기능으로 존재하고 있어 신속하고 체계적인 급경사지 관리에 어려움이 존재하고 있는 실정이다. 최근 빈번한 국지성 집중호우에 의한 우면산 산사태, 춘천 산사태 등의 대규모 산사태가 증가하고 있어 급경사지의 위험도가 급증하고 있으며, 국가 재해?재난이 빠른 추세로 증가하고 있다. 이에 대한 선제적 대응 및 관리의 고도화를 위해서는 급경사지 방재 및 관리를 위한 GIS 기반의 급경사지정보 통합관리시스템의 개발이 필요하다. 본 연구에서는 급경사지 재해?재난에 대한 선제적 대응 및 안전한 관리를 위한 국가 차원의 GIS 기술 기반의 급경사지정보 통합관리시스템을 개발하였다. 급경사지정보 통합관리시스템은 급경사지 일제조사서기반의 지표면정보와 지하공간정보의 입력 및 출력 DB를 설계?구축하여 개발하였다. 본 연구를 통하여 개발한 급경사지정보 통합관리시스템은 지표면정보 입력모듈, 급경사지 주변 지하공간정보 DB 실시간 연계 입력모듈, V-World 배경지도 기반의 급경사지 검색?분석?관리를 위한 GIS 모듈, 급경사지정보 통합정보시스템 사용자 관리모듈, 급경사지정보 활용 연계시스템과의 실시간 연계 인터페이스모듈로 구성된다. 또한 개발한 급경사지정보 통합관리시스템에 대하여 자료저장률, 동시접속 시 시스템 안정성, 처리속도의 일관성에 대한 안정성테스트를 수행하여 급경사지정보 통합관리시스템의 연결성을 확보하였다. Recently, the National Emergency Management Agency of Korea has been operating the National Disaster Management System. Nevertheless, there are numerous difficulties in systematic controlling the steep slope DB promptly, because the system’s functions in input and control for steep slope information are merely simple. Futhermore, the hazard degrees of steep slope lands nowadays have risen suddenly in accordance with the increase rate of large scale landslides such as the landslide cases of Umyeonmountain, Chuncheon province and others or sever rain storm cases. these lead to rapid increases in frequencies of nature disasters nationally. therefore, it is needed to develop the GIS-based integrated management system for steep slope information in order to manage disasters in advance or high-degree control. This study shows the national GIS-based integrated management system to prevent the disasters that caused by steep slope lands. The integrated management system developed in this study consists of surface information input modules, realtime DB liaison modules of integrated underground information, V-world background map-based GIS, integrated management system for steep slope information user modules, realtime liaison interface modules designed for utilizing steep slope information. Also, tests about stability of data storage, system stability and consistency of processing speed were performed.

Painful Hashimoto Thyroiditis in a 7-Year-Old Girl: Differential Diagnosis and Medical Treatment

( Gihong Park ),( Kyungchul Song ),( Hyun Joo Shin ),( Hyun Wook Chae ) 대한갑상선학회 2021 International Journal of Thyroidology Vol.14 No.1

Painful Hashimoto thyroiditis (HT) is a rare pediatric condition. Because of the rarity of painful HT, it can be misdiagnosed as other thyroid diseases, and there is limited evidence regarding its clinical course and treatment. A 7-year-old girl presented to the emergency room with neck pain. A physical examination revealed diffusely enlarged thyroid gland with firm consistency and without tenderness. Her serum free thyroxine level was decreased and levels of thyroid-stimulating hormone, thyroglobulin antibody, and thyroid-stimulating antibody were elevated. The ultrasonography revealed a diffusely enlarged thyroid gland with homogeneously hypoechoic parenchyma and lobulated contours. She was diagnosed with painful HT based on the clinical presentations, laboratory tests, and ultrasonography findings, and was treated with a steroid, levothyroxine, and nonsteroidal anti-inflammatory drugs, after which her clinical symptoms improved dramatically. We should consider the possibility of painful HT in children with neck pain; HT could be treated with medical treatment.

A case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma in a 15-year-old boy

Seo Youngseok,Song Kyungchul,Choi Han Saem,Suh Junghwan,Kwon Ahreum,Chae Hyun Wook,Kim Ho-Seong 대한소아내분비학회 2020 Annals of Pediatirc Endocrinology & Metabolism Vol.25 No.3

Hypercalcemia due to primary hyperparathyroidism (PHPT) is uncommon in children. PHPT is typically caused by a single parathyroid adenoma. Ectopic parathyroid adenomas account for 6%–16% of all parathyroid adenomas and are rare in children but should be considered in cases that present with hypercalcemia. We report the case of a 15-year-old boy with PHPT due to an intrathymic ectopic parathyroid adenoma. Neck ultrasonography and Tc-99m-sestamibi (MIBI) scanning with single-photon emission computed tomography/computed tomography (SPECT/CT) revealed ectopic parathyroid adenoma in the thymus. Video-assisted thoracoscopic surgery was performed to remove the ectopic parathyroid adenoma. Pathology showed intrathymic ectopic parathyroid adenoma. After surgery, the patient’s serum calcium level immediately normalized. Intact parathyroid hormone (iPTH) and alkaline phosphatase levels returned to normal ranges within 3 months. Delayed diagnosis of PHPT can cause end-organ damage; a timely diagnosis is especially critical to preserve bone and renal function. If ectopic parathyroid adenomas are well localized in preoperative imaging evaluation and intraoperative iPTH level decreases after resection, ectopic parathyroidectomy without bilateral neck exploration may be performed to avoid unnecessary morbidity.

Feedback 신호의 계단변화를 이용한 발전기 제어계 응동특성 연구

임익헌(Ickhun Lim),김경철(KyungChul Kim),박철우(Chulwoo Park),이주영(Juyung Lee),송서용(Seoyong Song),윤재호(Jaeho Yoon),이형찬(Hyungchan Lee) 대한전기학회 2019 대한전기학회 학술대회 논문집 Vol.2019 No.4