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( Sonali Gupta ),( Surinder P. Singh ),( Rajni Singh ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.5
We have synthesized gold nanoparticles (GNPs) using chicken feathers (poultry waste) and Bacillus subtilis RSE163. Disulfide reductase and keratinase produced by Bacillus subtilis during the degradation of chicken feather has been used to reduce Au3+ from HAuCl4 precursor to produce gold nanoparticles. The synthesized biogenic GNPs were characterized by UV-visible spectroscopy, transmission electron microscopy (TEM), and zeta potential measurements. Fourier transform infrared (FTIR) spectroscopy indicated the presence of protein capping on synthesized GNPs, imparting multifunctionality to the GNP surface. Furthermore, the nontoxic nature of biogenic GNPs was insured by interaction with Escherichia coli (ATCC11103), where TEM images and enhancement of growth rate of E. coli in log phase signified their nontoxic nature. The results indicate that the synthesis of biocompatible GNPs using poultry waste may find potential applications in drug delivery and sensing.
Rahul Sinha(Rahul Sinha ),Sonali Singh(Sonali Singh ),Gautam Kamila(Gautam Kamila ),Ashish Upadhyay(Ashish Upadhyay ) 대한소아신경학회 2022 대한소아신경학회지 Vol.31 No.1
Purpose: This study investigated the diagnostic utility of short-term video electroencephalography (EEG) recordings at a tertiary care center in North India. Methods: A retrospective analysis was conducted of 30 minutes of video EEG recordings done between January 2021 and January 2022 in children between 1 and 10 years of age. Demographic and clinical data were collected from the EEG register. Age, sex, the clinical diagnosis, the number of anti-seizure medicines (ASMs), the activation procedures used, and EEG abnormalities were recorded. Results: Data from 100 children (male-to-female ratio, 1.9:1) were analysed. The mean age was 5.39±2.02 years. The indications for EEG recordings were epileptic disorders, neurodevelopmental disorders, paroxysmal non-epileptic events, and miscellaneous in 66%, 18%, 9%, and 7% of children, respectively. EEG abnormalities were seen in 50 children (50%) and about 45% of children were on two or more ASMs. EEG abnormalities in sleep were seen in 35 of 66 (53%) children, whereas abnormalities were observed on awake recordings with activation procedures (hyperventilation and photic) in 23 of 34 (68%) children; this difference was not statistically significant (P=0.16) Conclusion: EEG abnormalities were significantly more common in children taking multiple ASMs; however, there was no statistically significant difference in the EEG yield between asleep and awake records with activation procedures. A better selection of patients for routine EEG, through an assessment of their clinical history and comorbidities, is warranted to increase its diagnostic yield.
Kochhar, Sonali,Excler, Jean-Louis,Bok, Karin,Gurwith, Marc,McNeil, Michael M.,Seligman, Stephen J.,Khuri-Bulos, Najwa,Klug, Bettina,Laderoute, Marian,Robertson, James S.,Singh, Vidisha,Chen, Robert T Elsevier Ltd. 2019 Vaccine Vol. No.
<P><B>Abstract</B></P> <P>Live viral vectors that express heterologous antigens of the target pathogen are being investigated in the development of novel vaccines against serious infectious agents like HIV and Ebola. As some live recombinant vectored vaccines may be replication-competent, a key challenge is defining the length of time for monitoring potential adverse events following immunization (AEFI) in clinical trials and epidemiologic studies. This time period must be chosen with care and based on considerations of pre-clinical and clinical trials data, biological plausibility and practical feasibility. The available options include: (1) adapting from the current relevant regulatory guidelines; (2) convening a panel of experts to review the evidence from a systematic literature search to narrow down a list of likely <I>potential or known</I> AEFI and establish the optimal risk window(s); and (3) conducting “near real-time“ prospective monitoring for <I>unknown</I> clustering’s of AEFI in validated large linked vaccine safety databases using Rapid Cycle Analysis for pre-specified adverse events of special interest (AESI) and Treescan to identify previously unsuspected outcomes. The risk window established by any of these options could be used along with (4) establishing a registry of clinically validated pre-specified AESI to include in case-control studies. Depending on the infrastructure, human resources and databases available in different countries, the appropriate option or combination of options can be determined by regulatory agencies and investigators.</P>
Link Prediction for Authorship Association in Heterogeneous Network Using Streaming Classification
Harshal Singh,Divya Tomar,Sonali Agarwal 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.4
Prediction of links or relations between the objects in any network is no longer a new task these days; in fact it has become a high rated area of research and has attracted many researchers seeking their contribution to the mentioned area. Research has seen an exponential growth over the passing years, and the active researchers do not hesitate in linking with fellow researchers working in same domain irrespective of their geographic location. However this in turn has generated a very complex network of objects and links which are needed to be analyzed and dealt with. Prediction of co-authorship is the sub domain of link prediction and with the increasing complexity of co-authorship network the authors are treated as heterogeneous entity not as homogeneous ones. The rule is simple analyze the data preprocess it, train the classifier according to desired classification rules and then get the classified form of data. But irrelevant features always reflect various impacts and issues on generation of a classifier and consequently the impact is sustained to further classification results. Therefore, this paper proposes streaming classification algorithm combined with Correlation based Feature selection as a solution to the stated problem. The consistent and relevant features are selected with the help of feature selection algorithm and then these features are classified with the help of streaming classification algorithm- Very Fast Decision Tree (VFDT). VFDT is a streaming classification algorithm and it takes the dataset in the form of continuous stream as an input. Finally the effectiveness of the proposed algorithm can be seen in the experimental results.
Rahul Sinha,Dharmesh Soneji,Gautam Kamila,Sonali Singh,Ashish Upadhyay 대한소아신경학회 2023 대한소아신경학회지 Vol.31 No.3
Purpose: The present study investigated the clinical profile of children with primary headache at a tertiary care center in North India. Methods: A retrospective observational study was conducted between January 2021 and October 2022. In total, 100 children 5 to 18 years of age who attended the pediatric outpatient department or the emergency department with primary headache were included. Children with secondary causes of headache were excluded. Results: This study included 100 children (40 boys, 60 girls), and the female-to-male ratio was 1.5:1. The patients ranged in age from 5 to 18 years (mean±standard deviation, 10.1±2.8). Migraine headaches were most commonly reported (60%) followed by tension-type headache (28%) and others (12%). The throbbing type of pain was most common (43%), followed by the tightening type in 32%. The pain location was bilateral frontal in 47% of patients, followed by bitemporal in 20% and occipital in 17%. Most of the children (87%) had a headache duration of 2 to 4 hours. The common precipitating factors were skipped meals (25%), bright light (18%), lack of sleep (16%), and schoolwork (15%). A family history was present in around 62%. Around 70% of children required prophylactic medications (flunarizine and propranolol). Long screen time (2 to 4 hours/day) and a family history of headache were significantly associated with primary headache (P<0.05). Conclusion: The present study highlights that migraine is most common cause of primary headache in children, and every effort should be made for the early detection and management of headaches among children.
Rahul Sinha,Ankit Kumar Meena,Maneesh Uniyal,Sonali Singh,Ashish Upadhyay 대한소아신경학회 2024 대한소아신경학회지 Vol.32 No.1
Purpose: This study aimed to evaluate the knowledge, attitudes, and practices (KAP) of parents or caregivers of children suffering from migraines at a tertiary care center in North India. Methods: We conducted a cross-sectional study involving 100 parents or caregivers, using convenience sampling. A 20-item questionnaire was administered in English and also translated into the local language (Hindi). The study included children with migraines who visited the pediatric outpatient department within a 6-month period (December 2022 to May 2023). Results: Over 60% of caregivers were aware of the chronic nature of the illness, its triggering factors, the role of family history, and the importance of lifestyle modifications. However, only 46% understood the pathophysiology of the illness, and 53% were aware of the medication used for childhood migraines. More than 85% of caregivers believed that recurrent headaches necessitate a doctor’s consultation, may require regular visits for optimal treatment, and were willing to alter their child’s lifestyle to prevent headaches. However, a significant percentage of caregivers (47%) practised self-medication for their children’s headaches. Most caregivers believed that lifestyle modifications and avoiding triggers were the best treatments for migraines. There were significant associations (P<0.05) between the level of education and responses to questions related to migraine definition, prophylaxis, treatment, investigations, lifestyle modifications, and screen time. Conclusion: Most participants were well-educated on migraine, and their KAP regarding migraine prevention and treatment were generally adequate. However, the practice of self-medication without professional guidance is a significant concern.
Integrin-Mediated Interactions Control Macrophage Polarization in 3D Hydrogels
Cha, Byung-Hyun,Shin, Su Ryon,Leijten, Jeroen,Li, Yi-Chen,Singh, Sonali,Liu, Julie C.,Annabi, Nasim,Abdi, Reza,Dokmeci, Mehmet R.,Vrana, Nihal Engin,Ghaemmaghami, Amir M.,Khademhosseini, Ali Wiley (John WileySons) 2017 Advanced healthcare materials Vol.6 No.21